Bioengineered gold nanoparticles targeted to mesenchymal cells from patients with bronchiolitis obliterans syndrome does not rise the inflammatory response and can be safely inhaled by rodents

References

• Alkilany AM, Murphy CJ. 2010. Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? J Nanopart Res 12:2313–33.
   PubMed Web of Science ®Google Scholar
• Araki K, Ellebedy AH, Ahmed R. 2011. TOR in the immune system. Curr Opin Cell Biol 23:707–15.
   PubMed Web of Science ®Google Scholar
• Baaten BJ, Li CR, Bradley LM. 2010. Multifaceted regulation of T cells by CD44. Commun Integr Biol 3:508–12.
   PubMedGoogle Scholar
• Badri L, Murray S, Liu LX, Walker NM, Flint A, Wadhwa A, et al. 2011. Mesenchymal stromal cells in bronchoalveolar lavage as predictors of bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 183:1062–70.
   PubMed Web of Science ®Google Scholar
• Balasubramanian SK, Poh KW, Ong CN, Kreyling WG, Ong WY, Yu LE. 2013. The effect of primary particle size on biodistribution of inhaled gold nano-agglomerates. Biomaterials 34:5439–52.
   PubMed Web of Science ®Google Scholar
• Bianco AM, Solari N, Miserere S, Pellegrini C, Vitulo P, Pozzi E, et al. 2005. The frequency of interleukin-10- and interleukin-5-secreting CD4+ T cells correlates to tolerance of transplanted lung. Transplant Proc 37:2255–6.
   PubMed Web of Science ®Google Scholar
• Biju V, Itoh T, Anas A, Sujith A, Ishikawa M. 2008. Semiconductor quantum dots and metal nanoparticles: syntheses, optical properties, and biological applications. Anal Bioanal Chem 391:2469–95.
   PubMed Web of Science ®Google Scholar
• Brust M, Walker M, Bethell D, Schriffin DJ, Whymann RJ. 1994. Synthesis of thiol-derivatized gold nanoparticles in a two phase liquid-liquid system. Chem Commun 7:801–4.
   Web of Science ®Google Scholar
• Cole LE, Ross RD, Tilley JM, Vargo-Gogola T, Roeder RK. 2015. Gold nanoparticles as contrast agents in x-ray imaging and computed tomography. Nanomedicine (Lond) 10:321–41.
   PubMed Web of Science ®Google Scholar
• Cooper DR, Bekah D, Nadeau JL. 2014. Gold nanoparticles and their alternatives for radiation therapy enhancement. Front Chem 2:86.
   PubMed Web of Science ®Google Scholar
• Cova E, Colombo M, Inghilleri S, Morosini M, Miserere S, Penaranda-Avila J, et al. 2015. Antibody-engineered nanoparticles selectively inhibit mesenchymal cells isolated from patients with chronic lung allograft dysfunction. Nanomedicine (Lond) 10:9–23.
   PubMed Web of Science ®Google Scholar
• Debes GF, Arnold CN, Young AJ, Krautwald S, Lipp M, Hay JB, Butcher EC. 2005. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nat Immunol 6:889–94.
   PubMed Web of Science ®Google Scholar
• El-Sayed IH, Huang X, El-Sayed MA. 2005. Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer. Nano Lett 5:829–34.
   PubMed Web of Science ®Google Scholar
• Elssner A, Vogelmeier C. 2001. The role of neutrophils in the pathogenesis of obliterative bronchiolitis after lung transplantation. Transpl Infect Dis 3:168–76.
   PubMedGoogle Scholar
• Faoro V, Fink B, Taudorf S, Dehnert C, Berger MM, Swenson ER, et al. 2011. Acute in vitro hypoxia and high-altitude (4,559 m) exposure decreases leukocyte oxygen consumption. Am J Physiol Regul Integr Comp Physiol 300:R32–9.
   PubMed Web of Science ®Google Scholar
• Fiandra L, Mazzucchelli S, De Palma C, Colombo M, Allevi R, Sommaruga S, et al. 2013. Assessing the in vivo targeting efficiency of multifunctional nanoconstructs bearing antibody-derived ligands. ACS Nano 7:6092–102.
   PubMed Web of Science ®Google Scholar
• Geiser M, Quaile O, Wenk A, Wigge C, Eigeldinger-Berthou S, Hirn S, et al. 2013. Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease. Part Fibre Toxicol 10:19.
   PubMed Web of Science ®Google Scholar
• Giljohann DA, Seferos DS, Daniel WL, Massich MD, Patel PC, Mirkin CA. 2010. Gold nanoparticles for biology and medicine. Angew Chem Int Ed Engl 49:3280–94.
   PubMed Web of Science ®Google Scholar
• Gosens I, Post JA, de la Fonteyne LJ, Jansen EH, Geus JW, Cassee FR, de Jong WH. 2010. Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation. Part Fibre Toxicol 7:37.
   PubMed Web of Science ®Google Scholar
• Guan H, Nagarkatti PS, Nagarkatti M. 2011. CD44 reciprocally regulates the differentiation of encephalitogenic Th1/Th17 and Th2/regulatory T cells through epigenetic modulation involving DNA methylation of cytokine gene promoters, thereby controlling the development of experimental autoimmune encephalomyelitis. J Immunol 186:6955–64.
   PubMed Web of Science ®Google Scholar
• Halloran PF, Afrouzian M, Ramassar V, Urmson J, Zhu LF, Helms LM, et al. 2001. Interferon-gamma acts directly on rejecting renal allografts to prevent graft necrosis. Am J Pathol 158:215–26.
   PubMed Web of Science ®Google Scholar
• Han SG, Lee JS, Ahn K, Kim YS, Kim JK, Lee JH, et al. 2015. Size-dependent clearance of gold nanoparticles from lungs of Sprague–Dawley rats after short-term inhalation exposure. Arch Toxicol 89:1083–94.
   PubMed Web of Science ®Google Scholar
• Hardison MT, Galin FS, Calderon CE, Djekic UV, Parker SB, Wille KM, et al. 2009. The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation. J Immunol 182:4423–31.
   PubMed Web of Science ®Google Scholar
• Heo DN, Yang DH, Moon HJ, Lee JB, Bae MS, Lee SC, et al. 2012. Gold nanoparticles surface-functionalized with paclitaxel drug and biotin receptor as theranostic agents for cancer therapy. Biomaterials 33:856–66.
   PubMed Web of Science ®Google Scholar
• Hidalgo LG, Halloran PF. 2002. Role of IFN-gamma in allograft rejection. Crit Rev Immunol 22:317–49.
   PubMed Web of Science ®Google Scholar
• Ishimoto T, Sugihara H, Watanabe M, Sawayama H, Iwatsuki M, Baba Y, et al. 2014. Macrophage-derived reactive oxygen species suppress miR-328 targeting CD44 in cancer cells and promote redox adaptation. Carcinogenesis 35:1003–11.
   PubMed Web of Science ®Google Scholar
• Khatwa UA, Kleibrink BE, Shapiro SD, Subramaniam M. 2010. MMP-8 promotes polymorphonuclear cell migration through collagen barriers in obliterative bronchiolitis. J Leukoc Biol 87:69–77.
   PubMed Web of Science ®Google Scholar
• Kreyling WG, Hirn S, Moller W, Schleh C, Wenk A, Celik G, et al. 2014. Air-blood barrier translocation of tracheally instilled gold nanoparticles inversely depends on particle size. ACS Nano 8:222–33.
   PubMed Web of Science ®Google Scholar
• Lee WL, Harrison RE, Grinstein S. 2003. Phagocytosis by neutrophils. Microbes Infect 5:1299–306.
   PubMed Web of Science ®Google Scholar
• Lin CA, Sperling RA, Li JK, Yang TY, Li PY, Zanella M, et al. 2008. Design of an amphiphilic polymer for nanoparticle coating and functionalization. Small 4:334–41.
   PubMed Web of Science ®Google Scholar
• Liu A, Ye B. 2013. Application of gold nanoparticles in biomedical researches and diagnosis. Clin Lab 59:23–36.
   PubMed Web of Science ®Google Scholar
• Mieszawska AJ, Mulder WJ, Fayad ZA, Cormode DP. 2013. Multifunctional gold nanoparticles for diagnosis and therapy of disease. Mol Pharm 10:831–47.
   PubMed Web of Science ®Google Scholar
• Mrakic-Sposta S, Gussoni M, Montorsi M, Porcelli S, Vezzoli A. 2012. Assessment of a standardized ROS production profile in humans by electron paramagnetic resonance. Oxid Med Cell Longev 2012:Article ID 973927.
   PubMed Web of Science ®Google Scholar
• Nakano K, Saito K, Mine S, Matsushita S, Tanaka Y. 2007. Engagement of CD44 up-regulates Fas ligand expression on T cells leading to activation-induced cell death. Apoptosis 12:45–54.
   PubMed Web of Science ®Google Scholar
• Niidome T, Yamagata M, Okamoto Y, Akiyama Y, Takahashi H, Kawano T, et al. 2006. PEG-modified gold nanorods with a stealth character for in vivo applications. J Control Release 114:343–7.
   PubMed Web of Science ®Google Scholar
• Palmer SM, Burch LH, Trindade AJ, Davis RD, Herczyk WF, Reinsmoen NL, Schwartz DA. 2005. Innate immunity influences long-term outcomes after human lung transplant. Am J Respir Crit Care Med 171:780–5.
   PubMed Web of Science ®Google Scholar
• Pellegrino T, Manna L, Kudera S, Liedl T, Koktysh D, Rogach AL, et al. 2004. Hydrophobic nanocrystals coated with an amphiphilic polymer shell: a general route to water soluble nanocrystals. Nano Lett 4:703.
   Web of Science ®Google Scholar
• Ramirez AM, Nunley DR, Rojas M, Roman J. 2008. Activation of tissue remodeling precedes obliterative bronchiolitis in lung transplant recipients. Biomark Insights 3:351–9.
   PubMedGoogle Scholar
• Russell JH. 1995. Activation-induced death of mature T cells in the regulation of immune responses. Curr Opin Immunol 7:382–8.
   PubMed Web of Science ®Google Scholar
• Sadauskas E, Jacobsen NR, Danscher G, Stoltenberg M, Vogel U, Larsen A, et al. 2009. Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation. Chem Cent J 3:16.
   PubMed Web of Science ®Google Scholar
• Shukla R, Bansal V, Chaudhary M, Basu A, Bhonde RR, Sastry M. 2005. Biocompatibility of gold nanoparticles and their endocytotic fate inside the cellular compartment: a microscopic overview. Langmuir 21:10644–54.
   PubMed Web of Science ®Google Scholar
• Summers C, Rankin SM, Condliffe AM, Singh N, Peters AM, Chilvers ER. 2010. Neutrophil kinetics in health and disease. Trends Immunol 31:318–24.
   PubMed Web of Science ®Google Scholar
• Sung JH, Ji JH, Park JD, Song MY, Song KS, Ryu HR, et al. 2011. Subchronic inhalation toxicity of gold nanoparticles. Part Fibre Toxicol 8:16.
   PubMed Web of Science ®Google Scholar
• Todd JL, Palmer SM. 2011. Bronchiolitis obliterans syndrome: the final frontier for lung transplantation. Chest 140:502–8.
   PubMed Web of Science ®Google Scholar
• Torres M, Hall FL, O’Neill K. 1993. Stimulation of human neutrophils with formyl-methionyl-leucyl-phenylalanine induces tyrosine phosphorylation and activation of two distinct mitogen-activated protein-kinases. J Immunol 150:1563–77.
   PubMed Web of Science ®Google Scholar
• Uchiyama MK, Deda DK, Rodrigues SF, Drewes CC, Bolonheis SM, Kiyohara PK, et al. 2014. In vivo and in vitro toxicity and anti-inflammatory properties of gold nanoparticle bioconjugates to the vascular system. Toxicol Sci 142:497–507.
   PubMed Web of Science ®Google Scholar
• Vanaudenaerde BM, Verleden SE, Vos R, De Vleeschauwer SI, Willems-Widyastuti A, Geenens R, et al. 2011. Innate and adaptive interleukin-17-producing lymphocytes in chronic inflammatory lung disorders. Am J Respir Crit Care Med 183:977–86.
   PubMed Web of Science ®Google Scholar
• Verleden SE, Vasilescu DM, McDonough JE, Ruttens D, Vos R, Vandermeulen E, et al. 2015. Linking clinical phenotypes of chronic lung allograft dysfunction to changes in lung structure. Eur Respir J 46:1430–9.
   PubMed Web of Science ®Google Scholar
• Weigt SS, DerHovanessian A, Wallace WD, Lynch JP 3rd, Belperio JA. 2013. Bronchiolitis obliterans syndrome: the Achilles’ heel of lung transplantation. Semin Respir Crit Care Med 34:336–51.
   PubMed Web of Science ®Google Scholar
• Wynn TA. 2011. Integrating mechanisms of pulmonary fibrosis. J Exp Med 208:1339–50.
   PubMed Web of Science ®Google Scholar
• Yu LE, Yung LL, Ong C, Tan Y, Balasubramaniam KS, Hartono D, et al. 2009. Translocation and effects of gold nanoparticles after inhalation exposure in rats. Nanotoxicology 1:235.
   Web of Science ®Google Scholar
• Zhao J, Wallace M, Melancon MP. 2014. Cancer theranostics with gold nanoshells. Nanomedicine (Lond) 9:2041–57.
   PubMed Web of Science ®Google Scholar