Silver nanoparticle-induced expression of proteins related to oxidative stress and neurodegeneration in an in vitro human blood-brain barrier model

References

• Abuznait, A. H., C. Cain, D. Ingram, D. Burk, and A. Kaddoumi. 2011. “Up-regulation of P-glycoprotein Reduces Intracellular Accumulation of Beta Amyloid: Investigation of P-glycoprotein as a Novel Therapeutic Target for Alzheimer's Disease.” Journal of Pharmacy and Pharmacology 63 (8):1111. doi:10.1111/j.2042-7158.2011.01309.x.
   PubMed Web of Science ®Google Scholar
• Abuznait, A. H., and A. Kaddoumi. 2012. “Role of ABC Transporters in the Pathogenesis of Alzheimer's Disease.” ACS Chemical Neuroscience 3 (11):820–831.
   PubMed Web of Science ®Google Scholar
• Ahamed, M., M. S. Alsalhi, and M. K. Siddiqui. 2010. “Silver Nanoparticle Applications and Human Health.” Clinica et Chimica Acta 411 (23-24):1841–1848. doi:10.1016/j.cca.2010.08.016.
   PubMed Web of Science ®Google Scholar
• Asharani, P. V., G. Low Kah Mun, M. P. Hande, and S. Valiyaveettil. 2009. “Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells.” ACS Nano 3 (2):279–290.
   PubMed Web of Science ®Google Scholar
• Banks, W. A., A. Kovac, and Y. Morofuji. 2018. “Neurovascular Unit Crosstalk: Pericytes and Astrocytes Modify Cytokine Secretion Patterns of Brain Endothelial Cells.” Journal of Cerebral Blood Flow & Metabolism 38 (6):1104–1118. doi:10.1177/0271678X17740793.
   PubMed Web of Science ®Google Scholar
• Bellinger, F. P., M. T. Bellinger, L. A. Seale, A. S. Takemoto, A. Raman, T. Miki, A. Manning-Bog, M. J. Berry, L. R. White, and G. W. Ross. 2011. “Glutathione Peroxidase 4 Is Associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's Brain.” Molecular Neurodegeneration 6 (1):8. doi:10.1186/1750-1326-6-8.
   PubMedGoogle Scholar
• Benvenisti-Zarom, L., and R. F. Regan. 2007. “Astrocyte-specific Heme Oxygenase-1 Hyperexpression Attenuates Heme-mediated Oxidative Injury.” Neurobiology of Disease 26 (3):688–695. doi:10.1016/j.nbd.2007.03.006.
   PubMed Web of Science ®Google Scholar
• Bindea, G., J. Galon, and B. Mlecnik. 2013. “CluePedia Cytoscape Plugin: Pathway Insights Using Integrated Experimental and in Silico Data.” Bioinformatics 29 (5):661–663. doi:10.1093/bioinformatics/btt019.
   PubMed Web of Science ®Google Scholar
• Bindea, G., B. Mlecnik, H. Hackl, P. Charoentong, M. Tosolini, A. Kirilovsky, W.-H. Fridman, F. Pagès, Z. Trajanoski, and J. Galon. 2009. “ClueGO: a Cytoscape Plug-in to Decipher Functionally Grouped Gene Ontology and Pathway Annotation Networks.” Bioinformatics 25 (8):1091–1093. doi:10.1093/bioinformatics/btp101.
   PubMed Web of Science ®Google Scholar
• Bobilya, D. J., N. A. Gauthier, S. Karki, B. J. Olley, and W. K. Thomas. 2008. “Longitudinal Changes in Zinc Transport Kinetics, Metallothionein and Zinc Transporter Expression in a Blood-Brain Barrier Model in Response to a Moderately Excessive Zinc Environment.” The Journal of Nutritional Biochemistry 19 (2):129–137. doi:10.1016/j.jnutbio.2007.06.014.
   PubMed Web of Science ®Google Scholar
• Bouwmeester, H., S. Dekkers, M. Y. Noordam, W. I. Hagens, A. S. Bulder, C. De Heer, S. E. TEN Voorde, S. W. Wijnhoven, H. J. Marvin, and A. J. Sips. 2009. “Review of Health Safety Aspects of Nanotechnologies in Food Production.” Regulatory Toxicology and Pharmacology: RTP 53 (1):52–62.
   PubMed Web of Science ®Google Scholar
• Chen, X., and H. J. Schluesener. 2008. “Nanosilver: A Nanoproduct in Medical Application.” Toxicology Letters 176 (1):1–12.
   PubMed Web of Science ®Google Scholar
• Chen-Roetling, J., P. Kamalapathy, Y. Cao, W. Song, H. M. Schipper, and R. F. Regan. 2017. “Astrocyte Heme Oxygenase-1 Reduces Mortality and Improves Outcome after Collagenase-induced Intracerebral Hemorrhage.” Neurobiology of Disease 102:140–146. doi:10.1016/j.nbd.2017.03.008.
   PubMed Web of Science ®Google Scholar
• Christensen, F. M., H. J. Johnston, V. Stone, R. J. Aitken, S. Hankin, S. Peters, and K. Aschberger. 2010. “Nano-silver - feasibility and Challenges for Human Health Risk Assessment Based on Open Literature.” Nanotoxicology 4 (3):284–295. doi:10.3109/17435391003690549.
   PubMed Web of Science ®Google Scholar
• Cucullo, L., N. Marchi, M. Marroni, V. Fazio, S. Namura, and D. Janigro. 2003. “Blood-brain Barrier Damage Induces Release of alpha2-Macroglobulin.” Molecular & Cellular Proteomics: MCP 2 (4):234–241.
   PubMed Web of Science ®Google Scholar
• Cui, H., C. Freeman, G. A. Jacobson, and D. H. Small. 2013. “Proteoglycans in the Central Nervous System: Role in Development, Neural Repair, and Alzheimer's Disease.” Intrnational Union of Biochemistry and Molecular Biology: Life 65 (2):108–120. doi:10.1002/iub.1118.
   Google Scholar
• Cutler, R. G., J. Kelly, K. Storie, W. A. Pedersen, A. Tammara, K. Hatanpaa, J. C. Troncoso, and M. P. Mattson. 2004. “Involvement of Oxidative Stress-induced Abnormalities in Ceramide and Cholesterol Metabolism in Brain Aging and Alzheimer's Disease.” Proceedings of the National Academy of Sciences 101 (7):2070–2075.
   PubMed Web of Science ®Google Scholar
• Dan, M., H. Wen, A. Shao, and L. Xu. 2018. “Silver Nanoparticle Exposure Induces Neurotoxicity in the Rat Hippocampus without Increasing the Blood-Brain Barrier Permeability.” Journal of Biomedicine Nanotechnology 14 (7):1330–1338.
   PubMed Web of Science ®Google Scholar
• Daniels, B. P., L. Cruz-Orengo, T. J. Pasieka, P. O. Couraud, I. A. Romero, B. Weksler, J. A. Cooper, T. L. Doering, and R. S. Klein. 2013. “Immortalized Human Cerebral Microvascular Endothelial Cells Maintain the Properties of Primary Cells in an in Vitro Model of Immune Migration across the Blood Brain Barrier.” Journal of Neuroscience Methods 212 (1):173–179. doi:10.1016/j.jneumeth.2012.10.001.
   PubMed Web of Science ®Google Scholar
• Dringen, R.,. G. M. Bishop, M. Koeppe, T. N. Dang, and S. R. Robinson. 2007. “The Pivotal Role of Astrocytes in the Metabolism of Iron in the Brain.” Neurochemical Research 32 (11):1884–1890.
   PubMed Web of Science ®Google Scholar
• Du, F., X. Wang, B. Shang, J. Fang, Y. Xi, A. Li, and Y. Diao. 2016. “Gastrodin Ameliorates Spinal Cord Injury via Antioxidant and anti-inflammatory Effects.” Acta Biochimica Polonica 63 (3):589–593.
   PubMed Web of Science ®Google Scholar
• Eigenmann, D. E., G. Xue, K. S. Kim, A. V. Moses, M. Hamburger, and M. Oufir. 2013. “Comparative Study of Four Immortalized Human Brain Capillary Endothelial Cell Lines, hCMEC/D3, hBMEC, TY10, and BB19, and Optimization of Culture Conditions, for an in Vitro Blood-brain Barrier Model for Drug Permeability Studies.” Fluids and Barriers of the CNS 10 (1):33. doi:10.1186/2045-8118-10-33.
   PubMedGoogle Scholar
• Forster, C., M. Burek, I. A. Romero, B. Weksler, P. O. Couraud, and D. Drenckhahn. 2008. “Differential Effects of Hydrocortisone and TNFalpha on Tight Junction Proteins in an in Vitro Model of the Human Blood-brain Barrier.” The Journal of Physiology 586:1937–1949. doi:10.1113/jphysiol.2007.146852.
   PubMed Web of Science ®Google Scholar
• Gao, M., Q. Dong, H. Yao, Y. Lu, X. Ji, M. Zou, Z. Yang, M. Xu, and R. Xu. 2017. “Systemic Administration of Induced Neural Stem Cells Regulates Complement Activation in Mouse Closed Head Injury Models.” Science Reports 7:45989.
   PubMed Web of Science ®Google Scholar
• Geppert, M., M. C. Hohnholt, S. Nurnberger, and R. Dringen. 2012. “Ferritin up-regulation and Transient ROS Production in Cultured Brain Astrocytes after Loading with Iron Oxide Nanoparticles.” Acta Biomaterialia 8 (10):3832–3839. doi:10.1016/j.actbio.2012.06.029.
   PubMed Web of Science ®Google Scholar
• Goedeke, L., and C. Fernandez-Hernando. 2014. “MicroRNAs: a Connection between Cholesterol Metabolism and Neurodegeneration.” Neurobiology of Disease 72:48–53. doi:10.1016/j.nbd.2014.05.034.
   PubMed Web of Science ®Google Scholar
• Hadrup, N., and H. R. Lam. 2014. “Oral Toxicity of Silver Ions, Silver Nanoparticles and Colloidal Silver–a Review.” Regulatory Toxicology and Pharmacology 68 (1):1–7. doi:10.1016/j.yrtph.2013.11.002.
   PubMed Web of Science ®Google Scholar
• Hejbol, E. K., J. Sellathurai, P. D. Nair, and H. D. Schroder. 2017. “Injectable Scaffold Materials Differ in Their Cell Instructive Effects on Primary Human Myoblasts.” Journal of Tissue Engineering 8:1–11. doi:10.1177/2041731417717677.
   Web of Science ®Google Scholar
• Hjerpe, R.,. J. S. Bett, M. J. Keuss, A. Solovyova, T. G. Mcwilliams, C. Johnson, I. Sahu, et al. 2016. “UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.” Cell 166 (4):935–949. doi:10.1016/j.cell.2016.07.001.
   PubMed Web of Science ®Google Scholar
• Hoepken, H. H., T. Korten, S. R. Robinson, and R. Dringen. 2004. “Iron Accumulation, Iron-Mediated Toxicity and Altered Levels of Ferritin and Transferrin Receptor in Cultured Astrocytes during Incubation with Ferric Ammonium Citrate.” Journal of Neurochemistry 88 (5):1194–1202. doi:10.1046/j.1471-4159.2003.02236.x.
   PubMed Web of Science ®Google Scholar
• Hoet, P. H., I. Bruske-Hohlfeld, and O. V. Salata. 2004. “Nanoparticles - known and Unknown Health Risks.” Journal of Nanobiotechnology 2 (1):12.
   PubMedGoogle Scholar
• Hughes, T. M., C. Rosano, R. W. Evans, and L. H. Kuller. 2013. “Brain Cholesterol Metabolism, Oxysterols, and Dementia.” Journal of Alzheimer's Disease : JAD 33 (4):891–911.
   PubMed Web of Science ®Google Scholar
• Iniaghe, L. O., P. R. Krafft, D. W. Klebe, E. K. I. Omogbai, J. H. Zhang, and J. Tang. 2015. “Dimethyl Fumarate Confers Neuroprotection by Casein Kinase 2 Phosphorylation of Nrf2 in Murine Intracerebral Hemorrhage.” Neurobiology of Disease 82:349–358. doi:10.1016/j.nbd.2015.07.001.
   PubMed Web of Science ®Google Scholar
• Janyou, A.,. P. Wicha, J. Jittiwat, A. Suksamrarn, C. Tocharus, and J. Tocharus. 2017. “Dihydrocapsaicin Attenuates Blood Brain Barrier and Cerebral Damage in Focal Cerebral Ischemia/Reperfusion via Oxidative Stress and Inflammatory.” Science Reports 7:10556.
   PubMed Web of Science ®Google Scholar
• Jensen, P., C. L. Myhre, P. S. Lassen, A. Metaxas, A. M. Khan, K. L. Lambertsen, A. A. Babcock, B. Finsen, M. R. Larsen, and S. J. Kempf. 2017. “TNFalpha Affects CREB-mediated Neuroprotective Signaling Pathways of Synaptic Plasticity in Neurons as Revealed by Proteomics and Phospho-Proteomics.” Oncotarget 8:60223–60242.
   PubMedGoogle Scholar
• Juarez-Rebollar, D., C. Rios, C. Nava-Ruiz, and M. Mendez-Armenta. 2017. “Metallothionein in Brain Disorders.” Oxidative Medicine and Cellular Longevity 2017:5828056.
   PubMed Web of Science ®Google Scholar
• Jumnongprakhon, P., P. Govitrapong, C. Tocharus, D. Pinkaew, and J. Tocharus. 2015. “Melatonin Protects Methamphetamine-Induced Neuroinflammation through NF-kappaB and Nrf2 Pathways in Glioma Cell Line.” Neurochemical Research 40 (7):1448–1456. doi:10.1007/s11064-015-1613-2.
   PubMed Web of Science ®Google Scholar
• Jurasin, D. D., M. Curlin, I. Capjak, T. Crnkovic, M. Lovric, M. Babic, D. Horak, I. Vinkovic Vrcek, and S. Gajovic. 2016. “Surface Coating Affects Behavior of Metallic Nanoparticles in a Biological Environment.” Beilstein Journal of Nanotechnology 7:246–262. doi:10.3762/bjnano.7.23.
   PubMed Web of Science ®Google Scholar
• Kanoh, Y., and H. Ohtani. 1997. “Levels of Interleukin-6, CRP and Alpha 2 Macroglobulin in Cerebrospinal Fluid (CSF) and Serum as Indicator of blood-CSF Barrier damage.” Biochemistry and Molecular Biology International 43 (2):269–278.
   PubMedGoogle Scholar
• Kumosa, L. S., V. Zetterberg, and J. Schouenborg. 2018. “Gelatin Promotes Rapid Restoration of the Blood Brain Barrier after Acute Brain Injury.” Acta Biomaterialia 65:137–149. doi:10.1016/j.actbio.2017.10.020.
   PubMed Web of Science ®Google Scholar
• Lara, H. H., E. N. Garza-Trevino, L. Ixtepan-Turrent, and D. K. Singh. 2011. “Silver Nanoparticles Are Broad-spectrum Bactericidal and Virucidal Compounds.” Journal of Nanobiotechnology 9 (1):30. doi:10.1186/1477-3155-9-30.
   PubMedGoogle Scholar
• Laursen, I., P. Hojrup, G. Houen, and M. Christiansen. 2008. “Characterisation of the 1st SSI Purified MBL Standard.” Clinica Chimica Acta; International Journal of Clinical Chemistry 395 (1-2):159–161.
   PubMed Web of Science ®Google Scholar
• Lee, D. Y., and E. J. Brown. 2012. “Ubiquilins in the Crosstalk Among Proteolytic Pathways.” Biological Chemistry 393 (6):441–447.
   PubMed Web of Science ®Google Scholar
• Lim, J. L., S. M. van der Pol, F. di Dio, B. van Het Hof, G. Kooij, H. E. de Vries, and J. van Horssen. 2016. “Protective Effects of Monomethyl Fumarate at the Inflamed Blood-brain Barrier.” Microvascular Research 105:61–69. doi:10.1016/j.mvr.2015.12.003.
   PubMed Web of Science ®Google Scholar
• Lin, C. C., C. C. Yang, L. D. Hsiao, S. Y. Chen, and C. M. Yang. 2017. “Heme Oxygenase-1 Induction by Carbon Monoxide Releasing Molecule-3 Suppresses Interleukin-1beta-Mediated Neuroinflammation.” Frontiers in Molecular Neuroscience 10:387.
   PubMed Web of Science ®Google Scholar
• Lindsberg, P. J., J. Ohman, T. Lehto, M. L. Karjalainen-Lindsberg, A. Paetau, T. Wuorimaa, O. Carpen, M. Kaste, and S. Meri. 1996. “Complement Activation in the Central Nervous System following Blood-brain Barrier Damage in Man.” Annals of Neurology 40 (4):587–596. doi:10.1002/ana.410400408.
   PubMed Web of Science ®Google Scholar
• Luther, E. M., M. M. Schmidt, J. Diendorf, M. Epple, and R. Dringen. 2012. “Upregulation of Metallothioneins after Exposure of Cultured Primary Astrocytes to Silver Nanoparticles.” Neurochemical Research 37 (8):1639–1648. doi:10.1007/s11064-012-0767-4.
   PubMed Web of Science ®Google Scholar
• Maynard, A. D. 2014. “Old Materials, new Challenges?.” Nature Nanotechnology 9 (9):658.
   PubMed Web of Science ®Google Scholar
• Mendes Arent, A., L. F. DE Souza, R. Walz, and A. L. Dafre. 2014. “Perspectives on Molecular Biomarkers of Oxidative Stress and Antioxidant Strategies in Traumatic Brain Injury.” Biomed Research International 2014:1. doi:10.1155/2014/723060.
   Google Scholar
• Miethling-Graff, R., R. Rumpker, M. Richter, T. Verano-Braga, F. Kjeldsen, J. Brewer, J. Hoyland, H. G. Rubahn, and H. Erdmann. 2014. “Exposure to Silver Nanoparticles Induces Size- and Dose-dependent Oxidative Stress and Cytotoxicity in Human Colon Carcinoma Cells.” Toxicology in Vitro 28 (7):1280–1289. doi:10.1016/j.tiv.2014.06.005.
   PubMed Web of Science ®Google Scholar
• Miranda, R. R., V. Gorshkov, B. Korzeniowska, S. J. Kempf, F. F. Neto, and F. Kjeldsen. 2018. “Co-exposure to Silver Nanoparticles and Cadmium Induce Metabolic Adaptation in HepG2 Cells.” Nanotoxicology 12 (7):781–795. doi:10.1080/17435390.2018.1489987.
   PubMed Web of Science ®Google Scholar
• Mirsattari, S. M., R. R. Hammond, M. D. Sharpe, F. Y. Leung, and G. B. Young. 2004. “Myoclonic Status Epilepticus Following Repeated Oral Ingestion of Colloidal Silver.” Neurology 62 (8):1408–1410.
   PubMed Web of Science ®Google Scholar
• Montagne, A., Z. Zhao, and B. V. Zlokovic. 2017. “Alzheimer's Disease: A Matter of Blood-Brain Barrier Dysfunction?” The Journal of Experimental Medicine 214 (11):3151–3169. doi:10.1084/jem.20171406.
   PubMed Web of Science ®Google Scholar
• Moore, D. J., A. B. West, V. L. Dawson, and T. M. Dawson. 2005. “Molecular Pathophysiology of Parkinson's disease.” Annual Review of Neuroscience 28:57–87.
   PubMed Web of Science ®Google Scholar
• Moura, R. P., A. Almeida, and B. Sarmento. 2017. “The Role of Non-Endothelial Cells on the Penetration of Nanoparticles through the Blood Brain Barrier.” Progress in Neurobiology 159:39–49. doi:10.1016/j.pneurobio.2017.09.001.
   PubMed Web of Science ®Google Scholar
• Nicolazzo, J. A., and D. C. Mehta. 2010. “Transport of Drugs across the Blood-Brain Barrier in Alzheimer's Disease.” Therapeutic Delivery 1 (4):595–611.
   PubMedGoogle Scholar
• Olesen, R. H., T. M. Hyde, J. E. Kleinman, K. Smidt, J. Rungby, and A. Larsen. 2016. “Obesity and Age-Related Alterations in the Gene Expression of Zinc-transporter Proteins in the Human Brain.” Translational Psychiatry 6 (6):e838. doi:10.1038/tp.2016.83.
   PubMedGoogle Scholar
• Pereira, C. D., F. Martins, J. Wiltfang, E. S. O. A. B. da Cruz, and S. Rebelo. 2018. “ABC Transporters Are Key Players in Alzheimer's Disease.” Journal of Alzheimer's Disease: JAD 61 (2):463–485.
   PubMed Web of Science ®Google Scholar
• Polpitiya, A. D., W. J. Qian, N. Jaitly, V. A. Petyuk, J. N. Adkins, D. G. Camp 2nd, G. A. Anderson, and R. D. Smith. 2008. “DAnTE: a Statistical Tool for Quantitative Analysis of -omics Data.” Bioinformatics (Oxford, England) 24 (13):1556–1558.
   PubMed Web of Science ®Google Scholar
• Porcellotti, S., F. Fanelli, A. Fracassi, S. Sepe, F. Cecconi, C. Bernardi, A. Cimini, M. P. Ceru, and S. Moreno. 2015. “Oxidative Stress during the Progression of beta-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease.” Oxidative Medicine and Cellular Longevity 2015:1. doi:10.1155/2015/967203.
   Google Scholar
• Rafalo-Ulinska, A., J. Piotrowska, A. Kryczyk, W. Opoka, M. Sowa-Kucma, P. Misztak, G. Rajkowska, et al. 2016. “Zinc Transporters Protein Level in Postmortem Brain of Depressed Subjects and Suicide Victims.” Journal of Psychiatric Research 83:220–229. doi:10.1016/j.jpsychires.2016.09.008.
   PubMed Web of Science ®Google Scholar
• Rahman, M. F., J. Wang, T. A. Patterson, U. T. Saini, B. L. Robinson, G. D. Newport, R. C. Murdock, J. J. Schlager, S. M. Hussain, and S. F. Ali. 2009. “Expression of Genes Related to Oxidative Stress in the Mouse Brain after Exposure to Silver-25 Nanoparticles.” Toxicology Letters 187 (1):15–21. doi:10.1016/j.toxlet.2009.01.020.
   PubMed Web of Science ®Google Scholar
• Rai, M., A. Yadav, and A. Gade. 2009. “Silver Nanoparticles as a New Generation of Antimicrobials.” Biotechnology Advances 27 (1):76–83.
   PubMed Web of Science ®Google Scholar
• Rapposelli, S., M. Digiacomo, and A. Balsamo. 2009. “P-gp Transporter and Its Role in Neurodegenerative Diseases.” Current Topics in Medicinal Chemistry 9 (2):209–217.
   PubMed Web of Science ®Google Scholar
• Rothenberg, C., and M. J. Monteiro. 2010. “Ubiquilin at a Crossroads in Protein Degradation Pathways.” Autophagy 6 (7):979–980.
   PubMed Web of Science ®Google Scholar
• Rus, H., C. Cudrici, S. David, and F. Niculescu. 2006. “The Complement System in Central Nervous System Diseases.” Autoimmunity 39 (5):395–402. doi:10.1080/08916930600739605.
   PubMed Web of Science ®Google Scholar
• Rus, H., and F. Niculescu. 2001. “The Complement System in Central Nervous System Diseases.” Immunologic Research 24 (1):79–86.
   PubMed Web of Science ®Google Scholar
• Schwammle, V., I. R. Leon, and O. N. Jensen. 2013. “Assessment and Improvement of Statistical Tools for Comparative Proteomics Analysis of Sparse Data Sets with Few Experimental Replicates.” Journal of Proteome Research 12:3874–3883. doi:10.1021/pr400045u.
   PubMed Web of Science ®Google Scholar
• Sharma, V. K. 2009. “Aggregation and Toxicity of Titanium Dioxide Nanoparticles in Aquatic Environment–a Review.” Journal of Environmental Science and Health Part A, Toxic/Hazardous Substances and Environmental Engineering 44 (14):1485–1495. doi:10.1080/10934520903263231.
   PubMed Web of Science ®Google Scholar
• Sharma, H. S., S. F. Ali, S. M. Hussain, J. J. Schlager, and A. Sharma. 2009a. “Influence of Engineered Nanoparticles from Metals on the Blood-brain Barrier Permeability, cerebral Blood Flow, Brain Edema and Neurotoxicity. An Experimental Study in the Rat and Mice Using Biochemical and Morphological Approaches.” Journal of Nanoscience and Nanotechnology 9 (8):5055–5072. doi:10.1166/jnn.2009.GR09.
   PubMed Web of Science ®Google Scholar
• Sharma, H. S., S. F. Ali, Z. R. Tian, S. M. Hussain, J. J. Schlager, P. O. Sjoquist, A. Sharma, and D. F. Muresanu. 2009b. “Chronic Treatment with Nanoparticles Exacerbate Hyperthermia Induced Blood-brain Barrier Breakdown, cognitive Dysfunction and Brain Pathology in the Rat. Neuroprotective Effects of Nanowired-antioxidant Compound H-290/51.” Journal of Nanoscience and Nanotechnology 9 (8):5073–5090. doi:10.1166/jnn.2009.GR10.
   PubMed Web of Science ®Google Scholar
• Silver, J., and J. H. Miller. 2004. “Regeneration beyond the Glial Scar.” Nature Reviews. Neuroscience 5 (2):146–156.
   PubMed Web of Science ®Google Scholar
• Srinivasan, B., A. R. Kolli, M. B. Esch, H. E. Abaci, M. L. Shuler, and J. J. Hickman. 2015. “TEER Measurement Techniques for in Vitro Barrier Model Systems.” Journal of Laboratory Automation 20 (2):107–126.
   PubMedGoogle Scholar
• Szewczyk, B. 2013. “Zinc Homeostasis and Neurodegenerative Disorders.” Frontiers in Aging Neuroscience 5:33.
   PubMed Web of Science ®Google Scholar
• Takano, T., H. Elimam, and A. V. Cybulsky. 2013. “Complement-Mediated Cellular Injury.” Seminars in Nephrology 33 (6):586–601. doi:10.1016/j.semnephrol.2013.08.009.
   PubMed Web of Science ®Google Scholar
• Tang, J., L. Xiong, S. Wang, J. Wang, L. Liu, J. Li, F. Yuan, and T. Xi. 2009. “Distribution, translocation and Accumulation of Silver Nanoparticles in Rats.” Journal of Nanoscience and Nanotechnology 9 (8):4924–4932. doi:10.1166/jnn.2009.1269.
   PubMed Web of Science ®Google Scholar
• Tang, J., L. Xiong, G. Zhou, S. Wang, J. Wang, L. Liu, J. Li, et al. 2010. “Silver Nanoparticles Crossing through and Distribution in the Blood-Brain Barrier in Vitro.” Journal of Nanoscience and Nanotechnology 10 (10):6313–6317. doi:10.1166/jnn.2010.2625.
   PubMed Web of Science ®Google Scholar
• TER Beek, J., A. Guskov, and D. J. Slotboom. 2014. “Structural Diversity of ABC Transporters.” The Journal of General Physiology 143 (4):419–435.
   PubMed Web of Science ®Google Scholar
• Thomas, K., and P. Sayre. 2005. “Research Strategies for Safety Evaluation of Nanomaterials, Part I: Evaluating the Human Health Implications of Exposure to Nanoscale Materials.” Toxicological Sciences 87 (2):316–321. doi:10.1093/toxsci/kfi270.
   PubMed Web of Science ®Google Scholar
• Thomsen, L. B., A. Burkhart, and T. Moos. 2015. “A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial Cells, Astrocytes and Pericytes.” Plos One 10 (8):e0134765. doi:10.1371/journal.pone.0134765.
   PubMed Web of Science ®Google Scholar
• Tiffany-Castiglion, E., and Y. Qian. 2001. “Astroglia as Metal Depots: Molecular Mechanisms for Metal Accumulation, Storage and Release.” Neurotoxicology 22:577–592. doi:10.1016/S0161-813X(01)00050-X.
   PubMed Web of Science ®Google Scholar
• Tolaymat, T. M., A. M. EL Badawy, A. Genaidy, K. G. Scheckel, T. P. Luxton, and M. Suidan. 2010. “An Evidence-based Environmental Perspective of Manufactured Silver Nanoparticle in Syntheses and Applications: A Systematic Review and Critical Appraisal of Peer-reviewed Scientific Papers.” Science of the Total Environment 408 (5):999–1006. doi:10.1016/j.scitotenv.2009.11.003.
   PubMed Web of Science ®Google Scholar
• Varma, V. R., S. A. N. Varma, Y. T. J. Hohman, S. Seddighi, R. Casanova, A. Beri, E. B. Dammer, et al. 2017. “Alpha-2 Macroglobulin in Alzheimer's Disease: a Marker of Neuronal Injury through the RCAN1 Pathway.” Molecular Psychiatry 22 (1):13–23. doi:10.1038/mp.2016.206.
   PubMed Web of Science ®Google Scholar
• Verano-Braga, T., R. Miethling-Graff, K. Wojdyla, A. Rogowska-Wrzesinska, J. R. Brewer, H. Erdmann, and F. Kjeldsen. 2014. “Insights into the Cellular Response Triggered by Silver Nanoparticles Using Quantitative Proteomics.” ACS Nano 8 (3):2161–75. doi:10.1021/nn4050744.
   PubMed Web of Science ®Google Scholar
• Veronesi, B., O. Makwana, M. Pooler, and L. C. Chen. 2005. “Effects of Subchronic Exposures to Concentrated Ambient Particles. VII. Degeneration of Dopaminergic Neurons in Apo E-/- Mice.” Inhalation Toxicology 17 (4-5):235–241. doi:10.1080/08958370590912888.
   PubMed Web of Science ®Google Scholar
• Vizcaino, J. A., R. G. Cote, A. Csordas, J. A. Dianes, A. Fabregat, J. M. Foster, J. Griss, et al. 2013. “The PRoteomics IDEntifications (PRIDE) Database and Associated Tools: Status in 2013.” Nucleic Acids Research 41:D1063–D1069. doi:10.1093/nar/gks1262.
   PubMed Web of Science ®Google Scholar
• Weiss, N., F. Miller, S. Cazaubon, and P. O. Couraud. 2009. “The Blood-brain Barrier in Brain Homeostasis and Neurological Diseases.” Biochimica Biophysica Acta 1788 (4):842–857. doi:10.1016/j.bbamem.2008.10.022.
   PubMed Web of Science ®Google Scholar
• Witsch-Baumgartner, M., J. Loffler, and G. Utermann. 2001. “Mutations in the Human DHCR7 Gene.” Human Mutation 17 (3):172–182.
   PubMed Web of Science ®Google Scholar
• Xu. L., M. Dan, A. Shao, X. Cheng, C. Zhang, R. A. Yokel, T. Takemura, N. Hanagata, M. Niwa, and D. Watanabe. 2015. “Silver Nanoparticles Induce Tight Junction Disruption and Astrocyte Neurotoxicity in a Rat Blood-brain Barrier Primary Triple Coculture Model.” International Journal of Nanomedicine 10:6105–6118.
   PubMed Web of Science ®Google Scholar
• Yan, X., H. Shen, H. Jiang, D. Hu, J. Wang, and X. Wu. 2018. “YXQ-EQ Induces Apoptosis and Inhibits Signaling Pathways Important for Metastasis in Non-Small Cell Lung Carcinoma Cells.” Cellular Physiology and Biochemistry 49 (3):911–919. doi:10.1159/000493223.
   PubMed Web of Science ®Google Scholar
• Yoo, M. H., X. Gu, X. M. Xu, J. Y. Kim, B. A. Carlson, A. D. Patterson, H. Cai, V. N. Gladyshev, and D. L. Hatfield. 2010. “Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells against Lipid Hydroperoxide Damage and in Alzheimer's Disease.” Antioxidants & Redox Signaling 12 (7):819–827. doi:10.1089/ars.2009.2891.
   PubMed Web of Science ®Google Scholar
• Zemolin, A. P., D. F. Meinerz, M. T. de Paula, D. O. Mariano, J. B. Rocha, A. B. Pereira, T. Posser, and J. L. Franco. 2012. “Evidences for a Role of Glutathione Peroxidase 4 (GPx4) in Methylmercury Induced Neurotoxicity in Vivo.” Toxicology 302 (1):60–67. doi:10.1016/j.tox.2012.07.013.
   PubMed Web of Science ®Google Scholar
• Zhang, H., K. J. A. Davies, and H. J. Forman. 2015. “Oxidative Stress Response and Nrf2 Signaling in Aging.” Free Radical Biology &Amp; Medicine 88 (Pt B):314–336.
   PubMedGoogle Scholar
• Zhang, J., and Q. Liu. 2015. “Cholesterol Metabolism and Homeostasis in the Brain.” Protein &Amp; Cell 6 (4):254–264.
   PubMed Web of Science ®Google Scholar
• Zhang, L. H., X. Wang, M. Stoltenberg, G. Danscher, L. Huang, and Z. Y. Wang. 2008. “Abundant Expression of Zinc Transporters in the Amyloid Plaques of Alzheimer's Disease Brain.” Brain Research Bulletin 77 (1):55–60. doi:10.1016/j.brainresbull.2008.03.014.
   PubMed Web of Science ®Google Scholar
• Zhang, L. H., X. Wang, Z. H. Zheng, H. Ren, M. Stoltenberg, G. Danscher, L. Huang, M. Rong, and Z. Y. Wang. 2010. “Altered Expression and Distribution of Zinc Transporters in APP/PS1 Transgenic Mouse Brain.” Neurobiology of Aging 31 (1):74–87. doi:10.1016/j.neurobiolaging.2008.02.018.
   PubMed Web of Science ®Google Scholar
• Zhang, X., C. Lv, Y. An, Q. Liu, H. Rong, L. Tao, Y. Wang, Y. Wang, and R. Xiao. 2018. “Increased Levels of 27-Hydroxycholesterol Induced by Dietary Cholesterol in Brain Contribute to Learning and Memory Impairment in Rats.” Molecular Nutrition & Food Research 62
   Web of Science ®Google Scholar
• Zhang, X., Y.-L. Ye, H. Zhu, S.-N. Sun, J. Zheng, H.-H. Fan, H.-M. Wu, S.-F. Chen, W.-H. Cheng, and J.-H. Zhu. 2016. “Selenotranscriptomic Analyses Identify Signature Selenoproteins in Brain Regions in a Mouse Model of Parkinson's Disease.” PLoS One 11 (9):e0163372. doi:10.1371/journal.pone.0163372.
   PubMed Web of Science ®Google Scholar