Acute exposure to C60 fullerene damages pulmonary mitochondrial function and mechanics

References

• Anjilvel, S., and B. Asgharian. 1995. “A Multiple-Path Model of Particle Deposition in the Rat Lung.” Fundamental and Applied Toxicology 28 (1): 41–50. doi:10.1006/faat.1995.1144.
   PubMedGoogle Scholar
• Anseth, J. W., A. J. Goffin, G. G. Fuller, A. J. Ghio, P. N. Kao, and D. Upadhyay. 2005. “Lung Surfactant Gelation Induced by Epithelial Cells Exposed to Air Pollution or Oxidative Stress.” American Journal of Respiratory Cell and Molecular Biology 33 (2): 161–168. doi:10.1165/rcmb.2004-0365OC.
   PubMed Web of Science ®Google Scholar
• Arick, D. Q., Y. H. Choi, H. C. Kim, and Y.-Y. Won. 2015. “Effects of Nanoparticles on the Mechanical Functioning of the Lung.” Advances in Colloid and Interface Science 225: 218–228. doi:10.1016/j.cis.2015.10.002.
   PubMed Web of Science ®Google Scholar
• Baker, G. L., A. Gupta, M. L. Clark, B. R. Valenzuela, L. M. Staska, S. J. Harbo, J. T. Pierce, and J. A. Dill. 2008. “Inhalation Toxicity and Lung Toxicokinetics of C60 Fullerene Nanoparticles and Microparticles.” Toxicological Sciences 101 (1): 122–131. doi:10.1093/toxsci/kfm243.
   PubMed Web of Science ®Google Scholar
• Barnoud, J., L. Urbini, and L. Monticelli. 2015. “C60 Fullerene Promotes Lung Monolayer Collapse.” Journal of the Royal Society, Interface 12 (104): 20140931. doi:10.1098/rsif.2014.0931.
   PubMed Web of Science ®Google Scholar
• Bedrov, D., G. D. Smith, H. Davande, and L. Li. 2008. “Passive Transport of C60 Fullerenes Through a Lipid Membrane: A Molecular Dynamics Simulation Study.” Journal of Physical Chemistry B 112 (7): 2078–2084. doi:10.1021/jp075149c.
   PubMed Web of Science ®Google Scholar
• Botelho, Danielle J., Bey Fen Leo, Christopher B. Massa, Srijata Sarkar, Terry D. Tetley, Kian Fan Chung, Shu Chen, et al. 2016. “Low-Dose AgNPs Reduce Lung Mechanical Function and Innate Immune Defense in the Absence of Cellular Toxicity.” Nanotoxicology 10 (1): 118–127. doi:10.3109/17435390.2015.1038330.
   PubMed Web of Science ®Google Scholar
• Buzea, C., I. I. Pacheco, and K. Robbie. 2007. “Nanomaterials and Nanoparticles: Sources and Toxicity.” Biointerphases 2 (4): MR17–MR71. doi:10.1116/1.2815690.
   PubMed Web of Science ®Google Scholar
• Carvalho, Giovanna Marcella Cavalcante, Lilian Katiê da Silva Nagato, Sheila da Silva Fagundes, Flávia Brandão Dos Santos, Andrea Surrage Calheiros, Olaf Malm, Patricia Torres Bozza, et al. 2014. “Time Course of Pulmonary Burden in Mice Exposed to Residual Oil Fly Ash.” Frontiers in Physiology 5: 366. doi:10.3389/fphys.2014.00366.
   PubMed Web of Science ®Google Scholar
• Chen, Qun, Ningning Wang, Mingjiang Zhu, Jianhong Lu, Huiqin Zhong, Xinli Xue, Shuoyuan Guo, et al. 2018. “TiO2 Nanoparticles Cause Mitochondrial Dysfunction, Activate Inflammatory Responses, and Attenuate Phagocytosis in Macrophages: A Proteomic and Metabolomic insight.” Redox Biology 15: 266–276. doi:10.1016/j.redox.2017.12.011.
   PubMed Web of Science ®Google Scholar
• Chiu, C.-C., W. Shinoda, R. H. Devane, and S. O. Nielsen. 2012. “Effects of Spherical Fullerene Nanoparticles on a Dipalmitoyl Phosphatidylcholine Lipid Monolayer: A Coarse Grain Molecular Dynamics Approach.” Soft Matter. 8 (37): 9610–9616. doi:10.1039/c2sm26357b.
   Web of Science ®Google Scholar
• Costa, C. S., J. V. V. Ronconi, J. F. Daufenbach, C. L. Gonçalves, G. T. Rezin, E. L. Streck, and M. M. Da Silva Paula. 2010. “In Vitro Effects of Silver Nanoparticles on the Mitochondrial Respiratory Chain.” Molecular and Cellular Biochemistry 342 (1-2): 51–56. doi:10.1007/s11010-010-0467-9.
   PubMed Web of Science ®Google Scholar
• Delgado-Buenrostro, N. L., V. Freyre-Fonseca, C. M. G. Cuéllar, Y. Sánchez-Pérez, E. B. Gutierrez-Cirlos, T. Cabellos-Avelar, M. Orozco-Ibarra, J. Pedraza-Chaverri, and Y. I. Chirino. 2013. “Decrease in Respiratory Function and Electron Transport Chain Induced by Airborne Particulate Matter (PM10) Exposure in Lung Mitochondria.” Toxicologic Pathology 41 (4): 628–638. doi:10.1177/0192623312463784.
   PubMed Web of Science ®Google Scholar
• Dong, P., J. H. Li, S. P. Xu, X. J. Wu, X. Xiang, Q. Q. Yang, J. C. Jin, Y. Liu, and F. L. Jiang. 2016. “Mitochondrial Dysfunction Induced by Ultra-Small Silver Nanoclusters with a Distinct Toxic Mechanism.” Journal of Hazardous Materials 308: 139–148. doi:10.1016/j.jhazmat.2016.01.017.
   PubMed Web of Science ®Google Scholar
• Ema, Makoto, Jin Tanaka, Norihiro Kobayashi, Masato Naya, Shigehisa Endoh, Junko Maru, Masayo Hosoi, et al. 2012. “Genotoxicity Evaluation of Fullerene C60 Nanoparticles in a Comet Assay Using Lung Cells of Intratracheally Instilled Rats.” Regulatory Toxicology and Pharmacology 62 (3): 419–424. doi:10.1016/j.yrtph.2012.01.003.
   PubMed Web of Science ®Google Scholar
• Fresta, C. G., A. Chakraborty, M. B. Wijesinghe, A. M. Amorini, G. Lazzarino, G. Lazzarino, B. Tavazzi, et al. 2018. “Non-Toxic Engineered Carbon Nanodiamond Concentrations Induce Oxidative/Nitrosative Stress, Imbalance of Energy Metabolism, and Mitochondrial Dysfunction in Microglial and Alveolar Basal Epithelial Cells.” Cell Death & Disease 9 (2): 245. doi:10.1038/s41419-018-0280-z.
   PubMed Web of Science ®Google Scholar
• Freyre-Fonseca, V., N. L. Delgado-Buenrostro, E. B. Gutiérrez-Cirlos, C. M. Calderón-Torres, T. Cabellos-Avelar, Y. Sánchez-Pérez, E. Pinzón, I. Torres, E. Molina-Jijón, and C. Zazueta. 2011. “Titanium Dioxide Nanoparticles Impair Lung Mitochondrial Function.” Toxicology Letters 202 (2): 111–119. doi:10.1016/j.toxlet.2011.01.025.
   PubMed Web of Science ®Google Scholar
• Goodman, G.,. M. E. Gershwin, and D. Bercovich. 2012. “Fullerene and the Origin of Life.” Israel Medical Association Journal 14: 602–606.
   PubMed Web of Science ®Google Scholar
• Gredilla, A., S. F.-O. De Vallejuelo, A. Rodriguez-Iruretagoiena, L. Gomez, M. L. Oliveira, G. Arana, A. De Diego, J. M. Madariaga, and L. F. Silva. 2019. “Evidence of Mercury Sequestration by Carbon Nanotubes and Nanominerals Present in Agricultural Soils from a Coal Fired Power Plant Exhaust.” Journal of Hazardous Materials 378: 120747. doi:10.1016/j.jhazmat.2019.120747.
   PubMed Web of Science ®Google Scholar
• Hantos, Z., A. Adamicza, E. Govaerts, and B. Daroczy. 1992. “Mechanical Impedances of Lungs and Chest Wall in the Cat.” Journal of Applied Physiology 73 (2): 427–433. doi:10.1152/jappl.1992.73.2.427.
   PubMed Web of Science ®Google Scholar
• He, X. C., M. Lin, F. Li, B. Y. Sha, F. Xu, Z. G. Qu, and L. Wang. 2015. “Advances in Studies of Nanoparticle-Biomembrane Interactions.” Nanomedicine (London, England) 10 (1): 121–141. doi:10.2217/nnm.14.167.
   PubMed Web of Science ®Google Scholar
• Hendren, Christine Ogilvie, Xavier Mesnard, Jocelyn Dröge, and Mark R. Wiesner. 2011. “Estimating Production Data for Five Engineered Nanomaterials as a Basis for Exposure Assessment.” Environmental Science & Technology 45 (7): 2562–2569. doi:10.1021/es103300g.
   PubMed Web of Science ®Google Scholar
• Hogeboom, G. H., W. C. Schneider, and G. E. Pallade. 1948. “Cytochemical Studies of Mammalian Tissues I. Isolation of Intact Mitochondria from Rat Liver; Some Biochemical Properties of Mitochondria and Submicroscopic Particulate Material.” Journal of Biological Chemistry 172: 619–635.
   PubMed Web of Science ®Google Scholar
• Inoue, H., A. Shimada, T. Kaewamatawong, M. Naota, T. Morita, Y. Ohta, K. Inoue, and H. Takano. 2009. “Ultrastructural Changes of the Air-Blood Barrier in Mice After Intratracheal Instillation of Lipopolysaccharide and Ultrafine Carbon Black Particles.” Experimental and Toxicologic Pathology 61 (1): 51–58. doi:10.1016/j.etp.2007.10.001.
   PubMedGoogle Scholar
• Jacobsen, N. R., G. Pojana, P. White, P. Møller, C. A. Cohn, K. Smith Korsholm, U. Vogel, A. Marcomini, S. Loft, and H. Wallin. 2008. “Genotoxicity, Cytotoxicity, and Reactive Oxygen Species Induced by Single-Walled Carbon Nanotubes and C(60) Fullerenes in the FE1-MutaMouse Lung Epithelial Cells.” Environmental and Molecular Mutagenesis 49 (6): 476–487. doi:10.1002/em.20406.
   PubMed Web of Science ®Google Scholar
• Kirkham, P. A., and P. J. Barnes. 2013. “Oxidative Stress in COPD.” Chest 144 (1): 266–273. doi:10.1378/chest.12-2664.
   PubMed Web of Science ®Google Scholar
• Kroto, H. W., J. R. Heath, S. C. O’Brien, R. F. Curl, and R. E. Smalley. 1985. “C60: Buckminsterfullerene.” Nature 318 (6042): 162–163. doi:10.1038/318162a0.
   Web of Science ®Google Scholar
• Laks, D., R. De Oliveira, P. De André, M. Macchione, M. Lemos, D. Faffe, P. H. Saldiva, and W. A. Zin. 2008. “Composition of Diesel Particles Influences Acute Pulmonary Toxicity: An Experimental Study in Mice.” Inhalation Toxicology 20 (11): 1037–1042. doi:10.1080/08958370802112922.
   PubMed Web of Science ®Google Scholar
• Lao, X., S. Chen, Y. Dai, and Y. Song. 2014. “Cellular Stress Response and Pulmonary Inflammation.” Microbes and Infection 16 (10): 871–876. doi:10.1016/j.micinf.2014.08.007.
   PubMed Web of Science ®Google Scholar
• Lee, C. M., S. T. Huang, S. H. Huang, H. W. Lin, H. P. Tsai, J. Y. Wu, C. M. Lin, and C. T. Chen. 2011. “C60 Fullerene-Pentoxifylline Dyad Nanoparticles Enhance Autophagy to Avoid Cytotoxic Effects Caused by the β-Amyloid Peptide.” Nanomedicine: Nanotechnology, Biology, and Medicine 7 (1): 107–114. doi:10.1016/j.nano.2010.06.009.
   PubMed Web of Science ®Google Scholar
• Li, J., Y. Zhang, Q. Xiao, F. Tian, X. Liu, R. Li, G. Zhao, F. Jiang, and Y. Liu. 2011. “Mitochondria as Target of Quantum Dots Toxicity.” Journal of Hazardous Materials 194: 440–444. doi:10.1016/j.jhazmat.2011.07.113.
   PubMed Web of Science ®Google Scholar
• Liu, C., P. Elvati, S. Majumder, Y. Wang, A. Liu, and A. Violi. 2019. “Predicting the Time of Entry of Nanoparticles in Cellular Membranes.” ACSNano 13 (9): 10221–10232. doi:10.1021/acsnano.9b03434.
   Google Scholar
• Liu, Y., G. Fiskum, and D. Schubert. 2002. “Generation of Reactive Oxygen Species by the Mitochondrial Electron Transport Chain.” Journal of Neurochemistry 80 (5): 780–787. doi:10.1046/j.0022-3042.2002.00744.x.
   PubMed Web of Science ®Google Scholar
• Maciel, L., D. F. De Oliveira, G. Monnerat, A. C. Campos De Carvalho, and J. H. M. Nascimento. 2020. “Exogenous 10 kDa-Heat Shock Protein Preserves Mitochondrial Function after Hypoxia/Reoxygenation.” Frontiers in Pharmacology 11. doi:10.3389/fphar.2020.00545.
   PubMed Web of Science ®Google Scholar
• Mazzoli-Rocha, F., G. M. Carvalho, M. Lanzetti, S. S. Valença, L. F. Silva, P. H. Saldiva, W. A. Zin, and D. S. Faffe. 2014. “Respiratory Toxicity of Repeated Exposure to Particles Produced by Traffic and Sugar Cane Burning.” Respiratory Physiology & Neurobiology 191: 106–113. doi:10.1016/j.resp.2013.11.004.
   PubMed Web of Science ®Google Scholar
• Moreno‐Sánchez, R.,  Hernández‐Esquivel, L. Rivero‐Segura, N. A. Marín‐Hernández, A. Neuzil, J. Ralph, and S. J. Rodríguez‐Enríquez. 2013. “Reactive Oxygen Species Are Generated by the Respiratory Complex II-Evidence for Lack of Contribution of the Reverse Electron Flow in Complex I.” FEBS Journal 280 (3): 927–938. doi:10.1111/febs.12086.
   PubMed Web of Science ®Google Scholar
• Moreno, A. J., T. L. Serafim, P. J. Oliveira, and V. M. Madeira. 2007. “Inhibition of Mitochondrial Bioenergetics by Carbaryl is Only Evident for Higher concentrations - Relevance for Carbaryl Toxicity Mechanisms.” Chemosphere 66 (3): 404–411. doi:10.1016/j.chemosphere.2006.06.030.
   PubMed Web of Science ®Google Scholar
• Oliveira, M. L., K. Da Boit, I. L. Schneider, E. C. Teixeira, T. J. C. Borrero, and L. F. Silva. 2018. “Study of Coal Cleaning Rejects by FIB and Sample Preparation for HR-TEM: Mineral Surface Chemistry and Nanoparticle-Aggregation Control for Health Studies.” Journal of Cleaner Production 188: 662–669. doi:10.1016/j.jclepro.2018.04.050.
   Web of Science ®Google Scholar
• Park, E.-J., H. Kim, Y. Kim, J. Yi, K. Choi, and K. Park. 2010. “Carbon Fullerenes (C60s) Can Induce Inflammatory Responses in the Lung of Mice.” Toxicology and Applied Pharmacology 244 (2): 226–233. doi:10.1016/j.taap.2009.12.036.
   PubMed Web of Science ®Google Scholar
• Pinheiro, F. G., M. D. Moreira-Gomes, M. N. Machado, T. dos Santos Almeida, P. D. P. A. Barboza, L. F. S. Oliveira, F. S. Á. Cavalcante, J. H. Leal-Cardoso, R. S. Fortunato, and W. A. Zin. 2021. “Eugenol Mitigated Acute Lung but Not Spermatic Toxicity of C60 Fullerene Emulsion in Mice.” Environmental Pollution 269: 116188. doi:10.1016/j.envpol.2020.116188.
   PubMed Web of Science ®Google Scholar
• Quinlan, C. L., A. L. Orr, I. V. Perevoshchikova, J. R. Treberg, B. A. Ackrell, and M. D. Brand. 2012. “Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions.” Journal of Biological Chemistry 287 (32): 27255–27264. doi:10.1074/jbc.M112.374629.
   PubMed Web of Science ®Google Scholar
• Rattanapinyopituk, K., A. Shimada, T. Morita, M. Togawa, T. Hasegawa, Y. Seko, K. Inoue, and H. Takano. 2013. “Ultrastructural Changes in the Air-Blood Barrier in Mice After Intratracheal Instillations of Asian Sand Dust and Gold Nanoparticles.” Experimental and Toxicologic Pathology 65 (7-8): 1043–1051. doi:10.1016/j.etp.2013.03.003.
   PubMedGoogle Scholar
• Riva, D., C. Magalhaes, A. A. Lopes, T. Lancas, T. Mauad, O. Malm, S. Valenca, P. Saldiva, D. Faffe, and W. Zin. 2011. “Low Dose of Fine Particulate Matter (PM2.5) Can Induce Acute Oxidative Stress, Inflammation and Pulmonary Impairment in Healthy Mice.” Inhalation Toxicology 23 (5): 257–267. doi:10.3109/08958378.2011.566290.
   PubMed Web of Science ®Google Scholar
• Saldiva, P., W. Zin, R. Santos, D. Eidelman, and J. Milic-Emili. 1992. “Alveolar Pressure Measurement in Open-Chest Rats.” Journal of Applied Physiology 72 (1): 302–306. doi:10.1152/jappl.1992.72.1.302.
   PubMed Web of Science ®Google Scholar
• Sanchez, F., and K. Sobolev. 2010. “Nanotechnology in Concrete–A Review.” Construction and Building Materials 24 (11): 2060–2071. doi:10.1016/j.conbuildmat.2010.03.014.
   Web of Science ®Google Scholar
• Sanchís, J., D. Božović, N. A. Al-Harbi, L. F. Silva, M. Farré, and D. Barceló. 2013. “Quantitative Trace Analysis of Fullerenes in River Sediment from Spain and Soils from Saudi Arabia.” Analytical and Bioanalytical Chemistry 405 (18): 5915–5923. doi:10.1007/s00216-013-6924-z.
   PubMed Web of Science ®Google Scholar
• Santos, S. M., A. M. Dinis, F. Peixoto, L. Ferreira, A. S. Jurado, and R. A. Videira. 2014. “Interaction of Fullerene Nanoparticles with Biomembranes: From the Partition in Lipid Membranes to Effects on Mitochondrial Bioenergetics.” Toxicological Sciences 138 (1): 117–129. doi:10.1093/toxsci/kft327.
   PubMed Web of Science ®Google Scholar
• Santos, L. J., G. P. Rocha, R. B. Alves, and R. P. De Freitas. 2010. “Fullerene C-60: Chemistry and Applications.” Química Nova 33 (3): 680–693. doi:10.1590/S0100-40422010000300036.
   Web of Science ®Google Scholar
• Sayers, Brian C., Nigel J. Walker, Joseph H. Roycroft, Dori R. Germolec, Gregory L. Baker, Mark L. Clark, Barry K. Hayden, et al. 2016. “Lung Deposition and Clearance of Microparticle and Nanoparticle C60 Fullerene Aggregates in B6C3F1 Mice and Wistar Han Rats Following Nose-Only Inhalation for 13 Weeks.” Toxicology 339: 87–96. doi:10.1016/j.tox.2015.11.003.
   PubMed Web of Science ®Google Scholar
• Seiffert, Joanna, Farhana Hussain, Coen Wiegman, Feng Li, Leo Bey, Warren Baker, Alexandra Porter, et al. 2015. “Pulmonary Toxicity of Instilled Silver Nanoparticles: influence of Size, Coating and Rat Strain.” PloS One 10 (3): e0119726. doi:1371/journal.pone.0119726.
   PubMed Web of Science ®Google Scholar
• Shinohara, N., M. Gamo, and J. Nakanishi. 2011. “Fullerene C60: inhalation Hazard Assessment and Derivation of a Period-Limited Acceptable Exposure Level.” Toxicological Sciences 123 (2): 576–589. doi:10.1093/toxsci/kfr192.
   PubMed Web of Science ®Google Scholar
• Spinelli, J. B., and M. C. Haigis. 2018. “The Multifaceted Contributions of Mitochondria to Cellular Metabolism.” Nature Cell Biology 20 (7): 745–754. doi:10.1038/s41556-018-0124-1.
   PubMed Web of Science ®Google Scholar
• Sumner, Susan C. J., Rodney W. Snyder, Christopher Wingard, Ninell P. Mortensen, Nathan A. Holland, Jonathan H. Shannahan, Suraj Dhungana, et al. 2015. “Distribution and Biomarkers of Carbon‐14‐Labeled Fullerene C60 ([14C (U)] C60) in Female Rats and Mice for up to 30 Days after Intravenous Exposure.” Journal of Applied Toxicology 35 (12): 1452–1464. doi:10.1002/jat.3110.
   PubMed Web of Science ®Google Scholar
• Tang, Y., F. Wang, C. Jin, H. Liang, X. Zhong, and Y. Yang. 2013. “Mitochondrial Injury Induced by Nanosized Titanium Dioxide in A549 Cells and Rats.” Environmental Toxicology and Pharmacology 36 (1): 66–72. doi:10.1016/j.etap.2013.03.006.
   PubMed Web of Science ®Google Scholar
• Teodoro, J. S., A. M. Simões, F. V. Duarte, A. P. Rolo, R. C. Murdoch, S. M. Hussain, and C. M. Palmeira. 2011. “Assessment of the Toxicity of Silver Nanoparticles in Vitro: A Mitochondrial Perspective.” Toxicology in Vitro 25 (3): 664–670. doi:10.1016/j.tiv.2011.01.004.
   PubMed Web of Science ®Google Scholar
• Toth, P. P., K. J. Sumerix, S. Ferguson-Miller, and C. H. Suelter. 1990. “Respiratory Control and ADP: O Coupling Ractions of Isolated Chick Heart Mitochondria.” Archives of Biochemistry and Biophysics 276 (1): 199–211. doi:10.1016/0003-9861(90)90027-V.
   PubMed Web of Science ®Google Scholar
• Utsunomiya, S., K. A. Jensen, G. J. Keeler, and R. C. Ewing. 2002. “Uraninite and Fullerene in Atmospheric Particulates.” Environmental Science & Technology 36 (23): 4943–4947. doi:10.1021/es025872a.
   PubMed Web of Science ®Google Scholar
• Van Der Toorn, M., D.-J. Slebos, H. G. De Bruin, H. G. Leuvenink, S. J. Bakker, R. O. Gans, G. H. Koëter, A. J. Van Oosterhout, and H. F. Kauffman. 2007. “Cigarette Smoke-Induced Blockade of the Mitochondrial Respiratory Chain Switches Lung Epithelial Cell Apoptosis into Necrosis.” American Journal of Physiology Lung Cellular and Molecular Physiology 292 (5): L1211–L1218. doi:10.1165/rcmb.2013-0505OC.
   PubMed Web of Science ®Google Scholar
• Weibel, E. R. 1990. “Morphometry: stereological Theory and Practical Methods.” In Models of Lung Disease-Microscopy and Structural Methods, edited by Gil, J.M.D, 199–247. New York: Marcel Dekker, Inc.
   Google Scholar
• Xu, Z. Q., Q. Q. Yang, J. Y. Lan, J. Q. Zhang, W. Peng, J. C. Jin, F. L. Jiang, and Y. Liu. 2016. “Interactions between Carbon Nanodots with Human Serum Albumin and γ-Globulins: The Effects on the Transportation Function.” Journal of Hazardous Materials 301: 242–249. doi:10.1016/j.jhazmat.2015.08.062.
   PubMed Web of Science ®Google Scholar
• Yang, L.-Y., J.-L. Gao, T. Gao, P. Dong, L. Ma, F.-L. Jiang, and Y. Liu. 2016. “Toxicity of Polyhydroxylated Fullerene to Mitochondria.” Journal of Hazardous Materials 301: 119–126. doi:10.1016/j.jhazmat.2015.08.046.
   PubMed Web of Science ®Google Scholar
• Zhou, R., A. S. Yazdi, P. Menu, and J. Tschopp. 2011. “A Role for Mitochondria in NLRP3 Inflammasome Activation.” Nature 469 (7329): 221–225. doi:10.1038/nature09663.
   PubMed Web of Science ®Google Scholar
• Zin, Walter A., Ana G. L. S. Silva, Clarissa B. Magalhães, Giovanna M. C. Carvalho, Douglas R. Riva, Crystianne C. Lima, Jose H. Leal-Cardoso, et al. 2012. “Eugenol Attenuates Pulmonary Damage Induced by Diesel Exhaust Particles.” Journal of Applied Physiology 112 (5): 911–917. doi:10.1152/japplphysiol.00764.2011.
   PubMed Web of Science ®Google Scholar