Evaluation of toxicological and teratogenic effects of carbosilane glucose glycodendrimers in zebrafish embryos and model rodent cell lines

References

• Appelhans, D., B. Klajnert-Maculewicz, A. Janaszewska, J. Lazniewska, and B. Voit. 2015. “Dendritic Glycopolymers Based on Dendritic Polyamine Scaffolds: View on Their Synthetic Approaches, Characteristics and Potential for Biomedical Applications.” Chemical Society Reviews 44 (12): 3968–3996. doi:10.1039/C4CS00339J.
   PubMed Web of Science ®Google Scholar
• Appelhans, D., Y. Zhong, H. Komber, P. Friedel, U. Oertel, U. Scheler, N. Morgner, et al. 2007. “Oligosaccharide-Modified Poly(Propyleneimine) Dendrimers: Synthesis, Structure Determination, and Cu(II) Complexation.” Macromolecular Bioscience 7 (3): 373–383. doi:10.1002/mabi.200600260.
   PubMed Web of Science ®Google Scholar
• Bayly, C. I., P. Cieplak, W. Cornell, and P. A. Kollman. 1993. “A Well-Behaved Electrostatic Potential Based Method Using Charge Restraints for Deriving Atomic Charges: The RESP Model.” The Journal of Physical Chemistry 97 (40): 10269–10280. doi:10.1021/j100142a004.
   Web of Science ®Google Scholar
• Belanger, S. E., J. M. Rawlings, and G. J. Carr. 2013. “Use of Fish Embryo Toxicity Tests for the Prediction of Acute Fish Toxicity to Chemicals.” Environmental Toxicology and Chemistry 32 (8): 1768–1783. doi:10.1002/etc.2244.
   PubMed Web of Science ®Google Scholar
• Bodewein, L., F. Schmelter, S. Di Fiore, H. Hollert, R. Fischer, and M. Fenske. 2016. “Differences in Toxicity of Anionic and Cationic PAMAM and PPI Dendrimers in Zebrafish Embryos and Cancer Cell Lines.” Toxicology and Applied Pharmacology 305: 83–92. doi:10.1016/j.taap.2016.06.008.
   PubMed Web of Science ®Google Scholar
• Boess, F. 2003. “Gene Expression in Two Hepatic Cell Lines, Cultured Primary Hepatocytes, and Liver Slices Compared to the in Vivo Liver Gene Expression in Rats: Possible Implications for Toxicogenomics.” Toxicological Sciences 73 (2): 386–402. doi:10.1093/toxsci/kfg064.
   PubMed Web of Science ®Google Scholar
• Böhme, S., H. J. Stärk, T. Reemtsma, and D. Kühnel. 2015. “Effect Propagation after Silver Nanoparticle Exposure in Zebrafish (Danio rerio) Embryos: A Correlation to Internal Concentration and Distribution Patterns.” Environmental Science: Nano 2 (6): 603–614. doi:10.1039/C5EN00118H.
   Web of Science ®Google Scholar
• Braunbeck, T., B. Kais, E. Lammer, J. Otte, K. Schneider, D. Stengel, R. Strecker, et al. 2015. “The Fish Embryo Test (FET): Origin, Applications, and Future.” Environmental Science and Pollution Research International 22 (21): 16247–16261. doi:10.1007/s11356-014-3814-7.
   PubMed Web of Science ®Google Scholar
• Burnison, B. K., T. Meinelt, R. Playle, M. Pietrock, A. Wienke, and C. E. W. Steinberg. 2006. “Cadmium Accumulation in Zebrafish (Danio rerio) Eggs Is Modulated by Dissolved Organic Matter (DOM).” Aquatic Toxicology 79 (2): 185–191. doi:10.1016/j.aquatox.2006.06.010.
   PubMed Web of Science ®Google Scholar
• Busquet, F., R. Strecker, J. M. Rawlings, S. E. Belanger, T. Braunbeck, G. J. Carr, P. Cenijn, et al. 2014. “OECD Validation Study to Assess Intra- and Inter-Laboratory Reproducibility of the Zebrafish Embryo Toxicity Test for Acute Aquatic Toxicity Testing.” Regulatory Toxicology and Pharmacology 69 (3): 496–511. doi:10.1016/j.yrtph.2014.05.018.
   PubMed Web of Science ®Google Scholar
• Calienni, M. N., D. A. Feas, D. E. Igartúa, N. S. Chiaramoni, S. D. V. Alonso, and M. J. Prieto. 2017. “Nanotoxicological and Teratogenic Effects: A Linkage between Dendrimer Surface Charge and Zebrafish Developmental Stages.” Toxicology and Applied Pharmacology 337: 1. doi:10.1016/j.taap.2017.10.003.
   PubMed Web of Science ®Google Scholar
• Carrière, M., L. Avoscan, R. Collins, F. Carrot, H. Khodja, E. Ansoborlo, B. Gouget, et al. 2004. “Influence of Uranium Speciation on Normal Rat Kidney (NRK-52E) Proximal Cell Cytotoxicity.” Chemical Research in Toxicology 17 (3): 446–452. doi:10.1021/tx034224h.
   PubMed Web of Science ®Google Scholar
• Case, D. A., D. S. Cerutti, T. E. Cheatham, III, T. A. Darden, R. E. Duke, T. J. Giese, H. Gohlke, et al. 2017. AMBER 2017. San Francisco, CA: University of California.
   Google Scholar
• Ciepluch, K., B. Ziemba, A. Janaszewska, D. Appelhans, B. Klajnert, M. Bryszewska, W. A. Fogel, et al. 2012. “Modulation of Biogenic Amines Content by Poly(Propylene Imine) Dendrimers in Rats.” Journal of Physiology and Biochemistry 68 (3): 447–454. doi:10.1007/s13105-012-0158-y.
   PubMed Web of Science ®Google Scholar
• Dai, Y. J., Y. F. Jia, N. Chen, W. P. Bian, Q. K. Li, Y. B. Ma, Y. L. Chen, et al. 2014. “Zebrafish as a Model System to Study Toxicology.” Environmental Toxicology and Chemistry 33 (1): 11–17. doi:10.1002/etc.2406.
   PubMed Web of Science ®Google Scholar
• Dayan, A. 2000. “General and Applied Toxicology, 2nd Edition.” Occupational and Environmental Medicine 57 (6): 431d–4431. doi:10.1136/oem.57.6.431d.
   PubMedGoogle Scholar
• de Esch, C., R. Slieker, A. Wolterbeek, R. Woutersen, and D. de Groot. 2012. “Zebrafish as Potential Model for Developmental Neurotoxicity Testing: A Mini Review.” Neurotoxicol Teratol 34 (6): 545–553. doi:10.1016/j.ntt.2012.08.006.
   PubMed Web of Science ®Google Scholar
• Dupradeau, F. Y., A. Pigache, T. Zaffran, C. Savineau, R. Lelong, N. Grivel, D. Lelong, et al. 2010. “The R.E.D. Tools: Advances in RESP and ESP Charge Derivation and Force Field Library Building.” Physical Chemistry Chemical Physics 12 (28): 7821–7839. doi:10.1039/c0cp00111b.
   PubMed Web of Science ®Google Scholar
• Fischer, M., D. Appelhans, S. Schwarz, B. Klajnert, M. Bryszewska, B. Voit, M. Rogers, et al. 2010. “Influence of Surface Functionality of Poly(Propylene Imine) Dendrimers on Protease Resistance and Propagation of the Scrapie Prion Protein.” Biomacromolecules 11 (5): 1314–1325. doi:10.1021/bm100101s.
   PubMed Web of Science ®Google Scholar
• Fleming, A. 2007. Zebrafish as an Alternative Model Organism for Disease Modelling and Drug Discovery: Implications for the 3Rs. Vol. 10. NC3Rs. London: National Centre for the Replacement, Refinement and Reduction of Animals in Research.
   Google Scholar
• Franiak-Pietryga, I., E. Ziółkowska, B. Ziemba, D. Appelhans, B. Voit, M. Szewczyk, J. Góra-Tybor, et al. 2013. “The Influence of Maltotriose-Modified Poly(Propylene Imine) Dendrimers on the Chronic Lymphocytic Leukemia Cells In Vitro: Dense Shell G4 PPI.” Molecular Pharmaceutics 10 (6): 2490–2501. doi:10.1021/mp400142p.
   PubMed Web of Science ®Google Scholar
• Gordon, M. S., and M. W. Schmidt. 2005. Advances in Electronic Structure Theory: GAMESS a Decade Later: Theory and Applications of Computational Chemistry: The First Forty Years. C. E. Dykstra, ed. New York, NY: Elsevier. p. 1167–1189.
   Google Scholar
• Götz, A. W., M. J. Williamson, D. Xu, D. Poole, S. Le Grand, and R. C. Walker. 2012. “Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born.” Journal of Chemical Theory and Computation 8 (5): 1542–1555. doi:10.1021/ct200909j.
   PubMed Web of Science ®Google Scholar
• Harper, B., D. Thomas, S. Chikkagoudar, N. Baker, K. Tang, A. Heredia-Langner, R. Lins, et al. 2015. “Comparative Hazard Analysis and Toxicological Modeling of Diverse Nanomaterials Using the Embryonic Zebrafish (EZ) Metric of Toxicity.” Journal of Nanoparticle Research 17 (6): 250. doi:10.1007/s11051-015-3051-0.
   PubMed Web of Science ®Google Scholar
• Henn, K., and T. Braunbeck. 2011. “Dechorionation as a Tool to Improve the Fish Embryo Toxicity Test (FET) with the Zebrafish (Danio rerio).” Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 153 (1): 91–98. doi:10.1016/j.cbpc.2010.09.003.
   PubMed Web of Science ®Google Scholar
• Höbel, S., A. Loos, D. Appelhans, S. Schwarz, J. Seidel, B. Voit, A. Aigner, et al. 2011. “Maltose- and Maltotriose-Modified, Hyperbranched Poly(Ethylene Imine)s (OM-PEIs): Physicochemical and Biological Properties of DNA and siRNA Complexes.” Journal of Controlled Release: Official Journal of the Controlled Release Society 149 (2): 146–158. doi:10.1016/j.jconrel.2010.10.008.
   PubMed Web of Science ®Google Scholar
• Howe, K., M. D. Clark, C. F. Torroja, J. Torrance, C. Berthelot, M. Muffato, J. E. Collins, et al. 2013. “The Zebrafish Reference Genome Sequence and Its Relationship to the Human Genome.” Nature 496 (7446): 498–503. doi:10.1038/nature12111.
   PubMed Web of Science ®Google Scholar
• Jain, K., P. Kesharwani, U. Gupta, and N. K. Jain. 2010. “Dendrimer Toxicity: Let’s Meet the Challenge.” International Journal of Pharmaceutics 394 (1–2): 122–142. doi:10.1016/j.ijpharm.2010.04.027.
   PubMed Web of Science ®Google Scholar
• Janaszewska, A., B. Ziemba, K. Ciepluch, D. Appelhans, B. Voit, B. Klajnert, M. Bryszewska, et al. 2012. “The Biodistribution of Maltotriose Modified Poly(Propylene Imine) (PPI) Dendrimers Conjugated with Fluorescein-Proofs of Crossing Blood-Brain-Barrier.” New Journal of Chemistry 36 (2): 350–353. doi:10.1039/C1NJ20444K.
   Web of Science ®Google Scholar
• Janaszewska, A., K. Mączyńska, G. Matuszko, D. Appelhans, B. Voit, B. Klajnert, M. Bryszewska, et al. 2012. “Cytotoxicity of PAMAM, PPI and Maltose Modified PPI Dendrimers in Chinese Hamster Ovary (CHO) and Human Ovarian Carcinoma (SKOV3) Cells.” New Journal of Chemistry 36 (2): 428–437. doi:10.1039/C1NJ20489K.
   Web of Science ®Google Scholar
• Janaszewska, A., M. Ciolkowski, D. Wróbel, J. F. Petersen, M. Ficker, J. B. Christensen, M. Bryszewska, et al. 2013. “Modified PAMAM Dendrimer with 4-Carbomethoxypyrrolidone Surface Groups Reveals Negligible Toxicity against Three Rodent Cell-Lines.” Nanomedicine: Nanotechnology, Biology, and Medicine 9 (4): 461–464. doi:10.1016/j.nano.2013.01.010.
   PubMed Web of Science ®Google Scholar
• Jinadatta, P., K. S. R. Rao, S. Rajshekarappa, S. G. P. Subbaiah, and M. Kenganora. 2017. “In Vitro Antioxidant and Hepatoprotective Activity of Bridelia Scandens (Roxb.) Willd.” Pharmacognosy Journal 9 (6s): s117–s121.10.5530/pj.2017.6s.167.
   Google Scholar
• Jorgensen, W. L., J. Chandrasekhar, J. D. Madura, R. W. Impey, and M. L. Klein. 1983. “Comparison of Simple Potential Functions for Simulating Liquid Water.” The Journal of Chemical Physics 79 (2): 926–935. doi:10.1063/1.445869.
   Web of Science ®Google Scholar
• Kim, K. T., and R. L. Tanguay. 2014. “The Role of Chorion on Toxicity of Silver Nanoparticles in the Embryonic Zebrafish Assay.” Environmental Health and Toxicology 29: e2014021. doi:10.5620/eht.e2014021.
   PubMedGoogle Scholar
• Kimmel, C. B., W. W. Ballard, S. R. Kimmel, B. Ullmann, and T. F. Schilling. 1995. “Stages of Embryonic Development of the Zebrafish.” Developmental Dynamics 203 (3): 253–310. doi:10.1002/aja.1002030302.
   PubMed Web of Science ®Google Scholar
• King Heiden, T. C., E. Dengler, W. J. Kao, W. Heideman, and R. E. Peterson. 2007. “Developmental Toxicity of Low Generation PAMAM Dendrimers in Zebrafish.” Toxicology and Applied Pharmacology 225 (1): 70–79. doi:10.1016/j.taap.2007.07.009.
   PubMed Web of Science ®Google Scholar
• Kirschner, K. N., A. B. Yongye, S. M. Tschampel, J. González-Outeiriño, C. R. Daniels, B. L. Foley, R. J. Woods, et al. 2008. “GLYCAM06: A Generalizable Biomolecular Force Field. Carbohydrates.” Journal of Computational Chemistry 29 (4): 622–655. doi:10.1002/jcc.20820.
   PubMed Web of Science ®Google Scholar
• Klajnert, B., D. Appelhans, H. Komber, N. Morgner, S. Schwarz, S. Richter, B. Brutschy, et al. 2008. “The Influence of Densely Organized Maltose Shells on the Biological Properties of Poly(Propylene Imine) Dendrimers: New Effects Dependent on Hydrogen Bonding.” Chemistry - A European Journal 14 (23): 7030–7041. doi:10.1002/chem.200800342.
   PubMed Web of Science ®Google Scholar
• Labieniec, M., and T. Gabryelak. 2003. “Effects of Tannins on Chinese Hamster Cell Line B14.” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 539 (1–2): 127–135. doi:10.1016/S1383-5718(03)00161-X.
   PubMed Web of Science ®Google Scholar
• Labieniec-Watala, M., and C. Watala. 2015. “PAMAM Dendrimers: Destined for Success or Doomed to Fail? Plain and Modified PAMAM Dendrimers in the Context of Biomedical Applications.” Journal of Pharmaceutical Sciences 104 (1): 2–14. doi:10.1002/jps.24222.
   PubMed Web of Science ®Google Scholar
• Lee, K. J., L. M. Browning, P. D. Nallathamby, T. Desai, P. K. Cherukuri, and X. H. N. Xu. 2012. “In Vivo Quantitative Study of Sized-Dependent Transport and Toxicity of Single Silver Nanoparticles Using Zebrafish Embryos.” Chemical Research in Toxicology 25 (5): 1029–1046. doi:10.1021/tx300021u.
   PubMed Web of Science ®Google Scholar
• Li, C., H. Liu, Y. Sun, H. Wang, F. Guo, S. Rao, J. Deng, et al. 2009. “PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway.” Journal of Molecular Cell Biology 1 (1): 37–45. doi:10.1093/jmcb/mjp002.
   PubMed Web of Science ®Google Scholar
• Lii, J. H., and N. L. Allinger. 1991. “The MM3 Force Field for Amides, Polypeptides and Proteins.” Journal of Computational Chemistry 12 (2): 186–199. doi:10.1002/jcc.540120208.
   Web of Science ®Google Scholar
• Maly, J., E. Pedziwiatr-Werbicka, M. Maly, A. Semeradtova, D. Appelhans, A. Danani, M. Zaborski, et al. 2012. “Highly Organized Self-Assembled Dendriplexes Based on Poly(Propylene Imine) Glycodendrimer and anti-HIV Oligodeoxynucleotides.” Current Medicinal Chemistry 19 (27): 4708–4719. doi:10.2174/092986712803306457.
   PubMed Web of Science ®Google Scholar
• Maly, J., O. Stanek, J. Frolik, M. Maly, F. Ennen, D. Appelhans, A. Semeradtova, et al. 2016. “Biocompatible Size-Defined Dendrimer–Albumin Binding Protein Hybrid Materials as a Versatile Platform for Biomedical Applications.” Macromolecular Bioscience 16 (4): 553–566. doi:10.1002/mabi.201500332.
   PubMed Web of Science ®Google Scholar
• Martinez, C. S., D. E. Igartúa, M. N. Calienni, D. A. Feas, M. Siri, J. Montanari, N. S. Chiaramoni, et al. 2017. “Relation between Biophysical Properties of Nanostructures and Their Toxicity on Zebrafish.” Biophysical Reviews 9: 775–791. doi:10.1007/s12551-017-0294-2.
   PubMedGoogle Scholar
• McCarthy, J. M., B. Rasines Moreno, D. Filippini, H. Komber, M. Maly, M. Cernescu, B. Brutschy, et al. 2013. “Influence of Surface Groups on Poly(Propylene Imine) Dendrimers Antiprion Activity.” Biomacromolecules 14 (1): 27–37. doi:10.1021/bm301165u.
   PubMed Web of Science ®Google Scholar
• McCollum, C. W., N. A. Ducharme, M. Bondesson, and J. A. Gustafsson. 2011. “Developmental Toxicity Screening in Zebrafish.” Birth Defects Research Part C Embryo Today Reviews 93 (2): 67–114. doi:10.1002/bdrc.20210.
   PubMedGoogle Scholar
• McGrath, P., and C. Q. Li. 2008. “Zebrafish: A Predictive Model for Assessing Drug-Induced Toxicity.” Drug Discovery Today 13 (9–10): 394–401. doi:10.1016/j.drudis.2008.03.002.
   PubMed Web of Science ®Google Scholar
• Mereyala, H. B., and S. R. Gurrala. 1998. “A Highly Diastereoselective, Practical Synthesis of Allyl, Propargyl 2,3,4,6-Tetra-O-Acetyl-β-d-Gluco, β-d-Galactopyranosides and Allyl, Propargyl Heptaacetyl-β-d-Lactosides.” Carbohydrate Research 307 (3–4): 351–354. doi:10.1016/S0008-6215(97)10104-5.
   Web of Science ®Google Scholar
• Naha, P. C., S. P. Mukherjee, and H. J. Byrne. 2018. “Toxicology of Engineered Nanoparticles: Focus on Poly(Amidoamine) Dendrimers.” International Journal of Environmental Research and Public Health 15 (2): 338. doi:10.3390/ijerph15020338.
   PubMed Web of Science ®Google Scholar
• Nishimura, Y., S. Murakami, Y. Ashikawa, S. Sasagawa, N. Umemoto, Y. Shimada, T. Tanaka, et al. 2015. “Zebrafish as a Systems Toxicology Model for Developmental Neurotoxicity Testing.” Congenital Anomalies (Kyoto) 55 (1): 1–16. doi:10.1111/cga.12079.
   PubMed Web of Science ®Google Scholar
• OECD. 2013. Test No. 236: Fish Embryo Acute Toxicity (FET) Test. Paris: OECD Publishing.
   Google Scholar
• Oliveira, E., M. Casado, M. Faria, A. M. V. M. Soares, J. M. Navas, C. Barata, B. Piña, et al. 2014. “Transcriptomic Response of Zebrafish Embryos to Polyaminoamine (PAMAM) Dendrimers.” Nanotoxicology 8 (1): 92–99. doi:10.3109/17435390.2013.858376.
   PubMedGoogle Scholar
• Pacheco, A. G., and M. d. Freitas Rebelo. 2013. “A Simple R-Based Function to Estimate Lethal Concentrations.” Marine Environmental Research 91: 41–44. doi:10.1016/j.marenvres.2013.08.003.
   PubMed Web of Science ®Google Scholar
• Panzica-Kelly, J. M., C. X. Zhang, and K. A. Augustine-Rauch. 2015. “Optimization and Performance Assessment of the Chorion-off [Dechorinated] Zebrafish Developmental Toxicity Assay.” Toxicological Sciences 146 (1): 127–134. doi:10.1093/toxsci/kfv076.
   PubMed Web of Science ®Google Scholar
• Pedziwiatr-Werbicka, E., D. Shcharbin, J. Maly, M. Maly, M. Zaborski, B. Gabara, P. Ortega, et al. 2012. “Carbosilane Dendrimers Are a Non-Viral Delivery System for Antisense Oligonucleotides: Characterization of Dendriplexes.” Journal of Biomedical Nanotechnology 8 (1): 57–73. doi:10.1166/jbn.2012.1369.
   PubMed Web of Science ®Google Scholar
• Pettersen, E. F., T. D. Goddard, C. C. Huang, G. S. Couch, D. M. Greenblatt, E. C. Meng, T. E. Ferrin, et al. 2004. “UCSF Chimera–A Visualization System for Exploratory Research and Analysis.” Journal of Computational Chemistry 25 (13): 1605–1612. doi:10.1002/jcc.20084.
   PubMed Web of Science ®Google Scholar
• Pryor, J. B., B. J. Harper, and S. L. Harper. 2014. “Comparative Toxicological Assessment of PAMAM and Thiophosphoryl Dendrimers Using Embryonic Zebrafish.” International Journal of Nanomedicine 9: 1947–1956. doi:10.2147/IJN.S60220.
   PubMed Web of Science ®Google Scholar
• Qi, R., Y. Gao, Y. Tang, R. R. He, T. L. Liu, Y. He, S. Sun, et al. 2009. “PEG-Conjugated PAMAM Dendrimers Mediate Efficient Intramuscular Gene Expression.” The AAPS Journal 11 (3): 395–405. doi:10.1208/s12248-009-9116-1.
   PubMed Web of Science ®Google Scholar
• Qiu, M., F. Shi, F. Dai, R. Song, S. Wang, Y. You, B. Zhao, et al. 2018. “A Reactive Oxygen Species Activation Mechanism Contributes to Sophoridine- Induced Apoptosis in Rat Liver BRL-3A Cells.” Journal of Ethnopharmacology 213: 376–383. doi:10.1016/j.jep.2017.10.030.
   PubMed Web of Science ®Google Scholar
• R:CoreTeam. 2014. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing.
   Google Scholar
• Roe, D. R., and T. E. Cheatham. 2013. “PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data.” Journal of Chemical Theory and Computation 9 (7): 3084–3095. doi:10.1021/ct400341p.
   PubMed Web of Science ®Google Scholar
• Ryckaert, J.-P., G. Ciccotti, and H. J. C. Berendsen. 1977. “Numerical Integration of the Cartesian Equations of Motion of a System with Constraints: Molecular Dynamics of n-Alkanes.” Journal of Computational Physics 23 (3): 327–341. doi:10.1016/0021-9991(77)90098-5.
   Web of Science ®Google Scholar
• Schmidt, M. W., K. K. Baldridge, J. A. Boatz, S. T. Elbert, M. S. Gordon, J. H. Jensen, S. Koseki, et al. 1993. “General Atomic and Molecular Electronic Structure System.” Journal of Computational Chemistry 14 (11): 1347–1363. doi:10.1002/jcc.540141112.
   Web of Science ®Google Scholar
• Scholz, S., S. Fischer, U. Gündel, E. Küster, T. Luckenbach, and D. Voelker. 2008. “The Zebrafish Embryo Model in Environmental Risk Assessment–Applications beyond Acute Toxicity Testing.” Environmental Science and Pollution Research 15 (5): 394–404. doi:10.1007/s11356-008-0018-z.
   PubMed Web of Science ®Google Scholar
• Strašák, T., J. Čermák, J. Sýkora, J. Horský, Z. Walterová, F. Jaroschik, D. Harakat, et al. 2012. “Carbosilane Metallodendrimers with Titanocene Dichloride End Groups.” Organometallics 31 (19): 6779–6786. doi:10.1021/om300559y.
   Web of Science ®Google Scholar
• Strašák, T., J. Malý, D. Wróbel, M. Malý, R. Herma, J. Čermák, M. Müllerová, et al. 2017. “Phosphonium Carbosilane Dendrimers for Biomedical Applications - Synthesis, Characterization and Cytotoxicity Evaluation.” RSC Advances 7 (30): 18724–18744. doi:10.1039/C7RA01845B.
   Web of Science ®Google Scholar
• Strojan, K., A. Leonardi, V. B. Bregar, I. Križaj, J. Svete, and M. Pavlin. 2017. “Dispersion of Nanoparticles in Different Media Importantly Determines the Composition of Their Protein Corona.” PLoS One 12 (1): e0169552. doi:10.1371/journal.pone.0169552.
   PubMed Web of Science ®Google Scholar
• Sze, A., D. Erickson, L. Ren, and D. Li. 2003. “Zeta-Potential Measurement Using the Smoluchowski Equation and the Slope of the Current-Time Relationship in Electroosmotic Flow.” Journal of Colloid and Interface Science 261 (2): 402–410. doi:10.1016/S0021-9797(03)00142-5.
   PubMed Web of Science ®Google Scholar
• Tong, Y., J. Chuan, L. Bai, J. Shi, L. Zhong, X. Duan, Y. Zhu, et al. 2018. “The Protective e Ff Ect of Shikonin on Renal Tubular Epithelial Cell Injury Induced by High Glucose.” Biomedicine & Pharmacotherapy 98: 701–708. doi:10.1016/j.biopha.2017.12.112.
   PubMed Web of Science ®Google Scholar
• Ulaszewska, M. M, M. D. Hernando, A. Ucles, R. Rosal, A. Rodrıguez, E. Garcia-Calvo, and A. R. Frndez-Alba. 2012. Chapter 6 - Chemical and Ecotoxicological Assessment of Dendrimers in the Aquatic Environment: Comprehensive Analytical Chemistry M. Farré and D. Barceló, editors. New York, NY: Elsevier. p. 197–233.
   Google Scholar
• van der Made, A. W., P. W. N. M. van Leeuwen, J. C. de Wilde, and R. A. C. Brandes. 1993. “Dendrimeric Silanes.” Advanced Materials 5 (6): 466–468. doi:10.1002/adma.19930050613.
   Web of Science ®Google Scholar
• Wang, J., R. M. Wolf, J. W. Caldwell, P. A. Kollman, and D. A. Case. 2004. “Development and Testing of a General Amber Force Field.” Journal of Computational Chemistry 25 (9): 1157–1174. doi:10.1002/jcc.20035.
   PubMed Web of Science ®Google Scholar
• Wrobel, D., D. Appelhans, M. Signorelli, B. Wiesner, D. Fessas, U. Scheler, B. Voit, et al. 2015. “Interaction Study between Maltose-Modified PPI Dendrimers and Lipidic Model Membranes.” Biochimica Et Biophysica Acta- Biomembranes 1848 (7): 1490–1501. doi:10.1016/j.bbamem.2015.03.033.
   PubMed Web of Science ®Google Scholar
• Wrobel, D., M. Marcinkowska, A. Janaszewska, D. Appelhans, B. Voit, B. Klajnert-Maculewicz, M. Bryszewska, et al. 2017. “Influence of Core and Maltose Surface Modification of PEIs on Their Interaction with Plasma Proteins—Human Serum Albumin and Lysozyme.” Colloids and Surfaces B: Biointerfaces 152: 18–28. doi:10.1016/j.colsurfb.2016.12.042.
   PubMed Web of Science ®Google Scholar
• Wu, X., and B. R. Brooks. 2003. “Self-Guided Langevin Dynamics Simulation Method.” Chemical Physics Letters 381 (3–4): 512–518. doi:10.1016/j.cplett.2003.10.013.
   Web of Science ®Google Scholar
• Yang, L., N. Y. Ho, R. Alshut, J. Legradi, C. Weiss, M. Reischl, R. Mikut, et al. 2009. “Zebrafish Embryos as Models for Embryotoxic and Teratological Effects of Chemicals.” Reproductive Toxicology 28 (2): 245–253. doi:10.1016/j.reprotox.2009.04.013.
   PubMed Web of Science ®Google Scholar
• Zhu, S., M. Hong, L. Zhang, G. Tang, Y. Jiang, and Y. Pei. 2010. “PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: In Vitro Evaluation and In Vivo Tumor Accumulation.” Pharmaceutical Research 27 (1): 161–174. doi:10.1007/s11095-009-9992-1.
   PubMed Web of Science ®Google Scholar
• Ziemba, B., A. Janaszewska, K. Ciepluch, M. Krotewicz, W. A. Fogel, D. Appelhans, B. Voit, et al. 2011. “In Vivo Toxicity of Poly(Propyleneimine) Dendrimers.” Journal of Biomedical Materials Research. Part A 99 (2): 261–268. doi:10.1002/jbm.a.33196.
   PubMedGoogle Scholar
• Ziemba, B., G. Matuszko, D. Appelhans, B. Voit, M. Bryszewska, and B. Klajnert. 2012. “Genotoxicity of Poly(Propylene Imine) Dendrimers.” Biopolymers 97 (8): 642–648. doi:10.1002/bip.22056.
   PubMed Web of Science ®Google Scholar
• Ziemba, B., I. Franiak-Pietryga, M. Pion, D. Appelhans, M. Á. Muñoz-Fernández, B. Voit, M. Bryszewska, et al. 2014. “Toxicity and Proapoptotic Activity of Poly(Propylene Imine) Glycodendrimers In Vitro: Considering Their Contrary Potential as Biocompatible Entity and Drug Molecule in Cancer.” International Journal of Pharmaceutics 461 (1–2): 391–402. doi:10.1016/j.ijpharm.2013.12.011.
   PubMed Web of Science ®Google Scholar
• Ziemba, B., I. Halets, D. Shcharbin, D. Appelhans, B. Voit, I. Pieszynski, M. Bryszewska, et al. 2012. “Influence of Fourth Generation Poly(Propyleneimine) Dendrimers on Blood Cells.” Journal of Biomedical Materials Research Part A 100 (11): 2870–2880. doi:10.1002/jbm.a.34222.
   PubMedGoogle Scholar