LC-MS-based lipidomics to examine acute rat pulmonary responses after nano- and fine-sized ZnO particle inhalation exposure

References

• Baisch, B. L., N. M. Corson, P. Wade-Mercer, R. Gelein, A. J. Kennell, G. Oberdörster, A. Elder, et al. 2014. “Equivalent Titanium Dioxide Nanoparticle Deposition by Intratracheal Instillation and Whole Body Inhalation: The Effect of Dose Rate on Acute Respiratory Tract Inflammation.” Particle and Fibre Toxicology 11: 5. doi: 10.1186/1743-8977-11-5.
   PubMed Web of Science ®Google Scholar
• Becker, J., C. Delayre-Orthez, N. Frossard, and F. Pons. 2008. “Regulation of Peroxisome proliferator-activated receptor-alpha expression during lung inflammation.” Pulmonary Pharmacology and Therapeutics 21 (2): 324–330. doi: 10.1016/j.pupt.2007.08.001.
   PubMed Web of Science ®Google Scholar
• Belvisi, M. G., and J. A. Mitchell. 2009. “Targeting PPAR Receptors in the Airway for the Treatment of Inflammatory Lung Disease.” British Journal of Pharmacology 158 (4): 994–1003. doi: 10.1111/j.1476-5381.2009.00373.x.
   PubMed Web of Science ®Google Scholar
• Benjamini, Y., and Y. Hochberg. 1995. “Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing.” Journal of the Royal Statistical Society. Series B (Methodological) 57: 289–300.
   Web of Science ®Google Scholar
• Bowler, R. P., S. Jacobson, C. Cruickshank, G. J. Hughes, C. Siska, D. S. Ory, I. Petrache, et al. 2015. “Plasma Sphingolipids Associated with Chronic Obstructive Pulmonary Disease Phenotypes.” American Journal of Respiratory and Critical Care Medicine 191 (3): 275–284. doi: 10.1164/rccm.201410-1771OC.
   PubMed Web of Science ®Google Scholar
• Braakhuis, H. M., I. Gosens, P. Krystek, J. A. F. Boere, F. R. Cassee, P. H. B. Fokkens, J. A. Post, et al. 2014. “Particle Size Dependent Deposition and Pulmonary Inflammation after Short-Term Inhalation of Silver Nanoparticles.” Particle and Fibre Toxicology 11 (1): 49. doi: 10.1186/s12989-014-0049-1.
   PubMedGoogle Scholar
• Braverman, N. E., and A. B. Moser. 2012. “Functions of Plasmalogen Lipids in Health and Disease.” Biochimica Et Biophysica Acta 1822 (9): 1442–1452. doi: 10.1016/j.bbadis.2012.05.008.
   PubMed Web of Science ®Google Scholar
• Broniec, A., R. Klosinski, A. Pawlak, M. Wrona-Krol, D. Thompson, and T. Sarna. 2011. “Interactions of Plasmalogens and Their Diacyl Analogs with Singlet Oxygen in Selected Model Systems.” Free Radical Biology and Medicine 50 (7): 892–898. doi: 10.1016/j.freeradbiomed.2011.01.002.
   PubMed Web of Science ®Google Scholar
• Chakravarthy, M. V., I. J. Lodhi, L. Yin, R. R. V. Malapaka, H. E. Xu, J. Turk, C. F. Semenkovich, et al. 2009. “Identification of a Physiologically Relevant Endogenous Ligand for PPARalpha in Liver.” Cell 138 (3): 476–488. doi: 10.1016/j.cell.2009.05.036.
   PubMed Web of Science ®Google Scholar
• Chen, W. L., C. Y. Lin, Y. H. Yan, K. T. Cheng, and T. J. Cheng. 2014. “Alterations in Rat Pulmonary Phosphatidylcholines after Chronic Exposure to Ambient Fine Particulate Matter.” Molecular Biosystems 10 (12): 3163–3169. doi: 10.1039/c4mb00435c.
   PubMed Web of Science ®Google Scholar
• Cho, H.-Y., W. Gladwell, X. Wang, B. Chorley, D. Bell, S. P. Reddy, S. R. Kleeberger, et al. 2010. “Nrf2-Regulated PPAR{Gamma} Expression Is Critical to Protection against Acute Lung Injury in Mice.” American Journal of Respiratory and Critical Care Medicine 182 (2): 170–182. doi: 10.1164/rccm.200907-1047OC.
   PubMed Web of Science ®Google Scholar
• Cho, W.-S., R. Duffin, C. A. Poland, A. Duschl, G. J. Oostingh, W. MacNee, M. Bradley, et al. 2012. “Differential Pro-Inflammatory Effects of Metal Oxide Nanoparticles and Their Soluble Ions in Vitro and in Vivo; Zinc and Copper Nanoparticles, but Not Their Ions, Recruit Eosinophils to the Lungs.” Nanotoxicology 6 (1): 22–35. doi: 10.3109/17435390.2011.552810.
   PubMed Web of Science ®Google Scholar
• Cho, W. S., R. Duffin, C. A. Poland, S. E. Howie, W. Macnee, M. Bradley, et al. 2010b. “Metal Oxide Nanoparticles Induce Unique Inflammatory Footprints in the Lung: important Implications for Nanoparticle Testing.” Environmental Health Perspectives 118: 1699–1706. doi: 10.1289/ehp.1002201.
   PubMed Web of Science ®Google Scholar
• Cui, Z., and M. Houweling. 2002. “Phosphatidylcholine and Cell Death.” Biochimica Et Biophysica Acta 1585 (2–3): 87–96.
   PubMed Web of Science ®Google Scholar
• Dushianthan, A., R. Cusack, V. Goss, A. D. Postle, and M. P. Grocott. 2012. “Clinical Review: Exogenous Surfactant Therapy for Acute Lung injury/acute respiratory distress syndrome-where do we go from here?” Critical Care (London, England) 16 (6): 238. doi: 10.1186/cc11512.
   PubMed Web of Science ®Google Scholar
• Feller, S. E., K. Gawrisch, and A. D. Mackerell. Jr. 2002. “Polyunsaturated Fatty Acids in Lipid Bilayers: intrinsic and Environmental Contributions to Their Unique Physical Properties.” Journal of the American Chemical Society 124 (2): 318–326.
   PubMed Web of Science ®Google Scholar
• Fine, J. M., T. Gordon, L. C. Chen, P. Kinney, G. Falcone, and W. S. Beckett. 1997. “Metal Fume Fever: Characterization of Clinical and Plasma IL-6 Responses in Controlled Human Exposures to Zinc Oxide Fume at and below the Threshold Limit value.” Journal of Occupational and Environmental Medicine 39 (8): 722–726. doi: 10.1097/00043764-199708000-00006.
   PubMed Web of Science ®Google Scholar
• Folch, J., M. Lees, and G. H. Sloane Stanley. 1957. “A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues.” The Journal of Biological Chemistry 226 (1): 497–509.
   PubMed Web of Science ®Google Scholar
• Fukui, H., M. Horie, S. Endoh, H. Kato, K. Fujita, K. Nishio, L. K. Komaba, et al. 2012. “Association of Zinc Ion Release and Oxidative Stress Induced by Intratracheal Instillation of ZnO Nanoparticles to Rat Lung.” Chemico-Biological Interactions 198 (1–3): 29–37. doi: 10.1016/j.cbi.2012.04.007.
   PubMed Web of Science ®Google Scholar
• Ghidoni, R., A. Caretti, and P. Signorelli. 2015. “Role of Sphingolipids in the Pathobiology of Lung Inflammation.” Mediators of Inflammation 2015: 487508. doi: 10.1155/2015/487508.
   PubMed Web of Science ®Google Scholar
• Gordon, T., and J. M. Fine. 1993. “Metal Fume Fever.” Occup Med 8: 505–517.
   Google Scholar
• Guo, S., Y. Wang, D. Zhou, and Z. Li. 2014. “Significantly Increased Monounsaturated Lipids Relative to Polyunsaturated Lipids in Six Types of Cancer Microenvironment Are Observed by Mass Spectrometry imaging.” Scientific Reports 4: 5959. doi: 10.1038/srep05959.
   PubMed Web of Science ®Google Scholar
• Henderson, R. F. 2005. “Use of Bronchoalveolar Lavage to Detect Respiratory Tract Toxicity of Inhaled Material.” Exp Toxicol Pathol 57(Suppl 1): 155–159.
   PubMed Web of Science ®Google Scholar
• Ho, M., K. Y. Wu, H. M. Chein, L. C. Chen, and T. J. Cheng. 2011. “Pulmonary Toxicity of Inhaled Nanoscale and Fine Zinc Oxide Particles: mass and Surface Area as an Exposure Metric.” Inhal Toxicol 23 (14): 947–956. doi: 10.3109/08958378.2011.629235.
   PubMed Web of Science ®Google Scholar
• Ho, W. E., Y. J. Xu, C. Cheng, H. Y. Peh, S. R. Tannenbaum, W. S. Wong, et al. 2014. “Metabolomics Reveals Inflammatory-Linked Pulmonary Metabolic Alterations in a Murine Model of House Dust Mite-Induced Allergic Asthma.” Journal Proteome Research. 13(8):3771–3782.doi: 10.1021/pr5003615.
   Web of Science ®Google Scholar
• Ho, W. E., Y.-J. Xu, F. Xu, C. Cheng, H. Y. Peh, S. R. Tannenbaum, W. S. F. Wong, et al. 2013. “Metabolomics Reveals Altered Metabolic Pathways in Experimental asthma.” American Journal of Respiratory Cell and Molecular Biology 48 (2): 204–211. doi: 10.1165/rcmb.2012-0246OC.
   PubMed Web of Science ®Google Scholar
• Kang, Y. P., W. J. Lee, J. Y. Hong, S. B. Lee, J. H. Park, D. Kim, S. Park, et al. 2014. “Novel Approach for Analysis of Bronchoalveolar Lavage Fluid (BALF) Using HPLC-QTOF-MS-Based Lipidomics: lipid Levels in Asthmatics and Corticosteroid-Treated Asthmatic Patients.” Journal of Proteome Research 13 (9): 3919–3929. doi: 10.1021/pr5002059.
   PubMed Web of Science ®Google Scholar
• Kersten, S. 2014. “Integrated Physiology and Systems Biology of PPARα.” Molecular Metabolism 3 (4): 354–371. doi: 10.1016/j.molmet.2014.02.002.
   PubMed Web of Science ®Google Scholar
• Lee, S. H., T. Y. Wang, J. H. Hong, T. J. Cheng, and C. Y. Lin. 2016. “NMR-Based Metabolomics to Determine Acute Inhalation Effects of Nano- and Fine-Sized ZnO Particles in the Rat Lung.” Nanotoxicology 10 (7): 924–934. doi: 10.3109/17435390.2016.1144825.
   PubMed Web of Science ®Google Scholar
• Ling, Y. S., H.-J. Liang, M.-H. Chung, M.-H. Lin, and C.-Y. Lin. 2014. “NMR- and MS-Based Metabolomics: Various Organ Responses following Naphthalene Intervention.” Molecular Biosystems 10 (7): 1918–1931. doi: 10.1039/c4mb00090k.
   PubMed Web of Science ®Google Scholar
• Liu, S., J. D. Brown, K. J. Stanya, E. Homan, M. Leidl, K. Inouye, P. Bhargava, et al. 2013. “A Diurnal Serum Lipid Integrates Hepatic Lipogenesis and Peripheral Fatty Acid Use.” Nature 502 (7472): 550–554. doi: 10.1038/nature12710.
   PubMed Web of Science ®Google Scholar
• Mangold, H. K., and N. Weber. 1987. “Biosynthesis and Biotransformation of Ether Lipids.” Lipids 22 (11): 789–799.
   PubMed Web of Science ®Google Scholar
• Moezzi, A., A. M. Mcdonagh, and M. B. Cortie. 2012. “Zinc Oxide Particles: Synthesis, Properties and Applications.” Chemical Engineering Journal 185–186: 1–22. doi: 10.1016/j.cej.2012.01.076.
   Web of Science ®Google Scholar
• Nel, A., T. Xia, L. Madler, and N. Li. 2006. “Toxic Potential of Materials at the Nanolevel.” Science (New York, N.Y.) 311 (5761): 622–627. doi: 10.1126/science.1114397.
   PubMed Web of Science ®Google Scholar
• Nicholson, J. K., and J. C. Lindon. 2008. “Systems Biology: Metabonomics.” Nature 455 (7216): 1054–1056.
   PubMed Web of Science ®Google Scholar
• Nishiyama, O., H. Kume, M. Kondo, Y. Ito, M. Ito, and K. Yamaki. 2004. “Role of Lysophosphatidylcholine in Eosinophil Infiltration and Resistance in Airways.” Clinical and Experimental Pharmacology and Physiology 31 (3): 179–184.
   PubMed Web of Science ®Google Scholar
• Oberdorster, G., E. Oberdorster, and J. Oberdorster. 2005. “Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles.” Environmental Health Perspectives 113 (7): 823–839.
   PubMed Web of Science ®Google Scholar
• Pluskal, T., S. Castillo, A. Villar-Briones, and M. Oresic. 2010. “MZmine 2: modular Framework for Processing, Visualizing, and Analyzing Mass Spectrometry-Based Molecular Profile Data.” BMC Bioinformatics 11: 395. doi: 10.1186/1471-2105-11-395.
   PubMed Web of Science ®Google Scholar
• Ramstedt, B., and J. P. Slotte. 2002. “Membrane Properties of sphingomyelins.” FEBS Letters 531 (1): 33–37.
   PubMed Web of Science ®Google Scholar
• Ravipati, S., D. R. Baldwin, H. L. Barr, A. W. Fogarty, and D. A. Barrett. 2015. “Plasma Lipid Biomarker Signatures in Squamous Carcinoma and Adenocarcinoma Lung Cancer Patients.” Metabolomics 11 (6): 1600–1611. doi: 10.1007/s11306-015-0811-x.
   Web of Science ®Google Scholar
• Reiss, D., K. Beyer, and B. Engelmann. 1997. “Delayed Oxidative Degradation of Polyunsaturated Diacyl Phospholipids in the Presence of Plasmalogen Phospholipids in Vitro.” Biochemical Journal 323 (3): 807–814.
   PubMedGoogle Scholar
• Ried, J. S., H. Baurecht, F. Stückler, J. Krumsiek, C. Gieger, J. Heinrich, M. Kabesch, et al. 2013. “Integrative Genetic and Metabolite Profiling Analysis Suggests Altered Phosphatidylcholine Metabolism in Asthma.” Allergy 68 (5): 629–636. doi: 10.1111/all.12110.
   PubMed Web of Science ®Google Scholar
• Sahu, D., G. M. Kannan, R. Vijayaraghavan, T. Anand, and F. Khanum. 2013. “Nanosized Zinc Oxide Induces Toxicity in Human Lung Cells.” International Scholarly Research Notices: Toxicology 2013: 316075. doi: 10.1155/2013/316075.
   Google Scholar
• Shoemaker, S. D., and T. K. Vanderlick. 2002. “Stress-Induced Leakage from Phospholipid Vesicles: Effect of Membrane Composition.” Industrial & Engineering Chemistry Research 41 (3): 324–329. doi: 10.1021/ie010049t.
   Web of Science ®Google Scholar
• Sindelar, P. J., Z. Guan, G. Dallner, and L. Ernster. 1999. “The Protective Role of Plasmalogens in iron-induced lipid peroxidation .” Free Radical Biology and Medicine 26 (3–4): 318–324.
   PubMed Web of Science ®Google Scholar
• Smith, H. L., M. C. Howland, A. W. Szmodis, Q. Li, L. L. Daemen, A. N. Parikh, J. Majewski, et al. 2009. “Early Stages of Oxidative Stress-Induced Membrane Permeabilization: A Neutron Reflectometry Study.” Journal of the American Chemical Society 131 (10): 3631–3638. doi: 10.1021/ja807680m.
   PubMed Web of Science ®Google Scholar
• Tang, C. H., P. N. Tsao, C. Y. Chen, M. S. Shiao, W. H. Wang, and C. Y. Lin. 2011. “Glycerophosphocholine Molecular Species Profiling in the Biological Tissue Using UPLC/MS/MS.” Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 879 (22): 2095–2106. doi: 10.1016/j.jchromb.2011.05.044.
   PubMed Web of Science ®Google Scholar
• Tang, C. H., P. N. Tsao, C. Y. Lin, L. S. Fang, S. H. Lee, and W. H. Wang. 2012. “Phosphorylcholine-Containing Lipid Molecular Species Profiling in Biological Tissue Using a Fast HPLC/QqQ-MS Method.” Analytical and Bioanalytical Chemistry 404 (10): 2949–2961. doi: 10.1007/s00216-012-6414-8.
   PubMed Web of Science ®Google Scholar
• Taniguchi, M., and T. Okazaki. 2014. “The Role of Sphingomyelin and Sphingomyelin Synthases in Cell Death, Proliferation and Migration-from Cell and Animal Models to Human Disorders.” Biochimica et Biophysica Acta 1841 (5): 692–703. doi: 10.1016/j.bbalip.2013.12.003.
   PubMed Web of Science ®Google Scholar
• Teichgräber, V., M. Ulrich, N. Endlich, J. Riethmüller, B. Wilker, C. C. De Oliveira-Munding, A. M. van Heeckeren, et al. 2008. “Ceramide Accumulation Mediates Inflammation, Cell Death and Infection Susceptibility in Cystic Fibrosis.” Nature Medicine 14 (4): 382–391. doi: 10.1038/nm1748.
   PubMed Web of Science ®Google Scholar
• Trifilieff, A., A. Bench, M. Hanley, D. Bayley, E. Campbell, and P. Whittaker. 2003. “PPAR-Alpha and -Gamma but Not -Delta Agonists Inhibit Airway Inflammation in a Murine Model of Asthma: In Vitro Evidence for an NF-kappaB-Independent Effect.” British Journal of Pharmacology 139 (1): 163–171. doi: 10.1038/sj.bjp.0705232.
   PubMed Web of Science ®Google Scholar
• Van Meer, G., D. R. Voelker, and G. W. Feigenson. 2008. “Membrane Lipids: where They Are and How They Behave.” Nature Reviews. Molecular Cell Biology 9 (2): 112–124. doi: 10.1038/nrm2330.
   PubMed Web of Science ®Google Scholar
• Wang-Sattler, R., Y. Yu, K. Mittelstrass, E. Lattka, E. Altmaier, C. Gieger, K. H. Ladwig, et al. 2008. “Metabolic Profiling Reveals Distinct Variations Linked to Nicotine Consumption in humans-first results from the KORA study.” PLoS One 3 (12): e3863. doi: 10.1371/journal.pone.0003863.
   PubMed Web of Science ®Google Scholar
• Westerhuis, J. A., H. C. J. Hoefsloot, S. Smit, D. J. Vis, A. K. Smilde, E. J. J. van Velzen, J. P. M. van Duijnhoven, et al. 2008. “Assessment of PLSDA Cross Validation.” Metabolomics 4 (1): 81–89. doi: 10.1007/s11306-007-0099-6.
   Web of Science ®Google Scholar
• Xia, J., D. I. Broadhurst, M. Wilson, and D. S. Wishart. 2013. “Translational Biomarker Discovery in Clinical Metabolomics: An Introductory tutorial.” Metabolomics: Official Journal of the Metabolomic Society 9 (2): 280–299. doi: 10.1007/s11306-012-0482-9.
   PubMed Web of Science ®Google Scholar
• Xia, T., M. Kovochich, M. Liong, L. Mädler, B. Gilbert, H. Shi, J. I. Yeh, et al. 2008. “Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties.” ACS Nano 2 (10): 2121–2134. doi: 10.1021/nn800511k.
   PubMed Web of Science ®Google Scholar
• Yan, G., Y. Huang, Q. Bu, L. Lv, P. Deng, J. Zhou, Y. Wang, et al. 2012. “Zinc Oxide Nanoparticles Cause Nephrotoxicity and Kidney Metabolism Alterations in Rats.” Journal of Environmental Science and Health. Part A, Toxic/Hazardous Substances and Environmental Engineering 47 (4): 577–588. doi: 10.1080/10934529.2012.650576.
   PubMed Web of Science ®Google Scholar
• Yoder, M., Y. Zhuge, Y. Yuan, O. Holian, S. Kuo, R. van Breemen, L. L. Thomas, et al. 2014. “Bioactive Lysophosphatidylcholine 16:0 and 18:0 Are Elevated in Lungs of Asthmatic Subjects.” Allergy, Asthma & Immunology Research 6 (1): 61–65. doi: 10.4168/aair.2014.6.1.61.
   PubMed Web of Science ®Google Scholar
• Zhao, J., L. Xu, T. Zhang, G. Ren, and Z. Yang. 2009. “Influences of Nanoparticle Zinc Oxide on Acutely Isolated Rat Hippocampal CA3 Pyramidal Neurons.” Neurotoxicology 30 (2): 220–230. doi: 10.1016/j.neuro.2008.12.005.
   PubMed Web of Science ®Google Scholar