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Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders Volume 5, 2004 - Issue sup1

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Study design

Improving efficiency of ALS clinical trials using lead‐in designs

Dan H Moore IICorrespondence[email protected]

Robert G Miller

Pages 57-60 | Published online: 10 Jul 2009

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https://doi.org/10.1080/17434470410019997

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Grizzle JE. The two-period cross-over design and its use in clinical trials, Biometrics 1965; 21:467–480.
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Piantadosi S. Clinical Trials. A Methodologic Perspective. John Wiley & Sons, Inc. New York, 1997.
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Pinheiro JC, Bates DM. Mixed-Effects Models in S and S-PLUS. Springer, New York, 2000.
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Miller RG, Moore DH, Barohn RJ et al. Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis. Neurology 2001; 56: 843–848.
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