Biokinetics of engineered nano-TiO₂ in rats administered by different exposure routes: implications for human health

References

• Baisch BL, Corson NM, Wade-Mercer P, Gelein R, Kennell AJ, Oberdörster G, et al. 2014. Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation. Part Fibre Toxicol 11:5.
   PubMed Web of Science ®Google Scholar
• Couvreur P, Kante B, Grislain L, Roland M, Speiser P. 1982. Toxicity of polyalkylcyanoacrylate nanoparticles II: doxorubicin-loaded nanoparticles. J Pharm Sci 71:790–92.
   PubMed Web of Science ®Google Scholar
• DeLoid GM, Cohen JM, Pyrgiotakis G, Demokritou P. 2017. Preparation, characterization, and in vitro dosimetry of dispersed, engineered nanomaterials. Nat Protoc 12:355–71.
   PubMed Web of Science ®Google Scholar
• DeLoid GM, Cohen JM, Pyrgiotakis G, Pirela SV, Pal A, Liu J. 2015. Advanced computational modeling for in vitro nanomaterial dosimetry. Part Fibre Toxicol 12:32.
   PubMed Web of Science ®Google Scholar
• Geiser M, Kreyling WG. 2010. Deposition and biokinetics of inhaled nanoparticles. Part Fibre Toxicol 7:2.
   PubMed Web of Science ®Google Scholar
• Geiser M, Stoeger T, Casaulta M, Chen S, Semmler-Behnke M, Bolle I, et al. 2014. Biokinetics of nanoparticles and susceptibility to particulate exposure in a murine model of cystic fibrosis. Part Fibre Toxicol 11:19.
   PubMed Web of Science ®Google Scholar
• Gregoratto D, Bailey MR, Marsh JW. 2010. Modelling particle retention in the alveolar-interstitial region of the human lungs. J Radiol Prot 30:491–512.
   PubMed Web of Science ®Google Scholar
• Heringa MB, Geraets L, van Eijkeren JC, Vandebriel RJ, de Jong WH, Oomen AG. 2016. Risk assessment of titanium dioxide nanoparticles via oral exposure, including toxicokinetic considerations. Nanotoxicology 10:1515–25.
   PubMed Web of Science ®Google Scholar
• Kreyling WG, Holzwarth U, Haberl N, Kozempel J, Hirn S, Wenk A, et al. 2017a. Quantitative biokinetics of titanium dioxide nanoparticles after intravenous injection in rats: Part 1. Nanotoxicology. [Epub ahead of print]. doi: 10.1080/17435390.2017.1306892
   Web of Science ®Google Scholar
• Kreyling WG, Holzwarth U, Haberl N, Kozempel J, Wenk A, Hirn S, et al. 2017b. Quantitative biokinetics of titanium dioxide nanoparticles after intratracheal instillation in rats: Part 3. Nanotoxicology. [Epub ahead of print]. doi: 10.1080/17435390.2017.1306894
   Web of Science ®Google Scholar
• Kreyling WG, Holzwarth U, Schleh C, Kozempel J, Wenk A, Haberl N, et al. 2017c. Quantitative biokinetics of titanium dioxide nanoparticles after oral application in rats: Part 2. Nanotoxicology. [Epub ahead of print]. doi: 10.1080/17435390.2017.1306893
   Web of Science ®Google Scholar
• Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H. 2002. Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J Toxicol Environ Health Part A 65:1513–30.
   PubMed Web of Science ®Google Scholar
• Lomer MC, Thompson RP, Commisso J, Keen CL, Powell JJ. 2000. Determination of titanium dioxide in foods using inductively coupled plasma optical emission spectrometry. Analyst 125:2339–2343.
   PubMed Web of Science ®Google Scholar
• Moller W, Felten K, Sommerer K, Scheuch G, Meyer G, Meyer P,. 2008. Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. Am J Respir Crit Care Med 177:426–32.
   PubMed Web of Science ®Google Scholar
• Nel AE. 2013. Implementation of alternative test strategies for the safety assessment of engineered nanomaterials. J Intern Med 274:561–77.
   PubMed Web of Science ®Google Scholar
• Nel A, Xia T, Meng H, , Wang X, Lin S, Ji Z, et al. 2013. Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res 46:607–21.
   PubMed Web of Science ®Google Scholar
• Nemmar A, Hoet PH, Vanquickenborne B, Dinsdale D, Thomeer M, Hoylaerts MF, et al. 2002. Passage of inhaled particles into the blood circulation in humans. Circulation 105:411–14.
   PubMed Web of Science ®Google Scholar
• Nikula KJ, Avila KJ, Griffith WC, Mauderly JL. 1997. Sites of particle retention and lung tissue responses to chronically inhaled diesel exhaust and coal dust in rats and cynomolgus monkeys. Environ Health Perspect 105:1231–4.
   PubMed Web of Science ®Google Scholar
• Oberdorster G, Oberdorster E, Oberdorster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–39.
   PubMed Web of Science ®Google Scholar
• Pal AK, Bello D, Cohen J, Demokritou P. 2015. Implications of in vitro dosimetry on toxicological ranking of low aspect ratio engineered nanomaterials. Nanotoxicology 9:871–85.
   PubMed Web of Science ®Google Scholar
• Rompelberg C, Heringa MB, van Donkersgoed G, Drijvers J, Roos A, Westenbrink S, et al. 2016. Oral intake of added titanium dioxide and its nanofraction from food products, food supplements and toothpaste by the dutch population. Nanotoxicology 10:1404–14.
   PubMed Web of Science ®Google Scholar
• Scheuch G, Kohlhaufl M, Moller W, Brand P, Meyer T, Haussinger K, et al. 2008. Particle clearance from the airways of subjects with bronchial hyperresponsiveness and with chronic obstructive pulmonary disease. Exp Lung Res 34:531–49.
   PubMed Web of Science ®Google Scholar
• Silva RM, Doudrick K, Franzi LM, TeeSy C, Anderson DS, Wu Z, et al. 2014. Instillation versus inhalation of multiwalled carbon nanotubes: exposure-related health effects, clearance, and the role of particle characteristics. ACS Nano 8:8911–31.
   PubMed Web of Science ®Google Scholar
• Watson CY, DeLoid GM, Pal A, Demokritou P. 2016. Buoyant nanoparticles: implications for nano-biointeractions in cellular studies. Small 12:3172–80.
   PubMed Web of Science ®Google Scholar
• Weir A, Westerhoff P, Fabricius L, von Goetz N. 2012. Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol 46:2242–50.
   PubMed Web of Science ®Google Scholar
• Zhang H, Ji Z, Xia T, Meng H, Low-Kam C, Liu R, et al. 2012. Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation. ACS Nano 6:4349–68.
   PubMed Web of Science ®Google Scholar