The nanomaterial-induced bystander effects reprogrammed macrophage immune function and metabolic profile

References

• Al-Mayah, A. H. J., S. L. Irons, R. C. Pink, D. R. F. Carter, and M. A. Kadhim. 2012. “Possible Role of Exosomes Containing RNA in Mediating Nontargeted Effect of Ionizing Radiation.” Radiation Research 177 (5): 539–545. doi:10.1667/rr2868.1.
   PubMed Web of Science ®Google Scholar
• Bai, X., S. Wang, X. Yan, H. Zhou, J. Zhan, S. Liu, V. K. Sharma, G. Jiang, H. Zhu, and B. Yan. 2020. “Regulation of Cell Uptake and Cytotoxicity by Nanoparticle Core under the Controlled Shape, Size, and Surface Chemistries.” ACS Nano 14 (1): 289–302. doi:10.1021/acsnano.9b04407.
   PubMed Web of Science ®Google Scholar
• Baranov, M. V., N. H. Revelo, I. Dingjan, R. Maraspini, M. ter Beest, A. Honigmann, and G. van den Bogaart. 2016. “SWAP70 Organizes the Actin Cytoskeleton and is Essential for Phagocytosis.” Cell Reports 17 (6): 1518–1531. doi:10.1016/j.celrep.2016.10.021.
   PubMed Web of Science ®Google Scholar
• Barger, S. R., N. S. Reilly, M. S. Shutova, Q. Li, P. Maiuri, J. M. Heddleston, M. S. Mooseker, et al. 2019. “Membrane-Cytoskeletal Crosstalk Mediated by myosin-I Regulates Adhesion Turnover during Phagocytosis.” Nature Communications 10 (1): 1249. doi:10.1038/s41467-019-09104-1.
   PubMedGoogle Scholar
• Bewicke-Copley, F., L. A. Mulcahy, L. A. Jacobs, P. Samuel, N. Akbar, R. C. Pink, and D. R. F. Carter. 2017. “Extracellular Vesicles Released following Heat Stress Induce Bystander Effect in Unstressed populations.” Journal of Extracellular Vesicles 6 (1): 1340746. doi:10.1080/20013078.2017.1340746.
   PubMed Web of Science ®Google Scholar
• Bhabra, G., A. Sood, B. Fisher, L. Cartwright, M. Saunders, W. H. Evans, A. Surprenant, et al. 2009. “Nanoparticles Can Cause DNA Damage across a Cellular barrier.” Nature Nanotechnology 4 (12): 876–883. doi:10.1038/Nnano.2009.313.
   PubMed Web of Science ®Google Scholar
• Bonizzi, G., and M. Karin. 2004. “The Two NF-kappaB activation pathways and their role in innate and adaptive immunity.” Trends in Immunology 25 (6): 280–288. doi:10.1016/j.it.2004.03.008.
   PubMed Web of Science ®Google Scholar
• Braydich-Stolle, L. K., J. L. Speshock, A. Castle, M. Smith, R. C. Murdock, and S. M. Hussain. 2010. “Nanosized Aluminum Altered Immune Function.” ACS Nano 4 (7): 3661–3670. doi:10.1021/nn9016789.
   PubMed Web of Science ®Google Scholar
• Buchman, J. T., N. V. Hudson-Smith, K. M. Landy, and C. L. Haynes. 2019. “Understanding Nanoparticle Toxicity Mechanisms to Inform Redesign Strategies to Reduce Environmental Impact.” Accounts of Chemical Research 52 (6): 1632–1642. doi:10.1021/acs.accounts.9b00053.
   PubMed Web of Science ®Google Scholar
• Chen, Y. M., X. G. Hu, J. Sun, and Q. X. Zhou. 2016. “Specific Nanotoxicity of Graphene Oxide during Zebrafish Embryogenesis.” Nanotoxicology 10 (1): 42–52. doi:10.3109/17435390.2015.1005032.
   PubMed Web of Science ®Google Scholar
• Cheng, L., J. J. Liu, X. Gu, H. Gong, X. Z. Shi, T. Liu, C. Wang, et al. 2014. “PEGylated WS(2) nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy.” Advanced Materials 26 (12): 1886–1893. doi:10.1002/adma.201304497.
   PubMed Web of Science ®Google Scholar
• Chong, J., O. Soufan, C. Li, I. Caraus, S. Li, G. Bourque, D. S. Wishart, and J. Xia. 2018. “MetaboAnalyst 4.0: Towards More Transparent and Integrative Metabolomics Analysis.” Nucleic Acids Research 46 (W1): W486–W494. doi:10.1093/nar/gky310.
   PubMed Web of Science ®Google Scholar
• Colegio, Oscar R., Ngoc-Quynh Chu, Alison L. Szabo, Thach Chu, Anne Marie Rhebergen, Vikram Jairam, Nika Cyrus, et al. 2014. “Functional Polarization of Tumour-Associated Macrophages by Tumour-Derived Lactic Acid.” Nature 513 (7519): 559–563. doi:10.1038/nature13490.
   PubMed Web of Science ®Google Scholar
• Dobrovolskaia, M. A., and S. E. McNeil. 2007. “Immunological Properties of Engineered Nanomaterials.” Nature Nanotechnology 2 (8): 469–478. doi:10.1038/nnano.2007.223.
   PubMed Web of Science ®Google Scholar
• Flavell, R. A., S. Sanjabi, S. H. Wrzesinski, and P. Licona-Limón. 2010. “The Polarization of Immune Cells in the Tumour Environment by TGFbeta.” Nature Reviews. Immunology 10 (8): 554–567. doi:10.1038/nri2808.
   PubMed Web of Science ®Google Scholar
• Fuchs, Ann-Kathrin, Tatiana Syrovets, Karina A. Haas, Cornelia Loos, Anna Musyanovych, Volker Mailänder, Katharina Landfester, and Thomas Simmet. 2016. “Carboxyl- and Amino-Functionalized Polystyrene Nanoparticles Differentially Affect the Polarization Profile of M1 and M2 Macrophage Subsets.” Biomaterials 85: 78–87. doi:10.1016/j.biomaterials.2016.01.064.
   PubMed Web of Science ®Google Scholar
• Geeraerts, X., E. Bolli, S.-M. Fendt, and J. A. Van Ginderachter. 2017. “Macrophage Metabolism as Therapeutic Target for Cancer, Atherosclerosis, and Obesity.” Frontiers in Immunology 8: 289. doi: 10.3389/fmmu.2017.00289.
   PubMed Web of Science ®Google Scholar
• Gu, Z., T. Liu, J. Tang, Y. Yang, H. Song, Z. K. Tuong, J. Fu, and C. Yu. 2019. “Mechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway.” Journal of the American Chemical Society 141 (15): 6122–6126. doi:10.1021/jacs.8b10904.
   PubMed Web of Science ®Google Scholar
• Guo, S., J. Zhou, X. Chen, Y. Yu, M. Ren, G. Hu, Y. Liu, and F. Zou. 2014. “Bystander Effects of PC12 Cells Treated with Pb2+ depend on ROS-mitochondria-dependent apoptotic signaling via gap-junctional intercellular communication.” Toxicology Letters 229 (1): 150–157. doi:10.1016/j.toxlet.2014.05.026.
   PubMed Web of Science ®Google Scholar
• Han, W., L. Wu, S. Chen, L. Bao, L. Zhang, E. Jiang, Y. Zhao, A. Xu, T. K. Hei, and Z. Yu. 2007. “Constitutive Nitric Oxide Acting as a Possible Intercellular Signaling Molecule in the Initiation of Radiation-Induced DNA Double Strand Breaks in Non-Irradiated Bystander Cells.” Oncogene 26 (16): 2330–2339. doi:10.1038/sj.onc.1210024.
   PubMed Web of Science ®Google Scholar
• Hawkins, S. J., L. A. Crompton, A. Sood, M. Saunders, N. T. Boyle, A. Buckley, A. M. Minogue, et al. 2018. “Nanoparticle-Induced Neuronal Toxicity across Placental Barriers is Mediated by Autophagy and Dependent on Astrocytes.” Nature Nanotechnology 13 (5): 427–433. doi:10.1038/s41565-018-0085-3.
   PubMed Web of Science ®Google Scholar
• Hoefert, S., C. S. Hoefert, A. Munz, H. Northoff, A. Yuan, K. Reichenmiller, S. Reinert, and M. Grimm. 2016. “Altered Macrophagic THP-1 Cell Phagocytosis and Migration in Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ).” Clinical Oral Investigations 20 (5): 1043–1054. doi:10.1007/s00784-015-1584-3.
   PubMed Web of Science ®Google Scholar
• Huang, Z., B. Xu, X. Huang, Y. Zhang, M. Yu, X. Han, L. Song, et al. 2019. “Metabolomics Reveals the Role of Acetyl-l-Carnitine Metabolism in gamma-Fe2O3 NP-Induced Embryonic Development Toxicity via Mitochondria Damage.” Nanotoxicology 13 (2): 204–220. doi:10.1080/17435390.2018.1537411.
   PubMed Web of Science ®Google Scholar
• Jha, Abhishek K., Stanley C.-C. Huang, A. Sergushichev, V. Lampropoulou, Y. Ivanova, E. Loginicheva, K. Chmielewski, et al. 2015. “Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules That Regulate Macrophage Polarization.” Immunity 42 (3): 419–430. doi:10.1016/j.immuni.2015.02.005.
   PubMed Web of Science ®Google Scholar
• Ji, Zhaoxia, Xue Jin, Saji George, Tian Xia, Huan Meng, Xiang Wang, Elizabeth Suarez, et al. 2010. “Dispersion and Stability Optimization of TiO2 Nanoparticles in Cell Culture Media.” Environmental Science and Technology 44 (19): 7309–7314.,doi:10.1021/es100417s.
   PubMed Web of Science ®Google Scholar
• Jiang, Y., X. Chen, W. Tian, X. Yin, J. Wang, and H. Yang. 2014. “The Role of TGF-β1-miR-21-ROS pathway in bystander responses induced by irradiated non-small-cell lung cancer cells.” British Journal of Cancer 111 (4): 772–780. doi:10.1038/bjc.2014.368.
   PubMed Web of Science ®Google Scholar
• Jin, C., S. Wu, X. Lu, Q. Liu, L. Zhang, J. Yang, Q. Xi, and Y. Cai. 2012. “Conditioned Medium from Actinomycin D-Treated Apoptotic Cells Induces Mitochondria-Dependent Apoptosis in Bystander Cells.” Toxicology Letters 211 (1): 45–53. doi:10.1016/j.toxlet.2012.02.020.
   PubMed Web of Science ®Google Scholar
• Kalluri, R., and V. S. LeBleu. 2020. “The Biology, Function, and Biomedical Applications of Exosomes.” Science 367 (6478): eaau6977. doi:10.1126/science. aau6977.
   PubMed Web of Science ®Google Scholar
• Kirolikar, S., P. Prasannan, G. V. Raghuram, N. Pancholi, T. Saha, P. Tidke, P. Chaudhari, et al. 2018. “Prevention of Radiation-Induced Bystander Effects by Agents That Inactivate Cell-Free Chromatin Released from Irradiated Dying Cells.” Cell Death & Disease 9 (12): 1142. doi:10.1038/s41419-018-1181-x.
   PubMedGoogle Scholar
• Klein, S. G., T. Serchi, L. Hoffmann, B. Blömeke, and A. C. Gutleb. 2013. “An Improved 3D Tetraculture System Mimicking the Cellular Organisation at the Alveolar Barrier to Study the Potential Toxic Effects of Particles on the lung.” Particle and Fibre Toxicology 10: 31. doi:10.1186/1743-8977-10-31.
   PubMed Web of Science ®Google Scholar
• Kodali, V., M. H. Littke, S. C. Tilton, J. G. Teeguarden, L. Shi, C. W. Frevert, W. Wang, J. G. Pounds, and B. D. Thrall. 2013. “Dysregulation of Macrophage Activation Profiles by Engineered nanoparticles.” ACS Nano 7 (8): 6997–7010. doi:10.1021/nn402145t.
   PubMed Web of Science ®Google Scholar
• Li, R. B., L. M. Guiney, C. H. Chang, N. D. Mansukhani, Z. X. Ji, X. Wang, Y. P. Liao, et al. 2018. “Surface Oxidation of Graphene Oxide Determines Membrane Damage, Lipid Peroxidation, and Cytotoxicity in Macrophages in a Pulmonary Toxicity Model.” ACS Nano 12 (2): 1390–1402. doi:10.1021/acsnano.7b07737.
   PubMed Web of Science ®Google Scholar
• Lim, S. L., C. T. Ng, L. Zou, Y. Lu, J. Chen, B. H. Bay, H.-M. Shen, and C. N. Ong. 2019. “Targeted Metabolomics Reveals Differential Biological Effects of Nanoplastics and nanoZnO in Human Lung Cells.” Nanotoxicology 13 (8): 1117–1132. doi:10.1080/17435390.2019.1640913.
   PubMed Web of Science ®Google Scholar
• Lindeque, J. Z., A. Matthyser, S. Mason, R. Louw, and C. J. F. Taute. 2018. “Metabolomics Reveals the Depletion of Intracellular Metabolites in HepG2 Cells after Treatment with Gold Nanoparticles.” Nanotoxicology 12 (3): 251–262. doi:10.1080/17435390.2018.1432779.
   PubMed Web of Science ®Google Scholar
• Liu, T., C. Wang, X. Gu, H. Gong, L. Cheng, X. Shi, L. Feng, B. Sun, and Z. Liu. 2014. “Drug Delivery with PEGylated MoS2 nano-sheets for combined photothermal and chemotherapy of cancer.” Advanced Materials 26 (21): 3433–3440. doi:10.1002/adma.201305256.
   PubMed Web of Science ®Google Scholar
• Mahler, B., V. Hoepfner, K. Liao, and G. A. Ozin. 2014. “Colloidal Synthesis of 1T-WS2 and 2H-WS2 Nanosheets: applications for Photocatalytic Hydrogen Evolution.” Journal of the American Chemical Society 136 (40): 14121–14127. doi:10.1021/ja506261t.
   PubMed Web of Science ®Google Scholar
• Mathieu, M.,. L. Martin-Jaular, G. Lavieu, and C. Théry. 2019. “Specificities of Secretion and Uptake of Exosomes and Other Extracellular Vesicles for Cell-to-Cell Communication.” Nature Cell Biology 21 (1): 9–17. doi:10.1038/s41556-018-0250-9.
   PubMed Web of Science ®Google Scholar
• Mo, J. B., Q. Y. Xie, W. Wei, and J. Zhao. 2018. “Revealing the Immune Perturbation of Black Phosphorus Nanomaterials to Macrophages by Understanding the Protein Corona.” Nature Communications 9 (1): 2480doi:10.1038/s41467-018-04873-7.
   PubMed Web of Science ®Google Scholar
• Mo, L.J., M. Song, Q.H. Huang, H. Guan, X.D. Liu, D.F. Xie, B. Huang, R.X. Huang, and P.K. Zhou. 2018. “Exosome-packaged miR-1246 contributes to bystander DNA damage by targeting LIG4.” British Journal of Cancer 119 (4): 492–502. doi:10.1038/s41416-018-0192-9.
   PubMed Web of Science ®Google Scholar
• Mu, Q. X., G. B. Jiang, L. X. Chen, H. Y. Zhou, D. Fourches, A. Tropsha, and B. Yan. 2014. “Chemical Basis of Interactions between Engineered Nanoparticles and Biological Systems.” Chemical Reviews 114 (15): 7740–7781. doi:10.1021/cr400295a.
   PubMed Web of Science ®Google Scholar
• Murray, Peter J., Judith E. Allen, Subhra K. Biswas, Edward A. Fisher, Derek W. Gilroy, Sergij Goerdt, Siamon Gordon, et al. 2014. “Macrophage Activation and Polarization: nomenclature and Experimental Guidelines.” Immunity 41 (1): 14–20. doi:10.1016/j.immuni.2014.06.008.
   PubMed Web of Science ®Google Scholar
• Ng, C. T., L. Y. L. Yung, H. L. F. Swa, R. W. Y. Poh, J. Gunaratne, and B. H. Bay. 2015. “Altered Protein Expression Profile Associated with Phenotypic Changes in Lung Fibroblasts co-Cultured with Gold Nanoparticle-Treated Small Airway Epithelial Cells.” Biomaterials 39: 31–38. doi:10.1016/j.biomaterials.2014.10.063.
   PubMed Web of Science ®Google Scholar
• O'Neill, L. A. J., R. J. Kishton, and J. Rathmell. 2016. “A Guide to Immunometabolism for Immunologists.” Nature Reviews. Immunology 16 (9): 553–565. doi:10.1038/nri.2016.70.
   PubMed Web of Science ®Google Scholar
• Pei, H., W. Hu, Z. Guo, H. Chen, J. Ma, W. Mao, B. Li, et al. 2018. “Long Non-Coding RNA CRYBG3 Blocks Cytokinesis by Directly Binding G-Actin.” Cancer Research 78 (16): 4563–4572. doi:10.1158/0008-5472.CAN-18-0988.
   PubMed Web of Science ®Google Scholar
• Peng, Y., M. Zhang, L. Zheng, Q. Liang, H. Li, J.-T. Chen, H. Guo, et al. 2017. “Cysteine Protease Cathepsin B Mediates Radiation-Induced Bystander Effects.” Nature 547 (7664): 458–462. doi:10.1038/nature23284.
   PubMed Web of Science ®Google Scholar
• Poyer, F., C. D. Thomas, G. Garcia, A. Croisy, D. Carrez, P. Maillard, M. Lupu, and J. Mispelter. 2012. “PDT Induced Bystander Effect on Human Xenografted Colorectal Tumors as Evidenced by Sodium MRI.” Photodiagnosis and Photodynamic Therapy 9 (4): 303–309. doi:10.1016/j.pdpdt.2012.03.001.
   PubMed Web of Science ®Google Scholar
• Puchalska, P., X. Huang, S. E. Martin, X. Han, G. J. Patti, and P. A. Crawford. 2018. “Isotope Tracing Untargeted Metabolomics Reveals Macrophage Polarization-State-Specific Metabolic Coordination across Intracellular Compartments.” iScience 9: 298–313. doi:10.1016/j.isci.2018.10.029.
   PubMed Web of Science ®Google Scholar
• Purschke, M., H.-J. Laubach, R. Rox Anderson, and D. Manstein. 2010. “Thermal Injury Causes DNA Damage and Lethality in Unheated Surrounding Cells: active Thermal Bystander Effect.” Journal of Investigative Dermatology 130 (1): 86–92. doi:10.1038/jid.2009.205.
   PubMed Web of Science ®Google Scholar
• Qu, G., T. Xia, W. Zhou, X. Zhang, H. Zhang, L. Hu, J. Shi, X.-F. Yu, and G. Jiang. 2020. “ Property-Activity Relationship of Black Phosphorus at the Nano-Bio Interface: From Molecules to Organisms.” Chemical Reviews 120 (4): 2288–2346. doi:10.1021/acs.chemrev.9b00445.
   PubMed Web of Science ®Google Scholar
• Rougerie, P., V. Miskolci, and D. Cox. 2013. “Generation of Membrane Structures during Phagocytosis and Chemotaxis of Macrophages: role and Regulation of the Actin Cytoskeleton.” Immunological Reviews 256 (1): 222–239. doi:10.1111/imr.12118.
   PubMed Web of Science ®Google Scholar
• Selvaraj, V., N. Nepal, S. Rogers, N. D. P. K. Manne, R. Arvapalli, K. M. Rice, S. Asano, et al. 2015. “Inhibition of MAP Kinase/NF-kB Mediated Signaling and Attenuation of Lipopolysaccharide Induced Severe Sepsis by Cerium Oxide Nanoparticles.” Biomaterials 59: 160–171. doi:10.1016/j.biomaterials.2015.04.025.
   PubMed Web of Science ®Google Scholar
• Shao, C., M. Folkard, and K. M. Prise. 2008. “Role of TGF-beta1 and Nitric Oxide in the Bystander Response of Irradiated Glioma Cells.” Oncogene 27 (4): 434–440. doi:10.1038/sj.onc.1210653.
   PubMed Web of Science ®Google Scholar
• Song, M. L., T. Liu, C. R. Shi, X. Z. Zhang, and X. Y. Chen. 2016. “Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia.” ACS Nano 10 (1): 633–647. doi:10.1021/acsnano.5b06779.
   PubMed Web of Science ®Google Scholar
• Sood, A., S. Salih, D. Roh, L. Lacharme-Lora, M. Parry, B. Hardiman, R. Keehan, et al. 2011. “Signalling of DNA Damage and Cytokines across Cell Barriers Exposed to Nanoparticles Depends on Barrier Thickness.” Nature Nanotechnology 6 (12): 824–833. doi:10.1038/Nnano.2011.188.
   PubMed Web of Science ®Google Scholar
• Sun, L., Y. Ying, H. Huang, Z. Song, Y. Mao, Z. Xu, and X. Peng. 2014. “Ultrafast Molecule Separation through Layered WS(2) nanosheet membranes.” ACS Nano 8 (6): 6304–6311. doi:10.1021/nn501786m.
   PubMed Web of Science ®Google Scholar
• Sun, S.-C. 2017. “The Non-Canonical NF-κB Pathway in Immunity and Inflammation.” Nature Reviews. Immunology 17 (9): 545–558. doi:10.1038/nri.2017.52.
   PubMed Web of Science ®Google Scholar
• Thubagere, A., and B. M. Reinhard. 2010. “Nanoparticle-Induced Apoptosis Propagates through Hydrogen-Peroxide-Mediated Bystander Killing: insights from a Human Intestinal Epithelium in Vitro Model.” ACS Nano. 4 (7): 3611–3622. doi:10.1021/nn100389a.
   PubMed Web of Science ®Google Scholar
• Ventura, C., J. F. S. Pereira, P. Matos, B. Marques, P. Jordan, A. Sousa-Uva, and M. J. Silva. 2020. “Cytotoxicity and Genotoxicity of MWCNT-7 and Crocidolite: assessment in Alveolar Epithelial Cells versus Their Coculture with Monocyte-Derived Macrophages.” Nanotoxicology 14 (4): 479–503. doi:10.1080/17435390.2019.1695975.
   PubMed Web of Science ®Google Scholar
• Verma, N., and A. B. Tiku. 2017. “Significance and Nature of Bystander Responses Induced by Various Agents.” Mutation Research 773: 104–121. doi:10.1016/j.mrrev.2017.05.003.
   PubMed Web of Science ®Google Scholar
• Yin, Wenyan, Liang Yan, Jie Yu, Gan Tian, Liangjun Zhou, Xiaopeng Zheng, Xiao Zhang, et al. 2014. “High-Throughput Synthesis of Single-Layer MoS2 Nanosheets as a near-Infrared Photothermal-Triggered Drug Delivery for Effective Cancer Therapy.” ACS Nano 8 (7): 6922–6933. doi:10.1021/nn501647j.
   PubMed Web of Science ®Google Scholar
• Yuan, P., Q. Zhou, and X. Hu. 2018. “The Phases of WS2 Nanosheets Influence Uptake, Oxidative Stress, Lipid Peroxidation, Membrane Damage, and Metabolism in Algae.” Environmental Science and Technology 52 (22): 13543–13552. doi:10.1021/acs.est.8b04444.
   PubMed Web of Science ®Google Scholar
• Yuan, P., Q. Zhou, and X. Hu. 2020. “WS2 Nanosheets at Noncytotoxic Concentrations Enhance the Cytotoxicity of Organic Pollutants by Disturbing the Plasma Membrane and Efflux Pumps.” Environmental Science and Technology 54 (3): 1698–1709. doi:10.1021/acs.est.9b05537.
   PubMed Web of Science ®Google Scholar
• Zanganeh, S., G. Hutter, R. Spitler, O. Lenkov, M. Mahmoudi, A. Shaw, J. S. Pajarinen, et al. 2016. “Iron Oxide Nanoparticles Inhibit Tumour Growth by Inducing Pro-Inflammatory Macrophage Polarization in Tumour Tissues.” Nature Nanotechnology 11 (11): 986–994. doi:10.1038/Nnano.2016.168.
   PubMed Web of Science ®Google Scholar
• Zhang, F., H. S. Wang, X. F. Wang, G. M. Jiang, H. Liu, G. Zhang, H. Wang, et al. 2016. “ TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a pro-inflammatory phenotype.” Oncotarget 7 (32): 52294–52306. doi:10.18632/oncotarget.10561.
   PubMedGoogle Scholar
• Zhang, H., X. Shao, H. Zhao, X. Li, J. Wei, C. Yang, and Z. Cai. 2019. “Integration of Metabolomics and Lipidomics Reveals Metabolic Mechanisms of Triclosan-Induced Toxicity in Human Hepatocytes.” Environmental Science and Technology 53 (9): 5406–5415. doi:10.1021/acs.est.8b07281.
   PubMed Web of Science ®Google Scholar
• Zheng, D. W., Q. Lei, J. Y. Zhu, J. X. Fan, C. X. Li, C. Li, Z. S. Xu, S. X. Cheng, and X. Z. Zhang. 2017. “Switching Apoptosis to Ferroptosis: metal-Organic Network for High-Efficiency Anticancer Therapy.” Nano Letters 17 (1): 284–291. doi:10.1021/acs.nanolett.6b04060.
   PubMed Web of Science ®Google Scholar
• Zhou, Q., Z. Yue, Q. Li, R. Zhou, and L. Liu. 2019. “Exposure to PbSe Nanoparticles and Male Reproductive Damage in a Rat Model.” Environmental Science and Technology 53 (22): 13408–13416. doi:10.1021/acs.est.9b03581.
   PubMed Web of Science ®Google Scholar
• Zhu, X. B., X. Y. Ji, N. Kong, Y. H. Chen, M. Mahmoudi, X. D. Xu, L. Ding, et al. 2018. “Intracellular Mechanistic Understanding of 2D MoS2 Nanosheets for anti-Exocytosis-Enhanced Synergistic Cancer Therapy.” ACS Nano 12 (3): 2922–2938. doi:10.1021/acsnano.8b00516.
   PubMed Web of Science ®Google Scholar