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Article

The Enchytraeus crypticus stress metabolome – CuO NM case study

ORCID Icon, , , , &
Pages 766-780 | Received 10 May 2017, Accepted 04 May 2018, Published online: 22 Jun 2018

References

  • Ahamed, M., H. A. Alhadlaq, M. A. M. Khan, P. Karuppiah, and N. A. Al-Dhabi. 2014. “Synthesis, Characterization, and Antimicrobial Activity of Copper Oxide Nanoparticles.” Journal of Nanomaterials 2014: 1–4. doi:10.1155/2014/637858.
  • Aledo, J. C. 2004. “Glutamine Breakdown in Rapidly Dividing Cells: Waste or Investment?” Bioessays 26 (7): 778–85. doi:10.1002/bies.20063.
  • Amorim, M. J. B., S. I. L. Gomes, A. M. V. M. Soares, and J. J. Scott-Fordsmand. 2012. “Energy Basal Levels and Allocation among Lipids, Proteins, and Carbohydrates in Enchytraeus Albidus: Changes Related to Exposure to Cu Salt and Cu Nanoparticles.” Water, Air, & Soil Pollution 223 (1): 477–82. doi:10.1007/s11270-011-0867-9.
  • Amorim, M. J. B., and J. J. Scott-Fordsmand. 2012. “Toxicity of Copper Nanoparticles and CuCl2 Salt to Enchytraeus albidus Worms: Survival, Reproduction and Avoidance Responses.” Environmental Pollution 164: 164–8. doi:10.1016/j.envpol.2012.01.015.
  • Berthold, M. R., N. Cebron, F. Dill, T. R. Gabriel, T. Kötter, T. Meinl, P. Ohl, C. Sieb, K. Thiel, and B. Wiswedel. 2008. KNIME: The Konstanz Information Miner. Berlin, Heidelberg: Springer, pp. 319–326. doi:10.1007/978-3-540-78246-9_38.
  • Bicho, R. C., S. I. L. Gomes, A. Soares, and M. J. B. Amorim. 2015. “Non-Avoidance Behaviour in Enchytraeids to Boric Acid Is Related to the GABAergic Mechanism.” Environmental Science and Pollution Research 22 (9): 6898–6903. doi:10.1007/s11356-014-3921-5.
  • Bicho, R., F. Santos, M. Gonçalves, A. Soares, and M. Amorim. 2015. “Enchytraeid Reproduction TestPLUS: Hatching, Growth and Full Life Cycle Test – An Optional Multi-Endpoint Test with Enchytraeus crypticus.” Ecotoxicology 24: 1053–1063. doi:10.1007/s10646-015-1445-5.
  • Bicho, R. C., F. C. F. Santos, J. J. Scott-Fordsmand, and M. J. B. Amorim. 2017a. “Effects of Copper Oxide Nanomaterials (CuONMs) Are Life Stage Dependent – Full Life Cycle in Enchytraeus crypticus.” Environmental Pollution 224: 117–24. doi:10.1016/j.envpol.2017.01.067.
  • Bicho, R. C., F. C. F. Santos, J. J. Scott-Fordsmand, and M. J. B. Amorim. 2017b. “Multigenerational Effects of Copper Nanomaterials (CuONMs) Are Different of Those of CuCl2: Exposure in the Soil Invertebrate Enchytraeus crypticus.” Scientific Reports 7 (1): 8457. doi:10.1038/s41598-017-08911-0.
  • Bloomfield, V. A. 2014. Using R for numerical analysis in science and engineering. Boca Raton, FL: CRC Press/Chapman and Hall. Accessed 5 May 2016. https://www.crcpress.com/Using-R-for-Numerical-Analysis-in-Science-and-Engineering/Bloomfield/9781439884485.
  • Boyles, M. S. P., C. Ranninger, R. Reischl, M. Rurik, R. Tessadri, O. Kohlbacher, A. Duschl, and C. G. Huber. 2016. “Copper Oxide Nanoparticle Toxicity Profiling Using Untargeted Metabolomics.” Particle and Fibre Toxicology 13 (1): 49. doi:10.1186/s12989-016-0160-6.
  • Broadley, K. J. 2010. “The Vascular Effects of Trace Amines and Amphetamines.” Pharmacology & Therapeutics 125 (3): 363–375. doi:10.1016/j.pharmthera.2009.11.005.
  • Brosnan, J. T. 2003. “Interorgan Amino Acid Transport and Its Regulation.” The Journal of Nutrition 133 (6 Suppl 1): 2068S–2072S.
  • Bulcke, F., and R. Dringen. 2016. “Handling of Copper and Copper Oxide Nanoparticles by Astrocytes.” Neurochemical Research 41 (1–2): 33–43. doi:10.1007/s11064-015-1688-9.
  • Bundy, J. G., J. K. Sidhu, F. Rana, D. J. Spurgeon, C. Svendsen, J. F. Wren, S. R. Stürzenbaum, A. J. Morgan, and P. Kille. 2008. “Systems Toxicology” Approach Identifies Coordinated Metabolic Responses to Copper in a Terrestrial Non-Model Invertebrate, the Earthworm Lumbricus rubellus.” BMC Biology 6 (1): 25. doi:10.1186/1741-7007-6-25.
  • Castro-Ferreira, M., T. de Boer, J. Colbourne, R. Vooijs, C. van Gestel, N. van Straalen, A. Soares, M. Amorim, and D. Roelofs. 2014. “Transcriptome Assembly and Microarray Construction for Enchytraeus crypticus, a Model Oligochaete to Assess Stress Response Mechanisms Derived from Soil Conditions.” BMC Genomics 15 (1): 302. doi:10.1186/1471-2164-15-302.
  • Chambers, M. C., Maclean, B. Burke, R. Amodei, D. Ruderman, D. L. Neumann, S. Gatto, L. Fischer, B. Pratt, B. Egertson. J. et al., and P. Mallik 2012. “A Cross-Platform Toolkit for Mass Spectrometry and Proteomics.” Nature Biotechnology 30 (10): 918–920. doi:10.1038/nbt.2377.
  • Chandrasekaran, S. 2013. “A Novel Single Step Synthesis, High Efficiency and Cost Effective Photovoltaic Applications of Oxidized Copper Nano Particles.” Solar Energy Materials and Solar Cells 109: 220–226. doi:10.1016/J.SOLMAT.2012.11.003.
  • Corbet, C., and O. Feron. 2015. “Metabolic and Mind Shifts: From Glucose to Glutamine and Acetate Addictions in Cancer.” Current Opinion in Clinical Nutrition & Metabolic Care 18 (4): 346–353. doi:10.1097/MCO.0000000000000178.
  • Cronholm, P., H. L. Karlsson, J. Hedberg, T. A. Lowe, L. Winnberg, K. Elihn, I. O. Wallinder, and L. Möller. 2013. “Intracellular Uptake and Toxicity of Ag and CuO Nanoparticles: A Comparison between Nanoparticles and Their Corresponding Metal Ions.” Small 9 (7): 970–982. doi:10.1002/smll.201201069.
  • Das, D., B. C. Nath, P. Phukon, and S. K. Dolui. 2013. “Synthesis and Evaluation of Antioxidant and Antibacterial Behavior of CuO Nanoparticles.” Colloids Surfaces B Biointerfaces 101: 430–433. doi:10.1016/J.COLSURFB.2012.07.002.
  • Fernandez-Ruiz, I., P. Puchalska, C. A. Narasimhulu, B. Sengupta, and S. Parthasarathy. 2016. “Differential Lipid Metabolism in Monocytes and Macrophages: Influence of Cholesterol Loading.” Journal of Lipid Research 57 (4): 574–586. doi:10.1194/jlr.M062752.
  • Ferreira, N. G. C., R. Saborano, R. Morgado, D. N. Cardoso, C. M. Rocha, A. M. V. M. Soares, S. Loureiro, and I. F. Duarte. 2015. “Metabolic Responses of the Isopod Porcellionides Pruinosus to Nickel Exposure Assessed by (1)H NMR Metabolomics.” Journal of Proteomics 137: 59–67. doi:10.1016/j.jprot.2015.09.018.
  • Gomes, S. I. L., M. Murphy, M. Nielsen, S. Kristiansen, M. J. B. Amorim, and J. J. Scott-Fordsmand. 2015a. “Cu-Nanoparticles Ecotoxicity–Explored and Explained?.” Chemosphere 139: 240–245. doi:10.1016/j.chemosphere.2015.06.045.
  • Gomes, S. I. L., S. C. Novais, C. Gravato, L. Guilhermino, J. J. Scott-Fordsmand, A. M. V. M. Soares, and M. J. B. Amorim. 2012a. “Effect of Cu-Nanoparticles versus One Cu-Salt: Analysis of Stress Biomarkers Response in Enchytraeus albidus (Oligochaeta).” Nanotoxicology 6 (2): 134–143. doi:10.3109/17435390.2011.562327.
  • Gomes, S. I. L., S. C. Novais, J. J. Scott-Fordsmand, W. De Coen, A. M. V. M. Soares, and M. J. B. Amorim. 2012b. “Effect of Cu-Nanoparticles versus Cu-Salt in Enchytraeus albidus (Oligochaeta): Differential Gene Expression through Microarray Analysis.” Comparative Biochemistry and Physiology -- Part C: Toxicology & Pharmacology 155 (2): 219–227. doi:10.1016/j.cbpc.2011.08.008.
  • Gomes, S. I. L., C. P. Roca, N. Pegoraro, T. Trindade, J. J. Scott-Fordsmand, and M. J. B. Amorim. 2018. “High-Throughput Tool to Discriminate Effects of NMs (Cu-NPs, Cu-Nanowires, CuNO3, and Cu Salt Aged): Transcriptomics in Enchytraeus crypticus.” Nanotoxicology 12: 325–340. doi:10.1080/17435390.2018.1446559.
  • Gomes, S. I. L., J. J. Scott-Fordsmand, and M. J. B. Amorim. 2014. “Profiling Transcriptomic Response of Enchytraeus albidus to Cu and Ni: Comparison with Cd and Zn.” Environmental Pollution 186: 75–82. doi:10.1016/j.envpol.2013.11.031.
  • Gomes, S. I. L., J. J. Scott-Fordsmand, and M. J. B. Amorim. 2015b. “Cellular Energy Allocation to Assess the Impact of Nanomaterials on Soil Invertebrates (Enchytraeids): The Effect of Cu and Ag.” International Journal of Environmental Research and Public Health 12 (6): 6858–6878. doi:10.3390/ijerph120606858.
  • Gomes, S. I. L., A. Soares, and M. J. B. Amorim. 2015c. “Changes in Cellular Energy Allocation in Enchytraeus crypticus Exposed to Copper and Silver–Linkage to Effects at Higher Level (Reproduction).” Environmental Science and Pollution Research 22 (18): 14241–14247. doi:10.1007/s11356-015-4630-4.
  • Gonçalves, M. F. M., R. C. Bicho, A. Rêma, A. M. V. M. Soares, A. M. R. Faustino, and M. J. B. Amorim. 2015. “Development of an Embryotoxicity Test for Enchytraeus crypticus – The Effect of Cd.” Chemosphere 139: 386–392. doi:10.1016/j.chemosphere.2015.07.021.
  • Gonçalves, M. F. G., S. I. L. Gomes, J. J. Scott-Fordsmand, and M. J. B. Amorim. 2017. “Shorter Lifetime of a Soil Invertebrate Species When Exposed to Copper Oxide Nanoparticles in a Full Lifespan Exposure Test.” Scientific Reports 7 (1): 1355. doi:10.1038/s41598-017-01507-8.
  • Hernandez, P. P., and M. L. Allende. 2008. “Zebrafish (Danio rerio) as a Model for Studying the Genetic Basis of Copper Toxicity, Deficiency, and Metabolism.” The American Journal of Clinical Nutrition 88 (3): 835S–839S.
  • Herring, B. E., K. Silm, R. H. Edwards, and R. A. Nicoll. 2015. “Is Aspartate an Excitatory Neurotransmitter?” Journal of Neuroscience 35 (28): 10168–10171. doi:10.1523/JNEUROSCI.0524-15.2015.
  • Hetenyi, G., P. J. Anderson, and G. A. Kinson. 1984. “Gluconeogenesis from Threonine in Normal and Diabetic Rats.” The Biochemical Journal 224 (2): 355–360.
  • Hou, J., X. Wang, T. Hayat, and X. Wang. 2017. “Ecotoxicological Effects and Mechanism of CuO Nanoparticles to Individual Organisms.” Environmental Pollution 221: 209–217. doi:10.1016/j.envpol.2016.11.066.
  • Howcroft, C., C. Gravato, M. Amorim, S. Novais, A. Soares, and L. Guilhermino. 2011. “Biochemical Characterization of Cholinesterases in Enchytraeus albidus and Assessment of In Vivo and In Vitro Effects of Different Soil Properties, Copper and Phenmedipham.” Ecotoxicology 20 (1): 119–130. doi:10.1007/s10646-010-0562-4.
  • ISO. 2004. Soil Quality – Effects of Pollutants on Enchytraeidae (Enchytraeus sp.) – Determination of Effects on Reproduction and Survival [ISO 16387]. Geneva: International Organization for Standardization.
  • Issaq, H. J., E. Abbott, and T. D. Veenstra. 2008. “Utility of Separation Science in Metabolomic Studies.” Journal of Separation Science 31 (11): 1936–1947. doi:10.1002/jssc.200700601.
  • Jammi, S., S. Sakthivel, L. Rout, T. Mukherjee, S. Mandal, R. Mitra, P. Saha, and T. Punniyamurthy. 2009. “CuO Nanoparticles Catalyzed C−N, C−O, and C−S Cross-Coupling Reactions: Scope and Mechanism.” The Journal of Organic Chemistry 74 (5): 1971–1976. doi:10.1021/jo8024253.
  • Keller, A. A., S. McFerran, A. Lazareva, and S. Suh. 2013. “Global Life Cycle Releases of Engineered Nanomaterials.” Journal of Nanoparticle Research 15 (6): 1692. doi:10.1007/s11051-013-1692-4.
  • Ko, J. W., S.-W. Kim, J. Hong, J. Ryu, K. Kang, and C. B. Park. 2012. “Synthesis of Graphene-Wrapped CuO Hybrid Materials by CO2 Mineralization.” Green Chemistry 14 (9): 2391. doi:10.1039/c2gc35560d.
  • Kovacević, Z., J. Popović, O. Brkljac, and S. Lelas. 1987. “Interaction of Metabolism of Aspartate and Inosine and Energy State of Malignant Cells.” Biochemical Journal 247 (1): 47–51.
  • Lankadurai, B. P., E. G. Nagato, A. J. Simpson, and M. J. Simpson. 2015. “Analysis of Eisenia fetida Earthworm Responses to Sub-Lethal C60 Nanoparticle Exposure Using (1)H-NMR Based Metabolomics.” Ecotoxicology and Environmental Safety 120: 48–58. doi:10.1016/j.ecoenv.2015.05.020.
  • Li, L.,. H. Wu, C. Ji, C. A. M. van Gestel, H. E. Allen, and W. J. G. M. Peijnenburg. 2015. “A Metabolomic Study on the Responses of Daphnia magna Exposed to Silver Nitrate and Coated Silver Nanoparticles.” Ecotoxicology and Environmental Safety 119: 66–73. doi:10.1016/j.ecoenv.2015.05.005.
  • Limbach, L. K., P. Wick, P. Manser, R. N. Grass, A. Bruinink, and W. J. Stark. 2007. “Exposure of Engineered Nanoparticles to Human Lung Epithelial Cells: Influence of Chemical Composition and Catalytic Activity on Oxidative Stress.” Environmental Science and Technology 41 (11): 4158–4163. doi:10.1021/es062629t.
  • Lindemann, L., and M. C. Hoener. 2005. “A Renaissance in Trace Amines Inspired by a Novel GPCR Family.” Trends in Pharmacological Sciences 26 (5): 274–281. doi:10.1016/j.tips.2005.03.007.
  • Maria, V. L., M. J. Ribeiro, S. Guilherme, A. M. V. M. Soares, J. J. Scott-Fordsmand, and M. J. B. Amorim. 2018. “Silver (Nano)Materials Cause Genotoxicity in Enchytraeus crypticus – As Determined by the Comet Assay.” Environmental Toxicology and Chemistry 37 (1): 184–191. doi:10.1002/etc.3944.
  • Meldrum, B. S. 2000. “Glutamate as a Neurotransmitter in the Brain: Review of Physiology and Pathology.” The Journal of Nutrition 130 (4S Suppl): 1007S–1015S.
  • Mendes, L. A., M. J. B. Amorim, and J. J. Scott-Fordsmand. 2018. “Interactions of Soil Species Exposed to CuO NMs Are Different from Cu Salt: A Multispecies Test.” Environmental Science Technology 52: 4413–4421. doi:10.1021/acs.est.8b00535.
  • Menezes-Oliveira, V. B., J. J. Scott-Fordsmand, A. Rocco, A. M. V. M. Soares, and M. J. B. Amorim. 2011. “Interaction between Density and Cu Toxicity for Enchytraeus crypticus and Eisenia fetida Reflecting Field Scenarios.” Science of the Total Environment 409 (18): 3370–3374. doi:10.1016/j.scitotenv.2011.04.033.
  • Menezes-Oliveira, V. B., J. J. Scott-Fordsmand, A. M. Soares, and M. J. B. Amorim. 2013. “Effects of Temperature and Copper Pollution on Soil Community–Extreme Temperature Events Can Lead to Community Extinction.” Environmental Toxicology and Chemistry 32 (12): 2678–2685. doi:10.1002/etc.2345.
  • Miller, M. G. 2007. “Environmental Metabolomics: A SWOT Analysis (Strengths, Weaknesses, Opportunities, and Threats).” Journal of Proteome Research 6 (2): 540–545. doi:10.1021/pr060623x.
  • Nagato, E. G., J. C. D’eon, B. P. Lankadurai, D. G. Poirier, E. J. Reiner, A. J. Simpson, and M. J. Simpson. 2013. 1H NMR-Based Metabolomics Investigation of Daphnia magna Responses to Sub-Lethal Exposure to Arsenic, Copper and Lithium. Chemosphere 93, 331–337. doi:10.1016/j.chemosphere.2013.04.085.
  • Navratilova, J., A. Praetorius, A. Gondikas, W. Fabienke, F. von der Kammer, and T. Hofmann. 2015. “Detection of Engineered Copper Nanoparticles in Soil Using Single Particle ICP-MS.” International Journal of Environmental Research and Public Health 12 (12): 15756–15768. doi:10.3390/ijerph121215020.
  • OECD. 2004a. Test no. 220: Enchytraeid reproduction test., OECD guidelines for the testing of chemicals, section 2. Paris: Organisation for Economic Co-operation and Development. doi:10.1787/9789264264472-en.
  • OECD. 2004b. Test No. 202: Daphnia sp. Acute Immobilisation Test. OECD Guideline for the Testing of Chemicals. Paris: Organisation for Economic Co-operation and Development. doi:10.1787/9789264069947-en.
  • OECD. 2012. Series on the Safety of Manufactured Nanomaterials, No. 36: Guidance on Sample Preparation and Dosimetry for the Safety Testing of Manufactured Nanomaterials. Paris: Organisation for Economic Co-operation and Development. doi:ENV/JM/MONO(2007)10.
  • Raïs, B., C. Chassagnole, T. Letellier, D. A. Fell, and J. P. Mazat. 2001. “Threonine Synthesis from Aspartate in Escherichia coli Cell-Free Extracts: Pathway Dynamics.” The Biochemical Journal 356 (Pt 2): 425–432.
  • Ranninger, C., M. Rurik, A. Limonciel, S. Ruzek, R. Reischl, A. Wilmes, P. Jennings, P. Hewitt, W. Dekant, O. Kohlbacher, and C. G. Huber. 2015. “Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-Based Experimental and Computational Pipeline.” Journal of Biological Chemistry 290 (31): 19121–19132. doi:10.1074/jbc.M115.644146.
  • Ribeiro, M. J., V. L. Maria, J. J. Scott-Fordsmand, and M. J. B. Amorim. 2015. “Oxidative Stress Mechanisms Caused by Ag Nanoparticles (NM300K) Are Different from Those of AgNO3: Effects in the Soil Invertebrate Enchytraeus crypticus.” International Journal of Environmental Research and Public Health 12 (8): 9589–9602. doi:10.3390/ijerph120809589.
  • Roelofs, D., R. Bicho, T. de Boer, M. Castro-Ferreira, K. Montagne-Wajer, C. van Gestel, A. Soares, N. van Straalen, and M. Amorim. 2016. “Mechanisms of Phenanthrene Toxicity in the Soil Invertebrate, Enchytraeus crypticus.” Environmental Toxicology and Chemistry 35 (11): 2713. doi:10.1002/etc.3433.
  • Rosa, R., and M. L. Nunes. 2005. “Seasonal Patterns of Nucleic Acid Concentrations and Amino Acid Profiles of Parapenaeus longirostris (Crustacea, Decapoda): Relation to Growth and Nutritional Condition.” Hydrobiologia 537 (1–3): 207–216. doi:10.1007/s10750-004-2841-7.
  • Schaechter, J. D., and R. J. Wurtman. 1990. “Serotonin Release Varies with Brain Tryptophan Levels.” Brain Research 532 (1–2): 203–210. doi:10.1016/0006-8993(90)91761-5.
  • Sharma, R. J., A. R. Fernando, and J. R. Griffiths. 1982. “Inosine Metabolism in the Rat.” The Biochemical Journal 208 (3): 839–844.
  • Smith, C. A., G. O'Maille, E. J. Want, C. Qin, S. A. Trauger, T. R. Brandon, D. E. Custodio, R. Abagyan, and G. Siuzdak. 2005. “METLIN: A Metabolite Mass Spectral Database.” Therapeutic Drug Monitoring 27 (6): 747–751.
  • Sturm, M., A. Bertsch, C. Gröpl, A. Hildebrandt, R. Hussong, E. Lange, N. Pfeifer, O. Schulz-Trieglaff, A. Zerck, K. Reinert, and O. Kohlbacher. 2008. “OpenMS – an Open-Source Software Framework for Mass Spectrometry.” BMC Bioinformatics 9 (1): 163. doi:10.1186/1471-2105-9-163.
  • Sumner, L. W., Amberg A., Barrett D., Beale M. H., Beger R., Daykin C. A., Fan T. W.-M., Fiehn O., Goodacre R., Griffin J. L. et al., and M. R. Viant 2007. “Proposed Minimum Reporting Standards for Chemical Analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI).” Metabolomics 3 (3): 211–221. doi:10.1007/s11306-007-0082-2.
  • Thauer, R. K. 1988. “Citric-Acid Cycle, 50 Years on. Modifications and an Alternative Pathway in Anaerobic Bacteria.” European Journal of Biochemistry 176 (3): 497–508. doi:10.1111/j.1432-1033.1988.tb14307.x.
  • Tran, T. H., and V. T. Nguyen. 2014. “Copper Oxide Nanomaterials Prepared by Solution Methods, Some Properties, and Potential Applications: A Brief Review.” International Scholarly Research Notices 2014: 1–14. doi:10.1155/2014/856592.
  • Triboulet, S., Aude-Garcia, C. Carrière, M. Diemer, H. Proamer, F. Habert, A. Chevallet, M. Collin-Faure, V. Strub, J.-M. Hanau, D., Van Dorsselaer, A., Herlin-Boime, N., and Rabilloud, T. 2013. “Molecular Responses of Mouse Macrophages to Copper and Copper Oxide Nanoparticles Inferred from Proteomic Analyses.” Molecular & Cellular Proteomics 12 (11): 3108–3122. doi:10.1074/mcp.M113.030742.
  • Unrine, J. M., O. V. Tsyusko, S. E. Hunyadi, J. D. Judy, and P. M. Bertsch. 2010. “Effects of Particle Size on Chemical Speciation and Bioavailability of Copper to Earthworms (Eisenia fetida) Exposed to Copper Nanoparticles.” Journal of Environment Quality 39 (6): 1942–1953. doi:10.2134/jeq2009.0387.
  • Viant, M. R. 2008. “Recent Developments in Environmental Metabolomics.” Molecular Biosystems 4 (10): 980–986. doi:10.1039/b805354e.
  • Wang, Z., N. Li, J. Zhao, J. C. White, P. Qu, and B. Xing. 2012. “CuO Nanoparticle Interaction with Human Epithelial Cells: Cellular Uptake, Location, Export, and Genotoxicity.” Chemical Research in Toxicology 25 (7): 1512–1521. doi:10.1021/tx3002093.
  • Wieser, M., G. Stadler, P. Jennings, B. Streubel, W. Pfaller, P. Ambros, C. Riedl, H. Katinger, J. Grillari, and R. Grillari-Voglauer. 2008. “hTERT Alone Immortalizes Epithelial Cells of Renal Proximal Tubules without Changing Their Functional Characteristics.” American Journal of Physiology -- Renal Physiology 295 (5): F1365–F1375. doi:10.1152/ajprenal.90405.2008.
  • Xiao, Y., W. J. G. M. Peijnenburg, G. Chen, and M. G. Vijver. 2018. “Impact of Water Chemistry on the Particle-Specific Toxicity of Copper Nanoparticles to Daphnia magna.” Science of the Total Environment 610–611: 1329–1335. doi:10.1016/J.SCITOTENV.2017.08.188.
  • Yuneva, M., N. Zamboni, P. Oefner, R. Sachidanandam, and Y. Lazebnik. 2007. “Deficiency in Glutamine but Not Glucose Induces MYC-Dependent Apoptosis in Human Cells.” The Journal of Cell Biology 178 (1): 93–105. doi:10.1083/jcb.200703099.
  • Zatta, P., and A. Frank. 2007. “Copper Deficiency and Neurological Disorders in Man and Animals.” Brain Research Reviews 54 (1): 19–33. doi:10.1016/j.brainresrev.2006.10.001.
  • Zhou, K., R. Wang, B. Xu, and Y. Li. 2006. “Synthesis, Characterization and Catalytic Properties of CuO Nanocrystals with Various Shapes.” Nanotechnology 17 (15): 3939–3943. doi:10.1088/0957-4484/17/15/055.

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