3,651
Views
49
CrossRef citations to date
0
Altmetric
Original Article

Biocompatibility and characterization of polyglycerol-based thermoresponsive nanogels designed as novel drug-delivery systems and their intracellular localization in keratinocytes

, , , , , , , , , , , , , & show all
Pages 267-277 | Received 21 Dec 2016, Accepted 03 Feb 2017, Published online: 22 Feb 2017

References

  • Ahlberg S, Meinke MC, Werner L, Epple M, Diendorf J, Blume-Peytavi U, et al. 2014. Comparison of silver nanoparticles stored under air or argon with respect to the induction of intracellular free radicals and toxic effects toward keratinocytes. Eur J Pharm Biopharm 88:651–7.
  • Asadian-Birjand M, Bergueiro J, Rancan F, Cuggino JC, Mutihac RC, Achazi K, et al. 2015. Engineering thermoresponsive polyether-based nanogels for temperature dependent skin penetration. Polym Chem 6:5827–31.
  • Asadian-Birjand M, Sousa-Herves A, Steinhilber D, Cuggino JC, Calderon M. 2012a. Functional Nanogels for Biomedical Applications. Curr Med Chem 19:5029–43.
  • Asadian-Birjand M, Sousa-Herves A, Steinhilber D, Cuggino JC, Calderon M. 2012b. Functional nanogels for biomedical applications. Curr Med Chem 19:5029–43.
  • Bergueiro J, Calderon M. 2015. Thermoresponsive nanodevices in biomedical applications. Macromol Biosci 15:183–99.
  • Contri RV, Fiel LA, Alnasif N, Pohlmann AR, Guterres SS, Schafer-Korting M. 2016. Skin penetration and dermal tolerability of acrylic nanocapsules: influence of the surface charge and a chitosan gel used as vehicle. Int J Pharm 507:12–20.
  • Cooke MS, Evans MD, Dizdaroglu M, Lunec J. 2003. Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 17:1195–214.
  • Cuggino JC, Alvarez CI, Strumia MC, Welker P, Licha K, Steinhilber D, et al. 2011a. Thermosensitive nanogels based on dendritic polyglycerol and N-isopropylacrylamide for biomedical applications. Soft Matter 7:11259–66.
  • Cuggino JC, Strumia MC, Igarzabal CIA. 2011b. Synthesis, characterization and slow drug delivery of hydrogels based in N-acryloyl-tris-(hydroxymethyl) aminomethane and N-isopropyl acrylamide. React Funct Polym 71:440–6.
  • Döge N, Hönzke S, Schumacher F, Balzus B, Colombo M, Hadam S, et al. 2016. Ethyl cellulose nanocarriers and nanocrystals differentially deliver dexamethasone into intact, tape-stripped or sodium lauryl sulfate-exposed ex vivo human skin – assessment by intradermal microdialysis and extraction from the different skin layers. J Control Release 242:25–34.
  • Dommerholt J, Schmidt S, Temming R, Hendriks LJ, Rutjes FP, Van Hest JC, et al. 2010. Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells. Angew Chem Int Ed Engl 49:9422–5.
  • Donaldson K, Stone V, Tran CL, Kreyling W, Borm PJ. 2004. Nanotoxicology. Occup Environ Med 61:727–8.
  • Eom HJ, Choi J. 2010. p38 MAPK activation, DNA damage, cell cycle arrest and apoptosis as mechanisms of toxicity of silver nanoparticles in Jurkat T cells. Environ Sci Technol 44:8337–42.
  • Fischer W, Calderon M, Schulz A, Andreou I, Weber M, Haag R. 2010. Dendritic polyglycerols with oligoamine shells show low toxicity and high siRNA transfection efficiency in vitro. Bioconjug Chem 21:1744–52.
  • Gervais M, Brocas AL, Cendejas G, Deffieux A, Carlotti S. 2010. Synthesis of linear high molar mass glycidol-based polymers by monomer-activated anionic polymerization. Macromolecules 43:1778–84.
  • Giulbudagian M, Asadian-Birjand M, Steinhilber D, Achazi K, Molina M, Calderon M. 2014. Fabrication of thermoresponsive nanogels by thermo-nanoprecipitation and in situ encapsulation of bioactives. Polym Chem 5:6909–13.
  • Goyal R, Macri LK, Kaplan HM, Kohn J. 2016. Nanoparticles and nanofibers for topical drug delivery. J Control Release 240:77–92.
  • Gysler A, Lange K, Korting HC, Schafer-Korting M. 1997. Prednicarbate biotransformation in human foreskin keratinocytes and fibroblasts. Pharm Res 14:793–7.
  • Hackenberg S, Scherzed A, Kessler M, Hummel S, Technau A, Froelich K, et al. 2011. Silver nanoparticles: evaluation of DNA damage, toxicity and functional impairment in human mesenchymal stem cells. Toxicol Lett 201:27–33.
  • Hofmann-Amtenbrink M, Grainger DW, Hofmann H. 2015. Nanoparticles in medicine: Current challenges facing inorganic nanoparticle toxicity assessments and standardizations. Nanomedicine 11:1689–94.
  • Hönzke S, Gerecke C, Elpelt A, Zhang N, Unbehauen M, Kral V, et al. 2016. Tailored dendritic core-multishell nanocarriers for efficient dermal drug delivery: a systematic top-down approach from synthesis to preclinical testing. J Control Release 242:50–63.
  • Iversen TG, Skotland T, Sandvig K. 2011. Endocytosis and intracellular transport of nanoparticles: present knowledge and need for future studies. Nano Today 6:176–85.
  • Kabanov AV, Vinogradov SV. 2009. Nanogels as pharmaceutical carriers: finite networks of infinite capabilities. Angew Chem Int Ed 48:5418–29.
  • Kim DH, Martin DC. 2006. Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery. Biomaterials 27:3031–7.
  • Kolle SN, Sauer UG, Moreno MC, Teubner W, Wohlleben W, Landsiedel R. 2016. Eye irritation testing of nanomaterials using the EpiOcular eye irritation test and the bovine corneal opacity and permeability assay. Part Fibre Toxicol 13:18.
  • Koster RA, Alffenaar JW, Greijdanus B, Uges DR. 2013. Fast LC-MS/MS analysis of tacrolimus, sirolimus, everolimus and cyclosporin A in dried blood spots and the influence of the hematocrit and immunosuppressant concentration on recovery. Talanta 115:47–54.
  • Kumar S, Alnasif N, Fleige E, Kurniasih I, Kral V, Haase A, et al. 2014. Impact of structural differences in hyperbranched polyglycerol-polyethylene glycol nanoparticles on dermal drug delivery and biocompatibility. Eur J Pharm Biopharm 88:625–34.
  • Kumaravel TS, Vilhar B, Faux SP, Jha AN. 2009. Comet Assay measurements: a perspective. Cell Biol Toxicol 25:53–64.
  • Lotz C, Schmid FF, Rossi A, Kurdyn S, Kampik D, De Wever B, et al. 2016. Alternative methods for the replacement of eye irritation testing. Altex 33:55–67.
  • Mak WC, Patzelt A, Richter H, Renneberg R, Lai KK, Ruhl E, et al. 2012. Triggering of drug release of particles in hair follicles. J Control Release 160:509–14.
  • Mukherjee SP, Byrne HJ. 2013. Polyamidoamine dendrimer nanoparticle cytotoxicity, oxidative stress, caspase activation and inflammatory response: experimental observation and numerical simulation. Nanomedicine 9:202–11.
  • Naha PC, Bhattacharya K, Tenuta T, Dawson KA, Lynch I, Gracia A, et al. 2010. Intracellular localisation, geno- and cytotoxic response of polyN-isopropylacrylamide (PNIPAM) nanoparticles to human keratinocyte (HaCaT) and colon cells (SW 480). Toxicol Lett 198:134–43.
  • Nel A, Xia T, Madler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311:622–7.
  • OECD. 2009. OECD, Test No. 437: Bovine corneal opacity and permeability test method for identifying i) chemicals inducing serious eye damage and ii) chemicals not requiring classification for eye irritation or serious eye damage. Paris, France: OECD Publishing.
  • Pape PU. 1992. Red Blood Cell Test System Invittox Protocol No. 37 ERGATT/FRAME Databank of In Vitro Techniques in Toxicology.
  • Petersen EJ, Nelson BC. 2010. Mechanisms and measurements of nanomaterial-induced oxidative damage to DNA. Anal Bioanal Chem 398:613–50.
  • Rancan F, Asadian-Birjand M, Dogan S, Graf C, Cuellar L, Lommatzsch S, et al. 2016. Effects of thermoresponsivity and softness on skin penetration and cellular uptake of polyglycerol-based nanogels. J Control Release 228:159–69.
  • Rancan F, Giulbudagian M, Jurisch J, Blume-Peytavi U, Calderon M, Vogt A. 2017. Drug delivery across intact and disrupted skin barrier: identification of cell populations interacting with penetrated thermoresponsive nanogels. Eur J Pharm Biopharm. [Epub ahead of print]. doi: http://dx.doi.org/10.1016/j.ejpb.2016.11.017.
  • Sahle FF, Giulbudagian M, Bergueiro J, Lademann J, Calderon M. 2017. Dendritic polyglycerol and N-isopropylacrylamide based thermoresponsive nanogels as smart carriers for controlled delivery of drugs through the hair follicle. Nanoscale 9:172–82.
  • Samah NA, Williams N, Heard CM. 2010. Nanogel particulates located within diffusion cell receptor phases following topical application demonstrates uptake into and migration across skin. Int J Pharm 401:72–8.
  • Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, et al. 2012. Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676–82.
  • Scott L, Eskes C, Hoffmann S, Adriaens E, Alepee N, Bufo M, et al. 2010. A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches. Toxicol in Vitro 24:1–9.
  • Shi M, Kwon HS, Peng Z, Elder A, Yang H. 2012. Effects of surface chemistry on the generation of reactive oxygen species by copper nanoparticles. ACS Nano 6:2157–64.
  • Sun C, Wang X, Zheng Z, Chen D, Shi F, Yu D, Wu H. 2015. A single dose of dexamethasone encapsulated in polyethylene glycol-coated polylactic acid nanoparticles attenuates cisplatin-induced hearing loss following round window membrane administration. Int J Nanomedicine 10:3567–79.
  • Wang Z, Cuddigan JL, Gupta SK, Meenach SA. 2016. Nanocomposite microparticles (nCmP) for the delivery of tacrolimus in the treatment of pulmonary arterial hypertension. Int J Pharm 512:305–13.
  • Warheit DB, Hoke RA, Finlay C, Donner EM, Reed KL, Sayes CM. 2007. Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management. Toxicol Lett 171:99–110.
  • Witting M, Molina M, Obst K, Plank R, Eckl KM, Hennies HC, et al. 2015. Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules. Nanomedicine 11:1179–87.
  • Xu W, Ling P, Zhang T. 2014. Toward immunosuppressive effects on liver transplantation in rat model: tacrolimus loaded poly(ethylene glycol)-poly(D,L-lactide) nanoparticle with longer survival time. Int J Pharm 460:173–80.
  • Yang Y, Sunoqrot S, Stowell C, Ji J, Lee CW, Kim JW, et al. 2012. Effect of size, surface charge, and hydrophobicity of poly(amidoamine) dendrimers on their skin penetration. Biomacromolecules 13:2154–62.
  • Zhang Z, Tsai PC, Ramezanli T, Michniak-Kohn BB. 2013. Polymeric nanoparticles-based topical delivery systems for the treatment of dermatological diseases. Wiley Interdiscip Rev Nanomed Nanobiotechnol 5:205–18.
  • Zhao L, Zhou Y, Gao Y, Ma S, Zhang C, Li J, et al. 2015. Bovine serum albumin nanoparticles for delivery of tacrolimus to reduce its kidney uptake and functional nephrotoxicity. Int J Pharm 483:180–7.