Radiation impacts on toxicity of cobalt–chromium (CoCr) implant debris

References

• Ahmad, R., G. Schettino, G. Royle, M. Barry, Q. A. Pankhurst, O. Tillement, B. Russell, and K. Ricketts. 2020. “Radiobiological Implications of Nanoparticles following Radiation Treatment.” Particle & Particle Systems Characterization: Measurement and Description of Particle Properties and Behavior in Powders and Other Disperse Systems 37 (4): 1900411. doi:10.1002/ppsc.201900411.
   PubMedGoogle Scholar
• Arnholt, C. M., J. B. White, J. A. Lowell, M. R. Perkins, W. M. Mihalko, and S. M. Kurtz. 2020. “Postmortem Retrieval Analysis of Metallosis and Periprosthetic Tissue Metal Concentrations in Total Knee Arthroplasty.” The Journal of Arthroplasty 35 (2): 569–578. doi:10.1016/j.arth.2019.08.038.
   PubMedGoogle Scholar
• ASTM International. 2018. Cobalt-28 Chromium-6 Molybdenum Alloy Castings and Casting Alloy for Surgical Implants (UNS R30075). F75-18. West Conshohocken, PA: ASTM International.
   Google Scholar
• Behl, B., I. Papageorgiou, C. Brown, R. Hall, J. L. Tipper, J. Fisher, and E. Ingham. 2013. “Biological Effects of Cobalt-Chromium Nanoparticles and Ions on Dural Fibroblasts and Dural Epithelial Cells.” Biomaterials 34 (14): 3547–3558. doi:10.1016/j.biomaterials.2013.01.023.
   PubMed Web of Science ®Google Scholar
• Besse, H. C., C. Bos, M. Zandvliet, K. VAN DER Wurff-Jacobs, C. T. W. Moonen, and R. Deckers. 2018. “Triggered Radiosensitizer Delivery Using Thermosensitive Liposomes and Hyperthermia Improves Efficacy of Radiotherapy: An in Vitro Proof of Concept Study.” PLoS One 13 (9): e0204063. doi:10.1371/journal.pone.0204063.
   PubMedGoogle Scholar
• Braselmann, H., A. Michna, J. Heß, and K. Unger. 2015. “CFAssay: Statistical Analysis of the Colony Formation Assay.” Radiation Oncology 10 (1): 223. doi:10.1186/s13014-015-0529-y.
   PubMedGoogle Scholar
• Bunderson-Schelvan, M., R. F. Hamilton, K. L. Trout, F. Jessop, M. Gulumian, and A. Holian. 2016. “Approaching a Unified Theory for Particle-Induced Inflammation.” Biological Effects of Fibrous and Particulate Substances. Berlin, Germany: Springer.
   Google Scholar
• Cheng, N. N., Z. Starkewolf, R. A. Davidson, A. Sharmah, C. Lee, J. Lien, and T. Guo. 2012. “Chemical Enhancement by Nanomaterials under X-Ray Irradiation.” Journal of the American Chemical Society 134 (4): 1950–1953. doi:10.1021/ja210239k.
   PubMed Web of Science ®Google Scholar
• Christiner, T., M. B. Pabbruwe, A. M. Kop, J. Parry, G. Clark, and D. Collopy. 2018. “Taper Corrosion and Adverse Local Tissue Reactions in Patients with a Modular Knee Prosthesis.” JB & JS Open Access 3 (4): e0019. doi:10.2106/JBJS.OA.18.00019.
   PubMedGoogle Scholar
• Cooper, H. J., C. J. DELLA Valle, R. A. Berger, M. Tetreault, W. G. Paprosky, S. M. Sporer, and J. J. Jacobs. 2012. “Corrosion at the Head-Neck Taper as a Cause for Adverse Local Tissue Reactions after Total Hip Arthroplasty.” The Journal of Bone and Joint Surgery 94 (18): 1655–1661. doi:10.2106/jbjs.k.01352.
   PubMed Web of Science ®Google Scholar
• Council, N. R. 2006. “Molecular and Cellular Responses to Ionizing Radiation.” Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2. Washington, DC: The National Academies Press.
   Google Scholar
• Curtin, B. M., L. C. Armstrong, B. T. Bucker, S. M. Odum, and W. A. Jiranek. 2016. “Patient Radiation Exposure during Fluoro-Assisted Direct Anterior Approach Total Hip Arthroplasty.” The Journal of Arthroplasty 31 (6): 1218–1221. doi:10.1016/j.arth.2015.12.012.
   PubMed Web of Science ®Google Scholar
• Desouky, O., N. Ding, and G. Zhou. 2015. “Targeted and Non-Targeted Effects of Ionizing Radiation.” Journal of Radiation Research and Applied Sciences 8 (2): 247–254. doi:10.1016/j.jrras.2015.03.003.
   Web of Science ®Google Scholar
• Edwards, H. H., Y. Y. Yeh, B. I. Tarnowski, and G. R. Schonbaum. 1992. “Acetonitrile as a Substitute for Ethanol/Propylene Oxide in Tissue Processing for Transmission Electron Microscopy: Comparison of Fine Structure and Lipid Solubility in Mouse Liver, Kidney, and Intestine.” Microscopy Research and Technique 21 (1): 39–50. doi:10.1002/jemt.1070210106.
   PubMedGoogle Scholar
• Eltit, F., Q. Wang, and R. Wang. 2019. “Mechanisms of Adverse Local Tissue Reactions to Hip Implants.” Frontiers in Bioengineering and Biotechnology 7: 176. doi: 10.3389/fbioe.2019.00176.
   PubMedGoogle Scholar
• Eriksson, D., and T. Stigbrand. 2010. “Radiation-Induced Cell Death Mechanisms.” Tumour Biology: The Journal of the International Society for Oncodevelopmental Biology and Medicine 31 (4): 363–372. doi:10.1007/s13277-010-0042-8.
   PubMedGoogle Scholar
• FDA. 2019. Biological Responses to Metal Implants. Silver Spring, MD: United States Food and Drug Administration.
   Google Scholar
• Franken, N. A., H. M. Rodermond, J. Stap, J. Haveman, and C. VAN Bree. 2006. “Clonogenic Assay of Cells in Vitro.” Nature Protocols 1 (5): 2315–2319. doi:10.1038/nprot.2006.339.
   PubMed Web of Science ®Google Scholar
• Ganswindt, U., F. Paulsen, A. G. Anastasiadis, A. Stenzl, M. Bamberg, and C. Belka. 2005. “70 Gy or More: Which Dose for Which Prostate Cancer?” Journal of Cancer Research and Clinical Oncology 131 (7): 407–419. doi:10.1007/s00432-005-0681-0.
   PubMedGoogle Scholar
• Gary, R. K., and S. M. Kindell. 2005. “Quantitative Assay of Senescence-Associated Beta-Galactosidase Activity in Mammalian Cell Extracts.” Analytical Biochemistry 343 (2): 329–334. doi:10.1016/j.ab.2005.06.003.
   PubMed Web of Science ®Google Scholar
• Gewirtz, D. A., S. E. Holt, and L. W. Elmore. 2008. “Accelerated Senescence: An Emerging Role in Tumor Cell Response to Chemotherapy and Radiation.” Biochemical Pharmacology 76 (8): 947–957. doi:10.1016/j.bcp.2008.06.024.
   PubMed Web of Science ®Google Scholar
• Gill, H. S., G. Grammatopoulos, S. Adshead, E. Tsialogiannis, and E. Tsiridis. 2012. “Molecular and Immune Toxicity of CoCr Nanoparticles in MoM Hip Arthroplasty.” Trends in Molecular Medicine 18 (3): 145–155. doi:10.1016/j.molmed.2011.12.002.
   PubMed Web of Science ®Google Scholar
• Gore, D., R. Q. Frazer, R. E. Kovarik, and J. E. Yepes. 2005. “Vitallium.” Journal of Long-Term Effects of Medical Implants 15 (6): 673–686. doi:10.1615/jlongtermeffmedimplants.v15.i6.90.
   PubMedGoogle Scholar
• Granchi, D., L. M. Savarino, G. Ciapetti, and N. Baldini. 2018. “Biological Effects of Metal Degradation in Hip Arthroplasties.” Critical Reviews in Toxicology 48 (2): 170–193. doi:10.1080/10408444.2017.1392927.
   PubMed Web of Science ®Google Scholar
• Guo, T. 2019. “Physical, Chemical and Biological Enhancement in X-Ray Nanochemistry.” Physical Chemistry Chemical Physics 21 (29): 15917–15931. doi:10.1039/c9cp03024g.
   PubMedGoogle Scholar
• Gupta, G., A. Gliga, J. Hedberg, A. Serra, D. Greco, I. Odnevall Wallinder, and B. Fadeel. 2020. “Cobalt Nanoparticles Trigger Ferroptosis-like Cell Death (Oxytosis) in Neuronal Cells: Potential Implications for Neurodegenerative Disease.” FASEB Journal 34 (4): 5262–5281. doi:10.1096/fj.201902191RR.
   PubMed Web of Science ®Google Scholar
• Hall, E. J. G., and J. Amato. 2018. “Cell Survival Curves.” Radiobiology for the Radiologist. 8th ed. Alphen aan den Rijn, Netherlands: Wolters Kluwer.
   Google Scholar
• Hallab, N. J. 2009. “A Review of the Biologic Effects of Spine Implant Debris: Fact from Fiction.” SAS Journal 3 (4): 143–160. doi:10.1016/j.esas.2009.11.005.
   PubMedGoogle Scholar
• Hallab, N. J., and J. J. Jacobs. 2020. “Orthopedic Applications.” Biomaterials Science. 4 ed. London: Royal Society of Chemistry.
   Google Scholar
• Harding, I., A. Bonomo, R. Crawford, V. Psychoyios, T. Delves, D. Murray, and P. Mclardy-Smith. 2002. “Serum Levels of Cobalt and Chromium in a Complex Modular Total Hip Arthroplasty System.” The Journal of Arthroplasty 17 (7): 893–895. doi:10.1054/arth.2002.34539.
   PubMedGoogle Scholar
• Hart, A. J., P. D. Quinn, B. Sampson, A. Sandison, K. D. Atkinson, J. A. Skinner, J. J. Powell, and J. F. Mosselmans. 2010. “The Chemical Form of Metallic Debris in Tissues Surrounding Metal-on-Metal Hips with Unexplained Failure.” Acta Biomaterialia 6 (11): 4439–4446. doi:10.1016/j.actbio.2010.06.006.
   PubMed Web of Science ®Google Scholar
• Hartmann, A., F. Hannemann, J. Lutzner, A. Seidler, H. Drexler, K. P. Gunther, and J. Schmitt. 2013. “Metal Ion Concentrations in Body Fluids after Implantation of Hip Replacements with Metal-on-Metal Bearing–Systematic Review of Clinical and Epidemiological Studies.” PLoS One 8 (8): e70359. doi:10.1371/journal.pone.0070359.
   PubMed Web of Science ®Google Scholar
• Hartung, T. 2018. “Perspectives on in Vitro to in Vivo Extrapolations.” Applied in Vitro Toxicology 4 (4): 305–316. doi:10.1089/aivt.2016.0026.
   PubMedGoogle Scholar
• ISO. 2019. “ISO 10993 Biological Evaluation of Medical Devices.” Part 9: Framework for Identification and Quantification of Potential Degradation Products. Geneva, Switzerland: International Organization for Standardization.
   Google Scholar
• Jain, S., J. A. Coulter, A. R. Hounsell, K. T. Butterworth, S. J. Mcmahon, W. B. Hyland, M. F. Muir, et al. 2011. “Cell-Specific Radiosensitization by Gold Nanoparticles at Megavoltage Radiation Energies.” International Journal of Radiation Oncology, Biology, Physics 79 (2): 531–539. doi:10.1016/j.ijrobp.2010.08.044.
   PubMed Web of Science ®Google Scholar
• Jenko, M., M. Gorenšek, M. Godec, M. Hodnik, B. Š. Batič, Č. Donik, J. T. Grant, and D. Dolinar. 2018. “Surface Chemistry and Microstructure of Metallic Biomaterials for Hip and Knee Endoprostheses.” Applied Surface Science 427: 584–593. doi:10.1016/j.apsusc.2017.08.007.
   Web of Science ®Google Scholar
• Jungmann, P. M., C. A. Agten, C. W. Pfirrmann, and R. Sutter. 2017. “Advances in MRI around Metal.” Journal of Magnetic Resonance Imaging 46 (4): 972–991. doi:10.1002/jmri.25708.
   PubMedGoogle Scholar
• Kataoka, M. L., M. G. Hochman, E. K. Rodriguez, P. J. Lin, S. Kubo, and V. D. Raptopolous. 2010. “A Review of Factors That Affect Artifact from Metallic Hardware on Multi-Row Detector Computed Tomography.” Current Problems in Diagnostic Radiology 39 (4): 125–136. doi:10.1067/j.cpradiol.2009.05.002.
   PubMedGoogle Scholar
• Knight, S. R., R. Aujla, and S. P. Biswas. 2011. “Total Hip Arthroplasty - over 100 Years of Operative History.” Orthopedic Reviews 3 (2): e16. doi:10.4081/or.2011.e16.
   Google Scholar
• Kovochich, M., B. L. Finley, R. Novick, A. D. Monnot, E. Donovan, K. M. Unice, E. S. Fung, D. Fung, and D. J. Paustenbach. 2018. “Understanding Outcomes and Toxicological Aspects of Second Generation Metal-on-Metal Hip Implants: A State-of-the-Art Review.” Critical Reviews in Toxicology 48 (10): 853–901. doi:10.1080/10408444.2018.1563048.
   PubMedGoogle Scholar
• Kuba, M., J. Gallo, T. Pluhacek, M. Hobza, and D. Milde. 2019. “Content of Distinct Metals in Periprosthetic Tissues and Pseudosynovial Joint Fluid in Patients with Total Joint Arthroplasty.” Journal of Biomedical Materials Research Part B, Applied Biomaterials 107 (2): 454–462. doi:10.1002/jbm.b.34137.
   PubMedGoogle Scholar
• Kusumoto, T., H. Kitamura, S. Hojo, T. Konishi, and S. Kodaira. 2020. “Significant Changes in Yields of 7-Hydroxy-Coumarin-3-Carboxylic Acid Produced under FLASH Radiotherapy Conditions.” RSC Advances 10 (63): 38709–38714. doi:10.1039/d0ra07999e.
   PubMed Web of Science ®Google Scholar
• Learmonth, I. D., C. Young, and C. Rorabeck. 2007. “The Operation of the Century: Total Hip Replacement.” Lancet (London, England) 370 (9597): 1508–1519. doi:10.1016/S0140-6736(07)60457-7.
   PubMed Web of Science ®Google Scholar
• Lechtman, E., and J. P. Pignol. 2017. “Interplay between the Gold Nanoparticle Sub-Cellular Localization, Size, and the Photon Energy for Radiosensitization.” Scientific Reports 7 (1): 13268. doi:10.1038/s41598-017-13736-y.
   PubMedGoogle Scholar
• Lee, B. Y., J. A. Han, J. S. Im, A. Morrone, K. Johung, E. C. Goodwin, W. J. Kleijer, D. Dimaio, and E. S. Hwang. 2006. “Senescence-Associated Beta-Galactosidase is Lysosomal Beta-Galactosidase.” Aging Cell 5 (2): 187–195. doi:10.1111/j.1474-9726.2006.00199.x.
   PubMed Web of Science ®Google Scholar
• Lehtovirta, L., A. Reito, J. Parkkinen, S. Peraniemi, J. Vepsalainen, and A. Eskelinen. 2018. “Association between Periprosthetic Tissue Metal Content, Whole Blood and Synovial Fluid Metal Ion Levels and Histopathological Findings in Patients with Failed Metal-on-Metal Hip Replacement.” PLoS One 13 (5): e0197614. doi:10.1371/journal.pone.0197614.
   PubMedGoogle Scholar
• Leonard, S., P. M. Gannett, Y. Rojanasakul, D. Schwegler-Berry, V. Castranova, V. Vallyathan, and X. Shi. 1998. “Cobalt-Mediated Generation of Reactive Oxygen Species and Its Possible Mechanism.” Journal of Inorganic Biochemistry 70 (3–4): 239–244. doi:10.1016/s0162-0134(98)10022-3.
   PubMedGoogle Scholar
• Liu, Y., W. Zhu, D. Ni, Z. Zhou, J. H. Gu, W. Zhang, H. Sun, and F. Liu. 2020. “Alpha Lipoic Acid Antagonizes Cytotoxicity of Cobalt Nanoparticles by Inhibiting Ferroptosis-like Cell Death.” Journal of Nanobiotechnology 18 (1): 141. doi:10.1186/s12951-020-00700-8.
   PubMed Web of Science ®Google Scholar
• Lohmann, C. H., H. Meyer, J. V. Nuechtern, G. Singh, S. Junk-Jantsch, H. Schmotzer, M. M. Morlock, and G. Pfluger. 2013. “Periprosthetic Tissue Metal Content but Not Serum Metal Content Predicts the Type of Tissue Response in Failed Small-Diameter Metal-on-Metal Total Hip Arthroplasties.” Journal of Bone and Joint Surgery 95 (17): 1561–1568. doi:10.2106/JBJS.L.01273.
   Google Scholar
• Madl, A. K., M. Kovochich, M. Liong, B. L. Finley, D. J. Paustenbach, and G. Oberdorster. 2015a. “Toxicology of Wear Particles of Cobalt-Chromium Alloy Metal-on-Metal Hip Implants Part II: Importance of Physicochemical Properties and Dose in Animal and in Vitro Studies as a Basis for Risk Assessment.” Nanomedicine 11 (5): 1285–1298. doi:10.1016/j.nano.2015.02.006.
   PubMedGoogle Scholar
• Madl, A. K., M. Liong, M. Kovochich, B. L. Finley, D. J. Paustenbach, and G. Oberdorster. 2015b. “Toxicology of Wear Particles of Cobalt-Chromium Alloy Metal-on-Metal Hip Implants Part I: Physicochemical Properties in Patient and Simulator Studies.” Nanomedicine 11 (5): 1201–1215. doi:10.1016/j.nano.2014.12.005.
   PubMed Web of Science ®Google Scholar
• Mán, I., G. J. Szebeni, I. Plangár, E. R. Szabó, T. Tőkés, Z. Szabó, Z. Nagy, et al. 2015. “Novel Real-Time Cell Analysis Platform for the Dynamic Monitoring of Ionizing Radiation Effects on Human Tumor Cell Lines and Primary Fibroblasts.” Molecular Medicine Reports 12 (3): 4610–1619. doi:10.3892/mmr.2015.4004.
   PubMedGoogle Scholar
• Manevich, Y., K. D. Held, and J. E. Biaglow. 1997. “Coumarin-3-Carboxylic Acid as a Detector for Hydroxyl Radicals Generated Chemically and by Gamma Radiation.” Radiation Research 148 (6): 580–591. doi: 10.2307/3579734.
   PubMedGoogle Scholar
• Mcmahon, S. J. 2018. “The Linear Quadratic Model: Usage, Interpretation and Challenges.” Physics in Medicine and Biology 64 (1): 01TR01. doi:10.1088/1361-6560/aaf26a.
   PubMed Web of Science ®Google Scholar
• Mettler, F. A. JR,., M. M. Chatfield, M. B. Chambers, C. E. Elee, J. G. Frush, D. P. Milano, M. T. Miller, et al. 2019. NCRP Report No. 184 – Medical Radiation Exposure of Patients in the United States. Bethesda, MD: National Council on Radiation Protection and Measurements (NCRP).
   Google Scholar
• Morrell, A. P., H. Floyd, J. F. W. Mosselmans, L. M. Grover, H. Castillo-Michel, E. T. Davis, J. E. Parker, R. A. Martin, and O. Addison. 2019. “Improving Our Understanding of Metal Implant Failures: Multiscale Chemical Imaging of Exogenous Metals in Ex-Vivo Biological Tissues.” Acta Biomaterialia 98: 284–293. doi:10.1016/j.actbio.2019.05.071.
   PubMedGoogle Scholar
• Mushtaq, N., K. To, C. Gooding, and W. Khan. 2019. “Radiological Imaging Evaluation of the Failing Total Hip Replacement.” Frontiers in Surgery 6: 35. doi:10.3389/fsurg.2019.00035.
   PubMedGoogle Scholar
• Nousiainen, T., S. Palosaari, S. Peraniemi, A. Tervahauta, J. Niinimaki, J. Leppilahti, and P. Lehenkari. 2020. “Retention of Metals in Periprosthetic Tissues of Patients with Metal-on-Metal Total Hip Arthroplasty is Reflected in the Synovial Fluid to Blood Cobalt Transfer Ratio in the Presence of a Pseudotumour.” BMC Musculoskeletal Disorders 21 (1): 610. doi:10.1186/s12891-020-03636-0.
   PubMedGoogle Scholar
• Papageorgiou, I., C. Brown, R. Schins, S. Singh, R. Newson, S. Davis, J. Fisher, E. Ingham, and C. P. Case. 2007. “The Effect of Nano- and Micron-Sized Particles of Cobalt-Chromium Alloy on Human Fibroblasts in Vitro.” Biomaterials 28 (19): 2946–2958. doi:10.1016/j.biomaterials.2007.02.034.
   PubMed Web of Science ®Google Scholar
• Paulus, A. C., K. Ebinger, X. Cheng, S. Hasselt, P. Weber, J. P. Kretzer, R. Bader, and S. Utzschneider. 2019. “Local Biological Reactions and Pseudotumor-Like Tissue Formation in Relation to Metal Wear in a Murine in Vivo Model.” Biomed Research International 2019: 3649838. doi: 10.1155/2019/3649838.
   PubMedGoogle Scholar
• Penninckx, S., A. C. Heuskin, C. Michiels, and S. Lucas. 2020. “Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient.” Cancers (Basel) 12: 2021. doi:10.3390/cancers12082021.
   PubMedGoogle Scholar
• Petrova, N. V., A. K. Velichko, S. V. Razin, and O. L. Kantidze. 2016. “Small Molecule Compounds That Induce Cellular Senescence.” Aging Cell 15 (6): 999–1017. doi:10.1111/acel.12518.
   PubMed Web of Science ®Google Scholar
• Posada, O. M., D. Gilmour, R. J. Tate, and M. H. Grant. 2014. “CoCr Wear Particles Generated from CoCr Alloy Metal-on-Metal Hip Replacements, and Cobalt Ions Stimulate Apoptosis and Expression of General Toxicology-Related Genes in Monocyte-like U937 Cells.” Toxicology and Applied Pharmacology 281 (1): 125–135. doi:10.1016/j.taap.2014.09.010.
   PubMedGoogle Scholar
• Raghunathan, V. K., M. Devey, S. Hawkins, L. Hails, S. A. Davis, S. Mann, I. T. Chang, et al. 2013. “Influence of Particle Size and Reactive Oxygen Species on Cobalt Chrome Nanoparticle-Mediated Genotoxicity.” Biomaterials 34 (14): 3559–3570. doi:10.1016/j.biomaterials.2013.01.085.
   PubMed Web of Science ®Google Scholar
• Reft, C., R. Alecu, I. J. DAS, B. J. Gerbi, P. Keall, E. Lief, B. J. Mijnheer, et al. 2003. “Dosimetric Considerations for Patients with HIP Prostheses Undergoing Pelvic Irradiation. Report of the AAPM Radiation Therapy Committee Task Group 63.” Medical Physics 30 (6): 1162–1182. doi:10.1118/1.1565113.
   PubMedGoogle Scholar
• Rehani, M. M., K. Yang, E. R. Melick, J. Heil, D. Salat, W. F. Sensakovic, and B. Liu. 2020. “Patients Undergoing Recurrent CT Scans: Assessing the Magnitude.” European Radiology 30 (4): 1828–1836. doi:10.1007/s00330-019-06523-y.
   PubMedGoogle Scholar
• Reito, A., J. Parkkinen, T. Puolakka, J. Pajamaki, and A. Eskelinen. 2015. “Diagnostic Utility of Joint Fluid Metal Ion Measurement for Histopathological Findings in Metal-on-Metal Hip Replacements.” BMC Musculoskeletal Disorders 16: 393. doi:10.1186/s12891-015-0851-4.
   PubMedGoogle Scholar
• Reynolds, E. S. 1963. “The Use of Lead Citrate at High pH as an Electron-Opaque Stain in Electron Microscopy.” The Journal of Cell Biology 17 (1): 208–212. doi:10.1083/jcb.17.1.208.
   PubMed Web of Science ®Google Scholar
• Rosengren, B., L. Wulff, E. Carlsson, J. Carlsson, K. G. Strid, and A. Montelius. 1993. “Backscatter Radiation at Tissue-Titanium Interfaces. Biological Effects from Diagnostic 65 kVp X-Rays.” Acta Oncologica (Stockholm, Sweden) 32 (1): 73–77. doi:10.3109/02841869309083889.
   PubMed Web of Science ®Google Scholar
• Salloum, Z., E. A. Lehoux, M. E. Harper, and I. Catelas. 2018. “Effects of Cobalt and Chromium Ions on Oxidative Stress and Energy Metabolism in Macrophages in Vitro.” Journal of Orthopaedic Research 36 (12): 3178–3187. doi:10.1002/jor.24130.
   PubMedGoogle Scholar
• Scharf, B., C. C. Clement, V. Zolla, G. Perino, B. Yan, S. G. Elci, E. Purdue, et al. 2014. “Molecular Analysis of Chromium and Cobalt-Related Toxicity.” Scientific Reports 4: 5729. doi:10.1038/srep05729.
   PubMed Web of Science ®Google Scholar
• Shellock, F. G. 2002. “Biomedical Implants and Devices: Assessment of Magnetic Field Interactions with a 3.0-Tesla MR System.” Journal of Magnetic Resonance Imaging 16 (6): 721–732. doi:10.1002/jmri.10207.
   PubMed Web of Science ®Google Scholar
• Song, O. K., Y. E. Chung, N. Seo, S. E. Baek, J. Y. Choi, M. S. Park, and M. J. Kim. 2019. “Metal Implants Influence CT Scan Parameters Leading to Increased Local Radiation Exposure: A Proposal for Correction Techniques.” PLoS One 14 (8): e0221692. doi:10.1371/journal.pone.0221692.
   PubMedGoogle Scholar
• Subiel, A., R. Ashmore, and G. Schettino. 2016. “Standards and Methodologies for Characterizing Radiobiological Impact of High-Z Nanoparticles.” Theranostics 6 (10): 1651–1671. doi:10.7150/thno.15019.
   PubMedGoogle Scholar
• Taggart, L. E., S. J. Mcmahon, K. T. Butterworth, F. J. Currell, G. Schettino, and K. M. Prise. 2016. “Protein Disulphide Isomerase as a Target for Nanoparticle-Mediated Sensitisation of Cancer Cells to Radiation.” Nanotechnology 27 (21): 215101. doi:10.1088/0957-4484/27/21/215101.
   PubMedGoogle Scholar
• Trout, K. L., and A. Holian. 2019. “Factors Influencing Multinucleated Giant Cell Formation in Vitro.” Immunobiology 224 (6): 834–842. doi:10.1016/j.imbio.2019.08.002.
   PubMedGoogle Scholar
• Urban, R. M., J. J. Jacobs, M. J. Tomlinson, J. Gavrilovic, J. Black, and M. Peoc’h. 2000. “Dissemination of Wear Particles to the Liver, Spleen, and Abdominal Lymph Nodes of Patients with Hip or Knee Replacement.” The Journal of Bone and Joint Surgery 82 (4): 457–476. doi:10.2106/00004623-200004000-00002.
   PubMed Web of Science ®Google Scholar
• Van den Wyngaert, T., K. Strobel, W. U. Kampen, T. Kuwert, W. VAN DER Bruggen, H. K. Mohan, G. Gnanasegaran, E., et al. 2016. “The EANM Practice Guidelines for Bone Scintigraphy.” European Journal of Nuclear Medicine and Molecular Imaging 43 (9): 1723–1738. doi:10.1007/s00259-016-3415-4.
   PubMed Web of Science ®Google Scholar
• Wang, H., X. Mu, H. He, and X. D. Zhang. 2018. “Cancer Radiosensitizers.” Trends in Pharmacological Sciences 39 (1): 24–48. doi:10.1016/j.tips.2017.11.003.
   PubMed Web of Science ®Google Scholar
• Wang, Q., F. Eltit, D. Garbuz, C. Duncan, B. Masri, N. Greidanus, and R. Wang. 2020. “CoCrMo Metal Release in Metal-on-Highly Crosslinked Polyethylene Hip Implants.” Journal of Biomedical Materials Research Part B: Applied Biomaterials 108 (4): 1213–1228. doi:10.1002/jbm.b.34470.
   PubMedGoogle Scholar
• Wang, Z., N. Liu, K. Liu, G. Zhou, J. Gan, Z. Wang, T. Shi, et al. 2015. “Autophagy Mediated CoCrMo Particle-Induced Peri-Implant Osteolysis by Promoting Osteoblast Apoptosis.” Autophagy 11 (12): 2358–2369. doi:10.1080/15548627.2015.1106779.
   PubMed Web of Science ®Google Scholar
• Wei, Z., J. Edin, A. E. Karlsson, K. Petrovic, I. L. Soroka, I. Odnevall Wallinder, and Y. Hedberg. 2018. “Can Gamma Irradiation during Radiotherapy Influence the Metal Release Process for Biomedical CoCrMo and 316L Alloys?” Journal of Biomedical Materials Research Part B, Applied Biomaterials 106 (7): 2673–2680. doi:10.1002/jbm.b.34084.
   PubMedGoogle Scholar
• Winter, L., F. Seifert, L. Zilberti, M. Murbach, and B. Ittermann. 2021. “MRI-Related Heating of Implants and Devices: A Review.” Journal of Magnetic Resonance Imaging 53 (6): 1646–1665. doi:10.1002/jmri.27194.
   PubMedGoogle Scholar
• Wunderlich, R., A. Ernst, F. Rodel, R. Fietkau, O. Ott, K. Lauber, B. Frey, and U. S. Gaipl. 2015. “Low and Moderate Doses of Ionizing Radiation up to 2 Gy Modulate Transmigration and Chemotaxis of Activated Macrophages, Provoke an anti-Inflammatory Cytokine Milieu, but Do Not Impact upon Viability and Phagocytic Function.” Clinical and Experimental Immunology 179 (1): 50–61. doi:10.1111/cei.12344.
   PubMed Web of Science ®Google Scholar
• Xia, Z., Y. M. Kwon, S. Mehmood, C. Downing, K. Jurkschat, and D. W. Murray. 2011. “Characterization of Metal-Wear Nanoparticles in Pseudotumor following Metal-on-Metal Hip Resurfacing.” Nanomedicine: Nanotechnology, Biology, and Medicine 7 (6): 674–681. doi:10.1016/j.nano.2011.08.002.
   PubMed Web of Science ®Google Scholar
• Xu, J., J. Yang, A. Nyga, M. Ehteramyan, A. Moraga, Y. Wu, L. Zeng, M. M. Knight, and J. C. Shelton. 2018. “Cobalt (II) Ions and Nanoparticles Induce Macrophage Retention by ROS-Mediated down-Regulation of RhoA Expression.” Acta Biomaterialia 72: 434–446. doi:10.1016/j.actbio.2018.03.054.
   PubMedGoogle Scholar
• Yang, F., J. Tang, K. Dai, and Y. Huang. 2019. “Metallic Wear Debris Collected from Patients Induces Apoptosis in Rat Primary Osteoblasts via Reactive Oxygen Speciesmediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress.” Molecular Medicine Reports 19: 1629–1637.
   PubMedGoogle Scholar