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Review Articles

Preclinical hazard evaluation strategy for nanomedicines

, , , , &
Pages 73-99 | Received 03 May 2018, Accepted 20 Jul 2018, Published online: 05 Sep 2018

References

  • Aderem, A. 2003. “Phagocytosis and the Inflammatory Response.” The Journal of Infectious Diseases 187 (s2): S340–S345. doi:10.1086/374747
  • Aguilar-Castillo, B. A., J. L. Santos, H. Luo, Y. E. Aguirre-Chagala, T. Palacios-Hernandez, and M. Herrera-Alonso. 2015. “Nanoparticle Stability in Biologically Relevant Media: influence of Polymer Architecture.” Soft Matter 11 (37): 7296–7307. doi:10.1039/C5SM01455G
  • Ahrens, N., L. Schewior, E. Garbe, H. Kiesewetter, and A. Salama. 2004. “Massive Haemolysis after Intramuscular Diclofenac in a Patient Who Apparently Tolerated Oral Medication.” Vox Sanguinis 86 (1): 71–74. doi:10.1111/j.0042-9007.2004.00389.x
  • Akthakul, A., A. I. Hochbaum, F. Stellacci, and A. M. Mayes. 2005. “Size Fractionation of Metal Nanoparticles by Membrane Filtration.” Advanced Materials 17 (5): 532–535. doi:10.1002/adma.200400636
  • Álvarez-Fuentes, J., L. Martín-Banderas, I. Muñoz-Rubio, M. A. Holgado, and M. Fernández-Arévalo. 2012. “Development and Validation of an RP-HPLC Method for CB13 Evaluation in Several PLGA Nanoparticle Systems [WWW Document].” The Scientific World Journal 2012: 737526. doi:10.1100/2012/737526
  • Ambrogio, M. W., C. R. Thomas, Y.-L. Zhao, J. I. Zink, and J. F. Stoddart. 2011. “Mechanized Silica Nanoparticles: A New Frontier in Theranostic Nanomedicine.” Accounts of Chemical Research 44 (10): 903–913. doi:10.1021/ar200018x
  • Amenabar, I., S. Poly, W. Nuansing, E. H. Hubrich, A. A. Govyadinov, F. Huth, R. Krutokhvostov, L. Zhang, M. Knez, J. Heberle. J., et al. 2013. “Structural Analysis and Mapping of Individual Protein Complexes by Infrared Nanospectroscopy.” Nature Communications 4 (1): 3890. Ncomms doi:10.1038/ncomms3890
  • Amidon, G. L., H. Lennernäs, V. P. Shah, and J. R. Crison. 1995. “A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability.” Pharmaceutical Research 12: 413–420. doi:10.1023/A:1016212804288
  • Ankley, G. T., R. S. Bennett, R. J. Erickson, D. J. Hoff, M. W. Hornung, R. D. Johnson, D. R. Mount, J. W. Nichols, C. L. Russom, P. K. Schmieder, et al. 2010. “Adverse Outcome Pathways: A Conceptual Framework to Support Ecotoxicology Research and Risk Assessment.” Environmental Toxicology and Chemistry 29 (3): 730–741. doi:10.1002/etc.34
  • Arap, W., R. Pasqualini, M. Montalti, L. Petrizza, L. Prodi, E. Rampazzo, N. Zaccheroni, and S. Marchiò. 2013. “Luminescent Silica Nanoparticles for Cancer Diagnosis.” Current Medicinal Chemistry 20 (17): 2195–2211. doi:10.2174/0929867311320170005
  • Arts, J. H. E., M. Hadi, M.-A. Irfan, A. M. Keene, R. Kreiling, D. Lyon, M. Maier, K. Michel, T. Petry, U. G. Sauer, et al. 2015a. “A Decision-Making Framework for the Grouping and Testing of Nanomaterials (DF4nanoGrouping).” Regulatory Toxicology and Pharmacology 71 (2): S1–S27. doi:10.1016/j.yrtph.2015.03.007
  • Atkinson, P. M., D. I. Taylor, and N. Chetty. 1985. “Inhibition of Platelet Aggregation by Ketamine Hydrochloride.” Thrombosis Research 40 (2): 227–234. doi:10.1016/0049-3848(85)90333-0
  • Bao, H., X. Yu, C. Xu, X. Li, Z. Li, D. Wei, and Y. Liu. 2015. “New Toxicity Mechanism of Silver Nanoparticles: Promoting Apoptosis and Inhibiting Proliferation.” PLoS One 10 (3): e0122535. doi:10.1371/journal.pone.0122535
  • Bartneck, M., H. A. Keul, S. Singh, K. Czaja, J. Bornemann, M. Bockstaller, M. Moeller, G. Zwadlo-Klarwasser, and J. Groll. 2010a. “Rapid Uptake of Gold Nanorods by Primary Human Blood Phagocytes and Immunomodulatory Effects of Surface Chemistry.” ACS Nano 4 (6): 3073–3086. doi:10.1021/nn100262h
  • Bartneck, M., H. A. Keul, G. Zwadlo-Klarwasser, and J. Groll. 2010b. “Phagocytosis Independent Extracellular Nanoparticle Clearance by Human Immune Cells.” Nano Letters 10 (1): 59–63. doi:10.1021/nl902830x
  • Berg, J. M., A. Romoser, N. Banerjee, R. Zebda, and C. M. Sayes. 2009. “The Relationship between pH and Zeta Potential of ∼30 Nm Metal Oxide Nanoparticle Suspensions Relevant to in Vitro Toxicological Evaluations.” Nanotoxicology 3 (4): 276–283. doi:10.3109/17435390903276941
  • Berger, M. 2009. “Size matters. Comparing the toxicity of micro- to nanoparticles” [WWW Document]. Accessed August 21 2017. http://www.nanowerk.com/spotlight/spotid=10128.php
  • Bhattacharjee, S. 2016. “DLS and Zeta Potential – What They Are and What They Are Not?.” Journal of Controlled Release 235: 337–351. doi:10.1016/j.jconrel.2016.06.017
  • Bleeker, E. A. J., W. H. de Jong, R. E. Geertsma, M. Groenewold, E. H. W. Heugens, M. Koers-Jacquemijns, D. van de Meent, J. R. Popma, A. G. Rietveld, S. W. P. Wijnhoven, et al. 2013. “Considerations on the EU Definition of a Nanomaterial: Science to Support Policy Making.” Regulatory Toxicology and Pharmacology 65 (1): 119–125. doi:10.1016/j.yrtph.2012.11.007
  • Bobo, D., K. J. Robinson, J. Islam, K. J. Thurecht, and S. R. Corrie. 2016. “Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date.” Pharmaceutical Research 33 (10): 2373–2387. doi:10.1007/s11095-016-1958-5
  • Boilard, S. P., P. R. Amyotte, F. I. Khan, A. G. Dastidar, and R. K. Eckhoff. 2013. “Explosibility of Micron- and Nano-Size Titanium Powders.” Journal of Loss Prevention in the Process Industries 26 (6): 1646–1654. doi:10.1016/j.jlp.2013.06.003
  • Bolt, H. M. 2014. “Grouping of Nanomaterials for Risk Assessment.” Archives of Toxicology 88 (12): 2077–2078. doi:10.1007/s00204-014-1416-2
  • Bozzuto, G., and A. Molinari. 2015. “Liposomes as Nanomedical Devices.” International Journal of Nanomedicine 10: 975–999. doi10.2147/IJN.S68861
  • Brown, J. S., T. Gordon, O. Price, and B. Asgharian. 2013. “Thoracic and Respirable Particle Definitions for Human Health Risk Assessment.” Particle and Fibre Toxicology 10 (1): 12. doi:10.1186/1743-8977-10-12
  • Buzea, C., I. I. Pacheco, and K. Robbie. 2007. “Nanomaterials and Nanoparticles: sources and Toxicity.” Biointerphases 2 (4): MR17–MR71. doi:10.1116/1.2815690
  • Casals, E., T. Pfaller, A. Duschl, G. J. Oostingh, and V. Puntes. 2010. “Time Evolution of the Nanoparticle Protein Corona.” ACS Nano 4 (7): 3623–3632. doi:10.1021/nn901372t
  • Champion, J. A., Y. K. Katare, and S. Mitragotri. 2007. “Particle Shape: A New Design Parameter for Micro- and Nanoscale Drug Delivery Carriers.” Official journal of the Controlled Release Society 121 (1–2): 3–9. doi:10.1016/j.jconrel.2007.03.022
  • Chen, F., G. Wang, J. I. Griffin, B. Brenneman, N. K. Banda, V. M. Holers, D. S. Backos, L. Wu, S. M. Moghimi, and D. Simberg. 2017. “Complement Proteins Bind to Nanoparticle Protein Corona and Undergo Dynamic Exchange In Vivo.” Nature Nanotechnology 12 (4): 387–393. doi:10.1038/nnano.2016.269
  • Chukwuocha, E. O., M. C. Onyeaju, and T. S. T. Harry. 2012. “Theoretical Studies on the Effect of Confinement on Quantum Dots Using the Brus Equation World Journal of Condensed Matter Physics 2 (2): 96–100. doi:10.4236/wjcmp.2012.22017
  • Cicha, I. 2016. “Strategies to Enhance Nanoparticle-Endothelial Interactions under Flow.” Journal of Cellular Biotechnology 1 (2): 191–208. doi:10.3233/JCB-15020
  • Clogston, J. D., and A. K. Patri. 2011. “Zeta Potential Measurement.” Methods in Molecular Biology (Clifton, N.J.) 697: 63–70. doi:10.1007/978-1-60327-198-1
  • Coti, K. K., M. E. Belowich, M. Liong, M. W. Ambrogio, Y. A. Lau, H. A. Khatib, J. I. Zink, N. M. Khashab, and J. F. Stoddart. 2009. “Mechanised Nanoparticles for Drug Delivery.” Nanoscale 1 (1): 16–39. doi:10.1039/b9nr00162j
  • Crawford, R., B. Dogdas, E. Keough, R. M. Haas, W. Wepukhulu, S. Krotzer, P. A. Burke, L. Sepp-Lorenzino, A. Bagchi, and B. J. Howell. 2011. “Analysis of Lipid Nanoparticles by Cryo-EM for Characterizing siRNA Delivery Vehicles.” International Journal of Pharmaceutics 403 (1–2): 237–44. doi:10.1016/j.ijpharm.2010.10.025
  • Davignon, J., and P. Ganz. 2004. “Role of Endothelial Dysfunction in Atherosclerosis.” Circulation 109 (23_suppl_1): III-27–III-32. doi:10.1161/01.CIR.0000131515.03336.f8
  • Deanfield, J., A. Donald, C. Ferri, C. Giannattasio, J. Halcox, S. Halligan, A. Lerman, G. Mancia, J. J. Oliver, A. C. Pessina, et al., Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. 2005. “Endothelial Function and Dysfunction. Part I: Methodological Issues for Assessment in the Different Vascular Beds: A Statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension.” Journal of Hypertension 23 (1): 7–17. doi:10.1097/00004872-200501000-00004
  • Dekkers, S., A. G. Oomen, E. A. J. Bleeker, R. J. Vandebriel, C. Micheletti, J. Cabellos, G. Janer, N. Fuentes, S. Vázquez-Campos, T. Borges, et al. 2016. “Towards a Nanospecific Approach for Risk Assessment.” Regulatory Toxicology and Pharmacology 80: 46–59. doi:10.1016/j.yrtph.2016.05.037
  • Dobrovolskaia, M. A., A. K. Patri, J. Simak, J. B. Hall, J. Semberova, S. H. De Paoli Lacerda, and S. E. McNeil. 2012. “Nanoparticle Size and Surface Charge Determine Effects of PAMAM Dendrimers on Human Platelets in Vitro.” Molecular Pharmaceutics 9 (3): 382–393. doi:10.1021/mp200463e
  • Docter, D., D. Westmeier, M. Markiewicz, S. Stolte, S. K. Knauer, and R. H. Stauber. 2015. “The Nanoparticle Biomolecule Corona: lessons Learned – Challenge Accepted?” Chemical Society Reviews 44: 6094–6121. doi:10.1039/C5CS00217F
  • Dongargaonkar, A. A., and J. D. Clogston. 2018. “Quantitation of Surface Coating on Nanoparticles Using Thermogravimetric Analysis.” In Characterization of Nanoparticles Intended for Drug Delivery, Methods in Molecular Biology, edited by McNeil S, 57–63. New York, NY: Humana Press. doi:10.1007/978-1-4939-7352-1_6
  • Droppo, I. G. 2006. “Filtration in Particle Size Analysis.” In Encyclopedia of Analytical Chemistry, edited by R. A. Meyers and R. B. Flippen. Hoboken, New Jersey: John Wiley & Sons, Ltd. doi:10.1002/9780470027318.a1506
  • Dusinska, M., M. Dusinska, L. Fjellsbø, Z. Magdolenova, A. Rinna, E. Runden Pran, A. Bartonova, E. Heimstad, M. Harju, L. Tran. et al. 2009. “Testing Strategies for the Safety of Nanoparticles Used in Medical Applications.” Nanomed 4 (6): 605–607. doi:10.2217/nnm.09.47
  • ECHA. 2013. “Grouping of Substances and Read-Across – ECHA” [WWW Document]. Accessed August 28 2017. https://echa.europa.eu/support/registration/how-to-avoid-unnecessary-testing-on-animals/grouping-of-substances-and-read-across
  • Elgqvist, J. 2017. “Nanoparticles as Theranostic Vehicles in Experimental and Clinical Applications—Focus on Prostate and Breast Cancer.” International Journal of Molecular Sciences 18 (5): 1102. doi:10.3390/ijms18051102
  • Ermidou-Pollet, S., H. Nounopoulos, N. Sdougas, M. Szilágyi, and S. Pollet. 2005. “Influence of Subcutaneous Injection of Essential Fatty Acids on the Stress-Induced Modifications of Rat Platelet Aggregation and Membrane Lipid Composition.” Acta Biologica Hungarica 56 (3–4): 247–259. doi:10.1556/ABiol.56.2005.3-4.8
  • Etheridge, M. L., S. A. Campbell, A. G. Erdman, C. L. Haynes, S. M. Wolf, and J. McCullough. 2013. “The Big Picture on Small Medicine: The State of Nanomedicine Products Approved for Use or in Clinical Trials.” Nanomedicine: Nanotechnology, Biology, and Medicine 9 (1): 1–14. doi:10.1016/j.nano.2012.05.013
  • European Medicines Agency - Multidisciplinary - Data requirements for intravenous iron-based nano-colloidal products developed with reference to an innovator medicinal product [WWW Document], n.d. Accessed January 19 2018. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2015/03/WC500184922.pdf
  • European Medicines Agency - Multidisciplinary - Joint MHLW/EMA reflection paper on the development of block copolymer micelle medicinal products [WWW Document], n.d. Accessed January 19 2018. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2013/02/WC500138390.pdf
  • European Medicines Agency - Multidisciplinary - Reflection paper on surface coatings: general issues for consideration regarding parenteral administration of coated nanomedicine products [WWW Document], n.d. Accessed January 19 2018. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2013/08/WC500147874.pdf
  • European Medicines Agency - Multidisciplinary - Reflection paper on the data requirements for intravenous liposomal products developed with reference to an innovator liposomal product [WWW Document], n.d. Accessed January 19 2018. http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2013/03/WC500140351.pdf
  • European Medicines Agency - Multidisciplinary - Reflection paper on nanotechnology-based medicinal products for human use [WWW Document], n.d. Accessed 19 Jan 2018. http://www.ema.europa.eu/docs/en_GB/document_library/Regulatory_and_procedural_guideline/2010/01/WC500069728.pdf
  • Fabricius, A.-L., L. Duester, B. Meermann, and T. A. Ternes. 2014. “ICP-MS-Based Characterization of Inorganic Nanoparticles—Sample Preparation and off-Line Fractionation Strategies.” Analytical and Bioanalytical Chemistry 406 (2): 467–479. doi:10.1007/s00216-013-7480-2
  • Fadeel, B. 2012. Clear and Present Danger? Engineered Nanoparticles and the Immune System [WWW document]. Swiss Med. Wkly. Accessed May 11 2016. http://blog.smw.ch/
  • Fadeel, B., A. Pietroiusti, and A. A. Shvedova. 2017. Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health. Cambridge, Massachusetts: Academic Press.
  • FDA. 2005. “Guidance for Industry on Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers.” Availability [WWW Document]. Fed. Regist. Accessed August 24 2017. https://www.federalregister.gov/documents/2005/07/22/05-14456/guidance-for-industry-on-estimating-the-maximum-safe-starting-dose-in-initial-clinical-trials-for
  • Félétou, M. 2011. “The Endothelium: Part 1: Multiple Functions of the Endothelial Cells—Focus on Endothelium-Derived Vasoactive Mediators.” In Integrated Systems Physiology: From Molecule to Function to Disease, edited by D. Neil Granger and Joey P. Granger, 1–306. San Rafael (CA): Morgan & Claypool Life Sciences.
  • Feliu, N., and B. Fadeel. 2010. “Nanotoxicology: No Small Matter.” Nanoscale 2 (12): 2514–2520. doi:10.1039/c0nr00535e
  • Friedrich, R. P., C. Janko, M. Poettler, P. Tripal, J. Zaloga, I. Cicha, S. Dürr, J. Nowak, S. Odenbach, I. Slabu. et al. 2015. “Flow Cytometry for Intracellular SPION Quantification: Specificity and Sensitivity in Comparison with Spectroscopic Methods.” International Journal of Nanomedicine 10: 4185–4201. doi:10.2147/IJN.S82714
  • Fröhlich, E. 2017. “Role of Omics Techniques in the Toxicity Testing of Nanoparticles.” Journal of Nanobiotechnology 15 (1): 84. doi:10.1186/s12951-017-0320-3
  • Fubini, B., M. Ghiazza, and I. Fenoglio. 2010. “Physico-Chemical Features of Engineered Nanoparticles Relevant to Their Toxicity.” Nanotoxicology 4 (4): 347–363. doi:10.3109/17435390.2010.509519
  • Gallud, A., and B. Fadeel. 2015. “Keeping It Small: Towards a Molecular Definition of Nanotoxicology.” European Journal of Nanomedicine 7: 143–151. doi:10.1515/ejnm-2015-0020
  • Garbovskiy, Y. 2017. “Biological Contamination of Nanoparticles and Its Manifestation in Optical Absorbance Measurements.” Analytical Chemistry 89 (14): 7282–7285. doi:10.1021/acs.analchem.7b01766
  • Gebel, T., H. Foth, G. Damm, A. Freyberger, P.-J. Kramer, W. Lilienblum, C. Röhl, T. Schupp, C. Weiss, K.-M. Wollin, et al. 2014. “Manufactured Nanomaterials: Categorization and Approaches to Hazard Assessment.” Archives of Toxicology 88 (12): 2191–2211. doi:10.1007/s00204-014-1383-7
  • Goldstein, A., Y. Soroka, M. Frušić-Zlotkin, I. Popov, and R. Kohen. 2014. “High Resolution SEM Imaging of Gold Nanoparticles in Cells and Tissues.” Journal of Microscopy 256 (3): 237–247. doi:10.1111/jmi.12179
  • Gottardo, S. 2017. “NANoREG Framework for the Safety Assessment of Nanomaterials - EU Science Hub - European Commission [WWW Document].” EU Science Hub. Accessed March 7 2018. https://ec.europa.eu/jrc/en/publication/eur-scientific-and-technical-research-reports/nanoreg-framework-safety-assessment-nanomaterials
  • Gregoriadis, G., 1985. Liposomes for drugs and vaccines. Trends Biotechnol. 3: 235–241. doi:10.1016/0167-7799(85)90014-9
  • Gregory, A. E., R. Titball, and D. Williamson. 2013. “Vaccine Delivery Using Nanoparticles.” Frontiers in Cellular and Infection Microbiology 3: 13. doi:10.3389/fcimb.2013.00013
  • Guadagnini, R., B. Halamoda Kenzaoui, L. Walker, G. Pojana, Z. Magdolenova, D. Bilanicova, M. Saunders, L. Juillerat-Jeanneret, A. Marcomini, A. Huk, et al. 2015. “Toxicity Screenings of Nanomaterials: Challenges Due to Interference with Assay Processes and Components of Classic in Vitro Tests.” Nanotoxicology 9 (Supp1): 13–24. doi:10.3109/17435390.2013.829590
  • Guarnieri, D., S. Sabella, O. Muscetti, V. Belli, M. A. Malvindi, S. Fusco, E. De Luca, P. P. Pompa, and P. A. Netti. 2014. “Transport across the Cell-Membrane Dictates Nanoparticle Fate and Toxicity: A New Paradigm in Nanotoxicology.” Nanoscale 6 (17): 10264–10273. doi:10.1039/C4NR02008A
  • Guha, S., M. Li, M. J. Tarlov, and M. R. Zachariah. 2012. “Electrospray–Differential Mobility Analysis of Bionanoparticles.” Trends Biotechnol 30 (5): 291–300. doi:10.1016/j.tibtech.2012.02.003
  • Guo, C., Y. Xia, P. Niu, L. Jiang, J. Duan, Y. Yu, X. Zhou, Y. Li, and Z. Sun. 2015. “Silica Nanoparticles Induce Oxidative Stress, Inflammation, and Endothelial Dysfunction in Vitro via Activation of the MAPK/Nrf2 Pathway and Nuclear Factor-κB Signaling.” International Journal of Nanomedicine 10: 1463–1477. doi:10.2147/IJN.S76114
  • Guo, C., and J. L. Yarger. 2018. “Characterizing Gold Nanoparticles by NMR Spectroscopy.” Magnetic Resonance in Chemistry. doi:10.1002/mrc.4753. [Epub ahead of print]
  • Hackley, V. A., and J. D. Clogston. 2011. “Measuring the Hydrodynamic Size of Nanoparticles in Aqueous Media Using Batch-Mode Dynamic Light Scattering.” In Characterization of Nanoparticles Intended for Drug Delivery, edited by S. E. McNeil, 35–52. Totowa, NJ: Humana Press. doi:10.1007/978-1-60327-198-1_4
  • Hadrup, N., A. K. Sharma, M. Poulsen, and E. Nielsen. 2015. “Toxicological Risk Assessment of Elemental Gold following Oral Exposure to Sheets and Nanoparticles - A Review.” Regulatory Toxicology and Pharmacology 72 (2): 216–221. doi:10.1016/j.yrtph.2015.04.017
  • Hole, P., K. Sillence, C. Hannell, C. M. Maguire, M. Roesslein, G. Suarez, S. Capracotta, Z. Magdolenova, L. Horev-Azaria, A. Dybowska, et al. 2013. “Interlaboratory Comparison of Size Measurements on Nanoparticles Using Nanoparticle Tracking Analysis (NTA).” Journal of Nanoparticle Research 15 (12): 2101. doi:10.1007/s11051-013-2101-8
  • Hung, H.-I., O. J. Klein, S. W. Peterson, S. R. Rokosh, S. Osseiran, N. H. Nowell, and C. L. Evans. 2016. “PLGA Nanoparticle Encapsulation Reduces Toxicity While Retaining the Therapeutic Efficacy of EtNBS-PDT In Vitro.” Scientific Reports 6 (1): 33234. doi:10.1038/srep33234
  • Huth, F., A. Govyadinov, S. Amarie, W. Nuansing, F. Keilmann, and R. Hillenbrand. 2012. “Nano-FTIR Absorption Spectroscopy of Molecular Fingerprints at 20 Nm Spatial Resolution.” Nano Letters 12 (8): 3973–3978. doi:10.1021/nl301159v
  • ISO. 2015. “ISO/TS 80004-2:2015(en), Nanotechnologies — Vocabulary — Part 2: Nano-objects.” [WWW Document]. Accessed August 28 2017. https://www.iso.org/obp/ui/#iso:std:iso:ts:80004:-2:ed-1:v1:en
  • Itoh, N., E. Yamamoto, T. Santa, T. Funatsu, and M. Kato. 2016. “Effect of Nanoparticle Surface on the HPLC Elution Profile of Liposomal Nanoparticles.” Pharmaceutical Research 33 (6): 1440–1446. doi:10.1007/s11095-016-1886-4
  • Jarockyte, G., E. Daugelaite, M. Stasys, U. Statkute, V. Poderys, T.-C. Tseng, S.-H. Hsu, V. Karabanovas, and R. Rotomskis. 2016. “Accumulation and Toxicity of Superparamagnetic Iron Oxide Nanoparticles in Cells and Experimental Animals.” International Journal of Molecular Sciences 17 (8): 1193. doi:10.3390/ijms17081193
  • Jong, W. 2010. “Scientific Basis for the Definition of the Term ‘nanomaterial’.” [WWW Document] Accessed 28 August 2017. http://ec.europa.eu/health/scientific_committees/emerging/docs/scenihr_o_032.pdf
  • Joris, F., D. Valdepérez, B. Pelaz, S. J. Soenen, B. B. Manshian, W. J. Parak, S. C. De Smedt, and K. Raemdonck. 2016. “The Impact of Species and Cell Type on the Nanosafety Profile of Iron Oxide Nanoparticles in Neural Cells.” Journal of Nanobiotechnology 14 (1): 69. doi:10.1186/s12951-016-0220-y
  • Junghanns, J.-U. A. H., and R. H. Müller. 2008. “Nanocrystal Technology, Drug Delivery and Clinical Applications.” International Journal of Nanomedicine 3 (3): 295–310.
  • Kaszuba, M., D. McKnight, M. T. Connah, F. K. McNeil-Watson, and U. Nobbmann. 2008. “Measuring Sub Nanometre Sizes Using Dynamic Light Scattering.” Journal of Nanoparticle Research 10 (5): 823–829. doi:10.1007/s11051-007-9317-4
  • Ke, P. C., S. Lin, W. J. Parak, T. P. Davis, and F. Caruso. 2017. “A Decade of the Protein Corona.” ACS Nano 11 (12): 11773–11776. doi:10.1021/acsnano.7b08008
  • Kennedy, I. M., D. Wilson, and A. I. Barakat; HEI Health Review Committee. 2009. “Uptake and Inflammatory Effects of Nanoparticles in a Human Vascular Endothelial Cell Line.” Research reports - Health Effects Institute 136: 3–32.
  • Kettiger, H., A. Schipanski, P. Wick, and J. Huwyler. 2013. “Engineered Nanomaterial Uptake and Tissue Distribution: From Cell to Organism.” International Journal of Nanomedicine 8: 3255–3269. doi:10.2147/IJN.S49770
  • Kievit, F. M., and M. Zhang. 2011. “Surface Engineering of Iron Oxide Nanoparticles for Targeted Cancer Therapy.” Accounts of Chemical Research 44 (10): 853–862. doi:10.1021/ar2000277
  • Kim, I.-Y., E. Joachim, H. Choi, and K. Kim. 2015. “Toxicity of Silica Nanoparticles Depends on Size, Dose, and Cell Type.” Nanomedicine: Nanotechnology, Biology, and Medicine 11 (6): 1407–1416. doi:10.1016/j.nano.2015.03.004
  • Krug, H. F. 2014. “Nanosafety Research – Are We On the Right Track?” Angewandte Chemie (International Ed. In English) 53 (46): 12304–12319. doi:10.1002/anie.201403367
  • Krug, H. F., and P. Wick. 2011. “Nanotoxicology: An Interdisciplinary Challenge.” Angewandte Chemie International Edition 50 (6): 1260–1278. doi:10.1002/anie.201001037
  • Laux, P., C. Riebeling, A. M. Booth, J. D. Brain, J. Brunner, C. Cerrillo, O. Creutzenberg, I. Estrela-Lopis, T. Gebel, G. Johanson, et al. 2017. “Biokinetics of Nanomaterials: The Role of Biopersistence.” NanoImpact 6: 69–80. doi:10.1016/j.impact.2017.03.003
  • Lee, J. H., Y. S. Kim, K. S. Song, H. R. Ryu, J. H. Sung, J. D. Park, H. M. Park, N. W. Song, B. S. Shin, D. Marshak, et al. 2013. “Biopersistence of Silver Nanoparticles in Tissues from Sprague–Dawley Rats.” Particle and Fibre Toxicology 10 (1): 36. doi:10.1186/1743-8977-10-36
  • Li, L. K. Y. Mak, J. Shi, C. H. Leung, C. M. Wong, C. W. Leung, C. S. K. Mak, K. Y. Chan, N. M. M. Chan, E. X. Wu, and P. W. T. Pong. 2013. “Sterilization on Dextran-Coated Iron Oxide Nanoparticles: Effects of Autoclaving, Filtration, UV Irradiation, and Ethanol Treatment.” Microelectronic Engineering 111: 310–313. doi:10.1016/j.mee.2013.02.021
  • Li, T., A. J. Senesi, and B. Lee. 2016. “Small Angle X-Ray Scattering for Nanoparticle Research.” Chemical Reviews 116 (18): 11128–11180. doi:10.1021/acs.chemrev.5b00690
  • Li, Y., and D. Boraschi. 2016. “Endotoxin Contamination: A Key Element in the Interpretation of Nanosafety Studies.” Nanomed 11 (3): 269–287. doi:10.2217/nnm.15.196
  • Li, Z., Y. Zhang, D. Zhu, S. Li, X. Yu, Y. Zhao, X. Ouyang, Z. Xie, and L. Li. 2017. “Transporting Carriers for Intracellular Targeting Delivery via Non-Endocytic Uptake Pathways.” Drug Delivery 24 (2): 45–55. doi:10.1080/10717544.2017.1391889
  • Lovestam, G. 2010. “Considerations on a Definition of Nanomaterial for Regulatory Purposes.” [WWW Document]. Accessed 28 August 2017. https://ec.europa.eu/jrc/sites/jrcsh/files/jrc_reference_report_201
  • Lu, M., M. H. Cohen, D. Rieves, and R. Pazdur. 2010. “FDA Report: Ferumoxytol for Intravenous Iron Therapy in Adult Patients with Chronic Kidney Disease.” American Journal of Hematology 85 (5): 315–319. doi:10.1002/ajh.21656
  • Maguire, C. M., Sillence, K. Roesslein, M. Hannell, C. Suarez, G. Sauvain, J.-J. Capracotta, S. Contal, S. Cambier, S. El Yamani. N. et al., 2017. “Benchmark of Nanoparticle Tracking Analysis on Measuring Nanoparticle Sizing and Concentration.” Journal of Micro and Nano-Manufacturing 5 (4): 041002–041010. doi:10.1115/1.4037124
  • Mahmoudi, M., H. Hofmann, B. Rothen-Rutishauser, and A. Petri-Fink. 2012. “Assessing the in Vitro and in Vivo Toxicity of Superparamagnetic Iron Oxide Nanoparticles.” Chemical Reviews 112 (4): 2323–2338. doi:10.1021/cr2002596
  • Mansfield, E., K. M. Tyner, C. M. Poling, and J. L. Blacklock. 2014. “Determination of Nanoparticle Surface Coatings and Nanoparticle Purity Using Microscale Thermogravimetric Analysis.” Analytical Chemistry 86: 1478–1484. doi:10.1021/ac402888v
  • McCormack, P. L. 2012. “Ferumoxytol: In Iron Deficiency Anaemia in Adults with Chronic Kidney Disease.” Drugs 72: 2013–2022. doi:10.2165/11209880-000000000-00000
  • Mehn, D., F. Caputo, M. Rösslein, L. Calzolai, F. Saint-Antonin, T. Courant, P. Wick, and D. Gilliland. 2017. “Larger or More? Nanoparticle Characterisation Methods for Recognition of Dimers.” RSC Advances 7 (44): 27747–27754. doi:10.1039/C7RA02432K
  • Meng, J., M. Yang, F. Jia, Z. Xu, H. Kong, and H. Xu. 2011. “Immune Responses of BALB/c Mice to Subcutaneously Injected Multi-Walled Carbon Nanotubes.” Nanotoxicology 5 (4): 583–591. doi:10.3109/17435390.2010.523483
  • Moghimi, S. M., and D. Simberg. 2017. “Complement Activation Turnover on Surfaces of Nanoparticles.” Nano Today 15: 8–10. doi:10.1016/j.nantod.2017.03.001
  • Moore, T. L., L. Rodriguez-Lorenzo, V. Hirsch, S. Balog, D. Urban, C. Jud, B. Rothen-Rutishauser, M. Lattuada, and A. Petri-Fink. 2015. “Nanoparticle Colloidal Stability in Cell Culture Media and Impact on Cellular Interactions.” Chemical Society Reviews 44 (17): 6287–6305. doi:10.1039/C4CS00487F
  • Mühlebach, S., G. Borchard, and S. Yildiz. 2015. “Regulatory Challenges and Approaches to Characterize Nanomedicines and Their Follow-on Similars.” Nanomed 10 (4): 659–674. doi:10.2217/nnm.14.189
  • Nair, A. B., and S. Jacob. 2016. “A Simple Practice Guide for Dose Conversion between Animals and Human.” Journal of Basic and Clinical Pharmacy 7 (2): 27–31. doi:10.4103/0976-0105.177703
  • Navya, P. N., and H. K. Daima. 2016. “Rational Engineering of Physicochemical Properties of Nanomaterials for Biomedical Applications with Nanotoxicological Perspectives.” Nano Converg 3 (1): 1. doi:10.1186/s40580-016-0064-z
  • Neagu, M., Z. Piperigkou, K. Karamanou, A. B. Engin, A. O. Docea, C. Constantin, C. Negrei, D. Nikitovic, and A. Tsatsakis. 2017. “Protein Bio-Corona: critical Issue in Immune Nanotoxicology.” Archives of Toxicology 91 (3): 1031–1048. doi:10.1007/s00204-016-1797-5
  • Nel, A., T. Xia, L. Mädler, and N. Li. 2006. “Toxic Potential of Materials at the Nanolevel.” Science 311 (5761): 622–627. doi:10.1126/science.1114397
  • Nemmar, A., P. Yuvaraju, S. Beegam, J. Yasin, E. E. Kazzam, and B. H. Ali. 2016. “Oxidative Stress, Inflammation, and DNA Damage in Multiple Organs of Mice Acutely Exposed to Amorphous Silica Nanoparticles.” International Journal of Nanomedicine 11: 919–928. doi:10.2147/IJN.S92278
  • NSCT/CoT/NSET. 2014. “2014 NNI Strategic Plan | Nano.” [WWW Document]. Accessed August 23 2017. https://www.nano.gov/node/1113
  • Oberdörster, G. 2010. “Safety Assessment for Nanotechnology and Nanomedicine: concepts of Nanotoxicology.” Journal of Internal Medicine 267 (1): 89–105. doi:10.1111/j.1365-2796.2009.02187.x
  • Oberdörster, G., V. Stone, and K. Donaldson. 2007. “Toxicology of Nanoparticles: A Historical Perspective.” Nanotoxicology 1 (1): 2–25. doi:10.1080/17435390701314761
  • Oh, N., and J.-H. Park. 2014. “Endocytosis and Exocytosis of Nanoparticles in Mammalian Cells.” International Journal of Nanomedicine 9: 51–63. doi:10.2147/IJN.S26592
  • Oomen, A. G., E. A. J. Bleeker, P. M. J. Bos, F. van Broekhuizen, S. Gottardo, M. Groenewold, D. Hristozov, K. Hund-Rinke, M.-A. Irfan, A. Marcomini, et al. 2015. “Grouping and Read-across Approaches for Risk Assessment of Nanomaterials.” International Journal of Environmental Research and Public Health 12 (10): 13415–13434. doi:10.3390/ijerph121013415
  • Panchal, J., J. Kotarek, E. Marszal, and E. M. Topp. 2014. “Analyzing Subvisible Particles in Protein Drug Products: A Comparison of Dynamic Light Scattering (DLS) and Resonant Mass Measurement (RMM).” The AAPS Journal 16 (3): 440–451. doi:10.1208/s12248-014-9579-6
  • Park, J.-B. 2003. “Phagocytosis Induces Superoxide Formation and Apoptosis in Macrophages.” Experimental & Molecular Medicine 35 (5): 325–335. doi:10.1038/emm.2003.44
  • Park, M. V. D. Z., A. M. Neigh, J. P. Vermeulen, L. J. J. de la Fonteyne, H. W. Verharen, J. J. Briedé, H. van Loveren, and W. H. de Jong. 2011. “The Effect of Particle Size on the Cytotoxicity, Inflammation, Developmental Toxicity and Genotoxicity of Silver Nanoparticles.” Biomaterials 32 (36): 9810–9817. doi:10.1016/j.biomaterials.2011.08.085
  • Pelaz, B., C. Alexiou, R. A. Alvarez-Puebla, F. Alves, A. M. Andrews, S. Ashraf, L. P. Balogh, L. Ballerini, A. Bestetti, C. Brendel, et al. 2017. “Diverse Applications of Nanomedicine.” ACS Nano 11 (3): 2313–2381. doi:10.1021/acsnano.6b06040
  • Potočnik, J. 2011. “Commission Recommendation of 18 October 2011 on the Definition Of Nanomaterial 2011/696/EU.” Accessed 28 August 2017. https://eur-lex.europa.eu/legal-content/EN/ALL/?uri=CELEX:32011H0696
  • Puri, A., K. Loomis, B. Smith, J.-H. Lee, A. Yavlovich, E. Heldman, and R. Blumenthal. 2009. “Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic.” Critical Reviews in Therapeutic Drug Carrier Systems 26 (6): 523–580. doi:10.1615/CritRevTherDrugCarrierSyst.v26.i6.10
  • Pyrz, W. D., and D. J. Buttrey. 2008. “Particle Size Determination Using TEM: A Discussion of Image Acquisition and Analysis for the Novice Microscopist.” Langmuir 24 (20): 11350–11360. doi:10.1021/la801367j
  • Rao, A., M. Schoenenberger, E. Gnecco, T. Glatzel, E. Meyer, D. Brändlin, and L. Scandella. 2007. “Characterization of Nanoparticles Using Atomic Force Microscopy.” Journal of Physics: Conference Series 61: 971. doi:10.1088/1742-6596/61/1/192
  • Roberson, S., and G. J. Weltje. 2014. “Inter-Instrument Comparison of Particle-Size Analysers.” Sedimentology 61 (4): 1157–1174. doi:10.1111/sed.12093
  • Robertson, J. D., L. Rizzello, M. Avila-Olias, J. Gaitzsch, C. Contini, M. S. Magoń, S. A. Renshaw, and G. Battaglia. 2016. “Purification of Nanoparticles by Size and Shape.” Scientific Reports 6 (1): 27494. doi:10.1038/srep27494
  • Ros, P. R., P. C. Freeny, S. E. Harms, S. E. Seltzer, P. L. Davis, T. W. Chan, A. E. Stillman, L. R. Muroff, V. M. Runge, and M. A. Nissenbaum. 1995. “Hepatic MR Imaging with Ferumoxides: A Multicenter Clinical Trial of the Safety and Efficacy in the Detection of Focal Hepatic Lesions.” Radiology 196 (2): 481–488. doi:10.1148/radiology.196.2.7617864
  • Sabella, S. R. P. Carney, V. Brunetti, M. A. Malvindi, N. Al-Juffali, G. Vecchio, S. M. Janes, O. M. Bakr, R. Cingolani, F. Stellacci, and P. P. Pompa. 2014. “A General Mechanism for Intracellular Toxicity of Metal-Containing Nanoparticles.” [†Electronic Supplementary Information (ESI) available. See doi:10.1039/c4nr01234h Click here for additional data file.] Nanoscale 6: 7052–7061.
  • Saraiva, C., C. Praça, R. Ferreira, T. Santos, L. Ferreira, and L. Bernardino. 2016. “Nanoparticle-Mediated Brain Drug Delivery: Overcoming Blood–Brain Barrier to Treat Neurodegenerative Diseases.” Journal of Controlled Release 235: 34–47. doi:10.1016/j.jconrel.2016.05.044
  • Sayes, C. M., N. Banerjee, and A. A. Romoser. 2009. “The Role of Oxidative Stress in Nanotoxicology.”In General, Applied and Systems Toxicology, edited by B. Ballantyne, T. C. Marrs, T. Syversen, D. A. Casciano and S. C. Sahu. Hoboken, New Jersey: John Wiley & Sons, Ltd. doi:10.1002/9780470744307.gat245
  • Sayes, C. M., P. A. Smith, and I. V. Ivanov. 2013. “A Framework for Grouping Nanoparticles Based on Their Measurable Characteristics.” International Journal of Nanomedicine 8: 45–56. doi:10.2147/IJN.S40521
  • Scott-Fordsmand, J. J., S. Pozzi-Mucelli, L. Tran, K. Aschberger, S. Sabella, U. Vogel, C. Poland, D. Balharry, T. Fernandes, S. Gottardo, et al. 2014. “A Unified Framework for Nanosafety Is Needed.” Nano Today 9 (5): 546–549. doi:10.1016/j.nantod.2014.07.001
  • Seaton, A., L. Tran, R. Aitken, and K. Donaldson. 2010. “Nanoparticles, Human Health Hazard and Regulation.” Journal of the Royal Society Interface 7 (Suppl_1): S119–S129. doi:10.1098/rsif.2009.0252.focus
  • Serpone, N., and S. Horikoshi. 2013. “Microwaves in Nanoparticle Synthesis: Fundamentals and Applications.” [WWW Document]. Accessed August 28 2017. http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527331972.html
  • Shannahan, J. 2017. “The Biocorona: A Challenge for the Biomedical Application of Nanoparticles.” Nanotechnology Reviews 6: 345–353. doi:10.1515/ntrev-2016-0098
  • Shimizu, K., H. Nakamura, and S. Watano. 2016. “MD Simulation Study of Direct Permeation of a Nanoparticle across the Cell Membrane under an External Electric Field.” Nanoscale 8 (23): 11897–11906. doi:10.1039/C6NR02051H
  • Shvedova, A. A., V. E. Kagan, and B. Fadeel. 2010. “Close Encounters of the Small Kind: adverse Effects of Man-Made Materials Interfacing with the Nano-Cosmos of Biological Systems.” Annual Review of Pharmacology and Toxicology 50 (1): 63–88. doi:10.1146/annurev.pharmtox.010909.105819
  • Siegrist, S., H. Kettiger, E. Fasler-Kan, and J. Huwyler. 2017. “Selective Stimulation of the JAK/STAT Signaling Pathway by Silica Nanoparticles in Human Endothelial Cells.” Toxicology In Vitro 42: 308–318. doi:10.1016/j.tiv.2017.05.002
  • Simkó, M., D. Nosske, and W. G. Kreyling. 2014. “Metrics, Dose, and Dose Concept: The Need for a Proper Dose Concept in the Risk Assessment of Nanoparticles.” International Journal of Environmental Research and Public Health 11 (4): 4026–4048. doi:10.3390/ijerph110404026
  • Simkó, M., S. Tischler, and M.-O. Mattsson. 2015. “Pooling and Analysis of Published in Vitro Data: A Proof of Concept Study for the Grouping of Nanoparticles.” International Journal of Molecular Sciences 16 (11): 26211–26236. doi:10.3390/ijms161125954
  • Singh, A. K. 2015. Engineered Nanoparticles: Structure, Properties and Mechanisms of Toxicity. Cambridge, Massachusetts: Academic Press.
  • Singh, N., G. J. Jenkins, R. Asadi, and S. H. Doak. 2010. “Potential Toxicity of Superparamagnetic Iron Oxide Nanoparticles (SPION).” Nano Rev 1 (1): 5358. doi:10.3402/nano.v1i0.5358
  • Stone, V., S. Pozzi-Mucelli, L. Tran, K. Aschberger, S. Sabella, U. Vogel, C. Poland, D. Balharry, T. Fernandes, S. Gottardo, et al. 2014. “ITS-NANO - Prioritising Nanosafety Research to Develop a Stakeholder Driven Intelligent Testing Strategy.” Particle and Fibre Toxicology 11 (1): 9. doi:10.1186/1743-8977-11-9
  • Szebeni, J., S. Fishbane, M. Hedenus, S. Howaldt, F. Locatelli, S. Patni, D. Rampton, G. Weiss, and J. Folkersen. 2015. “Hypersensitivity to Intravenous Iron: classification, Terminology, Mechanisms and Management.” British Journal of Pharmacology 172 (21): 5025–5036. doi:10.1111/bph.13268
  • Tämm, K., L. Sikk, J. Burk, R. Rallo, S. Pokhrel, L. Mädler, J. J. Scott-Fordsmand, P. Burk, and T. Tamm. 2016. “Parametrization of Nanoparticles: development of Full-Particle Nanodescriptors.” Nanoscale 8 (36): 16243–16250. doi:10.1039/C6NR04376C
  • Teeguarden, J. G., P. M. Hinderliter, G. Orr, B. D. Thrall, and J. G. Pounds. 2007. “Particokinetics in Vitro: dosimetry Considerations for in Vitro Nanoparticle Toxicity Assessments.” Toxicological Sciences 95 (2): 300–312. doi:10.1093/toxsci/kfl165
  • Tiwari, D., J. Takashi, and J. Behari. 2010. “Dose-Dependent In-Vivo Toxicity Assessment of Nanoparticle in Wistar Rats.” Toxicology Mechanisms and Methods 21 (1): 13–24. doi:10.3109/15376516.2010.529184
  • Toy, R., L. Bauer, C. Hoimes, K. B. Ghaghada, and E. Karathanasis. 2014. “Targeted Nanotechnology for Cancer Imaging.” Advanced Drug Delivery Reviews 76: 79–97. doi:10.1016/j.addr.2014.08.002
  • Treuel, L., D. Docter, M. Maskos, and R. H. Stauber. 2015. “Protein Corona – from Molecular Adsorption to Physiological Complexity.” Beilstein Journal of Nanotechnology 6: 857–873. doi:10.3762/bjnano.6.88
  • Turner, P. V., T. Brabb, C. Pekow, and M. A. Vasbinder. 2011. “Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider.” Journal of the American Association for Laboratory Animal Science 50 (5): 600–613.
  • Unfried, K., C. Albrecht, L.-O. Klotz, A. Von Mikecz, S Grether-Beck, R.P.F. Schins. 2007. “Cellular responses to nanoparticles: Target structures and mechanisms.” Nanotoxicology 1: 52–71. doi:10.1080/00222930701314932
  • Unterweger, H., C. Janko, M. Schwarz, L. Dézsi, R. Urbanics, J. Matuszak, E. Őrfi, T. Fülöp, T. Bäuerle, J. Szebeni. et al. 2017. “Non-Immunogenic Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles: A Biocompatible, Size-Tunable Contrast Agent for Magnetic Resonance Imaging.” International Journal of Nanomedicine 12: 5223–5238. doi:10.2147/IJN.S138108
  • Uskoković, V. 2013. “Entering the Era of Nanoscience: Time to Be so Small.” Journal of Biomedical Nanotechnology 9 (9): 1441–1470. doi:10.1166/jbn.2013.1642
  • van Teunenbroek, T. 2017. “NANoREG, A Common European Approach to the Regulatory Testing of Nanomaterials.” [WWW Document]. www.nanoreg.eu. Accessed December 21 2017. http://www.rivm.nl/en/About_RIVM/Mission_and_strategy/International_Affairs/International_Projects/Completed/NANoREG/NANoREG_Results_Repository_sub_page_Final_Report
  • Verhoef, J. J., and T. J. Anchordoquy. 2013. “Questioning the Use of PEGylation for Drug Delivery. Drug Deliv.” Drug Delivery and Translational Research 3 (6): 499–503. doi:10.1007/s13346-013-0176-5
  • Vermeij, E. A., M. I. Koenders, M. B. Bennink, L. A. Crowe, L. Maurizi, J.-P. Vallée, H. Hofmann, W. B. Berg, L. van den, P. L. E. M. van, Loo, and F. A. J. van de. 2015. “The in-Vivo Use of Superparamagnetic Iron Oxide Nanoparticles to Detect Inflammation Elicits a Cytokine Response but Does Not Aggravate Experimental Arthritis.” PLoS One 10 (5): e0126687. doi:10.1371/journal.pone.0126687
  • Vetten, M. A., C. S. Yah, T. Singh, and M. Gulumian. 2014. “Challenges Facing Sterilization and Depyrogenation of Nanoparticles: effects on Structural Stability and Biomedical Applications.” Nanomedicine: Nanotechnology, Biology, and Medicine 10 (7): 1391–1399. doi:10.1016/j.nano.2014.03.017
  • Vippola, M., M. Valkonen, E. Sarlin, M. Honkanen, and H. Huttunen. 2016. “Insight to Nanoparticle Size Analysis—Novel and Convenient Image Analysis Method versus Conventional Techniques.” Nanoscale Research Letters 11 (1): 169. doi:10.1186/s11671-016-1391-z
  • Weinstein, J. S., C. G. Varallyay, E. Dosa, S. Gahramanov, B. Hamilton, W. D. Rooney, L. L. Muldoon, and E. A. Neuwelt. 2010. “Superparamagnetic Iron Oxide Nanoparticles: diagnostic Magnetic Resonance Imaging and Potential Therapeutic Applications in Neurooncology and Central Nervous System Inflammatory Pathologies, A Review.” Journal of Cerebral Blood Flow & Metabolism 30 (1): 15–35. doi:10.1038/jcbfm.2009.192
  • Weissig, V., T. K. Pettinger, and N. Murdock. 2014. “Nanopharmaceuticals (Part 1): Products on the Market.” International Journal of Nanomedicine 9: 4357–4373. doi:10.2147/IJN.S46900
  • Weissleder, R., M. Nahrendorf, and M. J. Pittet. 2014. “Imaging Macrophages with Nanoparticles.” Nature Materials 13 (2): 125–138. doi:10.1038/nmat3780
  • Wen, H., M. Dan, Y. Yang, J. Lyu, A. Shao, X. Cheng, L. Chen, and L. Xu. 2017. “Acute Toxicity and Genotoxicity of Silver Nanoparticle in Rats.” PLoS One 12 (9): e0185554. doi:10.1371/journal.pone.0185554
  • Whitesides, G. M. 2003. “The “Right” Size in Nanobiotechnology.” Nature Biotechnology 21 (10): 1161–1165. doi:10.1038/nbt872
  • Witzigmann, D., M. Camblin, J. Huwyler, and V. Balasubramanian. 2015. “Nanomaterials: Therapeutic Applications.”In The Encyclopedia of Biomedical Polymers & Polymeric Biomaterials, edited by M. Mishra, 5364–5378. New York: Taylor & Francis.
  • Wolfram, J., M. Zhu, Y. Yang, J. Shen, E. Gentile, D. Paolino, M. Fresta, G. Nie, C. Chen, H. Shen. et al. 2015. “Safety of Nanoparticles in Medicine.” Current Drug Targets 16 (14): 1671–1681. doi:10.2174/1389450115666140804124808
  • Wu, X., Z.-R. Lu. 2016. “Nanoparticle–Tissue Interaction..” In Nanomaterials in Pharmacology. Methods in Pharmacology and Toxicology, edited by Z.-R. Lu, S. Sakuma, 201–218. New York, NY: Humana Press. doi:10.1007/978-1-4939-3121-7
  • Xie, J., S. Lee, and X. Chen. 2010. “Nanoparticle-Based Theranostic Agents.” Advanced Drug Delivery Reviews 62 (11): 1064–1079. doi:10.1016/j.addr.2010.07.009
  • Yameen, B., W. I. Choi, C. Vilos, A. Swami, J. Shi, and O. C. Farokhzad. 2014. “Insight into Nanoparticle Cellular Uptake and Intracellular Targeting.” 30th Anniversary Special Issue 190: 485–499. doi:10.1016/j.jconrel.2014.06.038
  • Yang, Y., Z. Qin, W. Zeng, T. Yang, Y. Cao, C. Mei, and Y. Kuang. 2017. “Toxicity Assessment of Nanoparticles in Various Systems and Organs.” Nanotechnology Reviews 6: 279. doi:10.1515/ntrev-2016-0047
  • Yildirimer, L., N. T. K. Thanh, M. Loizidou, and A. M. Seifalian. 2011. “Toxicology and Clinical Potential of Nanoparticles.” Nano Today 6 (6): 585–607. doi:10.1016/j.nantod.2011.10.001
  • Yuan, S. Y., and R. R. Rigor. 2010. The Endothelial Barrier. San Rafael, California: Morgan & Claypool Life Sciences.
  • Zaloga, J., C. Janko, J. Nowak, J. Matuszak, S. Knaup, D. Eberbeck, R. Tietze, H. Unterweger, R. P. Friedrich, S Duerr, et al. 2014. “Development of a Lauric Acid/Albumin Hybrid Iron Oxide Nanoparticle System with Improved Biocompatibility.” International Journal of Nanomedicine 9: 4847–4866. doi:10.2147/IJN.S68539
  • Zhang, H., Z. Ji, T. Xia, H. Meng, C. Low-Kam, R. Liu, S. Pokhrel, S. Lin, X. Wang, Y.-P. Liao, et al. 2012. “Use of Metal Oxide Nanoparticle Band Gap to Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation.” ACS Nano 6 (5): 4349–4368. doi:10.1021/nn3010087
  • Zhang, S., J. Li, G. Lykotrafitis, G. Bao, and S. Suresh. 2009. “Size-Dependent Endocytosis of Nanoparticles.” Advanced Materials 21 (4): 419–424. doi:10.1002/adma.200801393
  • Zhao, L., A. Seth, N. Wibowo, C.-X. Zhao, N. Mitter, C. Yu, and A. P. J. Middelberg. 2014. “Nanoparticle Vaccines.” Vaccine 32 (3): 327–337. doi:10.1016/j.vaccine.2013.11.069
  • Zheng, J., J. D. Clogston, A. K. Patri, M. A. Dobrovolskaia, and S. E. McNeil. 2011. “Sterilization of Silver Nanoparticles Using Standard Gamma Irradiation Procedure Affects Particle Integrity and Biocompatibility.” Journal of Nanomedicine & Nanotechnology S5 (01): 001. doi:10.4172/2157-7439.S5-001