References
- Abatangelo, L., R. Maglietta, A. Distaso, A. D'Addabbo, T. M. Creanza, S. Mukherjee, and N. Ancona. 2009. “Comparative Study of Gene Set Enrichment Methods.” BMC Bioinformatics 10: 275. doi:https://doi.org/10.1186/1471-2105-10-275.
- Abdelkhaliq, A., M. van der Zande, A. Punt, R. Helsdingen, S. Boeren, J. J. M. Vervoort, I. M. C. M. Rietjens, and H. Bouwmeester. 2018. “Impact of Nanoparticle Surface Functionalization on the Protein Corona and Cellular Adhesion, Uptake and Transport.” Journal of Nanobiotechnology 16 (1): 1–13. doi:https://doi.org/10.1186/s12951-018-0394-6.
- Allison, D. B., X. Cui, G. P. Page, and M. Sabripour. 2006. “Microarray Data Analysis: From Disarray to Consolidation and consensus.” Nat Rev Genet 7 (1): 55–65. doi:https://doi.org/10.1038/nrg1749.
- Bahadar, H., F. Maqbool, K. Niaz, and M. Abdollahi. 2016. “Toxicity of Nanoparticles and an Overview of Current Experimental Models.” Iranian Biomedical Journal 20 (1): 1–11. doi:https://doi.org/10.7508/ibj.2016.01.001.
- Bajak, E., M. Fabbri, J. Ponti, S. Gioria, I. Ojea-Jimenez, A. Collotta, V. Mariani, D. Gilliland, F. Rossi, and L. Gribaldo. 2015. “Changes in Caco-2 Cells Transcriptome Profiles upon Exposure to Gold Nanoparticles.” Toxicology Letters 233 (2): 187–199. doi:https://doi.org/10.1016/j.toxlet.2014.12.008.
- Beaurivage, C., E. Naumovska, Y. X. Chang, E. D. Elstak, A. Nicolas, H. Wouters, G. van Moolenbroek, et al. 2019. “Development of a Gut-On-A-Chip Model for High Throughput Disease Modeling and Drug Discovery.” International Journal of Molecular Sciences 20 (22): 5661. doi:https://doi.org/10.3390/ijms20225661.
- Bhise, N. S., J. Ribas, V. Manoharan, Y. S. Zhang, A. Polini, S. Massa, M. R. Dokmeci, and A. Khademhosseini. 2014. “Organ-on-a-Chip Platforms for Studying Drug Delivery Systems.” Journal of Controlled Release 190: 82–93. doi:https://doi.org/10.1016/j.jconrel.2014.05.004.
- Bolstad, B. M., R. A. Irizarry, M. Astrand, and T. P. Speed. 2003. “A Comparison of Normalization Methods for High Density Oligonucleotide Array Data Based on Variance and Bias.” Bioinformatics 19 (2): 185–193. doi:https://doi.org/10.1093/bioinformatics/19.2.185.
- Cao, Y., M. Roursgaard, A. Kermanizadeh, S. Loft, and P. Moller. 2015. “Synergistic Effects of Zinc Oxide Nanoparticles and Fatty Acids on Toxicity to Caco-2 Cells.” International Journal of Toxicology 34 (1): 67–76. doi:https://doi.org/10.1177/1091581814560032.
- Chen, G., M. H. Shaw, Y. G. Kim, and G. Nunez. 2009. “NOD-like Receptors: Role in Innate Immunity and Inflammatory Disease.” Annual Review of Pathology 4: 365–398. doi:https://doi.org/10.1146/annurev.pathol.4.110807.092239.
- Chen, N., Z. M. Song, H. Tang, W. S. Xi, A. Cao, Y. Liu, and H. Wang. 2016. “Toxicological Effects of Caco-2 Cells following Short-Term and Long-Term Exposure to Ag Nanoparticles.” International Journal of Molecular Sciences 17 (6): 1–17. doi:https://doi.org/10.3390/ijms17060974.
- Chi, M., B. Yi, S. Oh, D. J. Park, J. H. Sung, and S. Park. 2015. “A Microfluidic Cell Culture Device (μFCCD) to Culture Epithelial Cells with Physiological and Morphological Properties that Mimic those of the Human Intestine.” Biomedical Microdevices 17 (3): 9966. doi:https://doi.org/10.1007/s10544-015-9966-5.
- Cornu, T. I., S. Thibodeau-Beganny, E. Guhl, S. Alwin, M. Eichtinger, J. K. Joung, and T. Cathomen. 2008. “DNA-Binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases.” Molecular Therapy 16 (2): 352–358. doi:https://doi.org/10.1038/sj.mt.6300357.
- Dai, M. H., P. L. Wang, A. D. Boyd, G. Kostov, B. Athey, E. G. Jones, W. E. Bunney, et al. 2005. “Evolving Gene/Transcript Definitions Significantly Alter the Interpretation of GeneChip Data.” Nucleic Acids Research 33 (20): e175. doi:https://doi.org/10.1093/nar/gni179.
- Dekkers, S., P. Krystek, R. J. Peters, D. P. Lankveld, B. G. Bokkers, P. H. van Hoeven-Arentzen, H. Bouwmeester, and A. G. Oomen. 2011. “Presence and Risks of Nanosilica in Food Products.” Nanotoxicology 5 (3): 393–405. doi:https://doi.org/10.3109/17435390.2010.519836.
- de León-Rodríguez, Ponce, Maria del Carmen, Jean-Pierre Guyot, and Caroline Laurent-Babot. 2019. “Intestinal In Vitro Cell Culture Models and Their Potential to Study the Effect of Food Components on Intestinal Inflammation.” Critical Reviews in Food Science and Nutrition 59 (22): 3648–3666. doi:https://doi.org/10.1080/10408398.2018.1506734.
- Delon, L. C., Z. Guo, A. Oszmiana, C. C. Chien, R. Gibson, C. Prestidge, and B. Thierry. 2019. “A Systematic Investigation of the Effect of the Fluid Shear Stress on Caco-2 Cells Towards the Optimization of Epithelial Organ-on-Chip Models.” Biomaterials 225: 119521. doi:https://doi.org/10.1016/j.biomaterials.2019.119521.
- Dorier, M., D. Beal, C. Marie-Desvergne, M. Dubosson, F. Barreau, E. Houdeau, N. Herlin-Boime, and M. Carriere. 2017. “Continuous In Vitro Exposure of Intestinal Epithelial Cells to E171 Food Additive Causes Oxidative Stress, Inducing Oxidation of DNA Bases but No Endoplasmic Reticulum stress.” Nanotoxicology 11 (6): 751–761. doi:https://doi.org/10.1080/17435390.2017.1349203.
- Espitia, P. J. P., C. G. Otoni, and N. F. F. Soares. 2016. “Zinc Oxide Nanoparticles for Food Packaging Applications.” In Antimicrobial Food Packaging, edited by Jorge Barros-Velázquez, 425–431. Academic Press.
- Feng, S., S. Mao, Q. Zhang, W. Li, and J. M. Lin. 2019. “Online Analysis of Drug Toxicity to Cells with Shear Stress on an Integrated Microfluidic Chip.” ACS Sensors 4 (2): 521–527. doi:https://doi.org/10.1021/acssensors.8b01696.
- Geiss, Otmar, Jessica Ponti, Chiara Senaldi, Ivana Bianchi, Dora Mehn, Josefa Barrero, Douglas Gilliland, Reinhard Matissek, and Elke Anklam. 2020. “Characterisation of Food Grade Titania with Respect to Nanoparticle Content in Pristine Additives and in Their Related Food Products.” Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 37 (2): 239–253. doi:https://doi.org/10.1080/19440049.2019.1695067.
- Gerloff, K., D. I. Pereira, N. Faria, A. W. Boots, J. Kolling, I. Forster, C. Albrecht, J. J. Powell, and R. P. Schins. 2013. “Influence of Simulated Gastrointestinal Conditions on Particle-Induced Cytotoxicity and Interleukin-8 Regulation in Differentiated and Undifferentiated Caco-2 Cells.” Nanotoxicology 7 (4): 353–366. doi:https://doi.org/10.3109/17435390.2012.662249.
- Gerloff, K., I. Fenoglio, E. Carella, J. Kolling, C. Albrecht, A. W. Boots, I. Forster, and R. P. Schins. 2012. “Distinctive Toxicity of TiO2 Rutile/Anatase Mixed Phase Nanoparticles on Caco-2 Cells.” Chemical Research in Toxicology 25 (3): 646–655. doi:https://doi.org/10.1021/tx200334k.
- Ghasemi, M., B. Bakhshi, R. Khashei, and S. Soudi. 2020. “Modulatory Effect of Vibrio cholerae Toxin Co-regulated Pilus on Mucins, Toll-like Receptors and NOD Genes Expression in Co-culture Model of Caco-2 and Peripheral Blood Mononuclear Cells (PBMC).” Microbial Pathogenesis 149: 104566. doi:https://doi.org/10.1016/j.micpath.2020.104566.
- Harrison, D. A. 2012. “The Jak/STAT Pathway.” Cold Spring Harbor Perspectives in Biology 4 (3): a011205. doi:https://doi.org/10.1101/cshperspect.a011205.
- He, Y., S. Ingudam, S. Reed, A. Gehring, T. P. Strobaugh Jr., and P. Irwin. 2016. “Study on the Mechanism of Antibacterial Action of Magnesium Oxide Nanoparticles against Foodborne pathogens.” Journal of Nanobiotechnology 14 (1): 54. doi:https://doi.org/10.1186/s12951-016-0202-0.
- Helsper, J. P., R. J. Peters, M. E. van Bemmel, Z. E. Rivera, S. Wagner, F. von der Kammer, P. C. Tromp, T. Hofmann, and S. Weigel. 2016. “Physicochemical Characterization of Titanium Dioxide Pigments Using Various Techniques for Size Determination and Asymmetric Flow Field Flow Fractionation Hyphenated with Inductively Coupled Plasma Mass spectrometry.” Analytical and Bioanalytical Chemistry 408 (24): 6679–6691. doi:https://doi.org/10.1007/s00216-016-9783-6.
- Hinderliter, P. M., K. R. Minard, G. Orr, W. B. Chrisler, B. D. Thrall, J. G. Pounds, and J. G. Teeguarden. 2010. “ISDD: A Computational Model of Particle Sedimentation, Diffusion and Target Cell Dosimetry for In Vitro Toxicity Studies.” Particle and Fibre Toxicology 7 (1): 1–20. doi:https://doi.org/10.1186/1743-8977-7-36.
- Ho, E., and J. Woodgett. 2010. “Chapter 71 – Mitogen-Activated Protein Kinases.” In Handbook of Cell Signaling. 2nd ed., edited by R. A. Bradshaw and E. A. Dennis, 533–538. San Diego, CA: Academic Press.
- Hubatsch, I., E. G. Ragnarsson, and P. Artursson. 2007. “Determination of Drug Permeability and Prediction of Drug Absorption in Caco-2 Monolayers.” Nature Protocols 2 (9): 2111–2119. doi:https://doi.org/10.1038/nprot.2007.303.
- Jalili-Firoozinezhad, Sasan, Francesca S. Gazzaniga, Elizabeth L. Calamari, Diogo M. Camacho, Cicely W. Fadel, Amir Bein, Ben Swenor, et al. 2019. “A Complex Human Gut Microbiome Cultured in an Anaerobic Intestine-on-a-Chip.” Nature Biomedical Engineering 3 (7): 520–531. doi:https://doi.org/10.1038/s41551-019-0397-0.
- Jensen, K. A., Y. Kembouche, E. Christiansen, N. R. Jacobsen, H. Wallin, C. Guiot, O. Spalla, and O. Witschger. 2011. “Final Protocol for Producing Suitable Manufactured Nanomaterial Exposure Media.” In Towards a Method for Detecting the Potential Genotoxicity of Nanomaterials, edited by Keld Alstrup Jensen and Nathalie Thieriet. The National Research Centre for the Working Environment.
- Kämpfer, A. A. M., P. Urbán, R. La Spina, I. O. Jiménez, N. Kanase, V. Stone, and A. Kinsner-Ovaskainen. 2020. “Ongoing Inflammation Enhances the Toxicity of Engineered Nanomaterials: Application of an In Vitro Co-culture Model of the Healthy and Inflamed Intestine.” Toxicology In Vitro 63: 104738. doi:https://doi.org/10.1016/j.tiv.2019.104738.
- Kanehisa, M., M. Furumichi, M. Tanabe, Y. Sato, and K. Morishima. 2017. “KEGG: New Perspectives on Genomes, Pathways, Diseases and Drugs.” Nucleic Acids Res 45 (D1): D353–D361. doi:https://doi.org/10.1093/nar/gkw1092.
- Kasendra, Magdalena, Alessio Tovaglieri, Alexandra Sontheimer-Phelps, Sasan Jalili-Firoozinezhad, Amir Bein, Angeliki Chalkiadaki, William Scholl, et al. 2018. “Development of a Primary Human Small Intestine-on-a-Chip Using Biopsy-Derived Organoids.” Scientific Reports 8 (1): 2871. doi:https://doi.org/10.1038/s41598-018-21201-7.
- Kim, H. J., and D. E. Ingber. 2013. “Gut-on-a-Chip Microenvironment Induces Human Intestinal Cells to Undergo Villus Differentiation.” Integrative Biology: Quantitative Biosciences from Nano to Macro 5 (9): 1130–1140. doi:https://doi.org/10.1039/c3ib40126j.
- Kim, H. J., D. Huh, G. Hamilton, and D. E. Ingber. 2012. “Human Gut-on-a-chip Inhabited by Microbial Flora that Experiences Intestinal Peristalsis-like Motions and Flow.” Lab Chip 12 (12): 2165–2174. doi:https://doi.org/10.1039/c2lc40074j.
- Kim, H. J., H. Li, J. J. Collins, and D. E. Ingber. 2016. “Contributions of Microbiome and Mechanical Deformation to Intestinal Bacterial Overgrowth and Inflammation in a Human Gut-on-a-Chip.” Proceedings of the National Academy of Sciences of the United States of America 113 (1): E7–E15. doi:https://doi.org/10.1073/pnas.1522193112.
- Kim, S. W., J. Ehrman, M. R. Ahn, J. Kondo, A. A. M. Lopez, Y. S. Oh, X. H. Kim, et al. 2017. “Shear Stress Induces Noncanonical Autophagy in Intestinal Epithelial Monolayers.” Molecular Biology of the Cell 28 (22): 3043–3056. doi:https://doi.org/10.1091/mbc.E17-01-0021.
- Kimura, H., Y. Sakai, and T. Fujii. 2018. “Organ/Body-on-a-Chip Based on Microfluidic Technology for Drug Discovery.” Drug Metabolism and Pharmacokinetics 33 (1): 43–48. doi:https://doi.org/10.1016/j.dmpk.2017.11.003.
- Kulthong, K., L. Duivenvoorde, B. Z. Mizera, D. Rijkers, G. ten Dam, G. Oegema, T. Puzyn, H. Bouwmeester, and M. van der Zande. 2018. “Implementation of a Dynamic Intestinal Gut-on-a-Chip Barrier Model for Transport Studies of Lipophilic Dioxin Congeners.” RSC Advances 8 (57): 32440–32453. doi:https://doi.org/10.1039/C8RA05430D.
- Kulthong, K., L. Duivenvoorde, G. J. E. J. Hooiveld, I. Miro Estruch, V. Marin, and H. Bouwmeester, and M. van der Zande. 2021. “Transcriptome Comparisons of In Vitro Intestinal Epithelia Grown under Static and Microfluidic Gut-on-Chip Conditions with In Vivo Human Epithelia.” Scientific Reports 11 (1): 3234. doi:https://doi.org/10.1038/s41598-021-82853-6.
- Kulthong, K., L. Duivenvoorde, H. Sun, S. Confederat, J. Wu, B. Spenkelink, L. de Haan, V. Marin, M. van der Zande, and H. Bouwmeester. 2020. “Microfluidic Chip for Culturing Intestinal Epithelial Cell Layers: Characterization and Comparison of Drug Transport between Dynamic and Static Models.” Toxicology In Vitro 65: 104815. doi:https://doi.org/10.1016/j.tiv.2020.104815.
- Lai, X., Y. Wei, H. Zhao, S. Chen, X. Bu, F. Lu, D. Qu, L. Yao, J. Zheng, and J. Zhang. 2015. “The Effect of Fe2O3 and ZnO Nanoparticles on Cytotoxicity and Glucose Metabolism in Lung Epithelial cells.” Journal of Applied Toxicology 35 (6): 651–664. doi:https://doi.org/10.1002/jat.3128.
- Lin, K., H. Kools, P. J. de Groot, A. K. Gavai, R. K. Basnet, F. Cheng, J. Wu, et al. 2011. “MADMAX – Management and Analysis Database for Multiple Omics Experiments.” Journal of Integrative Bioinformatics 8 (2): 160. doi:https://doi.org/10.2390/biecoll-jib-2011-160.
- Mao, X., T. H. Nguyen, M. Lin, and A. Mustapha. 2016. “Engineered Nanoparticles as Potential Food Contaminants and Their Toxicity to Caco-2 Cells.” Journal of Food Science 81 (8): T2107–T2113. doi:https://doi.org/10.1111/1750-3841.13387.
- Mitchell, S., J. Vargas, and A. Hoffmann. 2016. “Signaling via the NFκB System.” Wiley Interdisciplinary Reviews. Systems Biology and Medicine 8 (3): 227–241. doi:https://doi.org/10.1002/wsbm.1331.
- Moos, P. J., K. Olszewski, M. Honeggar, P. Cassidy, S. Leachman, D. Woessner, N. S. Cutler, and J. M. Veranth. 2011. “Responses of Human Cells to ZnO Nanoparticles: A Gene Transcription Study.” Metallomics: Integrated Biometal Science 3 (11): 1199–1211. doi:https://doi.org/10.1039/c1mt00061f.
- Moreno-Olivas, F., E. Tako, and G. J. Mahler. 2019. “ZnO Nanoparticles Affect Nutrient Transport in an In Vitro Model of the Small Intestine.” Food and Chemical Toxicology 124: 112–127. doi:https://doi.org/10.1016/j.fct.2018.11.048.
- Mudunkotuwa, I. A., T. Rupasinghe, C. M. Wu, and V. H. Grassian. 2012. “Dissolution of ZnO Nanoparticles at Circumneutral pH: A Study of Size Effects in the Presence and Absence of Citric Acid.” Langmuir: The ACS Journal of Surfaces and Colloids 28 (1): 396–403. doi:https://doi.org/10.1021/la203542x.
- Naumovska, Elena, Germaine Aalderink, Christian Wong Valencia, Kinga Kosim, Arnaud Nicolas, Stephen Brown, Paul Vulto, Kai S. Erdmann, and Dorota Kurek. 2020. “Direct on-Chip Differentiation of Intestinal Tubules from Induced Pluripotent Stem Cells.” International Journal of Molecular Sciences 21 (14): 4964. doi:https://doi.org/10.3390/ijms21144964.
- Ning, Kang, Damian Fermin, and Alexey I. Nesvizhskii. 2012. “Comparative Analysis of Different Label-Free Mass Spectrometry Based Protein Abundance Estimates and Their Correlation with RNA-Seq Gene Expression Data.” Journal of Proteome Research 11 (4): 2261–2271. doi:https://doi.org/10.1021/pr201052x.
- Norppa, H., K. Siivola, V. Fessard, A. Tarantini, M. Apostolova, N. R. Jacobsen, H. Wallin, et al. 2013. In Vitro Testing Strategy for Nanomaterials Including Database. Helsinki: Finnish Institute of Occupational Health Nanosafety Research Center.
- Peters, R. J., G. van Bemmel, Z. Herrera-Rivera, H. P. Helsper, H. J. Marvin, S. Weigel, P. C. Tromp, A. G. Oomen, A. G. Rietveld, and H. Bouwmeester. 2014. “Characterization of Titanium Dioxide Nanoparticles in Food Products: analytical Methods to Define Nanoparticles.” Journal of Agricultural and Food Chemistry 62 (27): 6285–6293. doi:https://doi.org/10.1021/jf5011885.
- Proquin, H., C. Rodriguez-Ibarra, C. G. Moonen, I. M. Urrutia Ortega, J. J. Briede, T. M. de Kok, H. van Loveren, and Y. I. Chirino. 2017. “Titanium Dioxide Food Additive (E171) Induces ROS Formation and Genotoxicity: Contribution of Micro and Nano-Sized Fractions.” Mutagenesis 32 (1): 139–149. doi:https://doi.org/10.1093/mutage/gew051.
- Proquin, H., M. C. M. Jonkhout, M. J. Jetten, H. van Loveren, T. M. de Kok, and J. J. Briede. 2019. “Transcriptome Changes in Undifferentiated Caco-2 Cells Exposed to Food-Grade Titanium Dioxide (E171): Contribution of the Nano- and Micro- Sized Particles.” Scientific Reports 9 (1): 18287. doi:https://doi.org/10.1038/s41598-019-54675-0.
- Ranjan, S., N. Dasgupta, S. Singh, and M. Gandhi. 2019. “Toxicity and Regulations of Food Nanomaterials.” Environmental Chemistry Letters 17 (2): 929–944. doi:https://doi.org/10.1007/s10311-018-00851-z.
- Rasmussen, J. W., E. Martinez, P. Louka, and D. G. Wingett. 2010. “Zinc Oxide Nanoparticles for Selective Destruction of Tumor Cells and Potential for Drug Delivery applications.” Expert Opinion on Drug Delivery 7 (9): 1063–1077. doi:https://doi.org/10.1517/17425247.2010.502560.
- Ritchie, M. E., B. Phipson, D. Wu, Y. F. Hu, C. W. Law, W. Shi, and G. K. Smyth. 2015. “Limma Powers Differential Expression Analyses for RNA-Sequencing and Microarray Studies.” Nucleic Acids Research 43 (7): e47. doi:https://doi.org/10.1093/nar/gkv007.
- Rompelberg, C., M. B. Heringa, G. van Donkersgoed, J. Drijvers, A. Roos, S. Westenbrink, R. Peters, G. van Bemmel, W. Brand, and A. G. Oomen. 2016. “Oral Intake of Added Titanium Dioxide and Its Nanofraction from Food Products, Food Supplements and Toothpaste by the Dutch Population.” Nanotoxicology 10 (10): 1404–1414. doi:https://doi.org/10.1080/17435390.2016.1222457.
- Roy, R., S. K. Singh, L. K. Chauhan, M. Das, A. Tripathi, and P. D. Dwivedi. 2014. “Zinc Oxide Nanoparticles Induce Apoptosis by Enhancement of Autophagy via PI3K/Akt/mTOR Inhibition.” Toxicology Letters 227 (1): 29–40. doi:https://doi.org/10.1016/j.toxlet.2014.02.024.
- Sahu, S. C. 2016. “Altered Global Gene Expression Profiles in Human Gastrointestinal Epithelial Caco2 Cells Exposed to Nanosilver.” Toxicology Reports 3: 262–268. doi:https://doi.org/10.1016/j.toxrep.2016.01.012.
- Sakharov, D., D. Maltseva, E. Knyazev, S. Nikulin, A. Poloznikov, S. Shilin, A. Baranova, I. Tsypina, and A. Tonevitsky. 2019. “Towards Embedding Caco-2 Model of Gut Interface in a Microfluidic Device to Enable Multi-Organ Models for Systems Biology.” BMC Systems Biology 13 (Suppl 1): 19. doi:https://doi.org/10.1186/s12918-019-0686-y.
- Sakolish, C. M., B. Philip, and G. J. Mahler. 2019. “A Human Proximal Tubule-on-a-Chip to Study Renal Disease and Toxicity.” Biomicrofluidics 13 (1): 014107. doi:https://doi.org/10.1063/1.5083138.
- Santbergen, M. J. C., M. van der Zande, A. Gerssen, H. Bouwmeester, and M. W. F. Nielen. 2020. “Dynamic In Vitro Intestinal Barrier Model Coupled to Chip-Based Liquid Chromatography Mass Spectrometry for Oral Bioavailability Studies.” Analytical and Bioanalytical Chemistry 412 (5): 1111–1122. doi:https://doi.org/10.1007/s00216-019-02336-6.
- Sartor, M. A., C. R. Tomlinson, S. C. Wesselkamper, S. Sivaganesan, G. D. Leikauf, and M. Medvedovic. 2006. “Intensity-Based Hierarchical Bayes Method Improves Testing for Differentially Expressed Genes in Microarray Experiments.” BMC Bioinformatics 7 (1): 1–17. doi:https://doi.org/10.1186/1471-2105-7-538.
- Schimpel, Christa, Birgit Teubl, Markus Absenger, Claudia Meindl, Eleonore Fröhlich, Gerd Leitinger, Andreas Zimmer, and Eva Roblegg. 2014. “Development of an Advanced Intestinal In Vitro Triple Culture Permeability Model to Study Transport of Nanoparticles.” Molecular Pharmaceutics 11 (3): 808–818. doi:https://doi.org/10.1021/mp400507g.
- Shin, W., and H. J. Kim. 2018. “Intestinal Barrier Dysfunction Orchestrates the Onset of Inflammatory Host-Microbiome Cross-Talk in a Human Gut Inflammation-on-a-Chip.” Proceedings of the National Academy of Sciences of the United States of America 115 (45): E10539–E10547. doi:https://doi.org/10.1073/pnas.1810819115.
- Singh, C., S. Friedrichs, M. Levin, R. Birkedal, K. J. Jensen, G. Pojana, W. Wohlleben, et al. 2011. NM-Series of Representative Manufactured Nanomaterials – Zinc Oxide NM-110, NM-111, NM-112, NM-113: Characterisation and Test Item Preparation.
- Singh, S., T. Shi, R. Duffin, C. Albrecht, D. van Berlo, D. Hohr, B. Fubini, et al. 2007. “Endocytosis, Oxidative Stress and IL-8 Expression in Human Lung Epithelial Cells upon Treatment with Fine and Ultrafine TiO2: Role of the Specific Surface Area and of Surface Methylation of the Particles.” Toxicology and Applied Pharmacology 222 (2): 141–151. doi:https://doi.org/10.1016/j.taap.2007.05.001.
- Song, W. J., M. S. Jeong, D. M. Choi, K. N. Kim, and M. B. Wie. 2019. “Zinc Oxide Nanoparticles Induce Autophagy and Apoptosis via Oxidative Injury and Pro-Inflammatory Cytokines in Primary Astrocyte Cultures.” Nanomaterials 9 (7): 1043. doi:https://doi.org/10.3390/nano9071043.
- Stern, S. T., P. P. Adiseshaiah, and R. M. Crist. 2012. “Autophagy and Lysosomal Dysfunction as Emerging Mechanisms of Nanomaterial Toxicity.” Particle and Fibre Toxicology 9: 20. doi:https://doi.org/10.1186/1743-8977-9-20.
- Stetefeld, J., S. A. McKenna, and T. R. Patel. 2016. “Dynamic Light Scattering: A Practical Guide and Applications in Biomedical sciences.” Biophysical Reviews 8 (4): 409–427. doi:https://doi.org/10.1007/s12551-016-0218-6.
- Subramanian, A., P. Tamayo, V. K. Mootha, S. Mukherjee, B. L. Ebert, M. A. Gillette, A. Paulovich, et al. 2005. “Gene Set Enrichment Analysis: A Knowledge-Based Approach for Interpreting Genome-Wide Expression Profiles.” Proceedings of the National Academy of Sciences of the United States of America 102 (43): 15545–15550. doi:https://doi.org/10.1073/pnas.0506580102.
- Thompson, C. M., Y. Fedorov, D. D. Brown, M. Suh, D. M. Proctor, L. Kuriakose, L. C. Haws, and M. A. Harris. 2012. “Assessment of Cr(VI)-Induced Cytotoxicity and Genotoxicity Using High Content Analysis.” PLOS One 7 (8): e42720. doi:https://doi.org/10.1371/journal.pone.0042720.
- Ude, Victor C., David M. Brown, Luca Viale, Nilesh Kanase, Vicki Stone, and Helinor J. Johnston. 2017. “Impact of Copper Oxide Nanomaterials on Differentiated and Undifferentiated Caco-2 Intestinal Epithelial Cells; Assessment of Cytotoxicity, Barrier Integrity, Cytokine Production and Nanomaterial Penetration.” Particle and Fibre Toxicology 14 (1): 31. doi:https://doi.org/10.1186/s12989-017-0211-7.
- van der Zande, M., A. K. Undas, E. Kramer, M. P. Monopoli, R. J. Peters, D. Garry, E. C. Antunes Fernandes, et al. 2016. “Different Responses of Caco-2 and MCF-7 Cells to Silver Nanoparticles Are Based on Highly Similar Mechanisms of Action.” Nanotoxicology 10 (10): 1431–1441. doi:https://doi.org/10.1080/17435390.2016.1225132.
- Vance, M. E., T. Kuiken, E. P. Vejerano, S. P. McGinnis, M. F. Hochella Jr., D. Rejeski, and M. S. Hull. 2015. “Nanotechnology in the Real World: Redeveloping the Nanomaterial Consumer Products Inventory.” Beilstein Journal of Nanotechnology 6: 1769–1780. doi:https://doi.org/10.3762/bjnano.6.181.
- Walczak, Agata P., Evelien Kramer, Peter J. M. Hendriksen, Peter Tromp, Johannes P. F. G. Helsper, Meike van der Zande, Ivonne M. C. M. Rietjens, and Hans Bouwmeester. 2015. “Translocation of Differently Sized and Charged Polystyrene Nanoparticles in In Vitro Intestinal Cell Models of Increasing Complexity.” Nanotoxicology 9 (4): 453–461. doi:https://doi.org/10.3109/17435390.2014.944599.
- Wang, Y., Y. Wang, S. Liu, Y. Liu, H. Xu, J. Liang, J. Zhu, et al. 2018. “Upregulation of EID3 Sensitizes Breast Cancer Cells to Ionizing Radiation-Induced Cellular Senescence.” Biomedicine & Pharmacotherapy 107: 606–614. doi:https://doi.org/10.1016/j.biopha.2018.08.022.
- Warheit, D. B., and S. C. Brown. 2019. “What is the Impact of Surface Modifications and Particle Size on Commercial Titanium Dioxide Particle Samples? A review of In Vivo Pulmonary and Oral Toxicity Studies – Revised 11-6-2018.” Toxicology Letters 302: 42–59. doi:https://doi.org/10.1016/j.toxlet.2018.11.008.
- Weir, A., P. Westerhoff, L. Fabricius, K. Hristovski, and N. von Goetz. 2012. “Titanium Dioxide Nanoparticles in Food and Personal Care Products.” Environmental Science & Technology 46 (4): 2242–2250. doi:https://doi.org/10.1021/es204168d.
- Yang, Yu, Kyle Doudrick, Xiangyu Bi, Kiril Hristovski, Pierre Herckes, Paul Westerhoff, and Ralf Kaegi. 2014. “Characterization of Food-Grade Titanium Dioxide: The Presence of Nanosized Particles.” Environmental Science & Technology 48 (11): 6391–6400. doi:https://doi.org/10.1021/es500436x.
- Younes, M., G. Aquilina, L. Castle, K. H. Engel, P. Fowler, M. J. Frutos Fernandez, R. Gürtler, et al. 2019. “Scientific Opinion on the Proposed Amendment of the EU Specifications for Titanium Dioxide (E 171) with Respect to the Inclusion of Additional Parameters Related to Its Particle Size Distribution.” Additives, EFSA Panel on Food, Flavourings, EFSA Journal 17 (7): e05760. doi:https://doi.org/10.2903/j.efsa.2019.5760.