Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations

References

• Azim SA, Darwish HA, Rizk MZ, Ali SA, Kadry MO. 2015. Amelioration of titanium dioxide nanoparticles-induced liver injury in mice: possible role of some antioxidants. Exp Toxicol Pathol 67:305–14
   PubMed Web of Science ®Google Scholar
• Bachler G, von Goetz N, Hungerbuhler K. 2015. Using physiologically based pharmacokinetic (PBPK) modeling for dietary risk assessment of titanium dioxide (TiO2) nanoparticles. Nanotoxicology 9:373–80
   PubMed Web of Science ®Google Scholar
• CBS (Central Bureau for Statistics, the Netherlands). 2014. Levensverwachting; geslacht en leeftijd, vanaf 1950 (per jaar) [Life expectancy; gender and age, from 1950 (per year)] [Online]. Available at: http://statline.cbs.nl/StatWeb/publication/?VW=T&DM=SLNL&PA=37360NED&D1=3&D2=a&D3=0&D4=20-l&HD=130212-0832&HDR=T,G2,G1&STB=G3. Accessed on 12 July 2015
   Google Scholar
• Chen Z, Wang Y, Zhuo L, Chen S, Zhao L, Luan X, et al. 2015. Effect of titanium dioxide nanoparticles on the cardiovascular system after oral administration. Toxicol Lett 239:123–30
   PubMed Web of Science ®Google Scholar
• Cho WS, Kang BC, Lee JK, Jeong J, Che JH, Seok SH. 2013. Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration. Part Fibre Toxicol 10:9
   PubMed Web of Science ®Google Scholar
• Disdier C, Devoy J, Cosnefroy A, Chalansonnet M, Herlin-Boime N, Brun E, et al. 2015. Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat. Part Fibre Toxicol 12:27
   PubMed Web of Science ®Google Scholar
• ECHA (European Chemicals Agency) 2012. Guidance on information requirements and chemical safety assessment. Chapter R.8: Characterization of dose [concentration]-response for human health. Version 2.1. Helsinki: ECHA [Online]. Available at: http://echa.europa.eu/documents/10162/13632/information_requirements_r8_en.pdf. Accessed on 12 July 2015
   Google Scholar
• EFSA (European Food Safety Authority). 2004. Opinion of the Scientific Panel on Food Additives, Flavorings, Processing Aids and materials in Contact with Food on a request from the Commission related to the safety in use of rutile titanium dioxide as an alternative to the presently permitted anatase form. Question No. EFSA-Q-2004-103. EFSA J. 163:1–12
   Google Scholar
• Elgrabli D, Beaudouin R, Jbilou N, Floriani M, Pery A, Rogerieux F, Lacroix G. 2015. Biodistribution and Clearance of TiO2 Nanoparticles in Rats after Intravenous Injection. PLoS One 10:e0124490
   PubMed Web of Science ®Google Scholar
• FDA (Food and Drug Agency). 2015. Summary of Color Additives for Use in the United States in Foods, Drugs, Cosmetics, and Medical Devices [Online]. Available at : http://www.fda.gov/forindustry/coloradditives/coloradditiveinventories/ucm115641.htm. Accessed on 12 July 2015
   Google Scholar
• Geraets L, Oomen AG, Krystek P, Jacobsen NR, Wallin H, Laurentie M, et al. 2014. Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats. Part Fibre Toxicol 11:30
   PubMed Web of Science ®Google Scholar
• Gui S, Sang X, Zheng L, Ze Y, Zhao X, Sheng L, et al. 2015. Retraction note: intragastric exposure to titanium dioxide nanoparticles induced nephrotoxicity in mice, assessed by physiological and gene expression modifications. Part Fibre Toxicol 12:22
   PubMed Web of Science ®Google Scholar
• Iavicoli I, Leso V, Fontana L, Bergamaschi A. 2011. Toxicological effects of titanium dioxide nanoparticles: a review of in vitro mammalian studies. Eur Rev Med Pharmacol Sci 15:481–508
   PubMed Web of Science ®Google Scholar
• Iavicoli I, Leso V, Bergamaschi A. 2012. Toxicological effects of titanium dioxide nanoparticles: a review of in vivo studies. J Nanomaterials 2012:1–36
   Web of Science ®Google Scholar
• JECFA (Joint FAO/WHO Expert Committee on Food Additives). 1970. Specification for the identity and purity of food additives and their toxicological evaluation. Some food colors, emulsifiers, stabilizers, anticaking agents, and certain other substances. Thirteenth Report of the Joint FAO/WHO Expert Committee on Food Additives, Rome, 27 May- 4 June 1969. World Health Organization technical report series no. 445, FAO nutrition meetings report series no. 46. Geneva: FAO and WHO
   Google Scholar
• Jia F, Sun Z, Yan X, Zhou B, Wang J. 2014. Effect of pubertal nano-TiO2 exposure on testosterone synthesis and spermatogenesis in mice. Arch Toxicol 88:781–8
   PubMed Web of Science ®Google Scholar
• Komatsu T, Tabata M, Kubo-Irie M, Shimizu T, Suzuki K, Nihei Y, Takeda K. 2008. The effects of nanoparticles on mouse testis Leydig cells in vitro. Toxicol in Vitro 22:1825–31
   PubMed Web of Science ®Google Scholar
• Lankveld DP, Oomen AG, Krystek P, Neigh A, Troost-De Jong A, Noorlander CW, et al. 2010. The kinetics of the tissue distribution of silver nanoparticles of different sizes. Biomaterials 31:8350–61
   PubMed Web of Science ®Google Scholar
• Luecke RH, Pearce BA, Wosilait WD, Slikker W, Young JF. 2007. Postnatal Growth Considerations for PBPK Modeling. J Toxicol Environ Health Part A 70:1027–37
   PubMed Web of Science ®Google Scholar
• NCI (National Cancer Institute). 1979. Bioassay of titanium dioxide for possible carcinogenicity. Carcinogenesis Technical Report Series No 97. Bethesda (Maryland): U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health
   Google Scholar
• Orazizadeh M, Fakhredini F, Mansouri E, Khorsandi L. 2014. Effect of glycyrrhizic acid on titanium dioxide nanoparticles-induced hepatotoxicity in rats. Chem Biol Interact 220:214–21
   PubMed Web of Science ®Google Scholar
• Park MVDZ, Neigh AM, Vermeulen JP, De La Fonteyne LJJ, Verharen HW, Briedé JJ, et al. 2011. The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles. Biomaterials 32:9810–17
   PubMed Web of Science ®Google Scholar
• Peters RJ, Van Bemmel G, Herrera-Rivera Z, Helsper HP, Marvin HJ, Weigel S, et al. 2014. Characterization of titanium dioxide nanoparticles in food products: analytical methods to define nanoparticles. J Agric Food Chem 62:6285–93
   PubMed Web of Science ®Google Scholar
• Powell JJ, Faria N, Thomas-Mckay E, Pele LC. 2010. Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract. J Autoimmun 34:J226–33
   PubMed Web of Science ®Google Scholar
• Rompelberg C, Heringa MB, van Donkersgoed G, Drijvers J, Roos A, Westenbrink S, Peters R, van Bemmel G, Brand W, Oomen AG. 2016. Oral intake of added titanium dioxide and its nanofraction from food products, food supplements and toothpaste by the Dutch population. Nanotoxicology. [Epub ahead of print]. doi: 10.1080/17435390.2016.1222457
   PubMed Web of Science ®Google Scholar
• Sayes CM, Wahi R, Kurian PA, Liu Y, West JL, Ausman KD, et al. 2006. Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicol Sci 92:174–85
   PubMed Web of Science ®Google Scholar
• SCCS (Scientific Committee on Consumer Safety). 2013. Opinion on titanium dioxide (nano form). COLIPA no. S75. Report no. SCCS/1516/13. Revision of 22 April 2014 [Online]. Available at: http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_o_136.pdf. Accessed on 12 July 2015
   Google Scholar
• SCENIHR. 2009. Opinion. Risk assessment of products of nanotechnologies. Scientific Committee on Emerging and Newly Identified Health Risks, European Commission, DG SANCO, Brussels, Belgium [Online]. Available at: http://ec.europa.eu/health/archive/ph_risk/committees/04_scenihr/docs/scenihr_o_023.pdf. Accessed on 07 September 2015
   Google Scholar
• Shi H, Magaye R, Castranova V, Zhao J. 2013. Titanium dioxide nanoparticles: a review of current toxicological data. Part Fiber Toxicol 10:33
   PubMed Web of Science ®Google Scholar
• Shukla RK, Kumar A, Vallabani NV, Pandey AK, Dhawan A. 2014. Titanium dioxide nanoparticle-induced oxidative stress triggers DNA damage and hepatic injury in mice. Nanomedicine (Lond) 9:1423–34
   PubMed Web of Science ®Google Scholar
• Sinnecker H, Ramaker K, Frey A. 2014. Coating with luminal gut-constituents alters adherence of nanoparticles to intestinal epithelial cells. Beilstein J Nanotechnol 5:2308–15
   PubMed Web of Science ®Google Scholar
• Sprong C, Bakker M, Niekerk M, Vennemann M. 2016. Exposure assessment of the food additive titanium dioxide (E 171) based on use levels provided by the industry. Bilthoven, the Netherlands: RIVM report 2015-0195
   Google Scholar
• Takeda K, Suzuki K-I, Ishihara A, Kubo-Irie M, Fujimoto R, Tabata M, et al. 2009. Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems. J Health Sci 55:95–102
   Web of Science ®Google Scholar
• Tassinari R, Cubadda F, Moracci G, Aureli F, D'amato M, Valeri M, et al. 2014. Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen. Nanotoxicology 8:654–62
   PubMed Web of Science ®Google Scholar
• TDMA (Titanium Dioxide Manufacturers Association). 2013. About titanium dioxide [Online]. Available at: http://www.tdma.info/files/pdf/about_tio2/About_TiO2__Brochure__-_July_2013.pdf. Accessed on 12 July 2015
   Google Scholar
• Van Der Zande M, Vandebriel RJ, Groot MJ, Kramer E, Herrera Rivera ZE, Rasmussen K, et al. 2014. Sub-chronic toxicity study in rats orally exposed to nanostructured silica. Part Fibre Toxicol 11:8
   PubMed Web of Science ®Google Scholar
• Van Kesteren PC, Cubadda F, Bouwmeester H, Van Eijkeren JC, Dekkers S, De Jong WH, Oomen AG. 2015. Novel insights into the risk assessment of the nanomaterial synthetic amorphous silica, additive E551, in food. Nanotoxicology 9:442–52
   PubMed Web of Science ®Google Scholar
• Wang J, Zhou G, Chen C, Yu H, Wang T, Ma Y, et al. 2007. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168:176–85
   PubMed Web of Science ®Google Scholar
• Wang Y, Chen Z, Ba T, Pu J, Chen T, Song Y, et al. 2013. Susceptibility of young and adult rats to the oral toxicity of titanium dioxide nanoparticles. Small 9:1742–52
   PubMed Web of Science ®Google Scholar
• Warheit DB, Webb TR, Reed KL, Frerichs S, Sayes CM, et al. 2007. Pulmonary toxicity study in rats with three forms of ultrafine-TiO2 particles: Differential responses related to surface properties. Toxicology 230:90–104
   PubMed Web of Science ®Google Scholar
• Warheit DB, Brown SC, Donner EM. 2015a. Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles. Food Chem Toxicol 84:208–24
   PubMed Web of Science ®Google Scholar
• Warheit DB, Boatman R, Brown SC. 2015b. Developmental toxicity studies with 6 forms of titanium dioxide test materials (3 pigment-different grade & 3 nanoscale) demonstrate an absence of effects in orally-exposed rats. Reg Toxicol Pharmacol 73:887–96
   PubMed Web of Science ®Google Scholar
• Weir A, Westerhoff P, Fabricius L, Hristovski K, Von Goetz N. 2012. Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol 46:2242–50
   PubMed Web of Science ®Google Scholar
• Xie G, Wang C, Sun J, Zhong G. 2011. Tissue distribution and excretion of intravenously administered titanium dioxide nanoparticles. Toxicol Lett 205:55–61
   PubMed Web of Science ®Google Scholar
• Zhao X, Sheng L, Wang L, Hong J, Yu X, Sang X, et al. 2015. Retraction note: mechanisms of nanosized titanium dioxide-induced testicular oxidative stress and apoptosis in male mice. Part Fiber Toxicol 12:23
   PubMed Web of Science ®Google Scholar