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Article

Uptake and molecular impact of aluminum-containing nanomaterials on human intestinal caco-2 cells

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Pages 992-1013 | Received 02 May 2018, Accepted 20 Jul 2018, Published online: 14 Oct 2018

References

  • Alfrey, A. C., G. R. LeGendre, and W. D. Kaehny. 1976. “The Dialysis Encephalopathy Syndrome.” New England Journal of Medicine 294 (4): 184. doi:10.1056/nejm197601222940402.
  • Amador, F. C., M. S. Santos, and C. R. Oliveira. 1999. “Lipid Peroxidation Facilitates Aluminum Accumulation in Rat Brain Synaptosomes.” Journal of Toxicology and Environmental Health Part A 58: 427–435.
  • Arnich, N.,. V. Sirot, G. Riviere, J. Jean, L. Noel, T. Guerin, and J. C. Leblanc. 2012. “Dietary Exposure to Trace Elements and Health Risk Assessment in the 2nd French Total Diet Study.” Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 50 (7): 2432–2449. doi:10.1016/j.fct.2012.04.016.
  • Artursson, P., and J. Karlsson. 1991. “Correlation between Oral Drug Absorption in Humans and Apparent Drug Permeability Coefficients in Human Intestinal Epithelial (Caco-2) Cells.” Biochemical and Biophysical Research Communication 175 (3): 880–885.
  • Atienzar, F., D. Desor, D. Burnel, J. M. Keller, P. Lehr, and P. Vasseur. 1998. “Effect of Aluminum on Superoxide Dismutase Activity in the Adult Rat Brain.” Biological Trace Element Research 65 (1): 19–30. doi:10.1007/bf02784111.
  • Booth, A., T. Storseth, D. Altin, A. Fornara, A. Ahniyaz, H. Jungnickel, P. Laux, A. Luch, and L. Sorensen. 2015. “Freshwater Dispersion Stability of PAA-Stabilised Cerium Oxide Nanoparticles and Toxicity towards Pseudokirchneriella subcapitata.” Science of the Total Environment 505: 596–605. doi:10.1016/j.scitotenv.2014.10.010.
  • Bouwmeester, H., J. Poortman, R. J. Peters, E. Wijma, E. Kramer, S. Makama, K. Puspitaninganindita, H. J. Marvin, A. A. Peijnenburg, and P. J. Hendriksen. 2011. “Characterization of Translocation of Silver Nanoparticles and Effects on Whole-Genome Gene Expression Using an in Vitro Intestinal Epithelium Coculture Model.” ACS Nano 5 (5): 4091–103. doi:10.1021/nn2007145.
  • Buhrke, T., K. Schultrich, A. Braeuning, and A. Lampen. 2017. “Comparative Analysis of Transcriptomic Responses to Repeated-Dose Exposure to 2-MCPD and 3-MCPD in Rat Kidney, Liver and Testis.” Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 106 (Pt A): 36–46. doi:10.1016/j.fct.2017.05.028.
  • Castiaux, V., L. Laloux, Y. J. Schneider, and J. Mahillon. 2016. “Screening of Cytotoxic B. cereus on Differentiated Caco-2 Cells and in Co-Culture with Mucus-Secreting (HT29-MTX) Cells.” Toxins (Basel) 8 (11): 320. doi:10.3390/toxins8110320.
  • Conner, S. D., and S. L. Schmid. 2003. “Regulated Portals of Entry into the Cell.” Nature 422 (6927): 37–44. doi:10.1038/nature01451.
  • Darbre, P. D. 2009. “Underarm Antiperspirants/Deodorants and Breast Cancer.” Breast Cancer Research: Bcr 11 (Suppl 3): S5. doi:10.1186/bcr2424.
  • Des Rieux, A., V. Fievez, I. Theate, J. Mast, V. Preat, and Y. J. Schneider. 2007. “An Improved in Vitro Model of Human Intestinal Follicle-Associated Epithelium to Study Nanoparticle Transport by M Cells.” European Journal of Pharmaceutical Science 30 (5): 380–391. doi:10.1016/j.ejps.2006.12.006.
  • Des Rieux, A., E. G. Ragnarsson, E. Gullberg, V. Preat, Y. J. Schneider, and P. Artursson. 2005. “Transport of Nanoparticles across an in Vitro Model of the Human Intestinal Follicle Associated Epithelium.” European Journal of Pharmaceutical Science 25 (4-5): 455–465.
  • EFSA 2011. “Statement of EFSA on the Evaluation of a New Study Related to the Bioavailability of Aluminium in Food.” EFSA Journal 9 (5): 2157–16. doi:10.2903/j.efsa.2011.2157.
  • EL Hage Chahine, J. M., M. Hemadi, and N. T. Ha-Duong. 2012. “Uptake and Release of Metal Ions by Transferrin and Interaction with Receptor 1.” Biochimica Et Biophysica Acta 1820 (3): 334–347. doi:10.1016/j.bbagen.2011.07.008.
  • Exley, C. 2003. “A Biogeochemical Cycle for Aluminium?.” Journal of Inorganic Biochemistry 97 (1): 1–7.
  • Exley, C. 2016. “The Toxicity of Aluminium in Humans.” Morphologie : Bulletin De L'association Des Anatomistes 100 (329): 51–55. doi:10.1016/j.morpho.2015.12.003.
  • Felsenfeld, A. J., M. Rodriguez, M. Coleman, D. Ross, and F. Llach. 1989. “Desferrioxamine Therapy in Hemodialysis Patients with Aluminum-Associated Bone Disease.” Kidney International 35 (6): 1371–1378. doi:10.1038/ki.1989.136.
  • Fogh, J., J. M. Fogh, and T. Orfeo. 1977. “One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice.” Journal of the National Cancer Institute 59 (1): 221–226.
  • Fraga, C. G., P. I. Oteiza, M. S. Golub, M. E. Gershwin, and C. L. Keen. 1990. “Effects of Aluminum on Brain Lipid Peroxidation.” Toxicology Letters 51 (2): 213–219.
  • Froment, D. H., B. Buddington, N. L. Miller, and A. C. Alfrey. 1989a. “Effect of Solubility on the Gastrointestinal Absorption of Aluminum from Various Aluminum Compounds in the Rat.” Journal of Laboratory and Clinical Medicine 114: 237–242.
  • Froment, D. P., B. A. Molitoris, B. Buddington, N. Miller, and A. C. Alfrey. 1989b. “Site and Mechanism of Enhanced Gastrointestinal Absorption of Aluminum by Citrate.” Kidney International 36 (6): 978–984.
  • Gullberg, E.,. M. Leonard, J. Karlsson, A. M. Hopkins, D. Brayden, A. W. Baird, and P. Artursson. 2000. “Expression of Specific Markers and Particle Transport in a New Human Intestinal M-Cell Model.” Biochemical and Biophysical Research Communication 279 (3): 808–813. doi:10.1006/bbrc.2000.4038.
  • Gutteridge, J. M., G. J. Quinlan, I. Clark, and B. Halliwell. 1985. “Aluminium Salts Accelerate Peroxidation of Membrane Lipids Stimulated by Iron Salts.” Biochimica et Biophysica Acta 835 (3): 441–447.
  • Haase, A.,. H. F. Arlinghaus, J. Tentschert, H. Jungnickel, P. Graf, A. Mantion, and F. Draude, S. Galla, J. Plendl. M. E. Goetz and A Luch. 2011. “Application of Laser Postionization Secondary Neutral Mass Spectrometry/Time-of-Flight Secondary Ion Mass Spectrometry in Nanotoxicology: visualization of Nanosilver in Human Macrophages and Cellular Responses.” ACS Nano 5 (4): 3059–3068. doi:10.1016/j.taap.2010.10.007.
  • Haase, H.,. S. Hebel, G. Engelhardt, and L. Rink. 2015. “The Biochemical Effects of Extracellular Zn(2+) and Other Metal Ions Are Severely Affected by Their Speciation in Cell Culture Media.” Metallomics 7 (1): 102–111. doi:10.1039/c4mt00206g.
  • Hansen, U., and A. F. Thünemann. 2015. “Characterization of Silver Nanoparticles in Cell Culture Medium Containing Fetal Bovine Serum.” Langmuir 31 (24): 6842–6852. doi:10.1021/acs.langmuir.5b00687.
  • Hasanoglu, E., N. Altan, Ş. Sindel, C. Ö. Ongun, M. Bali, and E. Altintaş. 1994. “The Relationship between Erythrocyte Superoxide Dismutase Activity and Plasma Levels of Some Trace Elements (Al, Cu, Zn) of Dialysis Patients.” General Pharmacology 25 (1): 107–110.
  • Hsiao, I. L., Y. K. Hsieh, C. F. Wang, I. C. Chen, and Y. J. Huang. 2015. “Trojan-Horse Mechanism in the Cellular Uptake of Silver Nanoparticles Verified by Direct Intra- and Extracellular Silver Speciation Analysis.” Environmental Science & Technology 49 (6): 3813–3821. doi:10.1021/es504705p.
  • Je, H. J., E. S. Kim, J.S. Lee, and H. G. Lee. 2017. “Release Properties and Cellular Uptake in Caco-2 Cells of Size-Controlled Chitosan Nanoparticles.” Journal of Agricultural and Food Chemistry 65 (50): 10899–10906. doi:10.1021/acs.jafc.7b03627..
  • Juling, S., G. Bachler, N. VON Gotz, D. Lichtenstein, L. Bohmert, A. Niedzwiecka, S. Selve, A. Braeuning, and A. Lampen. 2016. “ In  vivo Distribution of Nanosilver in the Rat: The Role of Ions and de novo-formed Secondary Particles.” Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 97: 327–335. doi:10.1016/j.fct.2016.08.016.
  • Jungnickel, H., E. A. Jones, N. P. Lockyer, S. G. Oliver, G. M. Stephens, and J. C. Vickerman. 2005. “Application of TOF-SIMS with Chemometrics to Discriminate between Four Different Yeast Strains from the Species Candida glabrata and Saccharomyces cerevisiae.” Analytical Chemistry 77 (6): 1740–1745. doi:10.1021/ac048792t.
  • Kästner, C., and A. F. Thünemann. 2016. “Catalytic Reduction of 4-Nitrophenol Using Silver Nanoparticles with Adjustable Activity.” Langmuir 32 (29): 7383–7391. doi:10.1021/acs.langmuir.6b01477.
  • Kong, S., S. Liochev, and I. Fridovich. 1992. “Aluminum(III) Facilitates the Oxidation of NADH by the Superoxide Anion.” Free Radical Biology and Medicine 13 (1): 79–81.
  • Krause, B., T. Meyer, H. Sieg, C. Kastner, P. Reichardt, J. Tentschert, H. Jungnickel, I. Estrela-Lopis, A. Burel, and S. Chevance et al.. 2018. “Characterization of Aluminum, Aluminum Oxide and Titanium Dioxide Nanomaterials Using a Combination of Methods for Particle Surface and Size Analysis.” RSC Advances 8 (26): 14377–14388. doi:10.1039/C8RA00205C.
  • Krewski, D., R. A. Yokel, E. Nieboer, D. Borchelt, J. Cohen, J. Harry, S. Kacew, J. Lindsay, A. M. Mahfouz, and V. Rondeau. 2007. “Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide.” Journal of Toxicology and Environmental Health Part B Critical Review 10 (sup1): 1–269. doi:10.1080/10937400701597766.
  • Kumar, V., A. Bal, and K. D. Gill. 2009. “Aluminium-Induced Oxidative DNA Damage Recognition and Cell-Cycle Disruption in Different Regions of Rat Brain.” Toxicology 264 (3): 137–144. doi:10.1016/j.tox.2009.05.011.
  • Lampen, A.,. B. Ebert, L. Stumkat, J. Jacob, and A. Seidel. 2004. “Induction of Gene Expression of Xenobiotic Metabolism Enzymes and ABC-Transport Proteins by PAH and a Reconstituted PAH Mixture in Human Caco-2 Cells.” Biochimica et Biophysica Acta 1681 (1): 38–46. doi:10.1016/j.bbaexp.2004.09.010.
  • Lehmann, C., H. Sieg, A. Lampen, and A. Braeuning. 2016. “A. Lampen, A.Braeuning, Disturbance of Firefly Luciferase-Based Bioassays by Different Aluminum Species.” Analytical Biochemistry 504: 27–29. doi:10.1016/j.ab.2016.03.019.
  • Lesuffleur, T., A. Barbat, E. Dussaulx, and A. Zweibaum. 1990. “Growth Adaptation to Methotrexate of HT-29 Human Colon Carcinoma Cells Is Associated with Their Ability to Differentiate into Columnar Absorptive and Mucus-Secreting Cells.” Cancer Research 50: 6334–6343.
  • Lewis, J. G., and C. M. Andre. 1981. “Enhancement of Human Monocyte Phagocytic Function by Alpha 2HS Glycoprotein.” Immunology 42: 481–7.
  • Lichtenstein, D., J. Ebmeyer, P. Knappe, S. Juling, L. Bohmert, S. Selve, B. Niemann, A. Braeuning, A. F. Thunemann, and A. Lampen. 2015. “Impact of Food Components during in Vitro Digestion of Silver Nanoparticles on Cellular Uptake and Cytotoxicity in Intestinal Cells.” Biolgical Chemistry 396: 1255–1264. doi:10.1515/hsz-2015-0145.
  • Lichtenstein, D., J. Ebmeyer, T. Meyer, A. C. Behr, C. Kastner, L. Bohmert, S. Juling, B. Niemann, C. Fahrenson. S Selve. 2016. “It Takes More than a Coating to Get Nanoparticles through the Intestinal Barrier in Vitro.” European Journal of Pharmaceutics and Biopharmaceutics 118: 21–29. doi:10.1016/j.ejpb.2016.12.004.
  • Lichtenstein, D., T. Meyer, L. Bohmert, S. Juling, C. Fahrenson, S. Selve, A. Thunemann, J. Meijer, I. Estrela-Lopis, A. Braeuning, and A. Lampen. 2017. “Dosimetric Quantification of Coating-Related Uptake of Silver Nanoparticles.” Langmuir 33 (45): 13087–13097. doi:10.1021/acs.langmuir.7b01851.
  • Lidsky, T. I. 2014. “Is the Aluminum Hypothesis Dead?.” Journal of Occupational and Environmental Medicine 56 (5 Suppl): S73–S79. doi:10.1097/JOM.0000000000000063.
  • Lin, C. Y., W. C. Hsiao, C. J. Huang, C. F. Kao, and G. S. Hsu. 2013. “Heme Oxygenase-1 Induction by the ROS-JNK Pathway Plays a Role in Aluminum-Induced Anemia.” Journal of Inorganic Biochemistry 128: 221–8. doi:10.1016/j.jinorgbio.2013.07.026.
  • Lin, I. C., M. Liang, T. Y. Liu, M. J. Monteiro, and I. Toth. 2012. “Cellular Transport Pathways of Polymer Coated Gold Nanoparticles.” Nanomedicine 8 (1): 8–11. doi:10.1016/j.nano.2011.09.014.
  • Liukkonen-Lilja, H., and S. Piepponen. 1992. “Leaching of Aluminium from Aluminium Dishes and Packages.” Food Additives and Contaminants 9 (3): 213–23. doi:10.1080/02652039209374065.
  • Loeschner, K., M. Correia, L. Ó. P. E. Z. C. Chaves, I. Rokkjaer. and J. J Sloth. 2017. “Detection and Characterisation of Aluminium-Containing Nanoparticles in Chinese Noodles by Single Particle ICP-MS.” Food Additives & Contaminants: Part A 35 (1):86–93. doi:10.1080/19440049.2017.1382728.
  • Lote, C. J., and H. Saunders. 1991. “Aluminium: gastrointestinal Absorption and Renal Excretion.” Clinical Science (London, England: 1979) 81 (3): 289–295.
  • Martin, R. B. 1994. “Aluminum: A Neurotoxic Product of Acid Rain.” Accounts of Chemical Research 27 (7): 204–210. doi:10.1021/ar00043a004.
  • Millour, S., L. Noel, A. Kadar, R. Chekri, C. Vastel, V. Sirot, J. C. Leblanc, and T. Guerin. 2011. “Pb, Hg, Cd, as, Sb and Al Levels in Foodstuffs from the 2nd French Total Diet Study.” Food Chemistry 126 (4): 1787–1799. doi:10.1016/j.foodchem.2010.12.086.
  • Mujika, J. I., X. Lopez, E. Rezabal, R. Castillo, S. Marti, V. Moliner, and J. M. Ugalde. 2011. “A QM/MM Study of the Complexes Formed by Aluminum and Iron with Serum Transferrin at Neutral and Acidic pH.” Journal of Inorganic Biochemistry 105 (11): 1446–1456. doi:10.1016/j.jinorgbio.2011.07.019.
  • Mundy, W. R., T. M. Freudenrich, and P. R. Kodavanti. 1997. “Aluminum Potentiates Glutamate-Induced Calcium Accumulation and Iron-Induced Oxygen Free Radical Formation in Primary Neuronal Cultures.” Molecular and Chemical Neuropathology 32 (1–3): 41–57.
  • Oberemm, A., H. J. Bannasch, P. Ahr, H. Ellinger-Ziegelbauer, M. Gluckmann, J. Hellmann, C. Ittrich, A. Kopp-Schneider, P. J. Kramer, and E Krause. 2009. “Toxicogenomic Analysis of N-Nitrosomorpholine Induced Changes in Rat Liver: comparison of Genomic and Proteomic Responses and Anchoring to Histopathological Parameters.” Toxicology and Applied Pharmacology 241 (2): 230–245. doi:10.1016/j.taap.2009.08.020.
  • Oberemm, A., U. Hansen, L. Bohmert, C. Meckert, A. Braeuning, A. F. Thunemann, and A. Lampen. 2016. “Proteomic Responses of Human Intestinal Caco-2 Cells Exposed to Silver Nanoparticles and Ionic Silver.” Journal of Applied Toxicology 36 (3): 404–413. doi:10.1002/jat.3231.
  • Percy, M. E., T. P. Kruck, A. I. Pogue, and W. J. Lukiw. 2011. “Towards the Prevention of Potential Aluminum Toxic Effects and an Effective Treatment for Alzheimer's Disease.” Journal of Inorganic Biochemistry 105 (11): 1505–1512. doi:10.1016/j.jinorgbio.2011.08.001.
  • Powell, J. J., and R. P. Thompson. 1993. “The Chemistry of Aluminium in the Gastrointestinal Lumen and Its Uptake and Absorption.” The Proceedings of the Nutrition Society 52 (1): 241–253.
  • Rolfs, A., and M. A. Hediger. 1999. “Metal Ion Transporters in Mammals: structure, Function and Pathological Implications.” The Journal of Physiology 518 (Pt 1): 1–12.
  • Savory, J., M. M. Herman, and O. Ghribi. 2003. “Intracellular Mechanisms Underlying Aluminum-Induced Apoptosis in Rabbit Brain.” Journal of Inorganic Biochemistry 97 (1): 151–154.
  • Schönholzer, K. W., R. A. Walker, V. R. Sutton, V. Sossi, M. Schulzer, C. Orvig, E. Venczel, R. R. Johnson, D. Vetterli, and B Dittrich-Hannen. 1997. “Intestinal Absorption of Trace Amounts of Aluminium in Rats Studied with 26aluminium and Accelerator Mass Spectrometry.” Clinical Science 92 (4): 379–383.
  • Semisch, A., J. Ohle, B. Witt, and A. Hartwig. 2014. “Cytotoxicity and Genotoxicity of Nano - and Microparticulate Copper Oxide: role of Solubility and Intracellular Bioavailability.” Particle and Fibre Toxicology 11 (1): 10. doi:10.1186/1743-8977-11-10.
  • Sieg, H., C. Kästner, B. Krause, T. Meyer, A. Burel, L. Böhmert, D. Lichtenstein, H. Jungnickel, J. Tentschert, and P. Laux. 2017. “Impact of an Artificial Digestion Procedure on Aluminum-Containing Nanomaterials.” Langmuir 33 (40): 10726–10735. doi:10.1021/acs.langmuir.7b02729.
  • Stahl, T.,. H. Taschan, and H. Brunn. 2011. “Aluminium Content of Selected Foods and Food Products.” Environmental Sciences Europe 23 (1): 37. doi:10.1186/2190-4715-23-37.
  • Tentschert, J., F. Draude, H. Jungnickel, A. Haase, A. Mantion, S. Galla, A. F. Thünemann, A. Taubert, A. Luch, and H. F. Arlinghaus. 2013. “TOF-SIMS Analysis of Cell Membrane Changes in Functional Impaired Human Macrophages upon Nanosilver Treatment.” Surface and Interface Analysis 45 (1): 483–485. doi:10.1002/sia.5155.
  • Thompson, C. E., H. Jungnickel, N. P. Lockyer, G. M. Stephens, and J. C. Vickerman. 2004. “ToF-SIMS Studies as a Tool to Discriminate between Spores and Vegetative Cells of Bacteria.” Applied Surface Science 231–232: 420–423. doi:10.1016/j.apsusc.2004.03.154.
  • Van Oostdam, J. C., H. Zwanenburg, and J. R. Harrison. 1990. “Canadian Perspectives on Aluminum.” Environmental Geochemistry and Health 12 (1-2): 71–74. doi:10.1007/bf01734051.
  • Verissimo, J., O. Gomes, and M. Gomes. 2006. “Leaching of Aluminum from Cooking Pans and Food Containers.” Sensor Actuator B 118 (1–2): 192. doi:10.1016/j.snb.2006.04.061.
  • Vick, K. E., and C. A. Johnson. 1985. “Aluminum-Related Osteomalacia in Renal-Failure Patients.” Clinical Pharmacy 4 (4): 434–439.
  • Volkheimer, G. 1974. “Passage of Particles through the Wall of the Gastrointestinal Tract.” Environmental Health Perspectives 9: 215–225.
  • Wagner, W. 1999. Canadian Minerals Yearbook. Ottawa: Natural Resources Canada.
  • Waheed, A.,. R. S. Britton, J. H. Grubb, W. S. Sly, and R. E. Fleming. 2008. “HFE Association with Transferrin Receptor 2 Increases Cellular Uptake of Transferrin-Bound Iron.” Archives of Biochemistry and Biophysics 474 (1): 193–197. doi:10.1016/j.abb.2008.02.041.
  • Walczak, A. P., E. Kramer, P. J. Hendriksen, P. Tromp, J. P. Helsper, M. VAN DER Zande, I. M. Rietjens, and H. Bouwmeester. 2015. “Translocation of Differently Sized and Charged Polystyrene Nanoparticles in in Vitro Intestinal Cell Models of Increasing Complexity.” Nanotoxicology 9 (4): 453–461. doi:10.3109/17435390.2014.944599.
  • Walton, J. R. 2014. “Chronic Aluminum Intake Causes Alzheimer's Disease: applying Sir Austin Bradford Hill's Causality Criteria.” Journal of Alzheimer's Disease 40 (4): 765–838. doi:10.3233/JAD-132204.
  • Wen, Z., G. Li, D.-H. Lin, J.-T. Wang, L.-F. Qin, and G.-P. Guo. 2013. “Transport of PLGA Nanoparticles across Caco-2/HT29-MTX Co-Cultured Cells.” Yao Xue Xue Bao = Acta Pharmaceutica Sinica 48 (12): 1829–1835.
  • Willhite, C. C., G. L. Ball, and C. J. Mclellan. 2012. “Total Allowable Concentrations of Monomeric Inorganic Aluminum and Hydrated Aluminum Silicates in Drinking Water.” Critical Reviews in Toxicology 42 (5): 358–442. doi:10.3109/10408444.2012.674101.
  • Willhite, C. C., N. A. Karyakina, R. A. Yokel, N. Yenugadhati, T. M. Wisniewski, I. M. Arnold, F. Momoli, and D. Krewski. 2014. “Systematic Review of Potential Health Risks Posed by Pharmaceutical, Occupational and Consumer Exposures to Metallic and Nanoscale Aluminum, Aluminum Oxides, Aluminum Hydroxide and Its Soluble Salts.” Critical Reviews in Toxicology 44 (sup4): 1–80. doi:10.3109/10408444.2014.934439.
  • Xia, D., Y. He, Q. Li, C. Hu, W. Huang, Y. Zhang, F. Wan, C. Wang, and Y. Gan. 2018. “Transport Mechanism of Lipid Covered Saquinavir Pure Drug Nanoparticles in Intestinal Epithelium.” J Control Release 269: 159–70. doi:10.1016/j.jconrel.2017.11.012.
  • Yang, S., M. G. Damiano, H. Zhang, S. Tripathy, A. J. Luthi, J. S. Rink, A. V. Ugolkov, A. T. Singh, S. S. Dave, L. I. Gordon, and C. S. Thaxton. 2013. “Biomimetic, Synthetic HDL Nanostructures for Lymphoma.” Proceedings of the National Academy of Sciences of the United States of America 110 (7): 2511–2516. doi:10.1073/pnas.1213657110.
  • Ye, D., M. Bramini, D. R. Hristov, S. Wan, A. Salvati, C. Aberg, and K. A. Dawson. 2017. “Low Uptake of Silica Nanoparticles in Caco-2 Intestinal Epithelial Barriers.” Beilstein Journal of Nanotechnology 8: 1396–1406. doi:10.3762/bjnano.8.141.
  • Yokel, R. A., and P. J. Mcnamara. 1988. “Influence of Renal Impairment, Chemical Form, and Serum Protein Binding on Intravenous and Oral Aluminum Kinetics in the Rabbit.” Toxicology and Applied Pharmacology 95 (1): 32–43.
  • Yokel, R. A., and P. J. Mcnamara. 2001. “Aluminium Toxicokinetics: An Updated Minireview.” Pharmacology and Toxicology 88 (4): 159–167.
  • Yokel, R. A., A. A. Urbas, R. A. Lodder, J. P. Selegue, and R. L. Florence. 2005. “26Al-Containing Acidic and Basic Sodium Aluminum Phosphate Preparation and Use in Studies of Oral Aluminum Bioavailability from Foods Utilizing 26Al as an Aluminum Tracer.” Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 229 (3-4): 471–478. doi:10.1016/j.nimb.2004.12.130.
  • Zatta, P., T. Kiss, M. Suwalsky, and G. Berthon. 2002. “Aluminium(III) as a Promoter of Cellular Oxidation.” Coordination Chemistry Reviews 228 (2): 271–284. doi:10.1016/S0010-8545(02)00074-7.
  • Zhang, Q. L., M. Q. Li, J. W. Ji, F. P. Gao, R. Bai, C. Y. Chen, and Z. W. Wang et al.. 2011. “In Vivo Toxicity of Nano-Alumina on Mice Neurobehavioral Profiles and the Potential Mechanisms.” International Journal of Immunopathology and Pharmacology, 24, 23s–29s
  • Zhou, Y., and R. A. Yokel. 2005. “The Chemical Species of Aluminum Influences Its Paracellular Flux across and Uptake into Caco-2 Cells, a Model of Gastrointestinal Absorption.” Toxicological Sciences 87 (1): 15–26. doi:10.1093/toxsci/kfi216.

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