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Articles

Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status

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Pages 1087-1101 | Received 24 Jan 2019, Accepted 22 May 2019, Published online: 22 Jul 2019

References

  • Ammendolia, M. G., F. Iosi, F. Maranghi, R. Tassinari, F. Cubadda, F. Aureli, A. Raggi, F. Superti, A. Mantovani, and B. De Berardis. 2017. “Short-Term Oral Exposure to Low Doses of Nano-Sized TiO2 and Potential Modulatory Effects on Intestinal Cells.” Food and Chemical Toxicology 102: 63–75. doi:10.1016/j.fct.2017.01.031.
  • Baan, R., K. Straif, Y. Grosse, B. Secretan, F. E. Ghissassi, and V. Cogliano. 2006. “Carcinogenicity of Carbon Black, Titanium Dioxide, and Talc.” The Lancet Oncology 7(4): 295–296.
  • Bachler, G., N. von Goetz, and K. Hungerbuhler. 2015. “Using Physiologically Based Pharmacokinetic (PBPK) Modeling for Dietary Risk Assessment of Titanium Dioxide (TiO2) Nanoparticles.” Nanotoxicology 9(3): 373–380. doi:10.3109/17435390.2014.940404.
  • Bettini, S., E. Boutet-Robinet, C. Cartier, C. Coméra, E. Gaultier, J. Dupuy, N. Naud, et al. 2017. “Food-Grade TiO2 Impairs Intestinal and Systemic Immune Homeostasis, Initiates Preneoplastic Lesions and Promotes Aberrant Crypt Development in the Rat Colon.” Scientific Reports 7(1): 1–13. doi:10.1038/srep40373.
  • Butler, M., J. J. Boyle, J. J. Powell, R. J. Playford, and S. Ghosh. 2007. “Dietary Microparticles Implicated in Crohn’s Disease Can Impair Macrophage Phagocytic Activity and Act as Adjuvants in the Presence of Bacterial Stimuli.” Inflammation Research 56(9): 353–361. doi:10.1007/s00011-007-7068-4.
  • Candás-Zapico, S., D. J. Kutscher, M. Montes-Bayón, and J. Bettmer. 2018. “Single Particle Analysis of TiO2 in Candy Products Using Triple Quadrupole ICP-MS.” Talanta 180: 309–315. doi:10.1016/j.talanta.2017.12.041.
  • Catarinella, M., A. Monestiroli, G. Escobar, A. Fiocchi, N. L. Tran, R. Aiolfi, P. Marra, et al. 2016. “IFN Gene/Cell Therapy Curbs Colorectal Cancer Colonization of the Liver by Acting on the Hepatic Microenvironment.” EMBO Molecular Medicine 8(2): 155–170. doi:10.15252/emmm.201505395.
  • Cho, W.-S., B.-C. Kang, J. K. Lee, J. Jeong, J.-H. Che, and S. H. Seok. 2013. “Comparative Absorption, Distribution, and Excretion of Titanium Dioxide and Zinc Oxide Nanoparticles after Repeated Oral Administration.” Particle and Fibre Toxicology 10(1): 9. doi:10.1186/1743-8977-10-9.
  • Dudefoi, W., H. Terrisse, M. Richard-Plouet, E. Gautron, F. Popa, B. Humbert, and M.-H. Ropers. 2017. “Criteria to Define a More Relevant Reference Sample of Titanium Dioxide in the Context of Food: A Multiscale Approach.” Food Additives & Contaminants: Part A 34(5): 653–665.doi:10.1080/19440049.2017.1284346.
  • ECHA. 2017. “ECHA Proposes Classification of TiO 2 as Category 2 Carcinogen.” Additives for Polymers 2017(8): 9–10.
  • EFSA ANS Panel. 2016. “Re-Evaluation of Titanium Dioxide (E 171) as a Food Additive.” EFSA Journal 14(9): e04545.
  • FDA. 2002. 21 CFR73.2575, Title 21, Volume 1.
  • Fiordaliso, F., C. Foray, M. Salio, M. Salmona, and L. Diomede. 2018. “Realistic Evaluation of Titanium Dioxide Nanoparticle Exposure in Chewing Gum.” Journal of Agricultural and Food Chemistry 66(26): 6860–6868. doi:10.1021/acs.jafc.8b00747.
  • Geraets, L., A. G. Oomen, P. Krystek, N. R. Jacobsen, H. Wallin, M. Laurentie, H. W. Verharen, E. F. Brandon, and W. H. de Jong. 2014. “Tissue Distribution and Elimination after Oral and Intravenous Administration of Different Titanium Dioxide Nanoparticles in Rats.” Particle and Fibre Toxicology 11(1): 30. doi:10.1186/1743-8977-11-30.
  • Gloire, G., S. Legrand-Poels, and J. Piette. 2006. “NF-kappaB Activation by Reactive Oxygen Species: Fifteen Years Later.” Biochemical Pharmacology 72(11): 1493–1505. doi:10.1016/j.bcp.2006.04.011.
  • Guo, Z., N. J. Martucci, F. Moreno-Olivas, E. Tako, and G. J. Mahler. 2017. “Titanium Dioxide Nanoparticle Ingestion Alters Nutrient Absorption in an.” In Vitro Model of the Small Intestine. NanoImpact 5: 70–82. doi:10.1016/j.impact.2017.01.002.
  • Gurr, J.-R., A. S. S. Wang, C.-H. Chen, and K.-Y. Jan. 2005. “Ultrafine Titanium Dioxide Particles in the Absence of Photoactivation Can Induce Oxidative Damage to Human Bronchial Epithelial Cells.” Toxicology 213(1–2): 66–73. doi:10.1016/j.tox.2005.05.007.
  • Heringa, M. B., L. Geraets, J. C. H. van Eijkeren, R. J. Vandebriel, W. H. Jong, and A. G. de Oomen. 2016. “Risk Assessment of Titanium Dioxide Nanoparticles via Oral Exposure, Including Toxicokinetic Considerations.” Nanotoxicology 10(10): 1515–1525. doi:10.1080/17435390.2016.1238113.
  • Heringa, M. B., R. J. B. Peters, R. L. A. W. Bleys, M. K. van der Lee, P. C. Tromp, P. C. E. van Kesteren, J. C. H. van Eijkeren, A. K. Undas, A. G. Oomen, and H. Bouwmeester. 2018. “Detection of Titanium Particles in Human Liver and Spleen and Possible Health Implications.” Particle and Fibre Toxicology 15(1): 15–23. doi:10.1186/s12989-018-0251-7.
  • Hewitt, R. E., B. Vis, L. C. Pele, N. Faria, and J. J. Powell. 2017. “Imaging Flow Cytometry Assays for Quantifying Pigment Grade Titanium Dioxide Particle Internalization and Interactions with Immune Cells in Whole Blood.” Cytometry Part A 91(10): 1009–1020. doi:10.1002/cyto.a.23245.
  • IARC, Working Group on the Evaluation of Carcinogenic Risks to Humans. 2010. IARC monographs on the evaluation of carcinogenic risks to humans, p. 93.
  • Iavicoli, I., V. Leso, L. Fontana, and A. Bergamaschi. 2011. “Toxicological Effects of Titanium Dioxide Nanoparticles: A Review of in Vitro Mammalian Studies.” European Review for Medical and Pharmacological Sciences 15(5): 481–508. doi:10.1155/2012/964381.
  • Kim, N., C. Kim, S. Jung, Y. Park, Y. Lee, J. Jo, M. Hong, S. Lee, Y. Oh, and K. Jung. 2018. “Determination and Identification of Titanium Dioxide Nanoparticles in Confectionery Foods, Marketed in South Korea, Using Inductively Coupled Plasma Optical Emission Spectrometry and Transmission Electron Microscopy.” Food Additives & Contaminants: Part A 35(7): 1238–1246. doi:10.1080/19440049.2018.1482011.
  • Kreyling, W. G., U. Holzwarth, C. Schleh, J. Kozempel, A. Wenk, N. Haberl, S. Hirn, et al. 2017. “Quantitative Biokinetics of Titanium Dioxide Nanoparticles after Oral Application in Rats: Part 2.” Nanotoxicology 11(4): 443–453. doi:10.1080/17435390.2017.1306893.
  • Lazzari, S., D. Moscatelli, F. Codari, M. Salmona, M. Morbidelli, and L. Diomede. 2012. “Colloidal Stability of Polymeric Nanoparticles in Biological Fluids.” Journal of Nanoparticle Research 14(6): 920. doi:10.1007/s11051-012-0920-7.
  • Liepelt, A., and F. Tacke. 2016. “Stromal Cell-Derived Factor-1 (SDF-1) as a Target in Liver Diseases.” American Journal of Physiology-Gastrointestinal and Liver Physiology 311(2): G203–G209. doi:10.1152/ajpgi.00193.2016.
  • Livak, K. J., and T. D. Schmittgen. 2001. “Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2(−Delta Delta C(T)) Method.” Methods (San Diego, CA) 25(4): 402–408. doi:10.1006/meth.2001.1262.
  • Long, T. C., N. Saleh, R. D. Tilton, G. V. Lowry, and B. Veronesi. 2006. “Titanium Dioxide (P25) Produces Reactive Oxygen Species in Immortalized Brain Microglia (BV2): Implications for Nanoparticle Neurotoxicity.” Environmental Science & Technology 40(14): 4346–4352. doi:10.1021/es060589n.
  • Mantovani, A., and F. Marchesi. 2014. “IL-10 and Macrophages Orchestrate Gut Homeostasis.” Immunity 40(5): 637–639. doi:10.1016/j.immuni.2014.04.015.
  • Pele, L. C., V. Thoree, S. F. Bruggraber, D. Koller, R. P. Thompson, M. C. Lomer, and J. J. Powell. 2015. “Pharmaceutical/Food Grade Titanium Dioxide Particles Are Absorbed into the Bloodstream of Human Volunteers.” Particle and Fibre Toxicology 12(1): 26–31. doi:10.1186/s12989-015-0101-9.
  • Peters, R. J. B., G. van Bemmel, Z. Herrera-Rivera, H. P. F. G. Helsper, H. J. P. Marvin, S. Weigel, P. C. Tromp, A. G. Oomen, A. G. Rietveld, and H. Bouwmeester. 2014. “Characterization of Titanium Dioxide Nanoparticles in Food Products: Analytical Methods to Define Nanoparticles.” Journal of Agricultural and Food Chemistry 62(27): 6285–6293. doi:10.1021/jf5011885.
  • Proquin, H., M. J. Jetten, M. C. M. Jonkhout, L. G. Garduño-Balderas, J. J. Briedé, T. M. de Kok, Y. I. Chirino, and H. van Loveren. 2018. “Gene Expression Profiling in Colon of Mice Exposed to Food Additive Titanium Dioxide (E171).” Food and Chemical Toxicology 111: 153–165. doi:10.1016/j.fct.2017.11.011.
  • Proquin, H., C. Rodríguez-Ibarra, C. G. J. Moonen, I. M. Urrutia Ortega, J. J. Briedé, T. M. de Kok, H. van Loveren, and Y. I. Chirino. 2017. “Titanium Dioxide Food Additive (E171) Induces ROS Formation and Genotoxicity: Contribution of Micro and Nano-Sized Fractions.” Mutagenesis 32(1): 139–149. doi:10.1093/mutage/gew051.
  • Riedle, S., L. C. Pele, D. E. Otter, R. E. Hewitt, H. Singh, N. C. Roy, and J. J. Powell. 2017. “Pro-Inflammatory Adjuvant Properties of Pigment-Grade Titanium Dioxide Particles Are Augmented by a Genotype That Potentiates Interleukin 1β Processing.” Particle and Fibre Toxicology 14(1): 51–62. doi:10.1186/s12989-017-0232-2.
  • Rompelberg, C., M. B. Heringa, G. van Donkersgoed, J. Drijvers, A. Roos, S. Westenbrink, et al. 2016. “Oral Intake of Added Titanium Dioxide and Its Nanofraction from Food Products, Food Supplements and Toothpaste by the Dutch Population.” Nanotoxicology 10(10): 1404–1414. doi:10.1080/17435390.2016.1222457.
  • Ruiz, P. A., B. Morón, H. M. Becker, S. Lang, K. Atrott, M. R. Spalinger, M. Scharl, et al. 2017. “Titanium Dioxide Nanoparticles Exacerbate DSS-Induced Colitis: Role of the NLRP3 Inflammasome.” Gut 66(7): 1216–1224. doi:10.1136/gutjnl-2015-310297.
  • Shi, H., R. Magaye, V. Castranova, and J. Zhao. 2013. “Titanium Dioxide Nanoparticles: A Review of Current Toxicological Data.” Particle and Fibre Toxicology 10(1): 15. doi:10.1186/1743-8977-10-15.
  • Sitia, G., R. Aiolfi, P. Di Lucia, M. Mainetti, A. Fiocchi, F. Mingozzi, A. Esposito, et al. 2012. “Antiplatelet Therapy Prevents Hepatocellular Carcinoma and Improves Survival in a Mouse Model of Chronic Hepatitis B.” Proceedings of the National Academy of Sciences 109(32): E2165–E2172. doi:10.1073/pnas.1209182109.
  • Tassinari, R., F. Cubadda, G. Moracci, F. Aureli, M. D’Amato, M. Valeri, B. De Berardis, et al. 2014. “Oral, Short-Term Exposure to Titanium Dioxide Nanoparticles in Sprague-Dawley Rat: Focus on Reproductive and Endocrine Systems and Spleen.” Nanotoxicology 8(6): 654–662. doi:10.3109/17435390.2013.822114.
  • Weir, A., P. Westerhoff, L. Fabricius, K. Hristovski, and N. von Goetz. 2012. “Titanium Dioxide Nanoparticles in Food and Personal Care Products.” Environmental Science & Technology 46(4): 2242–2250. doi:10.1021/es204168d.
  • Winkler, H. C., T. Notter, U. Meyer, and H. Naegeli. 2018. “Critical Review of the Safety Assessment of Titanium Dioxide Additives in Food.” Journal of Nanobiotechnology 16(1): 51–69. doi:10.1186/s12951-018-0376-8.
  • Wisse, E., R. B. De Zanger, K. Charels, P. Van Der Smissen, and R. S. McCuskey. 1985. “The Liver Sieve: Considerations concerning the Structure and Function of Endothelial Fenestrae, the Sinusoidal Wall and the Space of Disse.” Hepatology (Baltimore, Md.) 5(4): 683–692. doi:10.1002/hep.1840050427.

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