Mechanisms for cellular uptake of nanosized clinical MRI contrast agents

References

• Abbe, E. 1873. “Beiträge Zur Theorie Des Mikroskops Und Der Mikroskopischen Wahrnehmung.” Archiv Für Mikroskopische Anatomie 9 (1): 413–418. doi:10.1007/BF02956173.
   Google Scholar
• Aderem, A., and D. M. Underhill. 1999. “Mechanisms of Phagocytosis in Macrophages.” Annual Review of Immunology 17 (1): 593–623. doi:10.1146/annurev.immunol.17.1.593.
   PubMed Web of Science ®Google Scholar
• Alexis, F., E. M. Pridgen, R Langer, and O. C. Farokhza. 2010. “Nanoparticle Technologies for Cancer Therapy.” Handbook of Experimental Pharmacology 2010 (197): 55–86. doi:10.1007/978-3-642-00477-3_2.
   Google Scholar
• Arbab, A. S., L. B. Wilson, P. Ashari, E. K. Jordan, B. K. Lewis, and J. A. Frank. 2005. “A Model of Lysosomal Metabolism of Dextran Coated Superparamagnetic Iron Oxide (SPIO) Nanoparticles: implications for Cellular Magnetic Resonance Imaging. NMR in Biomedicine 18 (6): 383–389. doi:10.1002/nbm.970.
   PubMed Web of Science ®Google Scholar
• Bahrami, B., M. Hojjat-Farsangi, H. Mohammadi, E. Anvari, G. Ghalamfarsa, M. Yousefi, F. Jadidi-Niaragh, et al. 2017. “Nanoparticles and Targeted Drug Delivery in Cancer Therapy.” Immunology Letters 190: 64–83. doi:10.1016/j.imlet.2017.07.015.
   PubMed Web of Science ®Google Scholar
• Bartczak, D., M.-O. Baradez, H. Goenaga-Infante, and D. Marshall. 2015. “Label-Free Monitoring of the Nanoparticle Surface Modification Effects on Cellular Uptake, Trafficking and Toxicity.” Toxicology Research 4 (1): 169–176. doi:10.1039/C4TX00105B.
   Web of Science ®Google Scholar
• Bean, C. P., and J. D. Livingston. 1959. “Superparamagnetism.” Journal of Applied Physics 30 (4): S120–S129. doi:10.1063/1.2185850.
   Google Scholar
• Bohmer, N., and A. Jordan. 2015. “Caveolin-1 and CDC42 Mediated Endocytosis of Silica-Coated Iron Oxide Nanoparticles in HeLa Cells.” Beilstein Journal of Nanotechnology 6 (1): 167–176. doi:10.3762/bjnano.6.16.
   PubMedGoogle Scholar
• Bolte, S., and F. P. Cordelieres. 2006. “A Guided Tour into Subcellular Colocalisation Analysis in Light Microscopy.” Journal of Microscopy 224 (3): 213–232. doi:10.1111/j.1365-2818.2006.01706.x.
   PubMed Web of Science ®Google Scholar
• Böse, K., M. Koch, C. Cavelius, A. K. Kiemer, and A. Kraegeloh. 2014. “A Correlative Analysis of Gold Nanoparticles Internalized by A549 Cells.” Particle & Particle Systems Characterization 31 (4): 439–448. doi:10.1002/ppsc.201300308.
   Web of Science ®Google Scholar
• Bucci, C., R. G. Parton, I. H. Mather, H. Stunnenberg, K. Simons, B. Hoflack, and M. Zerial. 1992. “The Small GTPase rab5 Functions as a Regulatory Factor in the Early Endocytic Pathway.” Cell 70 (5): 715–728. doi:10.1016/0092-8674(92)90306-W.
   PubMed Web of Science ®Google Scholar
• Bucci, C., P. Thomsen, P. Nicoziani, J. McCarthy, and B. van Deurs. 2000. “Rab7: A Key to Lysosome Biogenesis.” Molecular Biology of the Cell 11 (2): 467–480. doi:10.1091/mbc.11.2.467.
   PubMed Web of Science ®Google Scholar
• Bulte, J. W. M., and D. L. Kraitchman. 2004. “Iron Oxide MR Contrast Agents for Molecular and Cellular Imaging.” NMR in Biomedicine 17 (7): 484–499. doi:10.1002/nbm.924.
   PubMed Web of Science ®Google Scholar
• Byrne, J. D., T. Betancourt, and L. Brannon-Peppas. 2008. “Active Targeting Schemes for Nanoparticle Systems in Cancer Therapeutics.” Advanced Drug Delivery Reviews 60 (15): 1615–1626. doi:10.1016/j.addr.2008.08.005.
   PubMed Web of Science ®Google Scholar
• Calero, M., M. Chiappi, A. Lazaro-Carrillo, M. J. Rodríguez, F. J. Chichón, K. Crosbie-Staunton, A. Prina-Mello, et al. 2015. “Characterization of Interaction of Magnetic Nanoparticles with Breast Cancer Cells.” Journal of Nanobiotechnology 13 (1): 16. doi:10.1186/s12951-015-0073-9.
   PubMed Web of Science ®Google Scholar
• Chang, B.-J., S. H. Lin, L. J. Chou, and S. Y. Chiang. 2011. “Subdiffraction Scattered Light Imaging of Gold Nanoparticles Using Structured Illumination.” Optics Letters 36 (24): 4773–4775. doi:10.1364/OL.36.004773.
   PubMed Web of Science ®Google Scholar
• Choi, S. H., W. K. Moon, J. H. Hong, K. R. Son, N. Cho, B. J. Kwon, J. J. Lee, et al. 2007. “Lymph Node Metastasis: Ultrasmall Superparamagnetic Iron Oxide-Enhanced MR Imaging versus PET/CT in a Rabbit Model.” Radiology 242 (1): 137–143. doi:10.1148/radiol.2421060093.
   PubMed Web of Science ®Google Scholar
• Chung, T.-H., J.-K. Hsiao, M. Yao, S.-C. Hsu, H.-M. Liu, and D.-M. Huang. 2015. “Ferucarbotran, a Carboxydextran-Coated Superparamagnetic Iron Oxide Nanoparticle, Induces Endosomal Recycling, Contributing to Cellular and Exosomal EGFR Overexpression for Cancer Therapy.” RSC Advances 5 (109): 89932–89939. doi:10.1039/C5RA18810E.
   Web of Science ®Google Scholar
• Cox, G., and C. J. R. Sheppard. 2004. “Practical Limits of Resolution in Confocal and Non-Linear Microscopy.” Microscopy Research and Technique 63 (1): 18–22. doi:10.1002/jemt.10423.
   PubMed Web of Science ®Google Scholar
• Daigneault, M., J. A. Preston, H. M. Marriott, M. K. B. Whyte, and D. H. Dockrell. 2010. “The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages.” PloS One 5 (1): e8668. doi:10.1371/journal.pone.0008668.
   PubMed Web of Science ®Google Scholar
• Daldrup-Link, H. E., M. Rudelius, R. A. J. Oostendorp, M. Settles, G. Piontek, S. Metz, H. Rosenbrock, et al. 2003. “Targeting of Hematopoietic Progenitor Cells with MR Contrast Agents.” Radiology 228 (3): 760–767. doi:10.1148/radiol.2283020322.
   PubMed Web of Science ®Google Scholar
• Dave, P. N., and L. V. Chopda. 2014. “Application of Iron Oxide Nanomaterials for the Removal of Heavy Metals.” Journal of Nanotechnology 2014: 1–14. doi:10.1155/2014/398569.
   Google Scholar
• DeLoid, G. M., J. M. Cohen, G. Pyrgiotakis, S. V. Pirela, A. Pal, J. Liu, J. Srebric, and P. Demokritou. 2015. “Advanced Computational Modeling for In Vitro Nanomaterial Dosimetry.” Particle and Fibre Toxicology 12. doi:10.1186/s12989-015-0109-1.
   PubMed Web of Science ®Google Scholar
• Di Marco, M., et al. 2007. “Physicochemical Characterization of Ultrasmall Superparamagnetic Iron Oxide Particles (USPIO) for Biomedical Application as MRI Contrast Agents.” International Journal of Nanomedicine 2 (4): 609–622. doi: citeulike-article-id:2348535.
   PubMed Web of Science ®Google Scholar
• dos Santos, T., J. Varela, I. Lynch, A. Salvati, and K. A. Dawson. 2011a. “Effects of Transport Inhibitors on the Cellular Uptake of Carboxylated Polystyrene Nanoparticles in Different Cell Lines.” PLoS ONE 6 (9): e24438. doi:10.1371/journal.pone.0024438.
   PubMed Web of Science ®Google Scholar
• dos Santos, T., J. Varela, I. Lynch, A. Salvati, and K. A. Dawson. 2011b. “Quantitative Assessment of the Comparative Nanoparticle-Uptake Efficiency of a Range of Cell Lines.” Small 7 (23): 3341–3349. doi:10.1002/smll.201101076.
   PubMed Web of Science ®Google Scholar
• Duncan, R., and R. Gaspar. 2011. “Nanomedicine(s) under the Microscope.” Molecular Pharmaceutics 8 (6): 2101–2141. doi:10.1021/mp200394t.
   PubMed Web of Science ®Google Scholar
• Elkin, S. R., A. M. Lakoduk, and S. L. Schmid. 2016. “Endocytic Pathways and Endosomal Trafficking: A Primer.” Wiener Medizinische Wochenschrift 166 (7–8): 196–204. doi:10.1007/s10354-016-0432-7.
   PubMed Web of Science ®Google Scholar
• European Medicines Agency. 2008. Withdrawal Assessment Report for SINEREM. https://www.ema.europa.eu/en/documents/withdrawal-report/withdrawal-assessment-report-sinerem_en.pdf
   Google Scholar
• Feng, Y., B. Press, and A. Wandinger-Ness. 1995. “Rab 7: An Important Regulator of Late Endocytic Membrane Traffic.” The Journal of Cell Biology 131 (6): 1435–1452. doi:10.1083/jcb.131.6.1435.
   PubMed Web of Science ®Google Scholar
• Fortuin, A. S., R. Brüggemann, J. van der Linden, I. Panfilov, B. Israël, T. W. J. Scheenen, and J. O. Barentsz. 2017. “Ultra-Small Superparamagnetic Iron Oxides for Metastatic Lymph Node Detection: Back on the Block.” Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 10 (1): e1471. doi:10.1002/wnan.1471.
   Web of Science ®Google Scholar
• Freeman, M. W., A. Arrott, and J. H. L. Watson. 1960. “Magnetism in Medicine.” Journal of Applied Physics. 31 (5): S404. doi:10.1063/1.1984765.
   Web of Science ®Google Scholar
• Fuchigami, T., R. Kawamura, Y. Kitamoto, M. Nakagawa, and Y. Namiki. 2012. “A Magnetically Guided anti-Cancer Drug Delivery System Using Porous FePt Capsules.” Biomaterials 33 (5): 1682–1687. doi:10.1016/j.biomaterials.2011.11.016.
   PubMed Web of Science ®Google Scholar
• Gao, X., Y. Cui, R. M. Levenson, L. W. K. Chung, and S. Nie. 2004. “In Vivo Cancer Targeting and Imaging with Semiconductor Quantum Dots.” Nature Biotechnology 22: 969–976. doi:10.1038/nbt994.
   PubMed Web of Science ®Google Scholar
• Gargalovic, P., and L. Dory. 2001. “Caveolin-1 and Caveolin-2 Expression in Mouse Macrophages: High Density Lipoprotein 3-Stimulated Secretion and a Lack of Significant Subcellular co-Localization.” Journal of Biological Chemistry 276 (28): 26164–26170. doi:10.1074/jbc.M011291200.
   PubMed Web of Science ®Google Scholar
• Gaus, K., L. Kritharides, G. Schmitz, A. Boettcher, W. Drobnik, T. Langmann, C. M. Quinn, et al. 2004. “Apolipoprotein A-1 Interaction with Plasma Membrane Lipid Rafts Controls Cholesterol Export from Macrophages.” The FASEB Journal 18 (3): 574–576. doi:10.1016/S1567-5688(03)90298-4.
   PubMedGoogle Scholar
• Goodwin, S., C. Peterson, C. Hoh, and C. Bittner. 1999. “Targeting and Retention of Magnetic Targeted Carriers (MTCs) Enhancing Intra-Arterial Chemotherapy.” Journal of Magnetism and Magnetic Materials 194 (1–3): 132–139. doi:10.1016/S0304-8853(98)00584-8.
   Web of Science ®Google Scholar
• Gu, J., H. Xu, Y. Han, W. Dai, W. Hao, C. Wang, N. Gu, et al. 2011. “The Internalization Pathway, Metabolic Fate and Biological Effect of Superparamagnetic Iron Oxide Nanoparticles in the Macrophage-like RAW264.7 Cell.” Science China Life Sciences 54 (9): 793–805. doi:10.1007/s11427-011-4215-5.
   PubMed Web of Science ®Google Scholar
• Guggenheim, E. J., A. Khan, J. Pike, L. Chang, I. Lynch, and J. Z. Rappoport. 2016. “Comparison of Confocal and Super-Resolution Reflectance Imaging of Metal Oxide Nanoparticles.” PLOS One 11 (10): e0159980. doi:10.1371/journal.pone.0159980.
   PubMed Web of Science ®Google Scholar
• Guggenheim, E. J., I. Lynch, and J. Z. Rappoport. 2017. “Imaging in Focus: Reflected Light Imaging: Techniques and Applications.” The International Journal of Biochemistry & Cell Biology 83: 65–70. doi:10.1016/j.biocel.2016.12.008.
   PubMed Web of Science ®Google Scholar
• Guggenheim, E. J., S. Milani, P. J. F. Röttgermann, M. Dusinska, C. Saout, A. Salvati, J. O. Rädler, I. Lynch. 2018. “Refining In Vitro Models for Nanomaterial Exposure to Cells and Tissues.” NanoImpact 10: 121–142. doi:10.1016/j.impact.2018.02.008.
   Web of Science ®Google Scholar
• Handy, R. D., R. Owen, and E. Valsami-Jones. 2008. “The Ecotoxicology of Nanoparticles and Nanomaterials: current Status, Knowledge Gaps, Challenges, and Future Needs.” Ecotoxicology 17 (5): 315–325. doi:10.1007/s10646-008-0206-0.
   PubMed Web of Science ®Google Scholar
• Hanot, C., Y. Choi, T. Anani, D. Soundarrajan, and A. David. 2015. “Effects of Iron-Oxide Nanoparticle Surface Chemistry on Uptake Kinetics and Cytotoxicity in CHO-K1 Cells.” International Journal of Molecular Sciences 17 (1): 54. doi:10.3390/ijms17010054.
   Web of Science ®Google Scholar
• Hansen, S. F., E. S. Michelson, A. Kamper, P. Borling, F. Stuer-Lauridsen, and A. Baun. 2008. “Categorization Framework to Aid Exposure Assessment of Nanomaterials in Consumer Products.” Ecotoxicology 17 (5): 438–447. doi:10.1007/s10646-008-0210-4.
   PubMed Web of Science ®Google Scholar
• Harisinghani, M. G., J. Barentsz, P. F. Hahn, W. M. Deserno, S. Tabatabaei, C. H. van de Kaa, J. de la Rosette, et al. 2003. “Noninvasive Detection of Clinically Occult Lymph-Node Metastases in Prostate Cancer.” New England Journal of Medicine 348 (25): 2491–2499. doi:10.1056/NEJMoa022749.
   PubMed Web of Science ®Google Scholar
• Hofmann-Amtenbrink, M., et al. 2009. “Superparamagnetic Nanoparticles for Biomedical Applications.” Journal of Magnetism and Magnetic Materials 293 (1): 483–496. doi:10.1016/j.jmmm.2005.01.064..
   Google Scholar
• Ivanov A. I. 2008. Exocitosis and Endocytosis. Methods in Molecular Biology. Clifton, N.J: Humana Press.
   Google Scholar
• Iyer, A. K., G. Khaled, J. Fang, and H. Maeda. 2006. “Exploiting the Enhanced Permeability and Retention Effect for Tumor Targeting.” Drug Discovery Today 11 (17–18): 812–818. doi:10.1016/j.drudis.2006.07.005.
   PubMed Web of Science ®Google Scholar
• Johnston, H. J., M. Semmler-Behnke, D. M. Brown, W. Kreyling, L. Tran, and V. Stone. 2010. “Evaluating the Uptake and Intracellular Fate of Polystyrene Nanoparticles by Primary and Hepatocyte Cell Lines in Vitro.” Toxicology and Applied Pharmacology 242 (1): 66–78. doi:10.1016/j.taap.2009.09.015.
   PubMed Web of Science ®Google Scholar
• Jovic, M., M. Sharma, J. Rahajeng, and S. Caplan. 2010. “The Early Endosome: A Busy Sorting Station for Proteins at the Crossroads.” Histology and Histopathology 25 (1): 99–112. doi:10.1016/j.bbi.2008.05.010.
   PubMed Web of Science ®Google Scholar
• Kafshgari, M. H., F. J. Harding, and N. H. Voelcker. 2015. “Insights into Cellular Uptake of Nanoparticles.” Current Drug Delivery 12 (1): 63–77. doi:10.2174/1567201811666140821110631.
   PubMed Web of Science ®Google Scholar
• Karakatsanis, A., P. M. Christiansen, L. Fischer, C. Hedin, L. Pistioli, M. Sund, N. R. Rasmussen, et al. 2016. “The Nordic SentiMag Trial: A Comparison of Superparamagnetic Iron Oxide (SPIO) Nanoparticles versus Tc99and Patent Blue in the Detection of Sentinel Node (SN) in Patients with Breast Cancer and a Meta-Analysis of Earlier Studies.” Breast Cancer Research and Treatment 157 (2): 281–294. doi:10.1007/s10549-016-3809-9.
   PubMed Web of Science ®Google Scholar
• Karreman, M. A., V. Hyenne, Y. Schwab, and J. G. Goetz. 2016. “Intravital Correlative Microscopy: Imaging Life at the Nanoscale.” Trends in Cell Biology 26 (11): 848–863. doi:10.1016/j.tcb.2016.07.003.
   PubMed Web of Science ®Google Scholar
• Kievit, F. M., and M. Zhang. 2011. “Surface Engineering of Iron Oxide Nanoparticles for Targeted Cancer Therapy.” Accounts of Chemical Research 44 (10): 853–862. doi:10.1021/ar2000277.
   PubMed Web of Science ®Google Scholar
• Kolhatkar, A. G, A. C. Jamison, D. Litvinov, R. C. Willson, and T. R. Lee. 2013. “Tuning the Magnetic Properties of Nanoparticles.” International Journal of Molecular Sciences 14 (8): 15977–16009. doi:10.3390/ijms015977.
   PubMed Web of Science ®Google Scholar
• Kuhn, D. A., D. Vanhecke, B. Michen, F. Blank, P. Gehr, A. Petri-Fink, B. Rothen-Rutishauser, et al. 2014. “Different Endocytotic Uptake Mechanisms for Nanoparticles in Epithelial Cells and Macrophages.” Beilstein Journal of Nanotechnology 5 (1): 1625–1636. doi:10.3762/bjnano.5.174.
   PubMedGoogle Scholar
• Kumar, A., P. K. Jena, S. Behera, R. F. Lockey, S. Mohapatra, and S. Mohapatra. 2010. “Multifunctional Magnetic Nanoparticles for Targeted Delivery.” Nanomedicine: Nanotechnology, Biology, and Medicine 6 (1): 64–69. doi:10.1016/j.nano.2009.04.002.
   PubMed Web of Science ®Google Scholar
• Kwon, B., E. Han, W. Yang, W. Cho, W. Yoo, J. Hwang, B.-M. Kwon, et al. 2016. “Nano-Fenton Reactors as a New Class of Oxidative Stress Amplifying Anticancer Therapeutic Agents.” ACS Applied Materials & Interfaces 8 (9): 5887–5897. doi:10.1021/acsami.5b12523.
   PubMed Web of Science ®Google Scholar
• Lacaille-Dubois, M. A., and H. Wagner. 1996. “A Review of the Biological and Pharmacological Activities of Saponins.” Phytomedicine 2 (4): 363–386. doi:10.1016/S0944-7113(96)80081-X.
   PubMed Web of Science ®Google Scholar
• Levy, M., N. Luciani, D. Alloyeau, D. Elgrabli, V. Deveaux, C. Pechoux, S. Chat, et al. 2011. “Long Term in Vivo Biotransformation of Iron Oxide Nanoparticles.” Biomaterials 32 (16): 3988–3999. doi:10.1016/j.biomaterials.2011.02.031.
   PubMed Web of Science ®Google Scholar
• Li, L.,W. Jiang, K. Luo, H. Song, F. Lan, Y. Wu, Z. Gu, et al. 2013. “Superparamagnetic Iron Oxide Nanoparticles as MRI Contrast Agents for Non-Invasive Stem Cell Labeling and Tracking.” Theranostics 3 (8): 595–615. doi:10.7150/thno.5366.
   PubMed Web of Science ®Google Scholar
• Loehr, J., D. Pfeiffer, D. Schüler, and T. M. Fischer. 2016. “Magnetic Guidance of the Magnetotactic Bacterium Magnetospirillum gryphiswaldense.” Soft Matter 12 (15): 3631–3635. doi:10.1039/C6SM00384B.
   PubMed Web of Science ®Google Scholar
• Lunov, O., T. Syrovets, B. Büchele, X. Jiang, C. Röcker, K. Tron, G. U. Nienhaus, et al. 2010a. “The Effect of Carboxydextran-Coated Superparamagnetic Iron Oxide Nanoparticles on c-Jun N-Terminal Kinase-Mediated Apoptosis in Human Macrophages.” Biomaterials 31 (19): 5063–5071. doi:10.1016/j.biomaterials.2010.03.023.
   PubMed Web of Science ®Google Scholar
• Lunov, O., T. Syrovets, C. Röcker, K. Tron, G. U. Nienhaus, V. Rasche, V. Mailänder, et al. 2010b. “Lysosomal Degradation of the Carboxydextran Shell of Coated Superparamagnetic Iron Oxide Nanoparticles and the Fate of Professional Phagocytes.” Biomaterials 31 (34): 9015–9022. doi:10.1016/j.biomaterials.2010.08.003.
   PubMed Web of Science ®Google Scholar
• Lunov, O., V. Zablotskii, T. Syrovets, C. Röcker, K. Tron, G. U. Nienhaus, T. Simmet, et al. 2011. “Modeling Receptor-Mediated Endocytosis of Polymer-Functionalized Iron Oxide Nanoparticles by Human Macrophages.” Biomaterials 32 (2): 547–555. doi:10.1016/j.biomaterials.2010.08.111.
   PubMed Web of Science ®Google Scholar
• Lynch, I., A. Ahluwalia, D. Boraschi, H. J. Byrne, B. Fadeel, P. Gehr, A. C. Gutleb, M. Kendall, M. G. Papadopoulos. 2013. “The Bio-Nano-Interface in Predicting Nanoparticle Fate and Behaviour in Living Organisms: Towards Grouping and Categorising Nanomaterials and Ensuring Nanosafety by Design.” Bionanomaterials 14 (3–4): 195–216. doi:10.1515/bnm-2013-0011.
   Google Scholar
• Lynch, I., K. A. Dawson, J. R. Lead, and E. Valsami-Jones. 2014. “Macromolecular Coronas and Their Importance in Nanotoxicology and Nanoecotoxicology.” Frontiers of Nanoscience 7: 127–156. doi:10.1016/B978-0-08-099408-6.00004-9.
   Google Scholar
• Maher, B. A., I. A. M. Ahmed, V. Karloukovski, D. A. MacLaren, P. G. Foulds, D. Allsop, D. M. A. Mann, et al. 2016. “Magnetite Pollution Nanoparticles in the Human Brain.” Proceedings of the National Academy of Sciences 113 (39): 10797–10801. doi:10.1073/pnas.1605941113.
   PubMed Web of Science ®Google Scholar
• Mahmoudi, M., S. Sant, B. Wang, S. Laurent, and T. Sen. 2011. “Superparamagnetic Iron Oxide Nanoparticles (SPIONs): Development, Surface Modi fi Cation and Applications in Chemotherapy.” Advanced Drug Delivery Reviews 63 (1–2): 24–46. doi:10.1016/j.addr.2010.05.006.
   PubMed Web of Science ®Google Scholar
• Matuszewski, L., T. Persigehl, A. Wall, W. Schwindt, B. Tombach, M. Fobker, C. Poremba, W. Ebert, W. Heindel, and C. Bremer. 2005. “Cell Tagging with Clinically Approved Iron Oxides: feasibility and Effect of Lipofection, Particle Size, and Surface Coating on Labeling Efficiency.” Radiology 235 (1): 155–161. doi:10.1148/radiol.2351040094.
   PubMed Web of Science ®Google Scholar
• Mayor, S., E. Presley, and F. R. Maxfield. 1993. “Sorting of Membrane Components from Endosomes and Subsequent Recycling to the Cell Surface Occurs by a Bulk Flow Process.” The Journal of Cell Biology 121 (6): 1257–2018. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119709/pdf/jc12161257.pdf. doi:10.1083/jcb.121.6.1257.
   PubMed Web of Science ®Google Scholar
• Mazzolini, J., A. Khan, E. Guggenheim, R. Shaw, K. Chipman, R. J. M. Weber, H. S. Chen, M. Viant, and J. Z. Rappoport. 2015. “Protein Corona Modulates Cellular Entry and Toxicity of Nanoceria via Transferrin Dependent Clathrin-Mediated Endocytosis.” The Biological bulletin 231 (1): 40–60.
   Web of Science ®Google Scholar
• Miele, E., G. P. Spinelli, E. Miele, F. Tomao, and S. Tomao. 2009. “Albumin-Bound Formulation of Paclitaxel (Abraxane&Reg; ABI-007) in the Treatment of Breast Cancer.” International Journal of Nanomedicine 4: 99–105. doi:10.2147/IJN.S3061.
   PubMed Web of Science ®Google Scholar
• Monopoli, M. P., A. S. Pitek, I. Lynch, and K. A. Dawson. 2013. Nanomaterial Interfaces in Biology. Methods in Molecular Biology. Clifton, NJ: Humana Press.
   Google Scholar
• Moore, M. N. 2006. “Do Nanoparticles Present Ecotoxicological Risks for the Health of the Aquatic Environment?” Environment International 32 (8): 967–976. doi:10.1016/j.envint.2006.06.014.
   PubMed Web of Science ®Google Scholar
• Motley, A., N. A. Bright, M. N.J. Seaman, and M. S. Robinson. 2003. “Clathrin-Mediated Endocytosis in AP-2-Depleted Cells.” The Journal of Cell Biology 162 (5): 909–918. doi:10.1083/jcb.200305145.
   PubMed Web of Science ®Google Scholar
• Nemmar, A., S. Beegam, P. Yuvaraju, J. Yasin, S. Tariq, S. Attoub, and B.H. Ali. 2016. “Ultrasmall Superparamagnetic Iron Oxide Nanoparticles Acutely Promote Thrombosis and Cardiac Oxidative Stress and DNA Damage in Mice.” Particle and Fibre Toxicology 13 (1): 22. doi:10.1186/s12989-016-0132-x.
   PubMedGoogle Scholar
• Neuwelt, A., N. Sidhu, C.-A. A. Hu, G. Mlady, S. C. Eberhardt, and L. O. Sillerud. 2015. “Iron-Based Superparamagnetic Nanoparticle Contrast Agents for MRI of Infection and Inflammation.” American Journal of Roentgenology 204 (3): W302–13. doi:10.2214/AJR.14.12733.
   PubMed Web of Science ®Google Scholar
• Ong, K. J., T. J. MacCormack, R. J. Clark, J. D. Ede, V. A. Ortega, L. C. Felix, M. K. M. Dang, G. Ma, H. Fenniri, J. G. C. Veinot, and G. G. Goss. 2014. “Widespread Nanoparticle-Assay Interference: Implications for Nanotoxicity Testing.” PLOS One 9 (3): e90650. doi:10.1371/journal.pone.0090650.
   PubMed Web of Science ®Google Scholar
• Park, B., K. Donaldson, R. Duffin, L. Tran, F. Kelly, I. Mudway, J.-P. Morin, et al. 2008. “Hazard and Risk Assessment of a Nanoparticulate Cerium Oxide-Based Diesel Fuel Additive – a Case Study.” Inhalation Toxicology 20 (6): 547–566. doi:10.1080/08958370801915309.
   PubMed Web of Science ®Google Scholar
• Patskovsky, S., É. Bergeron, D. Rioux, M. Simard, and M. Meunier. 2014. “Hyperspectral Reflected Light Microscopy of Plasmonic Au/Ag Alloy Nanoparticles Incubated as Multiplex Chromatic Biomarkers with Cancer Cells.” The Analyst 139 (20): 5247–5253. doi:10.1039/C4AN01063A.
   PubMed Web of Science ®Google Scholar
• Pike, J. A., I. B. Styles, J. Z. Rappoport, and J. K. Heath. 2017. “Quantifying Receptor Trafficking and Colocalization with Confocal Microscopy.” Methods 115: 42. doi:10.1016/j.ymeth.2017.01.005.
   PubMed Web of Science ®Google Scholar
• Quinn, M. K., N. Gnan, S. James, A. Ninarello, F. Sciortino, E. Zaccarelli, J. J. McManus, et al. 2015. “How Fluorescent Labelling Alters the Solution Behaviour of Proteins.” Physical Chemistry Chemical Physics 17 (46): 31177–31187. doi:10.1039/C5CP04463D.
   PubMed Web of Science ®Google Scholar
• Rappoport, J. Z. and S. M. Simon. 2009. “Endocytic Trafficking of Activated EGFR is AP-2 Dependent and Occurs through Preformed Clathrin Spots.” Journal of Cell Science 122 (9): 1301–1305. doi:10.1242/jcs.040030.
   PubMed Web of Science ®Google Scholar
• Rastar, A., M. E. Yazdanshenas, A. Rashidi, and S. M. Bidoki. 2013. “Theoritical Review of Optical Properties of Nanoparticles.” Journal of Engineering Fibers and Fabrics 8 (2): 85–96. doi:10.1109/JLT.2005.861943.
   Web of Science ®Google Scholar
• Rayleigh, L. 1903. “On the Theory of Optical Images, with Special Reference to the Microscope.” Journal of the Royal Microscopical Society 23 (4): 474–482. doi:10.1111/j.1365-2818.1903.tb04831.x.
   Google Scholar
• Raynal, I., P. Prigent, S. Peyramaure, A. Najid, C. Rebuzzi, and C. Corot. 2004. “Macrophage Endocytosis of Superparamagnetic Iron Oxide Nanoparticles: mechanisms and Comparison of Ferumoxides and Ferumoxtran-10.” Investigative Radiology 39 (1): 56–63. doi:10.1097/01.rli.0000101027.57021.28.
   PubMed Web of Science ®Google Scholar
• Re, F., R. Moresco, and M. Masserini. 2012. “Nanoparticles for Neuroimaging.” Journal of Physics D: Applied Physics 45 (7). doi:10.1088/0022-3727/45/7/073001.
   Web of Science ®Google Scholar
• Reimer, P., N. Jähnke, M. Fiebich, W. Schima, F. Deckers, C. Marx, N. Holzknecht, and S. Saini. 2000. “Hepatic Lesion Detection and Characterization: Value of Nonenhanced MR Imaging, Superparamagnetic Iron Oxide–Enhanced MR Imaging, and Spiral CT—ROC Analysis.” Radiology 217 (1): 152–158. doi:10.1148/radiology.217.1.r00oc31152.
   PubMed Web of Science ®Google Scholar
• Reimer, P., and B. Tombach. 1998. “Hepatic MRI with SPIO: detection and Characterization of Focal Liver Lesions.” European Radiology 1204 (8): 1198–1204. doi:10.1007/s003300050535.
   Google Scholar
• Sahay, G., D. Y. Alakhova, and A. V. Kabanov. 2010. “Endocytosis of Nanomedicines.” Journal of Controlled Release 145 (3): 182–195. doi:10.1016/j.jconrel.2010.01.036.
   PubMed Web of Science ®Google Scholar
• Sakulkhu, U., M. Mahmoudi, L. Maurizi, J. Salaklang, and H. Hofmann. 2015. “Protein Corona Composition of Superparamagnetic Iron Oxide Nanoparticles with Various Physico-Chemical Properties and Coatings.” Scientific Reports 4 (1): 5020. doi:10.1038/srep05020.
   Google Scholar
• Sandin, P., L. W. Fitzpatrick, J. C. Simpson, and K. A. Dawson. 2012. “High-Speed Imaging of Rab Family Small GTPases Reveals Rare Events in Nanoparticle Trafficking in Living Cells.” ACS Nano American Chemical Society, 6 (2): 1513–1521. doi:10.1021/nn204448x.
   PubMed Web of Science ®Google Scholar
• Santra, S., C. Kaittanis, J. Grimm, and J. M. Perez. 2009. “Drug/Dye-Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging.” Small 5 (16): 1862–1868. doi:10.1002/smll.200900389.
   PubMed Web of Science ®Google Scholar
• Schlorf, T., M. Meincke, E. Kossel, C.-C. Glüer, O. Jansen, and R. Mentlein. 2010. “Biological Properties of Iron Oxide Nanoparticles for Cellular and Molecular Magnetic Resonance Imaging.” International Journal of Molecular Sciences 12 (1): 12–23. doi:10.3390/ijms1012.
   PubMed Web of Science ®Google Scholar
• Schütz, C. A., L. Juillerat-Jeanneret, H. Mueller, I. Lynch, and M. Riediker. 2013. “Therapeutic Nanoparticles in Clinics and Under Clinical Evaluation.” Nanomedicine 8 (3): 449–467. doi:10.2217/nnm.13.8.
   PubMed Web of Science ®Google Scholar
• Shen, Y., Z. Huang, X. Liu, J. Qian, J. Xu, X. Yang, A. Sun, et al. 2015. “Iron-Induced Myocardial Injury: An Alarming Side Effect of Superparamagnetic Iron Oxide Nanoparticles.” Journal of Cellular and Molecular Medicine 19 (8): 2032–2035. doi:10.1111/jcmm.12582.
   PubMed Web of Science ®Google Scholar
• Shipley, H. J., K. E. Engates, and A. M. Guettner. 2011. “Study of Iron Oxide Nanoparticles in Soil for Remediation of Arsenic.” Journal of Nanoparticle Research 13 (6): 2387–2397. doi:10.1007/s11051-010-9999-x.
   Web of Science ®Google Scholar
• Sigmund, W., H. El-Shall, D. O. Shah, and B. M. Moudgil. 2008. Particulate Systems in Nano- and Biotechnologies. Boca Raton, FL: CRC Press. https://books.google.com/books?id=3MWSicRibZsC&pgis=1.
   Google Scholar
• Silva, A. H., E. Lima, M. V. Mansilla, R. D. Zysler, H. Troiani, M. L. M. Pisciotti, C. Locatelli, et al. 2016. “Superparamagnetic Iron-Oxide Nanoparticles mPEG350- and mPEG2000-Coated: Cell Uptake and Biocompatibility Evaluation.” Nanomedicine: Nanotechnology, Biology, and Medicine 12 (4): 909–919. doi:10.1016/j.nano.2015.12.371.
   PubMed Web of Science ®Google Scholar
• Singh, N. 2010. “Potential Toxicity of Superparamagnetic Iron Oxide Nanoparticles (SPION).” Nano Reviews 1: 1–15. doi:10.3402/nano.v1i0.5358.
   Google Scholar
• Smith, P. J., M. Giroud, H. L. Wiggins, F. Gower, J. A. Thorley, B. Stolpe, J. Mazzolini, et al. 2012. “Cellular Entry of Nanoparticles via Serum Sensitive Clathrin-Mediated Endocytosis, and Plasma Membrane Permeabilization.” International Journal of Nanomedicine 7: 2045–2055. doi:10.2147/IJN.S29334.
   PubMed Web of Science ®Google Scholar
• Soenen, S. J. H., N. Nuytten, S. F. De Meyer, S. C. De Smedt, and M. De Cuyper. 2010a. “High Intracellular Iron Oxide Nanoparticle Concentrations Affect Cellular Cytoskeleton and Focal Adhesion Kinase-Mediated Signaling.” Small 6 (7): 832–842. doi:10.1002/smll.200902084.
   PubMed Web of Science ®Google Scholar
• Soenen, S. J. H., U. Himmelreich, N. Nuytten, T. R. Pisanic, A. Ferrari, and M. De Cuyper. 2010b. “Intracellular Nanoparticle Coating Stability Determines Nanoparticle Diagnostics Efficacy and Cell Functionality.” Small 6 (19): 2136–2145. doi:10.1002/smll.201000763.
   PubMed Web of Science ®Google Scholar
• Sokolov, K., M. Follen, J. Aaron, I. Pavlova, A. Malpica, R. Lotan, and R. Richards-Kortum 2003. “Real-Time Vital Optical Imaging of Precancer Using anti-Epidermal Growth Factor Receptor Antibodies Conjugated to Gold Nanoparticles ” Cancer Research. 63 (9): 1999–2004.
   PubMed Web of Science ®Google Scholar
• Sonvico, F., S. Mornet, S. Vasseur, C. Dubernet, D. Jaillard, J. Degrouard, J. Hoebeke, et al. 2005. “Folate-Conjugated Iron Oxide Nanoparticles for Solid Tumor Targeting as Potential Specific Magnetic Hyperthermia Mediators: Synthesis, Physicochemical Characterization, and in Vitro Experiments.” Bioconjugate Chemistry 16 (5): 1181–1188. doi:10.1021/bc050050z.
   PubMed Web of Science ®Google Scholar
• Stark, D. D., R. Weissleder, G. Elizondo, P. F. Hahn, S. Saini, L. E. Todd, J. Wittenberg, et al. 1988. “Superparamagnetic Iron Oxide: clinical Application as a Contrast Agent for MR Imaging of the Liver.” Radiology 168 (2): 297–301. doi:10.1148/radiology.168.2.3393649.
   PubMed Web of Science ®Google Scholar
• Stebounova, L. V., E. Guio, and V. H. Grassian. 2011. “Silver Nanoparticles in Simulated Biological Media: A Study of Aggregation, Sedimentation, and Dissolution.” Journal of Nanoparticle Research 13 (1): 233–244. doi:10.1007/s11051-010-0022-3.
   Web of Science ®Google Scholar
• Sugden, J. K. 2004. “Photochemistry of Dyes and Fluorochromes Used in Biology and Medicine: some Physicochemical Background and Current Applications.” Biotechnic & Histochemistry 79 (2): 71–90. doi:10.1080/10520290412331292400.
   PubMed Web of Science ®Google Scholar
• Thomsen, L. B., T. Linemann, K. M. Pondman, J. Lichota, K. S. Kim, R. J. Pieters, G. M. Visser, et al. 2013. “Uptake and Transport of Superparamagnetic Iron Oxide Nanoparticles through Human Brain Capillary Endothelial Cells.” ACS Chemical Neuroscience 4 (10): 1352–1360. doi:10.1021/cn400093z.
   PubMed Web of Science ®Google Scholar
• Trono, J. D., K. Mizuno, N. Yusa, T. Matsukawa, K. Yokoyama, and M. Uesaka. 2011. “Size, Concentration and Incubation Time Dependence of Gold Nanoparticle Uptake into Pancreas Cancer Cells and Its Future Application to X-Ray Drug Delivery System.” Journal of Radiation Research 52 (1): 103–109. doi:10.1269/jrr.10068.
   PubMed Web of Science ®Google Scholar
• Ullrich, O., S Reinsch, S. Urb, M. Zerial, and R. G. Parton 1996. “Rab11 Regulates Recycling through the Pericentriolar Recycling Endosome.” The Journal of Cell Biology 135 (4): 913–924. doi:10.1083/jcb.135.4.913.
   PubMed Web of Science ®Google Scholar
• Vanlandingham, P. A., and B. P. Ceresa. 2009. “Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration.” Journal of Biological Chemistry 284 (18): 12110–12124. doi:10.1074/jbc.M809277200.
   PubMed Web of Science ®Google Scholar
• Venditto, V. J., and F. C. Szoka. 2013. “Cancer Nanomedicines: So Many Papers and so Few Drugs!.” Advanced Drug Delivery Reviews 65 (1): 80–88. doi:10.1016/j.addr.2012.09.038.
   PubMed Web of Science ®Google Scholar
• Verdat M. E. 1869. Leçons D’optique Physique. Paris: L’Imprimierie Imperiale.
   Google Scholar
• Wahajuddin   and S. Arora. 2012. “Superparamagnetic Iron Oxide Nanoparticles: magnetic Nanoplatforms as Drug Carriers.” International Journal of Nanomedicine 7: 3445–3471. doi:10.2147/IJN.S30320.
   PubMed Web of Science ®Google Scholar
• Wang, Y. J. 2011. “Superparamagnetic Iron Oxide Based MRI Contrast Agents: Current Status of Clinical Application.” Quantitative Imaging in Medicine and Surgery 1 (1): 35–40. doi:10.3978/j.issn.2223-4292.2011.08.03.
   PubMedGoogle Scholar
• Wang, Y.-X. J. 2015. “Current Status of Superparamagnetic Iron Oxide Contrast Agents for Liver Magnetic Resonance Imaging.” World Journal of Gastroenterology 21 (47): 13400–13402. doi:10.3748/wjg.v21.i47.13400.
   PubMed Web of Science ®Google Scholar
• Wang, Z., and A. Cuschieri. 2013. “Tumour Cell Labelling by Magnetic Nanoparticles with Determination of Intracellular Iron Content and Spatial Distribution of the Intracellular Iron.” International Journal of Molecular Sciences 14 (5): 9111–9125. doi:10.3390/ijms14059111.
   PubMed Web of Science ®Google Scholar
• Xu, H., W. Dai, Y. Han, W. Hao, F. Xiong, Y. Zhang, J.-M. Cao, et al. 2010. “Differential Internalization of Superparamagnetic Iron Oxide Nanoparticles in Different Types of Cells.” Journal of Nanoscience and Nanotechnology 10 (11): 7406–7410. doi:10.1166/jnn.2010.2830.
   PubMed Web of Science ®Google Scholar
• Yang, C. Y., M.-F. Tai, C.-P. Lin, C.-W. Lu, J.-L. Wang, J.-K. Hsiao, and H.-M. Liu. 2011. “Mechanism of Cellular Uptake and Impact of Ferucarbotran on Macrophage Physiology.” PLOS One 6 (9): e25524. doi:10.1371/journal.pone.0025524.
   PubMed Web of Science ®Google Scholar
• Yang, L., H. Kuang, W. Zhang, Z. P. Aguilar, Y. Xiong, W. Lai, H. Xu, et al. 2015. “Size Dependent Biodistribution and Toxicokinetics of Iron Oxide Magnetic Nanoparticles in Mice.” Nanoscale 7 (2): 625–636. doi:10.1039/C4NR05061D.
   PubMed Web of Science ®Google Scholar
• Zhang, J., Y. Nazarenko, L. Zhang, L. Calderon, K.-B. Lee, E. Garfunkel, and S. Schwander. 2013. “Impacts of a Nanosized Ceria Additive on Diesel Engine Emissions of Particulate and Gaseous Pollutants.” Environmental Science & Technology 47 (22): 13077–13085. doi:10.1021/es402140u.
   PubMed Web of Science ®Google Scholar
• Zhang, L. W., and N. A. Monteiro-Riviere. 2009. “Mechanisms of Quantum Dot Nanoparticle Cellular Uptake.” Toxicological Sciences 110 (1): 138–155. doi:10.1093/toxsci/kfp087.
   PubMed Web of Science ®Google Scholar
• Zhang, Z., R. D. Ross, and R. K. Roeder. 2010. “Preparation of Functionalized Gold Nanoparticles as a Targeted X-ray Contrast Agent for Damaged Bone Tissue.” Nanoscale 2 (4): 582–586. doi:10.1039/b9nr00317g.
   PubMed Web of Science ®Google Scholar
• Zhao, F., Y. Zhao, Y. Liu, X. Chang, C. Chen, and Y. Zhao. 2011. “Cellular Uptake, Intracellular Trafficking, and Cytotoxicity of Nanomaterials.” Small 7 (10): 1322–1337. doi:10.1002/smll.201100001.
   PubMed Web of Science ®Google Scholar