Food-grade titanium dioxide (E171) and zinc oxide nanoparticles induce mitochondrial permeability and cardiac damage after oral exposure in rats

References

• Amara, S., W. Khemissi, I. Mrad, N. Rihane, I. Ben Slama, L. E. Mir, M. Jeljeli, K. Ben Rhouma, H. Abdelmelek, and M. Sakly. 2013. “Effect of TiO2 Nanoparticles on Emotional Behavior and Biochemical Parameters in Adult Wistar Rats.” General Physiology and Biophysics 32 (2): 229–234. https://doi.org/10.4149/gpb_2013015
   PubMed Web of Science ®Google Scholar
• Amigo, I., S. L. Menezes-Filho, L. A. Luévano-Martínez, B. Chausse, and A. J. Kowaltowski. 2017. “Caloric Restriction Increases Brain Mitochondrial Calcium Retention Capacity and Protects against Excitotoxicity.” Aging Cell 16 (1): 73–81. https://doi.org/10.1111/acel.12527
   PubMed Web of Science ®Google Scholar
• Baek, M., H. E. Chung, J. Yu, J. A. Lee, T. H. Kim, J. M. Oh, W. J. Lee, et al. 2012. “Pharmacokinetics, Tissue Distribution, and Excretion of Zinc Oxide Nanoparticles.” International Journal of Nanomedicine 7: 3081–3097. https://doi.org/10.2147/IJN.S32593
   PubMed Web of Science ®Google Scholar
• Bertero, E., and C. Maack. 2018. “Calcium Signaling and Reactive Oxygen Species in Mitochondria.” Circulation Research 122 (10): 1460–1478. https://doi.org/10.1161/CIRCRESAHA.118.310082
   PubMed Web of Science ®Google Scholar
• Bettini, S., E. Boutet-Robinet, C. Cartier, C. Coméra, E. Gaultier, J. Dupuy, N. Naud, et al. 2017. “Food-Grade TiO2 Impairs Intestinal and Systemic Immune Homeostasis, Initiates Preneoplastic Lesions and Promotes Aberrant Crypt Development in the Rat Colon.” Scientific Reports 7 (1). https://doi.org/10.1038/srep40373
   PubMedGoogle Scholar
• Cao, Y., Y. Gong, W. Liao, Y. Luo, C. Wu, M. Wang, and Q. Yang. 2018. “A Review of Cardiovascular Toxicity of TiO2, ZnO and Ag Nanoparticles (NPs).” Biometals 31 (4): 457–476. https://doi.org/10.1007/s10534-018-0113-7
   PubMed Web of Science ®Google Scholar
• Chen, Z., S. Han, P. Zheng, D. Zhou, S. Zhou, and G. Jia. 2020. “Effect of Oral Exposure to Titanium Dioxide Nanoparticles on Lipid Metabolism in Sprague-Dawley Rats.” Nanoscale 12 (10): 5973–5986. https://doi.org/10.1039/c9nr10947a
   PubMed Web of Science ®Google Scholar
• Cho, W. S., R. Duffin, S. E. M. Howie, C. J. Scotton, W. A. H. Wallace, W. Macnee, M. Bradley, I. L. Megson, and K. Donaldson. 2011. “Progressive Severe Lung Injury by Zinc Oxide Nanoparticles; the Role of Zn2+ Dissolution inside Lysosomes.” Particle and Fibre Toxicology 8 (1): 27. https://doi.org/10.1186/1743-8977-8-27
   PubMedGoogle Scholar
• Coméra, C., C. Cartier, E. Gaultier, O. Catrice, Q. Panouille, S. El Hamdi, Z. K. Tire, I. Nelissen, V. Théodorou, and E. Houdeau. 2020. “Jejunal Villus Absorption and Paracellular Tight Junction Permeability Are Major Routes for Early Intestinal Uptake of Food-Grade TiO2 Particles: An in Vivo and Ex Vivo Study in Mice.” Particle and Fibre Toxicology 17 (1): 26. https://doi.org/10.1186/s12989-020-00357-z
   PubMed Web of Science ®Google Scholar
• Correa, F., N. Pavón, M. Buelna-Chontal, N. Chiquete-Félix, L. Hernández-Esquivel, and E. Chávez. 2018. “Calcium Induces Mitochondrial Oxidative Stress Because of Its Binding to Adenine Nucleotide Translocase.” Cell Biochemistry and Biophysics 76 (4): 445–450. https://doi.org/10.1007/s12013-018-0856-3
   PubMed Web of Science ®Google Scholar
• Czyżowska, A., and A. Barbasz. 2020. “A Review: Zinc Oxide Nanoparticles – Friends or Enemies?” International Journal of Environmental Health Research 32 (4): 885–901. https://doi.org/10.1080/09603123.2020.1805415
   PubMed Web of Science ®Google Scholar
• De Cavanagh, E. M., J. E. Toblli, L. Ferder, B. Piotrkowski, I. Stella, C. G. Fraga, and F. Inserra. 2005. “Angiotensin II Blockade Improves Mitochondrial Function in Spontaneously Hypertensive Rats.” Cellular and Molecular Biology (Noisy-le-Grand, France) 51 (6): 573–578.
   PubMed Web of Science ®Google Scholar
• Dikalov, S. L., and Z. Ungvari. 2013. “Role of Mitochondrial Oxidative Stress in Hypertension.” American Journal of Physiology. Heart and Circulatory Physiology 305 (10): H1417–H1427. https://doi.org/10.1152/ajpheart.00089.2013
   PubMed Web of Science ®Google Scholar
• Dorier, M., D. Béal, C. Marie-Desvergne, M. Dubosson, F. Barreau, E. Houdeau, N. Herlin-Boime, and M. Carriere. 2017. “Continuous in Vitro Exposure of Intestinal Epithelial Cells to E171 Food Additive Causes Oxidative Stress, Inducing Oxidation of DNA Bases but No Endoplasmic Reticulum Stress.” Nanotoxicology 11 (6): 751–761. https://doi.org/10.1080/17435390.2017.1349203
   PubMed Web of Science ®Google Scholar
• ECHA (European Chemicals Agency). 2022. Nanomaterials. Accessed November 10, 2022. https://echa.europa.eu/regulations/nanomaterials.
   Google Scholar
• EFSA Panel on Food Additives and Flavourings (FAF), Younes, M., G. Aquilina, L. Castle, K. H. Engel, P. Fowler, M. J. Frutos Fernandez, et al. 2021. “Safety Assessment of Titanium Dioxide (E171) as a Food Additive.” EFSA Journal 19 (5): e06585. https://doi.org/10.2903/j.efsa.2021.6585
   PubMed Web of Science ®Google Scholar
• EFSA. 2016. “Re-evaluation of Titanium Dioxide (E 171) as a Food Additive EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS).” EFSA Journal 14: 4545. https://doi.org/10.2903/j.efsa.2016.4545
   Google Scholar
• Fan, P., C. Yang, L. Wang, Q. Wang, Y. Zhang, J. Zhou, J. Weng, and B. Feng. 2021. “ZnO Nanoparticles Stimulate Oxidative Stress to Induce Apoptosis of B16F10 Melanoma Cells: In Vitro and in Vivo Studies.” Biomedical Physics & Engineering Express 7 (6): 065014. https://doi.org/10.1088/2057-1976/ac251f
   Web of Science ®Google Scholar
• Flores Chávez, P. L., L. E. Santos Martínez, R. Martínez Memije, T. Salvador Cortes, G. Sánchez Torres, and O. Infante Vázquez. 2007. “Confiabilidad de la presión arterial sistémica determinada por un método no invasivo en ratas normo-tensas.” Revista del Instituto Nacional de Enfermedades Respiratorias 20 (4): 247–254.
   Google Scholar
• Flores Chávez, P. L., O. Infante Vázquez, G. Sánchez Torres, R. Martínez Memije, and G. Rodríguez Rossini. 2022. “Detección de signos vitales en ratas mediante métodos no invasivos.” Veterinaria México 33 (2): 179–187.
   Google Scholar
• Freyre-Fonseca, V., N. L. Delgado-Buenrostro, E. B. Gutiérrez-Cirlos, C. M. Calderón-Torres, T. Cabellos-Avelar, Y. Sánchez-Pérez, E. Pinzón, et al. 2011. “Titanium Dioxide Nanoparticles Impair Lung Mitochondrial Function.” Toxicology Letters 202 (2): 111–119. https://doi.org/10.1016/j.toxlet.2011.01.025
   PubMed Web of Science ®Google Scholar
• Geraets, L., A. G. Oomen, P. Krystek, N. R. Jacobsen, H. Wallin, M. Laurentie, H. W. Verharen, E. F. Brandon, and W. H. de Jong. 2014. “Tissue Distribution and Elimination after Oral and Intravenous Administration of Different Titanium Dioxide Nanoparticles in Rats.” Particle and Fibre Toxicology 11 (1): 30. https://doi.org/10.1186/1743-8977-11-30
   PubMedGoogle Scholar
• Gong, Y., Y. Ji, F. Liu, J. Li, and Y. Cao. 2017. “Cytotoxicity, Oxidative Stress and Inflammation Induced by ZnO Nanoparticles in Endothelial Cells: Interaction with Palmitate or Lipopolysaccharide.” Journal of Applied Toxicology: JAT 37 (8): 895–901. https://doi.org/10.1002/jat.3415
   PubMed Web of Science ®Google Scholar
• González-Mingot, C., F. J. Miana-Mena, P. J. Iñarrea, C. Iñiguez, J. L. Capablo, R. Osta, A. Gil-Sánchez, L. Brieva, and P. Larrodé. 2023. “Mitochondrial Aconitase Enzymatic Activity: A Potential Long-Term Survival Biomarker in the Blood of ALS Patients.” Journal of Clinical Medicine 12 (10): 3560. https://doi.org/10.3390/jcm12103560
   PubMed Web of Science ®Google Scholar
• Han, H. Y., M. J. Yang, C. Yoon, G. H. Lee, D. W. Kim, T. W. Kim, M. Kwak, et al. 2021. “Toxicity of Orally Administered Food-Grade Titanium Dioxide Nanoparticles.” Journal of Applied Toxicology 41 (7): 1127–1147. https://doi.org/10.1002/jat.4099
   PubMed Web of Science ®Google Scholar
• Hausladen, A., and I. Fridovich. 1994. “Superoxide and Peroxynitrite Inactivate Aconitases, but Nitric Oxide Does Not.” Journal of Biological Chemistry 269 (47): 29405–29408. https://doi.org/10.1016/S0021-9258(18)43893-8
   PubMed Web of Science ®Google Scholar
• Hernández-Esquivel, L., N. Pavón, M. Buelna-Chontal, H. González-Pacheco, J. Belmont, and E. Chávez. 2015. “Cardioprotective Properties of Citicoline against Hyperthyroidism-Induced Reperfusion Damage in Rat Hearts.” Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire 93 (3): 185–191. https://doi.org/10.1139/bcb-2014-0116
   PubMedGoogle Scholar
• Herrera-Rodríguez, M. A., M. P. Ramos-Godinez, A. Cano-Martínez, F. C. Segura, A. Ruiz-Ramírez, N. Pavón, E. Lira-Silva, et al. 2023. “Food-Grade Titanium Dioxide and Zinc Oxide Nanoparticles Induce Toxicity and Cardiac Damage after Oral Exposure in Rats.” Particle and Fibre Toxicology 20 (1): 43. https://doi.org/10.1186/s12989-023-00553-7
   PubMed Web of Science ®Google Scholar
• Hong, J. S., M. K. Park, M. S. Kim, J. H. Lim, G. J. Park, E. H. Maeng, J. H. Shin, et al. 2014. “Prenatal Development Toxicity Study of Zinc Oxide Nanoparticles in Rats.” International Journal of Nanomedicine 9 (Suppl. 2): 159–171. https://doi.org/10.2147/IJN.S57932
   PubMedGoogle Scholar
• Jia, L., K. Yiyuan, Z. Wei, S. Bin, W. Limin, C. Liangjiao, and S. Longquan. 2017. “Ion-Shedding Zinc Oxide Nanoparticles Induce Microglial BV2 Cell Proliferation via the ERK and Akt Signaling Pathways.” Toxicological Sciences 156: 167–178. https://doi.org/10.1093/toxsci/kfw241
   Web of Science ®Google Scholar
• Jones, K., J. Morton, I. Smith, K. Jurkschat, A. H. Harding, and G. Evans. 2015. “Human In Vivo and In Vitro Studies on Gastrointestinal Absorption of Titanium Dioxide Nanoparticles.” Toxicology Letters 233 (2): 95–101. https://doi.org/10.1016/j.toxlet.2014.12.005
   PubMed Web of Science ®Google Scholar
• Karpha, M., and G. V. Lip. 2006. “The Pathophysiology of Target Organ Damage in Hypertension.” Minerva Cardioangiologica 54 (4): 417–429.
   PubMedGoogle Scholar
• Lai, J. C., M. B. Lai, S. Jandhyam, V. V. Dukhande, A. Bhushan, C. K. Daniels, and S. W. Leung. 2008. “Exposure to Titanium Dioxide and Other Metallic Oxide Nanoparticles Induces Cytotoxicity on Human Neural Cells and Fibroblasts.” International Journal of Nanomedicine 3 (4): 533–545. https://doi.org/10.2147/ijn.s3234
   PubMed Web of Science ®Google Scholar
• Li, B., S. L. Chu, D. Yu, S. H. Chan, and A. Li. 2021. “Separation and Size Characterization of Highly Polydisperse Titanium Dioxide Nanoparticles (E171) in Powdered Beverages by Using Asymmetric Flow Field-Flow Fractionation Hyphenated with Multi-Angle Light Scattering and Inductively Coupled Plasma Mass Spectrometry.” Journal of Chromatography A 1643: 462059. https://doi.org/10.1016/j.chroma.2021.462059
   PubMed Web of Science ®Google Scholar
• Limongelli, Giuseppe, Daniele Masarone, Raffaella D’Alessandro, and Perry M. Elliott. 2012. “Mitochondrial Diseases and the Heart: An Overview of Molecular Basis, Diagnosis, Treatment and Clinical Course.” Future Cardiology 8 (1): 71–88. https://doi.org/10.2217/fca.11.79
   PubMedGoogle Scholar
• Lowry, O. H., N. J. Rosebrough, A. Farr, and R. J. Randall. 1951. “Protein Measurement with the Folin Phenol Reagent.” Journal of Biological Chemistry 193 (1): 265–275.
   PubMed Web of Science ®Google Scholar
• Maiuri, M. C., E. Zalckvar, A. Kimchi, and G. Kroemer. 2007. “Self-Eating and Self-Killing: Crosstalk between Autophagy and Apoptosis.” Nature Reviews. Molecular Cell Biology 8 (9): 741–752. https://doi.org/10.1038/nrm2239
   PubMed Web of Science ®Google Scholar
• Majima, E., H. Koike, Y. M. Hong, Y. Shinohara, and H. Terada. 1993. “Characterization of Cysteine Residues of Mitochondrial ADP/ATP Carrier with the SH-Reagents Eosin 5-Maleimide and N-Ethylmaleimide.” Journal of Biological Chemistry 268 (29): 22181–22187.
   PubMed Web of Science ®Google Scholar
• Marín-García, J., A. T. Akhmedov, and G. W. Moe. 2013. “Mitochondria in Heart Failure: The Emerging Role of Mitochondrial Dynamics.” Heart Failure Reviews 18 (4): 439–456. https://doi.org/10.1007/s10741-012-9330-2
   PubMed Web of Science ®Google Scholar
• Mihai, C., W. B. Chrisler, Y. Xie, D. Hu, C. J. Szymanski, A. Tolic, J. A. Klein, J. N. Smith, B. J. Tarasevich, and G. Orr. 2015. “Intracellular Accumulation Dynamics and Fate of Zinc Ions in Alveolar Epithelial Cells Exposed to Airborne ZnO Nanoparticles at the Air–Liquid Interface.” Nanotoxicology 9 (1): 9–22. https://doi.org/10.3109/17435390.2013.859319
   PubMed Web of Science ®Google Scholar
• Mu, W., Y. Wang, C. Huang, Y. Fu, J. Li, H. Wang, X. Jia, and Q. Ba. 2019. “Effect of Long-Term Intake of Dietary Titanium Dioxide Nanoparticles on Intestine Inflammation in Mice.” Journal of Agricultural and Food Chemistry 67 (33): 9382–9389. https://doi.org/10.1021/acs.jafc.9b02391
   PubMed Web of Science ®Google Scholar
• Nagarajan, M., G. B. Maadurshni, G. K. Tharani, I. Udhayakumar, G. Kumar, K. P. Mani, J. Sivasubramanian, and J. Manivannan. 2022. “Exposure to Zinc Oxide Nanoparticles (ZnO-NPs) Induces Cardiovascular Toxicity and Exacerbates Pathogenesis – Role of Oxidative Stress and MAPK Signaling.” Chemico-Biological Interactions 351: 109719. https://doi.org/10.1016/j.cbi.2021.109719
   PubMed Web of Science ®Google Scholar
• Nguyen, B. Y., A. Ruiz-Velasco, T. Bui, L. Collins, X. Wang, and W. Liu. 2019. “Mitochondrial Function in the Heart: The Insight into Mechanisms and Therapeutic Potentials.” British Journal of Pharmacology 176 (22): 4302–4318. https://doi.org/10.1111/bph.14431
   PubMed Web of Science ®Google Scholar
• [NOM 062-ZOO-1999]. Diario Oficial de la Federación. 15. México: Organización Mundial de Sanidad Animal.
   Google Scholar
• Paek, H. J., Y. J. Lee, H. E. Chung, N. H. Yoo, J. A. Lee, M. K. Kim, J. K. Lee, J. Jeong, and S. J. Choi. 2013. “Modulation of the Pharmacokinetics of Zinc Oxide Nanoparticles and Their Fates In Vivo.” Nanoscale 5 (23): 11416–11427. https://doi.org/10.1039/c3nr02140h
   PubMed Web of Science ®Google Scholar
• Pandurangan, M., and D. H. Kim. 2015. “In Vitro Toxicity of Zinc Oxide Nanoparticles: A Review.” Journal of Nanoparticle Research 17 (3): 158. https://doi.org/10.1007/s11051-015-2958-9
   Web of Science ®Google Scholar
• Persaud, I., A. J. Raghavendra, A. Paruthi, N. B. Alsaleh, V. C. Minarchick, J. R. Roede, R. Podila, and J. M. Brown. 2020. “Defect-Induced Electronic States Amplify the Cellular Toxicity of ZnO Nanoparticles.” Nanotoxicology 14 (2): 145–161. https://doi.org/10.1080/17435390.2019.1668067
   PubMed Web of Science ®Google Scholar
• Proquin, Héloïse, Carolina Rodríguez-Ibarra, Carolyn G. J. Moonen, Ismael M. Urrutia Ortega, Jacob J. Briedé, Theo M. de Kok, Henk van Loveren, and Yolanda I. Chirino. 2018. “Titanium Dioxide Food Additive (E171) Induces ROS Formation and Genotoxicity: Contribution of Micro and Nano-Sized Fractions.” Mutagenesis 32 (1): 139–149. https://doi.org/10.1093/mutage/gew051
   Web of Science ®Google Scholar
• Quirós, P. M. 2018. “Determination of Aconitase Activity: A Substrate of the Mitochondrial Lon Protease.” Methods in Molecular Biology (Clifton, N.J.) 1731: 49–56. https://doi.org/10.1007/978-1-4939-7595-2_5
   PubMedGoogle Scholar
• Rubattu, S., B. Pagliaro, G. Pierelli, C. Santolamazza, S. D. Castro, S. Mennuni, and M. Volpe. 2014. “Pathogenesis of Target Organ Damage in Hypertension: Role of Mitochondrial Oxidative Stress.” International Journal of Molecular Sciences 16 (1): 823–839. https://doi.org/10.3390/ijms16010823
   PubMed Web of Science ®Google Scholar
• Sharma, V., D. Anderson, and A. Dhawan. 2012. “Zinc Oxide Nanoparticles Induce Oxidative DNA Damage and ROS-Triggered Mitochondria Mediated Apoptosis in Human Liver Cells (HepG2).” Apoptosis 17 (8): 852–870. https://doi.org/10.1007/s10495-012-0705-6
   PubMed Web of Science ®Google Scholar
• Singh, S. 2019. “Zinc Oxide Nanoparticles Impacts: Cytotoxicity, Genotoxicity, Developmental Toxicity, and Neurotoxicity.” Toxicology Mechanisms and Methods 29 (4): 300–311. https://doi.org/10.1080/15376516.2018.1553221
   PubMed Web of Science ®Google Scholar
• Skocaj, M., M. Filipic, J. Petkovic, and S. Novak. 2011. “Titanium Dioxide in Our Everyday Life; Is It Safe?” Radiology and Oncology 45 (4): 227–247. https://doi.org/10.2478/v10019-011-0037-0
   PubMed Web of Science ®Google Scholar
• Subramaniam, V. D., S. V. Prasad, A. Banerjee, M. Gopinath, R. Murugesan, F. Marotta, X. F. Sun, and S. Pathak. 2019. “Health Hazards of Nanoparticles: Understanding the Toxicity Mechanism of Nanosized ZnO in Cosmetic Products.” Drug and Chemical Toxicology 42 (1): 84–93. https://doi.org/10.1080/01480545.2018.1491987
   PubMed Web of Science ®Google Scholar
• Talamini, L., S. Gimondi, B. Violatto, F. Fiordaliso, F. Pedica, N. L. Tran, G. Sitia, et al. 2019. “Repeated Administration of the Food Additive E171 to Mice Results in Accumulation in Intestine and Liver and Promotes an Inflammatory Status.” Nanotoxicology 13 (8): 1087–1101. https://doi.org/10.1080/17435390.2019.1640910
   PubMed Web of Science ®Google Scholar
• Vandebriel, R. J., and W. H. De Jong. 2012. “A Review of Mammalian Toxicity of ZnO Nanoparticles.” Nanotechnology, Science and Applications 5: 61–71. https://doi.org/10.2147/NSA.S23932
   PubMedGoogle Scholar
• Varughese, J. T., S. K. Buchanan, and A. S. Pitt. 2021. “The Role of Voltage-Dependent Anion Channel in Mitochondrial Dysfunction and Human Disease.” Cells 10 (7): 1737. https://doi.org/10.3390/cells10071737
   PubMed Web of Science ®Google Scholar
• Wang, C., J. Lu, L. Zhou, J. Li, J. Xu, W. Li, L. Zhang, X. Zhong, and T. Wang. 2016. “Effects of Long-Term Exposure to Zinc Oxide Nanoparticles on Development, Zinc Metabolism and Biodistribution of Minerals (Zn, Fe, Cu, Mn) in Mice.” PLOS One 11 (10): e0164434. https://doi.org/10.1371/journal.pone.0164434
   PubMed Web of Science ®Google Scholar
• Weir, A., P. Westerhoff, L. Fabricius, K. Hristovski, and N. von Goetz. 2012. “Titanium Dioxide Nanoparticles in Food and Personal Care Product.” Environmental Science & Technology 46 (4): 2242–2250. https://doi.org/10.1021/es204168d
   PubMed Web of Science ®Google Scholar
• Wu, D., A. Dasgupta, A. D. Read, R. E. T. Bentley, M. Motamed, K. H. Chen, R. Al-Qazazi, et al. 2021. “Oxygen Sensing, Mitochondrial Biology and Experimental Therapeutics for Pulmonary Hypertension and Cancer.” Free Radical Biology & Medicine 170: 150–178. https://doi.org/10.1016/j.freeradbiomed.2020.12.452
   PubMed Web of Science ®Google Scholar
• Xue, C., J. Wu, F. Lan, W. Liu, X. Yang, F. Zeng, and H. Xu. 2010. “Nano Titanium Dioxide Induces the Generation of ROS and Potential Damage in HaCaT Cells under UVA Irradiation.” Journal of Nanoscience and Nanotechnology 10 (12): 8500–8507. https://doi.org/10.1166/jnn.2010.2682
   PubMed Web of Science ®Google Scholar
• Zhao, J., L. Bowman, X. Zhang, V. Vallyathan, S. H. Young, V. Castranova, and M. Ding. 2009. “Titanium Dioxide (TiO2) Nanoparticles Induce JB6 Cell Apoptosis through Activation of the Caspase-8/Bid and Mitochondrial Pathways.” Journal of Toxicology and Environmental Health. Part A 72 (19): 1141–1149. https://doi.org/10.1080/15287390903091764
   PubMed Web of Science ®Google Scholar
• Ziglari, T., D. S. Anderson, and A. Holian. 2020. “Determination of the Relative Contribution of the Non-Dissolved Fraction of ZnO NP on Membrane Permeability and Cytotoxicity.” Inhalation Toxicology 32 (2): 86–95. https://doi.org/10.1080/08958378.2020.1743394
   PubMed Web of Science ®Google Scholar