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Article

RNA sequencing analysis shows that titanium dioxide nanoparticles induce endoplasmic reticulum stress, which has a central role in mediating plasma glucose in mice

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Pages 341-356 | Received 01 Sep 2017, Accepted 24 Feb 2018, Published online: 06 Mar 2018

References

  • Archuleta, T. L., A. M. Lemieux, V. Saengsirisuwan, M. K. Teachey, K. A. Lindborg, J. S. Kim, and E. J. Henriksen. 2009. “Oxidant Stress-Induced Loss of IRS-1 and IRS-2 Proteins in Rat Skeletal Muscle: Role of p38 MAPK.” Free Radical Biology and Medicine 47 (10): 1486–1493. doi:10.1016/j.freeradbiomed.2009.08.014.
  • Biazi, B. I., T. A. Zanetti, A. Baranoski, A. C. Corveloni, and M. S. Mantovani. 2017. “Cis-Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation.” Basic & Clinical Pharmacology & Toxicology 121 (4): 334–341. doi:10.1111/bcpt.12772.
  • Brumfiel, G. 2003. “Nanotechnology: A Little Knowledge.” Nature 424 (6946): 246–248. doi:10.1038/424246a.
  • Brun, E., F. Barreau, G. Veronesi, B. Fayard, S. Sorieul, C. Chanéac, C. Carapito, et al. 2014. “Titanium Dioxide Nanoparticle Impact and Translocation through Ex Vivo, in Vivo, and in Vitro Gutepithelia.” Particle and Fibre Toxicology 11 (1): 13. doi:10.1186/1743-8977-11-13.
  • Chen, Z., Y. Wang, L. Zhuo, S. Chen, L. Zhao, X. Luan, H. Wang, and G. Jia. 2015. “Effect of Titanium Dioxide Nanoparticles on the Cardiovascular System after Oral Administration.” Toxicology Letters 239 (2): 123–130. doi:10.1016/j.toxlet.2015.09.013.
  • Ekstrand-Hammarström, B., C. M. Akfur, P. O. Andersson, C. Lejon, L. Osterlund, and A. Bucht. 2012. “Human Primary Bronchial Epithelial Cells Respond Differently to Titanium Dioxide Nanoparticles than the Lung Epithelial Cell Lines A549 and BEAS-2B.” Nanotoxicology 6 (6): 623–634. doi:10.3109/17435390.2011.598245.
  • Escobar, G. A., R. C. McIntyre, Jr., E. E. Moore, F. Gamboni-Robertson, and A. Banerjee. 2006. “Clathrin Heavy Chain Is Required for TNF-Induced Inflammatory Signaling.” Surgery 140: 268–272. doi:10.1016/j.surg.2006.03.008.
  • Geraerts, L., A. G. Oomen, P. Krystek, N. R. Jacobsen, H. Wallin, M. Laurentie, H. W. Verharen, E. F. Brandon, and W. H. de Jong. 2014. “Tissue Distribution and Elimination after Oral and Intravenous Administration of Different Titanium Dioxide Nanoparticles in Rats.” Particle and Fibre Toxicology 11: 30. doi:10.1186/1743-8977-11-30.
  • Gu, N., H. Hu, Q. Guo, S. Jin, C. Wang, Y. Oh, Y. Feng, and Q. Wu. 2015. “Effects of Oral Administration of Titanium Dioxide Fine-Sized Particles on Plasma Glucose in Mice.” Food and Chemical Toxicology 86: 124–131. doi:10.1016/j.fct.2015.10.003.
  • Guerrero-Hernández, A., D. Leon-Aparicio, J. Chavez-Reyes, J. A. Olivares-Reyes, and S. DeJesus. 2014. “Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes.” Cell Calcium 56 (5): 311–322. doi: 10.1016/j.ceca.2014.08.006.
  • Heringa, M. B., L. Geraets, J. C. van Eijkeren, R. J. Vandebriel, W. H. de Jong, and A. G. Oomen. 2016. “Risk Assessment of Titanium Dioxide Nanoparticles via Oral Exposure, Including Toxicokinetic Considerations.” Nanotoxicology 10 (10): 1515–1525. doi:10.1080/17435390.2016.1238113.
  • Hu, H., L. Li, Q. Guo, S. Jin, Y. Zhou, Y. Oh, Y. Feng, Q. Wu, and N. Gu. 2016. “A Mechanistic Study to Increase Understanding of Titanium Dioxide Nanoparticles-Increased Plasma Glucose in Mice.” Food and Chemical Toxicology 95: 175–187. doi:10.1016/j.fct.2016.07.010.
  • Hotamisligil, G. S. 2010. “Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease.” Cell 140 (6): 900–917. doi:10.1016/j.cell.2010.02.034.
  • Kim, H. R., G. H. Lee, E. Y. Cho, S. W. Chae, T. Ahn, and H. J. Chae. 2009. “Bax Inhibitor 1 Regulates ER-Stress-Induced ROS Accumulation through the Regulation of Cytochrome P450 2E1.” Journal of Cell Science 122 (8): 1126–1133. doi:10.1242/jcs.038430.
  • Kreyling, W. G., U. Holzwarth, C. Schleh, J. Kozempel, A. Wenk, N. Haberl, S. Hirn, et al. 2017. “Quantitative Biokinetics of Titanium Dioxide Nanoparticles after Oral Application in Rats: Part 2.” Nanotoxicology 11 (4): 443–453. doi:10.1080/17435390.2017.1306893.
  • Lee, G. H., K. J. Oh, H. R. Kim, H. S. Han, H. Y. Lee, K. G. Park, K. H. Nam, S. H. Koo, and H. J. Chae. 2016. “Effect of BI-1 on Insulin Resistance through Regulation of CYP2E1.” Scientific Reports 6: 32229. doi:10.1038/srep32229.
  • Li, S., W. Jiang, S. Hu, W. Song, L. Ji, Y. Wang, and L. Cai. 2015. “Fucosylated Chondroitin Sulphate from Cusumaria Frondosa Mitigates Hepatic Endoplasmic Reticulum Stress and Inflammation in Insulin Resistant Mice.” Food & Function 6 (5): 1547–1556. doi:10.1039/C4FO01153H.
  • Liu, J., D. Ibi, K. Taniguchi, J. Lee, H. Herrema, B. Akosman, P. Mucka, et al. 2016. “Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction.” Cell 167 (4): 1052–1066.e18. doi:10.1016/j.cell.2016.10.015.
  • Longo, M., R. Spinelli, V. D’Esposito, F. Zatterale, F. Fiory, C. Nigro, G. A. Raciti, et al. 2016. “Pathologic Endoplasmic Reticulum Stress Induced by Glucotoxic Insults Inhibits Adipocyte Differentiation and Induces an Inflammatory Phenotype.” Biochimica et Biophysica Acta (BBA) – Molecular Cell Research 1863: 1146–1156. doi:10.1016/j.bbamcr.2016.02.019.
  • Luizon, M. R., W. L. Eckalbar, Y. Wang, S. L. Jones, R. P. Smith, M. Laurance, L. Lin, et al. 2016. “Genomic Characterization of Metformin Hepatic Response.” PLoS Genetics 12 (11): e1006449. doi:10.1371/journal.pgen.1006449.
  • Rompelberg, C., M. B. Heringa, G. van Donkersgoed, J. Drijvers, A. Roos, S. Westenbrink, R. Peters, G. van Bemmel, W. Brand, and A. G. Oomen. 2016. “Oral Intake of Added Titanium Dioxide and Its Nanofraction from Food Products, Food Supplements and Toothpaste by the Dutch Population.” Nanotoxicology 10 (10): 1404–1414. doi:10.1080/17435390.2016.1222457.
  • Service, R. F. 2003. “Nanomaterials Show Signs of Toxicity.” Science 300 (5617): 243a. doi:10.1126/science.300.5617.243a.
  • Shi, H., R. Magaye, V. Castranova, and J. Zhao. 2013. “Titanium Dioxide Nanoparticles: A Review of Current Toxicological Data.” Particle and Fibre Toxicology 10 (1): 15. doi:10.1186/1743-8977-10-15.
  • Shrivastava, R., S. Raza, A. Yadav, P. Kushwaha, and S. J. Flora. 2014. “Effects of Sub-Acute Exposure to TiO2, ZnO and Al2O3 Nanoparticles on Oxidative Stress and Histological Changes in Mouse Liver and Brain.” Drug and Chemical Toxicology 37 (3): 336–347. doi:10.3109/01480545.2013.866134.
  • Shoeb, M., V. Kodali, B. Farris, L. M. Bishop, T. Meighan, R. Salmen, T. Eye, et al. 2017. “Evaluation of the Molecular Mechanisms Associated with Cytotoxicity and Inflammation after Pulmonary Exposure to Different Metal-Rich Welding Particles.” Nanotoxicology 18: 1–12. doi:10.1080/17435390.2017.1349200.
  • Sohm, B., F. Immel, P. Bauda, and C. Pagnout. 2015. “Insight into the Primary Mode of Action of TiO2 Nanoparticles on Escherichia coli in the Dark.” Proteomics 15 (1): 98–113. doi:10.1002/pmic.201400101.
  • Spahis, S., E. Delvin, J. M. Borys, and E. Levy. 2017. “Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver Disease Pathogenesis.” Antioxid Redox Signal 26 (10): 519–541. doi:10.1089/ars.2016.6776.
  • Szczesna-Skorupa, E., C. D. Chen, H. Liu, and B. Kemper. 2004. “Gene Expression Changes Associated with the Endoplasmic Reticulum Stress Response Induced by Microsomal Cytochrome p450 Overproduction.” Journal of Biological Chemistry 279 (14): 13953–13961. doi:10.1074/jbc.M312170200.
  • Tsyusko, O. V., J. M. Unrine, D. Spurgeon, E. Blalock, D. Starnes, M. Tseng, G. Joice, and P. M. Bertsch. 2012. “Toxicogenomic Responses of the Model Organism Caenorhabditis elegans to Gold Nanoparticles.” Environmental Science & Technology 46 (7): 4115–4124. doi:10.1021/es2033108.
  • Weir, A., P. Westerhoff, L. Fabricius, K. Hristovski, and N. von-Goetz. 2012. “Titanium Dioxide Nanoparticles in Food and Personal Care Products.” Environmental Science & Technology 46 (4): 2242–2250. doi:10.1021/es204168d.
  • Winkler, C., F. Ferdous, M. Dimmick, and T. Scott. 2017. “Lipopolysaccharide Induced Interleukin-6 Production Is Mediated through Activation of ERK 1/2, p38 MAPK, MEK, and NFκB in Chicken Thrombocytes.” Developmental and Comparative Immunology 73: 124–130. doi:10.1016/j.dci.2017.03.017.
  • Xu, Y., M. T. Wei, H. D. Ou-Yang, S. G. Walker, H. Z. Wang, C. R. Gordon, S. Guterman, et al. 2016. “Exposure to TiO2 Nanoparticles Increases Staphylococcus aureus Infection of HeLa Cells.” Journal of Nanobiotechnology 14 (1): 34. doi:10.1186/s12951-016-0184-y.
  • Zangar, R. C., D. R. Davydov, and S. Verma. 2004. “Mechanisms That Regulate Production of Reactive Oxygen Species by Cytochrome P450.” Toxicology and Applied Pharmacology 199 (3): 316–331. doi:10.1016/j.taap.2004.01.018.

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