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Review Article

8-Hydroxy-2′-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage induced by occupational exposure to nanomaterials: a systematic review

ORCID Icon & ORCID Icon
Pages 850-864 | Received 28 Apr 2021, Accepted 24 May 2021, Published online: 25 Jun 2021

References

  • Agrawal, A., and M. Rasouli. 2019. "Creating Bibliographies Using EndNote." In EndNote 1-2-3 Easy! 211–276. Cham: Springer.
  • Akpinar-Elci, M., K. J. Stemple, P. L. Enright, J. V. Fahy, T. A. Bledsoe, K. Kreiss, and D. N. J. C. Weissman. 2005. Induced Sputum Evaluation in Microwave Popcorn Production Workers. Occupational and Environmental Lung Disease 128: 991–997.
  • An, Hongmei, Chunmei Ling, Mengchuan Xu, Mingjuan Hu, Haixia Wang, Jiaqing Liu, Guangling Song, and Jiaming Liu. 2020. “Oxidative Damage Induced by Nano-Titanium Dioxide in Rats and Mice: A Systematic Review and Meta-Analysis.” Biological Trace Element Research 194 (1): 184–202. doi:10.1007/s12011-019-01761-z.
  • Beard, John D., Aaron Erdely, Matthew M. Dahm, Marie A. de Perio, M. Eileen Birch, Douglas E. Evans, Joseph E. Fernback, et al. 2018. “Carbon Nanotube and Nanofiber Exposure and Sputum and Blood Biomarkers of Early Effect among US Workers.” Environment International 116: 214–228. doi:10.1016/j.envint.2018.04.004.
  • Bergamaschi, E., M. Gulumian, J. Kanno, and K. Savolainen. 2019. “Engineered Nanomaterials: Biomarkers of Exposure and Effect”. In Biomarkers in Toxicology. New York, NY: Elsevier.
  • Bláhová, Lucie, Zuzana Nováková, Zbyněk Večeřa, Lucie Vrlíková, Bohumil Dočekal, Jana Dumková, Kamil Křůmal, et al. 2020. “The Effects of Nano-Sized PbO on Biomarkers of Membrane Disruption and DNA Damage in a Sub-Chronic Inhalation Study on Mice.” Nanotoxicology 14 (2): 214–231. doi:10.1080/17435390.2019.1685696.
  • Boccuni, F., D. Gagliardi, R. Ferrante, B. M. Rondinone, and S. Iavicoli. 2017. “Measurement Techniques of Exposure to Nanomaterials in the Workplace for Low- and Medium-Income Countries: A Systematic Review.” International Journal of Hygiene and Environmental Health 220 (7): 1089–1097. doi:10.1016/j.ijheh.2017.06.003.
  • Brown, T. A., J. W. Lee, A. Holian, V. Porter, H. Fredriksen, M. Kim, and Y. H. Cho. 2016. “Alterations in DNA Methylation Corresponding with Lung Inflammation and as a Biomarker for Disease Development after MWCNT Exposure.” Nanotoxicology 10 (4): 453–461. doi:10.3109/17435390.2015.1078852.
  • Cadet, J., C. D'Ham, T. Douki, J.-P. Pouget, J.-L. Ravanat, and S. Sauvaigo. 1998. “Facts and Artifacts in the Measurement of Oxidative Base Damage to DNA.” Free Radical Research 29 (6): 541–550. doi:10.1080/10715769800300581.
  • Datz, F. L. 1994. “Indium-111-Labeled Leukocytes for the Detection of Infection: Current Status.” Seminars in Nuclear Medicine 24 (2): 92–109. doi:10.1016/S0001-2998(05)80225-9.
  • Djurišić, Aleksandra B., Yu Hang Leung, Alan M. C. Ng, Xiao Ying Xu, Patrick K. H. Lee, Natalie Degger, and R. S. S. Wu. 2015. “Toxicity of Metal Oxide Nanoparticles: Mechanisms, Characterization, and Avoiding Experimental Artefacts.” Small (Weinheim an Der Bergstrasse, Germany) 11 (1): 26–44. doi:10.1002/smll.201303947.
  • Downe‐Wamboldt, B. 1992. “Content Analysis: Method, Applications, and Issues.” Health Care for Women International 13 (3): 313–321. doi:10.1080/07399339209516006.
  • Du, H., X. Zhu, C. Fan, S. Xu, Y. Wang, and Y. Zhou. 2012. “Oxidative Damage and OGG1 Expression Induced by a Combined Effect of Titanium Dioxide Nanoparticles and Lead Acetate in Human Hepatocytes.” Environmental Toxicology 27 (10): 590–597. doi:10.1002/tox.20682.
  • Elsaesser, A., and C. V. Howard. 2012. “Toxicology of Nanoparticles.” Advanced Drug Delivery Reviews 64 (2): 129–137. doi:10.1016/j.addr.2011.09.001.
  • Fadeel, B., A. Pietroiusti, and A. A. Shvedova. 2017. Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health. London: Academic Press.
  • Fu, Peter P., Qingsu Xia, Huey-Min Hwang, Paresh C. Ray, and Hongtao Yu. 2014. “Mechanisms of Nanotoxicity: Generation of Reactive Oxygen Species.” Journal of Food and Drug Analysis 22 (1): 64–75. doi:10.1016/j.jfda.2014.01.005.
  • Ghafari, J., N. Moghadasi, and S. Omari Shekaftik. 2020. “Oxidative Stress Induced by Occupational Exposure to Nanomaterials: A Systematic Review.” Industrial Health 58 (6): 492–502. doi:10.2486/indhealth.2020-0073.
  • Goyer, R. A., and T. W. Clarkson. 1996. “Toxic Effects of Metals.” In Casarett & Doull’s Toxicology. The Basic Science of Poisons, Fifth Edition, edited by Klaassen, C.D., Vol. 23, 813–858. New York, NY: McGraw-Hill Health Professions Division.
  • Graczyk, H., N. Lewinski, J. Zhao, J.-J. Sauvain, G. Suarez, P. Wild, B. Danuser, and M. Riediker. 2015. “Increase in Oxidative Stress Levels following Welding Fume Inhalation: A Controlled Human Exposure Study.” Particle and Fibre Toxicology 13 (1): 1–14. doi:10.1186/s12989-016-0143-7.
  • Graczyk, H., N. Lewinski, J. Zhao, J. J. Sauvain, G. Suarez, P. Wild, B. Danuser, and M. Riediker. 2016. “Increase in Oxidative Stress Levels following Welding Fume Inhalation: A Controlled Human Exposure Study.” Particle and Fibre Toxicology 13:31.
  • Graille, M., P. Wild, J. Sauvain, M. Hemmendinger, I. G. Canu, and N. J. T. L. Hopf. 2020a. “Urinary 8-Isoprostane as a Biomarker for Oxidative Stress. A Systematic Review and Meta-Analysis.” Toxicology Letters 328: 19–27. doi:10.1016/j.toxlet.2020.04.006.
  • Graille, M., P. Wild, J.-J. Sauvain, M. Hemmendinger, I. Guseva Canu, and N. B. Hopf. 2020b. “Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis.” International Journal of Molecular Sciences 21 (11): 3743. doi:10.3390/ijms21113743.
  • Guyatt, G., A. D. Oxman, E. A. Akl, R. Kunz, G. Vist, J. Brozek, S. Norris, Y. Falck-Ytter, P. Glasziou, and H. Debeer. 2011. “GRADE Guidelines: 1. Introduction—GRADE Evidence Profiles and Summary of Findings Tables.” Journal of Clinical Epidemiology 64 (4): 383–394. doi:10.1016/j.jclinepi.2010.04.026.
  • Henderson, L. K., J. C. Craig, N. S. Willis, D. Tovey, and A. C. Webster. 2010. “How to Write a Cochrane Systematic Review.” Nephrology (Carlton, Vic.) 15 (6): 617–624. doi:10.1111/j.1440-1797.2010.01380.x.
  • Herzog, E., H. J. Byrne, M. Davoren, A. Casey, A. Duschl, and G. J. Oostingh. 2009. “Dispersion Medium Modulates Oxidative Stress Response of Human Lung Epithelial Cells upon Exposure to Carbon Nanomaterial Samples.” Toxicology and Applied Pharmacology 236 (3): 276–281. doi:10.1016/j.taap.2009.02.007.
  • Homma, S., A. Miyamoto, S. Sakamoto, K. Kishi, N. Motoi, and K. Yoshimura. 2005. “Pulmonary Fibrosis in an Individual Occupationally Exposed to Inhaled Indium-Tin Oxide.” European Respiratory Journal 25 (1): 200–204. doi:10.1183/09031936.04.10012704.
  • Homma, T., T. Ueno, K. Sekizawa, A. Tanaka, and M. Hirata. 2003. “Interstitial Pneumonia Developed in a Worker Dealing with Particles Containing Indium-Tin Oxide.” Journal of Occupational Health 45 (3): 137–139. doi:10.1539/joh.45.137.
  • Horie, M., H. Kato, and H. Iwahashi. 2013. “Cellular Effects of Manufactured Nanoparticles: Effect of Adsorption Ability of Nanoparticles.” Archives of Toxicology 87 (5): 771–781. doi:10.1007/s00204-013-1033-5.
  • Hurbánková, M., Hrašková, D. Marcišiaková, J. Kysucká, K. and Moricová. Š. 2015. “Nanoparticles from Welding and Their Effects on Health.” Pracovni Lekarstvi 67: 12–17.
  • INIC. 2018. “Iran's Contribution to the Global Nanotechnology Market.” Journal of Nanotechnology 252: 20.
  • Kasai, H. 2003. “A New Automated Method to Analyze Urinary 8-Hydroxydeoxyguanosine by a High-Performance Liquid Chromatography-Electrochemical Detector System.” Journal of Radiation Research 44 (2): 185–189. doi:10.1269/jrr.44.185.
  • Kasai, H., H. Hayami, Z. Yamaizumi, H. Saito, and S. Nishimura. 1984. “Detection and Identification of Mutagens and Carcinogens as Their Adducts with Guanosine Derivatives.” Nucleic Acids Research 12: 2127–2136.
  • Kasai, H., and S. Nishimura. 1984. “DNA Damage Induced by Asbestos in the Presence of Hydrogen Peroxide.” GANN Japanese Journal of Cancer Research 75 (10): 841–844.
  • Khatri, M., D. Bello, P. Gaines, J. Martin, A. K. Pal, R. Gore, and S. Woskie. 2013. “Nanoparticles from Photocopiers Induce Oxidative Stress and Upper Respiratory Tract Inflammation in Healthy Volunteers.” Nanotoxicology 7 (5): 1014–1027. doi:10.3109/17435390.2012.691998.
  • Kim, J. Y., S. Mukherjee, L. C. Ngo, and D. C. Christiani. 2004. “Urinary 8-Hydroxy-2'-Deoxyguanosine as a Biomarker of Oxidative DNA Damage in Workers Exposed to Fine Particulates.” Environmental Health Perspectives 112 (6): 666–671. doi:10.1289/ehp.6827.
  • Klaunig, J. E., and L. M. Kamendulis. 2004. “The Role of Oxidative Stress in Carcinogenesis.” Annual Review of Pharmacology and Toxicology 44: 239–267. doi:10.1146/annurev.pharmtox.44.101802.121851.
  • Lai, C., S. Liou, H. Lin, T. Shih, P. Tsai, J. Chen, T. Yang, J. Jaakkola, and P. Strickland. 2005. “Exposure to Traffic Exhausts and Oxidative DNA Damage.” Occupational and Environmental Medicine 62 (4): 216–222. doi:10.1136/oem.2004.015107.
  • Lee, N., C. H. Lim, T. Kim, E. K. Son, G. S. Chung, C. J. Rho, S. R. Lee, and I. J. J. G. W. H. O. Yu. 2017. Which Hazard Category Should Specific Nanomaterials or Groups of Nanomaterials be Assigned to and How. Geneva: WHO.
  • Liou, Saou-Hsing, Tsui-Chun Tsou, Shu-Li Wang, Lih-Ann Li, Hung-Che Chiang, Wan-Fen Li, Pin-Pin Lin, et al. 2012a. “Epidemiological Study of Health Hazards among Workers Handling Engineered Nanomaterials.” Journal of Nanoparticle Research 14 (8): 1–15. doi:10.1007/s11051-012-0878-5.
  • Liou, Saou-Hsing, Tsui-Chun Tsou, Shu-Li Wang, Lih-Ann Li, Hung-Che Chiang, Wan-Fen Li, Pin-Pin Lin, et al. 2012b. “Epidemiological Study of Health Hazards among Workers Handling Engineered Nanomaterials.” Journal of Nanoparticle Research 14 (8): 1–15. doi:10.1007/s11051-012-0878-5.
  • Liou, S.-H., W.-T. Wu, H.-Y. Liao, C.-Y. Chen, C.-Y. Tsai, W.-T. Jung, and H.-L. Lee. 2017. “Global DNA Methylation and Oxidative Stress Biomarkers in Workers Exposed to Metal Oxide Nanoparticles.” Journal of Hazardous Materials 331: 329–335. doi:10.1016/j.jhazmat.2017.02.042.
  • Maynard, A. D. J. N. N. 2015. “Navigating the Fourth Industrial Revolution.” Nature Nanotechnology 10 (12): 1005–1006. doi:10.1038/nnano.2015.286.
  • Mendoza, R. P., and J. M. Brown. 2019. “Engineered Nanomaterials and Oxidative Stress: Current Understanding and Future Challenges.” Current Opinion in Toxicology 13: 74–80. doi:10.1016/j.cotox.2018.09.001.
  • Morgan, Rebecca L., Kristina A. Thayer, Nancy Santesso, Alison C. Holloway, Robyn Blain, Sorina E. Eftim, Alexandra E. Goldstone, et al. 2019. “A Risk of Bias Instrument for Non-Randomized Studies of Exposures: A Users' Guide to Its Application in the Context of GRADE.” Environment International 122: 168–184. doi:10.1016/j.envint.2018.11.004.
  • Nasirzadeh, N., M. R. Azari, Y. Rasoulzadeh, and Y. Mohammadian. 2019. “An Assessment of the Cytotoxic Effects of Graphene Nanoparticles on the Epithelial Cells of the Human Lung.” Toxicology and Industrial Health 35 (1): 79–87. doi:10.1177/0748233718817180.
  • Nasirzadeh, N., Y. Mohammadian, and Y. Fakhri. 2020a. “Concentration and Cancer Risk Assessment of Asbestos in Middle East Countries: A Systematic Review-Meta-Analysis.” International Journal of Environmental Analytical Chemistry 7: 1–5
  • Nasirzadeh, N., Y. Rasoulzadeh, M. Rezazadeh Azari, and Y. Mohammadian. 2020b. “Cellular Toxicity of Multi-Walled Carbon Nanotubes on Human Lung Cells.” Journal of Chemical Health Risks 10: 135–144.
  • Ng, C.T., J.J. Li, B.-H. Bay, and L.-Y. Lanry Yung. 2010. “Current Studies into the Genotoxic Effects of Nanomaterials.” Journal of Nucleic Acids 2010: 947859.
  • Nilsson, R., R. Nordlinder, B. Moen, S. Øvrebø, K. Bleie, A. Skorve, B. Hollund, and C. Tagesson. 2004. “Increased Urinary Excretion of 8-Hydroxydeoxyguanosine in Engine Room Personnel Exposed to Polycyclic Aromatic Hydrocarbons.” Occupational and Environmental Medicine 61 (8): 692–696. doi:10.1136/oem.2003.007435.
  • Omari Shekaftik, S., A. Ashtarinezhad, F. H. Shirazi, A. Hosseini, and R. Yarahmadi. 2019a. “Assessing the Risk of Main Activities of Nanotechnology Companies by the NanoTool Method.” International Journal of Occupational Safety and Ergonomics 2020: 1–9.
  • Omari Shekaftik, S., A. Ashtarinezhad, R. Yarahmadi, M. Rasouli, M. Soleimani, and F. Hosseini Shirazi. 2020a. “Relationship between Chemical Composition and Physical State of Used Nanomaterials in Nanotechnology Companies with Type and Prevalence of Symptoms of Employees of These Companies in Tehran.” Iran. IOH 17: 1–12.
  • Omari Shekaftik, S., F. H. Shirazi, R. Yarahmadi, M. Rasouli, M. Solaymani Dodaran, and A. Ashtarinezhad. 2019b. Exploratory Study of Nanoworkers’ Symptoms & Work-Relatedness of These Symptoms. MSc. Iran: Iran University of Medical Sciences.
  • Omari Shekaftik, S., Shirazi, H. F., Yarahmadi, R. Rasouli, M., and Ashtarinezhad A. 2020b. “Investigating the Relationship between Occupational Exposure to Nanomaterials and Symptoms of Nanotechnology Companies' Employees.” Archives of Environmental & Occupational Health 16: 1–1
  • Omari Shekaftik, S., R. Yarahmadi, N. Moghadasi, Z. Sedghi Noushabadi, A. F. Hosseini, and A. Ashtarinezhad. 2020c. “Investigation of Recommended Good Practices to Reduce Exposure to Nanomaterials in Nanotechnology Laboratories in Tehran.” Journal of Nanoparticle Research 22 (3): 59. doi:10.1007/s11051-020-4764-2.
  • Pelclova, D., V. Zdimal, Z. Fenclova, S. Vlckova, J. Schwarz, J. Pusman, N. Zikova, K. Syslova, M. Kuzma, and T. Navratil. 2012a. Markers of oxidative stress are elevated in workers exposed to nanoparticles. Proceedings of the 4th International Conference on NANOCON, 23–25.
  • Pelclova, D., V. Zdimal, Z. Fenclova, S. Vlckova, J. Schwarz, J. Pusman, N. Zikova, K. Syslova, M. Kuzma, and T. Navratil, S. Zakharov, and P. Kacer. 2012b. Markers of oxidative stress are elevated in workers exposed to nanoparticles. NANOCON 2012 – Conference Proceedings, 4th International Conference, 654–658.
  • Pelclova, D., V. Zdimal, Z. Fenclova, S. Vlckova, F. Turci, I. Corazzari, PJ. Kacer, et al. 2016a. “Markers of Oxidative Damage of Nucleic Acids and Proteins among Workers Exposed to TiO2 (Nano) Particles.” Occupational and Environmental Medicine 73 (2): 110–118. doi:10.1136/oemed-2015-103161.
  • Pelclova, D., V. Zdimal, P. Kacer, S. Vlckova, Z. Fenclova, T. Navratil, M. Komarc, J. Schwarz, N. Zikova, and O. Makes. 2016b. “Markers of Nucleic Acids and Proteins Oxidation among Office Workers Exposed to Air Pollutants Including (Nano) TiO2 Particles.” Neuroendocrinology Letters 37: 13–16.
  • Pelclova, D., V. Zdimal, P. Kacer, S. Vlckova, Z. Fenclova, T. Navratil, M. Komarc, et al. 2016c. “Markers of Nucleic Acids and Proteins Oxidation among Office Workers Exposed to Air Pollutants Including (Nano)TiO < Inf > 2</Inf > Particles.” Neuroendocrinology Letters 37: 13–16.
  • Pelclova, D., V. Zdimal, M. Komarc, J. Schwarz, J. Ondracek, L. Ondrackova, M. Kostejn, S. Vlckova, Z. Fenclova, and S. J. N. Dvorackova. 2020. “Three-Year Study of Markers of Oxidative Stress in Exhaled Breath Condensate in Workers Producing Nanocomposites.” Extended by Plasma and Urine Analysis in Last Two Years 10: 2440.
  • Pelclova, Daniela, Vladimir Zdimal, Jaroslav Schwarz, Stepanka Dvorackova, Martin Komarc, Jakub Ondracek, Martin Kostejn, et al. 2018a. “Markers of Oxidative Stress in the Exhaled Breath Condensate of Workers Handling Nanocomposites.” Nanomaterials 8 (8): 611. doi:10.3390/nano8080611.
  • Pelclova, D., V. Zdimal, J. Schwarz, S. Dvorackova, M. Komarc, J. Ondracek, M. Kostejn, et al. 2018b. “Markers of Oxidative Stress in the Exhaled Breath Condensate of Workers Handling Nanocomposites.” Nanomaterials 8: 611.
  • Pilger, A., and H. Rüdiger. 2006. “8-Hydroxy-2'Deoxyguanosine as a Marker of Oxidative DNA Damage Related to Occupational and Environmental Exposures.” International Archives of Occupational and Environmental Health 80 (1): 1–15. doi:10.1007/s00420-006-0106-7.
  • Pollock, M., R. M. Fernandes, D. Pieper, A. C. Tricco, M. Gates, A. Gates, and L. Hartling. 2019. “Preferred Reporting Items for Overviews of Reviews (PRIOR): A Protocol for Development of a Reporting Guideline for Overviews of Reviews of Healthcare Interventions.” Systematic Reviews 8 (1): 1–9. doi:10.1186/s13643-019-1252-9.
  • Savolainen, K. 2014. “Chapter 1 – General Introduction.” In Handbook of Nanosafety, edited by Vogel, U., Savolainen, K., Wu, Q., van Tongeren, M., Brouwer, D. & Berges, M. San Diego, CA: Academic Press.
  • Schulte, Paul A., Ivo Iavicoli, Jorma H. Rantanen, Dirk Dahmann, Sergio Iavicoli, Rüdiger Pipke, Irina Guseva Canu, et al. 2016. “Assessing the Protection of the Nanomaterial Workforce.” Nanotoxicology 10 (7): 1013–1019. doi:10.3109/17435390.2015.1132347.
  • Schulte, P., V. Leso, M. Niang, and I. Iavicoli. 2018. “Biological Monitoring of Workers Exposed to Engineered Nanomaterials.” Toxicology Letters 298: 112–124. doi:10.1016/j.toxlet.2018.06.003.
  • Setyaningsih, Y., A. H. Husodo, and I. Astuti. 2015. “Detection of Urinary 8-Hydroxydeoxyguanosine (8-OHdG) Levels as a Biomarker of Oxidative DNA Damage among Home Industry Workers Exposed to Chromium.” Procedia Environmental Sciences 23: 290–296. doi:10.1016/j.proenv.2015.01.043.
  • Skalska, Joanna, and Lidia Strużyńska. 2015. “Toxic Effects of Silver Nanoparticles in Mammals-Does a Risk of Neurotoxicity Exist?” Folia Neuropathologica 53 (4): 281–300. doi:10.5114/fn.2015.56543.
  • Stone, Vicki, Mark R. Miller, Martin J. D. Clift, Alison Elder, Nicholas L. Mills, Peter Møller, Roel P. F. Schins, et al. 2017. “Nanomaterials versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge.” Environmental Health Perspectives 125 (10): 106002. doi:10.1289/EHP424.
  • Syama, S., S. Reshma, P. Sreekanth, H. Varma, and P. Mohanan. 2013. “Effect of Zinc Oxide Nanoparticles on Cellular Oxidative Stress and Antioxidant Defense Mechanisms in Mouse Liver.” Toxicological & Environmental Chemistry 95 (3): 495–503. doi:10.1080/02772248.2013.789606.
  • Tanaka, M., H. Takano, Y. Fujitani, S. Hirano, T. Ichinose, A. Shimada, and K.-I. Inoue. 2013. “Effects of Exposure to Nanoparticle-Rich Diesel Exhaust on 8-OHdG Synthesis in the Mouse Asthmatic Lung.” Experimental and Therapeutic Medicine 6 (3): 703–706. doi:10.3892/etm.2013.1198.
  • Valavanidis, A., T. Vlachogianni, and C. Fiotakis. 2009. “8-Hydroxy-2′-Deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis.” Journal of Environmental Science and Health, Part C 27 (2): 120–139. doi:10.1080/10590500902885684.
  • Valko, M., M. Izakovic, M. Mazur, C. J. Rhodes, and J. Telser. 2004. “Role of Oxygen Radicals in DNA Damage and Cancer Incidence.” Molecular and Cellular Biochemistry 266 (1–2): 37–56. doi:10.1023/b:mcbi.0000049134.69131.89.
  • Westmeier, D., S. K. Knauer, R. H. Stauber, and D. Docter. 2017. “Chapter 1 – Bio-Nano Interactions.” In Adverse Effects of Engineered Nanomaterials, edited by Fadeel, B., Pietroiusti, A. and Shvedova, A. A., 2nd ed. London: Academic Press.
  • WHO. 2017. WHO Guidelines on Protecting Workers from Potential Risks of Manufactured Nanomaterials. Geneva: World Health Organization.
  • Yang, D., X. Yang, F. Deng, and X. Guo. 2017. “Ambient Air Pollution and Biomarkers of Health Effect”. In Ambient Air Pollution and Health Impact in China. New York, NY: Springer.
  • Zalk, D. M., and S. Y. Paik. 2016. “Chapter 6 – Risk Assessment Using Control Banding.” In Assessing Nanoparticle Risks to Human Health, edited by Ramachandran, G., 2nd ed. Oxford: William Andrew Publishing.

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