Evaluation of cytotoxicity and biodistribution of mesoporous carbon nanotubes (pristine/-OH/-COOH) to HepG2 cells in vitro and healthy mice in vivo

References

• Alarifi, S., D. Ali, A. Verma, F. N. Almajhdi, and A. A. Al-Qahtani. 2014. “Single-Walled Carbon Nanotubes Induce Cytotoxicity and DNA Damage via Reactive Oxygen Species in Human Hepatocarcinoma Cells.” In vitro Cellular & Developmental Biology. Animal 50 (8): 714–722.
   PubMed Web of Science ®Google Scholar
• Andraos, C., I. J. Yu, and M. Gulumian. 2020. “Interference: A Much-Neglected Aspect in High-Throughput Screening of Nanoparticles.” International journal of Toxicology 39 (5): 397–421.
   PubMed Web of Science ®Google Scholar
• Basagiannis, D., S. Zografou, E. Goula, D. Gkeka, E. Kolettas, and S. Christoforidis. 2021. “Chemical Inhibitors of Dynamin Exert Differential Effects in VEGF Signaling.” Cells 10 (5): 997. doi:10.3390/cells10050997.
   PubMed Web of Science ®Google Scholar
• Bouvet, V., M. Wuest, H. S. Jans, N. Janzen, A. R. Genady, J. F. Valliant, F. Benard, and F. Wuest. 2016. “Automated synthesis of [(18)F]DCFPyL via Direct Radiofluorination and Validation in Preclinical Prostate Cancer Models.” EJNMMI research 6 (1): 40.
   PubMedGoogle Scholar
• Chen, K., X. Huang, C. Wan, and H. Liu. 2015. “Efficient oxygen Reduction Catalysts Formed of Cobalt Phosphide Nanoparticle Decorated Heteroatom-Doped Mesoporous Carbon Nanotubes.” Chemical communications (Cambridge, England) 51 (37): 7891–7894.
   PubMed Web of Science ®Google Scholar
• Costa, P. M., M. Bourgognon, J. T. Wang, and K. T. Al-Jamal. 2016. “Functionalised carbon Nanotubes: From Intracellular Uptake and Cell-Related Toxicity to Systemic Brain Delivery.” Journal of Controlled Release : official Journal of the Controlled Release Society 241: 200–219.
   PubMed Web of Science ®Google Scholar
• de Barros, A. L., K. S. de Oliveira Ferraz, T. C. Dantas, G. F. Andrade, V. N. Cardoso, and E. M. Sousa. 2015. “Synthesis, Characterization, and Biodistribution Studies of (99m)Tc-Labeled SBA-16 Mesoporous Silica Nanoparticles.” Materials science & Engineering. C, Materials for Biological Applications 56: 181–188.
   PubMed Web of Science ®Google Scholar
• De la Zerda, A., C. Zavaleta, S. Keren, S. Vaithilingam, S. Bodapati, Z. Liu, J. Levi, et al. 2008. “Carbon nanotubes as Photoacoustic Molecular Imaging Agents in Living Mice.” Nature nanotechnology 3 (9): 557–562.
   PubMed Web of Science ®Google Scholar
• Devi, R. K., G. Muthusankar, S. M. Chen, and G. Gopalakrishnan. 2021. “In situ Formation of Co3O4 Nanoparticles Embedded N-Doped Porous Carbon Nanocomposite: A Robust Material for Electrocatalytic Detection of Anticancer Drug Flutamide and Supercapacitor Application.” Mikrochimica acta 188 (6): 196.
   PubMed Web of Science ®Google Scholar
• Du, Y., Z. Chen, P. Yan, C. Zhang, X. Duan, X. Chen, M. Liu, et al. 2021. “Arginine-Arginine-Leucine Peptide Targeting Heat Shock Protein 70 for Cancer Imaging.” Molecular pharmaceutics 18 (10): 3750–3762.
   PubMed Web of Science ®Google Scholar
• Frohlich, E., C. Meindl, A. Hofler, G. Leitinger, and E. Roblegg. 2013. “Combination of Small Size and Carboxyl Functionalisation Causes Cytotoxicity of Short Carbon Nanotubes.” Nanotoxicology 7 (7): 1211–1224.
   PubMed Web of Science ®Google Scholar
• Gao, G., Q. Zhang, X. B. Cheng, J. G. Shapter, T. Yin, R. Sun, and D. Cui. 2015. “Ultrafine ferroferric Oxide Nanoparticles Embedded into Mesoporous Carbon Nanotubes for Lithium Ion Batteries.” Scientific reports 5: 17553.
   PubMed Web of Science ®Google Scholar
• Girotti, A. W. 1985. “Mechanisms of Lipid Peroxidation.” Journal of Free Radicals in Biology & Medicine 1 (2): 87–95. doi:10.1016/0748-5514(85)90011-x.
   PubMedGoogle Scholar
• Gravely, M., and D. Roxbury. 2021. Multispectral Fingerprinting Resolves Dynamics of Nanomaterial Trafficking in Primary Endothelial Cells. ACS Nano 15 (7):12388-12404. doi:10.1021/acsnano.1c04500.
   Google Scholar
• Guo, B., C. Liao, X. Liu, and J. Yi. 2018. “Preliminary study on Conjugation of Formononetin with Multiwalled Carbon Nanotubes for Inducing Apoptosis via ROS Production in HeLa Cells.” Drug Design, Development and Therapy ume 12: 2815–2826. doi:10.2147/DDDT.S169767.
   Web of Science ®Google Scholar
• Guo, Y. Y., J. Zhang, Y. F. Zheng, J. Yang, and X. Q. Zhu. 2011. “Cytotoxic and Genotoxic Effects of Multi-Wall Carbon Nanotubes on Human Umbilical Vein Endothelial Cells in Vitro.” Mutation research 721 (2): 184–191.
   PubMed Web of Science ®Google Scholar
• Horie, M., and Y. Tabei. 2021. “Role of Oxidative Stress in Nanoparticles Toxicity.” Free radical Research 55 (4): 331–342.
   PubMed Web of Science ®Google Scholar
• Jacobsen, N. R., P. Moller, P. A. Clausen, A. T. Saber, C. Micheletti, K. A. Jensen, H. Wallin, and U. Vogel. 2017. “Biodistribution of Carbon Nanotubes in Animal Models.” Basic & Clinical Pharmacology & Toxicology 121 (Suppl 3): 30–43. doi:10.1111/bcpt.12705.
   PubMedGoogle Scholar
• Jia, G., H. Wang, L. Yan, X. Wang, R. Pei, T. Yan, Y. Zhao, and X. Guo. 2005. “Cytotoxicity of Carbon Nanomaterials: single-Wall Nanotube, Multi-Wall Nanotube, and Fullerene.” Environmental science & Technology 39 (5): 1378–1383.
   PubMed Web of Science ®Google Scholar
• Jones, A. T. 2007. “Macropinocytosis: searching for an Endocytic Identity and Role in the Uptake of Cell Penetrating Peptides.” Journal of Cellular and Molecular Medicine 11 (4): 670–684.
   PubMed Web of Science ®Google Scholar
• Kaloudi, A., E. Lymperis, P. Kanellopoulos, B. Waser, M. de Jong, E. P. Krenning, J. C. Reubi, B. A. Nock, and T. Maina. 2019. “Localization of (99m)Tc-GRP Analogs in GRPR-Expressing Tumors: Effects of Peptide Length and Neprilysin Inhibition on Biological Responses.” Pharmaceuticals (Basel) 12 (1):42-56. doi:10.3390/ph12010042.
   PubMedGoogle Scholar
• Kamal, R., V. D. Chadha, and D. K. Dhawan. 2018. “Physiological uptake and Retention of Radiolabeled Resveratrol Loaded Gold Nanoparticles ((99m)Tc-Res-AuNP) in Colon Cancer Tissue.” Nanomedicine-Uk 14 (3): 1059–1071. doi:10.1016/j.nano.2018.01.008.
   PubMed Web of Science ®Google Scholar
• Kumarathasan, P., D. Breznan, D. Das, M. A. Salam, Y. Siddiqui, C. MacKinnon-Roy, J. Guan, N. de Silva, B. Simard, and R. Vincent. 2015. “Cytotoxicity of Carbon Nanotube Variants: A Comparative in Vitro Exposure Study with A549 Epithelial and J774 Macrophage Cells.” Nanotoxicology 9 (2): 148–161.
   PubMed Web of Science ®Google Scholar
• Lindner, T., A. Altmann, S. Kramer, C. Kleist, A. Loktev, C. Kratochwil, F. Giesel, et al. 2020. “Design and Development of (99m)Tc-Labeled FAPI Tracers for SPECT Imaging and (188)Re Therapy.” Journal of Nuclear Medicine 61 (10): 1507–1513. doi:10.2967/jnumed.119.239731.
   PubMed Web of Science ®Google Scholar
• Liu, N., and M. Tang. 2020. “Toxic effects and Involved Molecular Pathways of Nanoparticles on Cells and Subcellular Organelles.” Journal of Applied Toxicology : JAT 40 (1): 16–36.
   PubMed Web of Science ®Google Scholar
• Lovell, T. C., S. G. Bolton, J. P. Kenison, J. Shangguan, C. E. Otteson, F. Civitci, X. Nan, M. D. Pluth, and R. Jasti. 2021. “Subcellular Targeted Nanohoop for One- and Two-Photon Live Cell Imaging.” ACS nano 15 (9): 15285–15293.
   PubMed Web of Science ®Google Scholar
• Madani, F., S. Lindberg, U. Langel, S. Futaki, and A. Graslund. 2011. “Mechanisms of Cellular Uptake of Cell-Penetrating Peptides.” Journal of Biophysics (Hindawi Publishing Corporation : Online) 2011: 414729.
   PubMedGoogle Scholar
• Moller, P., D. V. Christophersen, D. M. Jensen, A. Kermanizadeh, M. Roursgaard, N. R. Jacobsen, J. G. Hemmingsen, et al. 2014. “Role of Oxidative Stress in Carbon Nanotube-Generated Health Effects.” Archives of Toxicology 88 (11): 1939–1964.
   PubMed Web of Science ®Google Scholar
• Nikeafshar, S., A. Khazaei, and R. Tahvilian. 2021. "Inhibition of Methamphetamine-Induced Cytotoxicity in the U87-Cell Line by Atorvastatin-Conjugated Carbon Nanotubes.” Applied Biochemistry and Biotechnology 194(1): 479–503.
   Google Scholar
• Ong, L. C., F. F. Chung, Y. F. Tan, and C. O. Leong. 2016. “Toxicity of Single-Walled Carbon Nanotubes.” Archives of Toxicology 90 (1): 103–118.
   PubMed Web of Science ®Google Scholar
• Orecna, M., S. H. De Paoli, O. Janouskova, T. Z. Tegegn, M. Filipova, J. E. Bonevich, K. Holada, and J. Simak. 2014. “Toxicity of Carboxylated Carbon Nanotubes in Endothelial Cells is Attenuated by Stimulation of the Autophagic Flux with the Release of Nanomaterial in Autophagic Vesicles.” Nanomedicine : nanotechnology, Biology, and Medicine 10 (5): 939–948.
   PubMed Web of Science ®Google Scholar
• Pathak, A., P. Kumar, K. Chuttani, S. Jain, A. K. Mishra, S. P. Vyas, and K. C. Gupta. 2009. “Gene expression, Biodistribution, and Pharmacoscintigraphic Evaluation of Chondroitin sulfate-PEI Nanoconstructs Mediated Tumor Gene Therapy.” ACS nano 3 (6): 1493–1505.
   PubMed Web of Science ®Google Scholar
• Ren, X., M. Yan, Q. Yan, and C. Ge. 2016. “Controllable modification of Nanostructured Carbon with Hollow Macroporous Core/Mesoporous Shell and Its Application as Templates in Aqueous Solution.” Chemical Physics Letters 662: 286–290. doi:10.1016/j.cplett.2016.09.057.
   Web of Science ®Google Scholar
• Ren, X., M. Yan, Q. Yan, and C. Ge. 2019. “Full filling of Mesoporous Carbon Nanotubes by Aqueous Solution at Room Temperature.” Chinese Physics B. 28: 03680.
   Web of Science ®Google Scholar
• Ren, X., M. Yan, Q. Yan, and C. Ge. 2020. “Utilising the Adsorptivity of Mesoporous Carbon Nanotubes to Prepare Nanomaterials: A Shape-Controllable and Catalyst-Free Preparation Mechanism of Tungsten Nanowire and Nanodots.” Chemical Physics Letters. 739: 136978. doi:10.1016/j.cplett.2019.136978.
   Web of Science ®Google Scholar
• Rhee, M., and P. Davis. 2006. “Mechanism of Uptake of C105Y, a Novel Cell-Penetrating Peptide.” The Journal of Biological Chemistry 281 (2): 1233–1240.
   PubMed Web of Science ®Google Scholar
• Shafaq-Zadah, M., E. Dransart, and L. Johannes. 2020. “Clathrin-Independent Endocytosis, Retrograde Trafficking, and Cell Polarity.” Current opinion in Cell Biology 65: 112–121.
   PubMed Web of Science ®Google Scholar
• Shah, S. S. A., T. Najam, C. Cheng, L. Peng, R. Xiang, L. Zhang, J. Deng, W. Ding, and Z. Wei. 2018. “Exploring Fe-Nx for Peroxide Reduction: Template-Free Synthesis of Fe-Nx Traumatized Mesoporous Carbon Nanotubes as an ORR Catalyst in Acidic and Alkaline Solutions.” Chemistry - A European Journal 24 (42): 10630–10635. doi:10.1002/chem.201802453.
   PubMed Web of Science ®Google Scholar
• Shvedova, A. A., V. Castranova, E. R. Kisin, D. Schwegler-Berry, A. R. Murray, V. Z. Gandelsman, A. Maynard, and P. Baron. 2003. “Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells.” Journal of Toxicology and Environmental Health, Part A 66 (20): 1909–1926. doi:10.1080/713853956
   PubMed Web of Science ®Google Scholar
• Stone, V., and K. Donaldson. 2006. “Nanotoxicology: signs of Stress.” Nature nanotechnology 1 (1): 23–24.
   PubMed Web of Science ®Google Scholar
• Sun, Y., J. Gong, and Y. Cao. 2019. “Multi-Walled Carbon Nanotubes (MWCNTs) Activate Apoptotic Pathway through ER Stress: Does Surface Chemistry Matter?” International journal of Nanomedicine 14: 9285–9294.
   PubMed Web of Science ®Google Scholar
• Tian, F., D. Cui, H. Schwarz, G. G. Estrada, and H. Kobayashi. 2006. “Cytotoxicity of Single-Wall Carbon Nanotubes on Human Fibroblasts.” Toxicology in Vitro : An International Journal Published in Association with BIBRA 20 (7): 1202–1212.
   PubMed Web of Science ®Google Scholar
• Wang, B., P. Liu, H. Huang, X. Wang, M. Zhang, J. Huang, F. Lu, J. Chen, Y. Liu, and Z. Kang. 2021. “Carbon dots up-Regulate Heme Oxygenase-1 Expression towards Acute Lung Injury Therapy.” Journal of Materials Chemistry. B 9 (43): 9005–9011.
   PubMed Web of Science ®Google Scholar
• Wang, H., S. T. Yang, A. Cao, and Y. Liu. 2013. “Quantification of Carbon Nanomaterials in Vivo.” Accounts of Chemical Research 46 (3): 750–760.
   PubMed Web of Science ®Google Scholar
• Wu, B., M. Jiang, X. Liu, C. Huang, Z. Gu, and Y. Cao. 2020. “Evaluation of Toxicity of Halloysite Nanotubes and Multi-Walled Carbon Nanotubes to Endothelial Cells in Vitro and Blood Vessels in Vivo.” Nanotoxicology 14 (8): 1017–1038.
   PubMed Web of Science ®Google Scholar
• Wu, M., W. Chen, Y. Chen, H. Zhang, C. Liu, Z. Deng, Z. Sheng, et al. 2018. “Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment.” Advanced science (Weinheim, Baden-Wurttemberg, Germany) 5 (4): 1700474.
   PubMedGoogle Scholar
• Yang, P., H. Xu, Z. Zhang, L. Yang, H. Kuang, and Z. P. Aguilar. 2018. “Surface modification Affect the Biodistribution and Toxicity Characteristics of Iron Oxide Magnetic Nanoparticles in Rats.” IET nanobiotechnology 12 (5): 562–568.
   PubMed Web of Science ®Google Scholar
• Zhang, Y., Y. Xu, Z. Li, T. Chen, S. M. Lantz, P. C. Howard, M. G. Paule, W. Jr. Slikker, F. Watanabe, T. Mustafa, A. S. Biris, and S. F. Ali. 2011. “Mechanistic Toxicity Evaluation of Uncoated and Pegylated Single-Walled Carbon Nanotubes in Neuronal PC12 Cells.” ACS Nano 5 (9): 7020–7033. doi:10.1021/nn2016259.
   PubMed Web of Science ®Google Scholar
• Zhang, H., F. Song, C. Dong, L. Yu, C. Chang, and Y. Chen. 2021a. “Co-Delivery of Nanoparticle and Molecular Drug by Hollow Mesoporous Organosilica for Tumor-Activated and Photothermal-Augmented Chemotherapy of Breast Cancer.” Journal of Nanobiotechnology 19 (1): 290. doi:10.1186/s12951-021-01025-w.
   PubMed Web of Science ®Google Scholar
• Zhang, M., Y. Xu, M. Yang, M. Yudasaka, and T. Okazaki, 2021b. “Comparative assessments of the Biodistribution and Toxicity of Oxidized Single-Walled Carbon Nanotubes Dispersed with Two Different Reagents after Intravenous Injection.” Nanotoxicology 15 (6): 798–811.
   Google Scholar
• Zhang, J., A. Rakhimbekova, X. Duan, Q. Yin, C. A. Foss, Y. Fan, Y. Xu, et al. 2021c. “A prostate-Specific Membrane Antigen Activated Molecular Rotor for Real-Time Fluorescence Imaging.” Nature Communications 12 (1): 5460. doi:10.1038/s41467-021-25746-6.
   Google Scholar