Investigation of sex-based differences in the immunotoxicity of silver nanoparticles

References

• Ajdary, M., S. Eghbali, V. P. Mahabadi, F. Keyhanfar, and R. S. Varma. 2021. “Toxicity of Silver Nanoparticles on Endometrial Receptivity in Female Mice.” Canadian Journal of Physiology and Pharmacology 99 (12): 1264–1271. https://doi.org/10.1139/cjpp-2021-0094
   PubMed Web of Science ®Google Scholar
• Alqahtani, S., L. M. Kobos, L. Xia, C. Ferreira, J. Franco, X. Du, and J. H. Shannahan. 2020. “Exacerbation of Nanoparticle-Induced Acute Pulmonary Inflammation in a Mouse Model of Metabolic Syndrome.” Frontiers in Immunology 11: 818. https://doi.org/10.3389/fimmu.2020.00818
   PubMed Web of Science ®Google Scholar
• ASTM E3238-20. 2020. Standard Test Method for Quantitative Measurement of the Chemoattractant Capacity of a Nanoparticulate Material In Vitro. West Conshohocken, PA: ASTM International Book of Standards 14.02. https://doi.org/10.1520/E3238-20
   Google Scholar
• Boudreau, M. D., M. S. Imam, A. M. Paredes, M. S. Bryant, C. K. Cunningham, R. P. Felton, M. Y. Jones, K. J. Davis, and G. R. Olson. 2016. “Differential Effects of Silver Nanoparticles and Silver Ions on Tissue Accumulation, Distribution, and Toxicity in the Sprague Dawley Rat following Daily Oral Gavage Administration for 13 Weeks.” Toxicological Sciences: An Official Journal of the Society of Toxicology 150 (1): 131–160. https://doi.org/10.1093/toxsci/kfv318
   PubMed Web of Science ®Google Scholar
• Chamekh, M., and G. Casimir. 2019. “Editorial: Sexual Dimorphism of the Immune Inflammatory Response in Infectious and Non-Infectious Diseases.” Frontiers in Immunology 10: 107. https://doi.org/10.3389/fimmu.2019.00107
   PubMed Web of Science ®Google Scholar
• Chen, J., H. Wang, W. Long, X. Shen, D. Wu, S. S. Song, Y. M. Sun, et al. 2013. “Sex Differences in the Toxicity of Polyethylene Glycol-Coated Gold Nanoparticles in Mice.” International Journal of Nanomedicine 8: 2409–2419. https://doi.org/10.2147/IJN.S46376
   PubMed Web of Science ®Google Scholar
• Chen, S., J. L. Markman, K. Shimada, T. R. Crother, M. Lane, A. Abolhesn, P. K. Shah, and M. Arditi. 2020. “Sex-Specific Effects of the Nlrp3 Inflammasome on Atherogenesis in LDL Receptor-Deficient Mice.” JACC. Basic to Translational Science 5 (6): 582–598. https://doi.org/10.1016/j.jacbts.2020.03.016
   PubMedGoogle Scholar
• Cedrone, E., T. Potter, B. Neun, and M. Dobrovolskaia. 2020. AND NCL Method ITA-12: In vitro Analysis of Nanoparticle Effects on Plasma Coagulation Time. https://ncl.cancer.gov/resources/assay-cascade-protocols https://doi.org/10.17917/7SF3-7A88
   Google Scholar
• Deerinck, T. J., E. A. Bushong, M. H. Ellisman, and A. Thor. 2022. AND Preparation of Biological Tissues for Serial Block Face Scanning Electron Microscopy. Berkeley: Protocols.io.
   Google Scholar
• Datta, S., and N. Sarvetnick. 2009. “Lymphocyte Proliferation in Immune-Mediated Diseases.” Trends in Immunology 30 (9): 430–438. https://doi.org/10.1016/j.it.2009.06.002
   PubMed Web of Science ®Google Scholar
• David, C. A. W., M. Barrow, P. Murray, M. J. Rosseinsky, A. Owen, and N. J. Liptrott. 2020. “In Vitro Determination of the Immunogenic Impact of Nanomaterials on Primary Peripheral Blood Mononuclear Cells.” International Journal of Molecular Sciences 21 (16): 5610. https://doi.org/10.3390/ijms21165610
   PubMed Web of Science ®Google Scholar
• DE Jong, W. H., L. T. M. Van Der Ven, A. Sleijffers, M. V. D. Z. Park, E. H. J. M. Jansen, H. VAN Loveren, and R. J. Vandebriel. 2013. “Systemic and Immunotoxicity of Silver Nanoparticles in an Intravenous 28 Days Repeated Dose Toxicity Study in Rats.” Biomaterials 34 (33): 8333–8343. https://doi.org/10.1016/j.biomaterials.2013.06.048
   PubMed Web of Science ®Google Scholar
• DE Nardo, C. M., and E. Latz. 2013. The Inflammasome: Methods and Protocols, New York: Springer.
   Google Scholar
• Devanabanda, M., S. A. Latheef, and R. Madduri. 2016. “Immunotoxic Effects of Gold and Silver Nanoparticles: Inhibition of Mitogen-Induced Proliferative Responses and Viability of Human and Murine Lymphocytes in Vitro.” Journal of Immunotoxicology 13 (6): 897–902. https://doi.org/10.1080/1547691X.2016.1234522
   PubMed Web of Science ®Google Scholar
• Dobrovolskaia, M. A., and S. E. Mcneil. 2013. “Understanding the Correlation between in Vitro and in Vivo Immunotoxicity Tests for Nanomedicines.” Journal of Controlled Release: official Journal of the Controlled Release Society 172 (2): 456–466. https://doi.org/10.1016/j.jconrel.2013.05.025
   PubMed Web of Science ®Google Scholar
• Fathi, N., S. M. Hoseinipanah, Z. Alizadeh, M. J. Assari, A. Moghimbeigi, M. Mortazavi, M. H. Hosseini, and M. Bahmanzadeh. 2019. “The Effect of Silver Nanoparticles on the Reproductive System of Adult Male Rats: A Morphological, Histological and DNA Integrity Study.” Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University 28 (3): 299–305. https://doi.org/10.17219/acem/81607
   PubMed Web of Science ®Google Scholar
• Feng, L., Y. Zhao, H. Zhao, and Z. Shao. 2014. “Effects of Storage Time and Temperature on Coagulation Tests and Factors in Fresh Plasma.” Scientific Reports 4 (1): 3868. https://doi.org/10.1038/srep03868
   PubMedGoogle Scholar
• Ferdous, Z., and A. Nemmar. 2020. “Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity following Various Routes of Exposure.” International Journal of Molecular Sciences 21 (7): 2375. https://doi.org/10.3390/ijms21072375
   PubMed Web of Science ®Google Scholar
• Fink, S. L., and B. T. Cookson. 2006. “Caspase-1-Dependent Pore Formation during Pyroptosis Leads to Osmotic Lysis of Infected Host Macrophages.” Cellular Microbiology 8 (11): 1812–1825. https://doi.org/10.1111/j.1462-5822.2006.00751.x
   PubMed Web of Science ®Google Scholar
• Gabor, F. 2011. “Characterization of Nanoparticles Intended for Drug Delivery.” Scientia Pharmaceutica 79 (3): 701–702. https://doi.org/10.3797/scipharm.br-11-01
   Google Scholar
• Gaidt, M. M., T. S. Ebert, D. Chauhan, T. Schmidt, J. L. Schmid-Burgk, F. Rapino, A. A. Robertson, M. A. Cooper, T. Graf, and V. Hornung. 2016. “Human Monocytes Engage an Alternative Inflammasome Pathway.” Immunity 44 (4): 833–846. https://doi.org/10.1016/j.immuni.2016.01.012
   PubMed Web of Science ®Google Scholar
• Galbiati, V., L. Cornaghi, E. Gianazza, M. A. Potenza, E. Donetti, M. Marinovich, and E. Corsini. 2018. “In Vitro Assessment of Silver Nanoparticles Immunotoxicity.” Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 112: 363–374. https://doi.org/10.1016/j.fct.2017.12.023
   PubMed Web of Science ®Google Scholar
• Gaya DA Costa, M., F. Poppelaars, C. VAN Kooten, T. E. Mollnes, F. Tedesco, R. Würzner, L. A. Trouw, et al. 2018. “Age and Sex-Associated Changes of Complement Activity and Complement Levels in a Healthy Caucasian Population.” Frontiers in Immunology 9: 2664–2664. https://doi.org/10.3389/fimmu.2018.02664
   PubMed Web of Science ®Google Scholar
• Ghonime, M. G., O. R. Shamaa, S. DAS, R. A. Eldomany, T. Fernandes-Alnemri, E. S. Alnemri, M. A. Gavrilin, and M. D. Wewers. 2014. “Inflammasome Priming by Lipopolysaccharide is Dependent upon ERK Signaling and Proteasome Function.” Journal of Immunology (Baltimore, Md.: 1950) 192 (8): 3881–3888. https://doi.org/10.4049/jimmunol.1301974
   PubMed Web of Science ®Google Scholar
• Gliga, A. R., S. Skoglund, I. Odnevall Wallinder, B. Fadeel, and H. L. Karlsson. 2014. “Size-Dependent Cytotoxicity of Silver Nanoparticles in Human Lung Cells: The Role of Cellular Uptake, Agglomeration and Ag Release.” Particle and Fibre Toxicology 11 (1): 11. https://doi.org/10.1186/1743-8977-11-11
   PubMed Web of Science ®Google Scholar
• Gokulan, K., K. Williams, S. Orr, and S. Khare. 2020. “Human Intestinal Tissue Explant Exposure to Silver Nanoparticles Reveals Sex Dependent Alterations in Inflammatory Responses and Epithelial Cell Permeability.” International Journal of Molecular Sciences 22 (1): 9. https://doi.org/10.3390/ijms22010009
   PubMed Web of Science ®Google Scholar
• Gómez, D. M., S. Urcuqui-Inchima, and J. C. Hernandez. 2017. “Silica Nanoparticles Induce NLRP3 Inflammasome Activation in Human Primary Immune Cells.” Innate Immunity 23 (8): 697–708. https://doi.org/10.1177/1753425917738331
   PubMed Web of Science ®Google Scholar
• Greulich, C., J. Diendorf, J. Gessmann, T. Simon, T. Habijan, G. Eggeler, T. A. Schildhauer, M. Epple, and M. Köller. 2011. “Cell Type-Specific Responses of Peripheral Blood Mononuclear Cells to Silver Nanoparticles.” Acta Biomaterialia 7 (9): 3505–3514. https://doi.org/10.1016/j.actbio.2011.05.030
   PubMed Web of Science ®Google Scholar
• Gritsenko, A., S. Yu, F. Martin-Sanchez, I. Diaz-DEL-Olmo, E.-M. Nichols, D. M. Davis, D. Brough, and G. Lopez-Castejon. 2020. “Priming is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes in Vitro.” Frontiers in Immunology 11: 565924–565924. https://doi.org/10.3389/fimmu.2020.565924
   PubMed Web of Science ®Google Scholar
• Hadrup, N., and H. R. Lam. 2014. “Oral Toxicity of Silver Ions, Silver Nanoparticles and Colloidal Silver – a Review.” Regulatory Toxicology and Pharmacology: RTP 68 (1): 1–7. https://doi.org/10.1016/j.yrtph.2013.11.002
   PubMed Web of Science ®Google Scholar
• Heydrnejad, M. S., R. J. Samani, and S. Aghaeivanda. 2015. “Toxic Effects of Silver Nanoparticles on Liver and Some Hematological Parameters in Male and Female Mice (Mus musculus).” Biological Trace Element Research 165 (2): 153–158. https://doi.org/10.1007/s12011-015-0247-1
   PubMed Web of Science ®Google Scholar
• Huang, H., W. Lai, M. Cui, L. Liang, Y. Lin, Q. Fang, Y. Liu, and L. Xie. 2016. “An Evaluation of Blood Compatibility of Silver Nanoparticles.” Scientific Reports 6 (1): 25518. https://doi.org/10.1038/srep25518
   PubMed Web of Science ®Google Scholar
• Ilinskaya, A. N., and M. A. Dobrovolskaia. 2013. “Nanoparticles and the Blood Coagulation System. Part II: safety Concerns.” Nanomedicine 8 (6): 969–981. https://doi.org/10.2217/nnm.13.49
   PubMed Web of Science ®Google Scholar
• Izak-Nau, E., A. Huk, B. Reidy, H. Uggerud, M. Vadset, S. Eiden, M. Voetz, et al. 2015. “Impact of Storage Conditions and Storage Time on Silver Nanoparticles’ Physicochemical Properties and Implications for Their Biological Effects.” RSC Advances 5 (102): 84172–84185. https://doi.org/10.1039/C5RA10187E
   Web of Science ®Google Scholar
• Jo, E. K., J. K. Kim, D. M. Shin, and C. Sasakawa. 2016. “Molecular Mechanisms Regulating NLRP3 Inflammasome Activation.” Cellular & Molecular Immunology 13 (2): 148–159. https://doi.org/10.1038/cmi.2015.95
   PubMed Web of Science ®Google Scholar
• Kaplan, A., G. Akalin Ciftci, and H. M. Kutlu. 2016. “Cytotoxic, anti-Proliferative and Apoptotic Effects of Silver Nitrate against H-Ras Transformed 5RP7.” Cytotechnology 68 (5): 1727–1735. https://doi.org/10.1007/s10616-015-9922-5
   PubMed Web of Science ®Google Scholar
• Kelley, N., D. Jeltema, Y. Duan, and Y. He. 2019. “The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation.” International Journal of Molecular Sciences 20 (13): 3328. https://doi.org/10.3390/ijms20133328
   PubMed Web of Science ®Google Scholar
• Khan, A. M., B. Korzeniowska, V. Gorshkov, M. Tahir, H. Schrøder, L. Skytte, K. L. Rasmussen, S. Khandige, J. Møller-Jensen, and F. Kjeldsen. 2019. “Silver Nanoparticle-Induced Expression of Proteins Related to Oxidative Stress and Neurodegeneration in an in Vitro Human Blood-Brain Barrier Model.” Nanotoxicology 13 (2): 221–239. https://doi.org/10.1080/17435390.2018.1540728
   PubMed Web of Science ®Google Scholar
• Kim, S., J. E. Choi, J. Choi, K. H. Chung, K. Park, J. Yi, and D. Y. Ryu. 2009. “Oxidative Stress-Dependent Toxicity of Silver Nanoparticles in Human Hepatoma Cells.” Toxicology in Vitro: An International Journal Published in Association with BIBRA 23 (6): 1076–1084. https://doi.org/10.1016/j.tiv.2009.06.001
   PubMed Web of Science ®Google Scholar
• Kim, Y. S., J. S. Kim, H. S. Cho, D. S. Rha, J. M. Kim, J. D. Park, B. S. Choi, et al. 2008. “Twenty-Eight-Day Oral Toxicity, Genotoxicity, and Gender-Related Tissue Distribution of Silver Nanoparticles in Sprague-Dawley Rats.” Inhalation Toxicology 20 (6): 575–583. https://doi.org/10.1080/08958370701874663
   PubMed Web of Science ®Google Scholar
• Kittler, S., C. Greulich, J. Diendorf, M. Köller, and M. Epple. 2010. “Toxicity of Silver Nanoparticles Increases during Storage Because of Slow Dissolution under Release of Silver Ions.” Chemistry of Materials 22 (16): 4548–4554. https://doi.org/10.1021/cm100023p
   Web of Science ®Google Scholar
• Klein, S. L., and K. L. Flanagan. 2016. “Sex Differences in Immune Responses.” Nature Reviews. Immunology 16 (10): 626–638. https://doi.org/10.1038/nri.2016.90
   PubMed Web of Science ®Google Scholar
• Kleiveland, C. R. 2015. “Peripheral Blood Mononuclear Cells.” In The Impact of Food Bioactives on Health: In Vitro and Ex Vivo Models, edited by Verhoeckx Kitty, Cotter Paul, López-Expósito Iván, et al., 161–167. Cham: Springer.
   Google Scholar
• Kolling, J., J. Tigges, B. Hellack, C. Albrecht, and R. P. F. Schins. 2020. “Evaluation of the NLRP3 Inflammasome Activating Effects of a Large Panel of TiO(2) Nanomaterials in Macrophages.” Nanomaterials 10 (9): 1876. https://doi.org/10.3390/nano10091876
   Web of Science ®Google Scholar
• Kovats, S. 2015. “Estrogen Receptors Regulate Innate Immune Cells and Signaling Pathways.” Cellular Immunology 294 (2): 63–69. https://doi.org/10.1016/j.cellimm.2015.01.018
   PubMed Web of Science ®Google Scholar
• Kraśniewska, K., S. Galus, and M. Gniewosz. 2020. “Biopolymers-Based Materials Containing Silver Nanoparticles as Active Packaging for Food Applications–a Review.” International Journal of Molecular Sciences 21 (3): 698. https://doi.org/10.3390/ijms21030698
   PubMed Web of Science ®Google Scholar
• Kverneland, A. H., M. Streitz, E. Geissler, J. Hutchinson, K. Vogt, D. Boës, N. Niemann, A. E. Pedersen, S. Schlickeiser, and B. Sawitzki. 2016. “Age and Gender Leucocytes Variances and References Values Generated Using the Standardized ONE-Study Protocol.” Cytometry. Part A: The Journal of the International Society for Analytical Cytology 89 (6): 543–564. https://doi.org/10.1002/cyto.a.22855
   PubMedGoogle Scholar
• LA-Beck, N. M., M. R. Islam, and M. M. Markiewski. 2020. “Nanoparticle-Induced Complement Activation: Implications for Cancer Nanomedicine.” Frontiers in Immunology 11: 603039–603039. https://doi.org/10.3389/fimmu.2020.603039
   PubMed Web of Science ®Google Scholar
• Liu, S. G., X. X. Wu, T. Hua, X. Y. Xin, D. L. Feng, S. Q. Chi, X. X. Wang, and H. B. Wang. 2019. “NLRP3 Inflammasome Activation by Estrogen Promotes the Progression of Human Endometrial Cancer.” OncoTargets and Therapy 12: 6927–6936. https://doi.org/10.2147/OTT.S218240
   PubMed Web of Science ®Google Scholar
• Luczak, E. D., and L. A. Leinwand. 2009. “Sex-Based Cardiac Physiology.” Annual Review of Physiology 71 (1): 1–18. https://doi.org/10.1146/annurev.physiol.010908.163156
   PubMedGoogle Scholar
• Mackevica, A., M. E. Olsson, and S. F. Hansen. 2017. “The Release of Silver Nanoparticles from Commercial Toothbrushes.” Journal of Hazardous Materials 322 (Pt A): 270–275. https://doi.org/10.1016/j.jhazmat.2016.03.067
   PubMedGoogle Scholar
• Martínez-Gutierrez, F., E. P. Thi, J. M. Silverman, C. C. DE Oliveira, S. L. Svensson, A. Vanden Hoek, E. M. Sánchez, et al. 2012. “Antibacterial Activity, Inflammatory Response, Coagulation and Cytotoxicity Effects of Silver Nanoparticles.” Nanomedicine: nanotechnology, Biology, and Medicine 8 (3): 328–336. https://doi.org/10.1016/j.nano.2011.06.014
   PubMed Web of Science ®Google Scholar
• Mbanga, O., E. Cukrowska, and M. Gulumian. 2022. “Dissolution Kinetics of Silver Nanoparticles: Behaviour in Simulated Biological Fluids and Synthetic Environmental Media.” Toxicology Reports 9: 788–796. https://doi.org/10.1016/j.toxrep.2022.03.044
   PubMedGoogle Scholar
• Mcneil, S. E. 2011. Characterization of Nanoparticles Intended for Drug Delivery, New York: Springer.
   Google Scholar
• Merle, N. S., S. E. Church, V. Fremeaux-Bacchi, and L. T. Roumenina. 2015. “Complement System Part I – Molecular Mechanisms of Activation and Regulation.” Frontiers in Immunology 6: 262. https://doi.org/10.3389/fimmu.2015.00262
   PubMed Web of Science ®Google Scholar
• Mishra, A. R., J. Zheng, X. Tang, and P. L. Goering. 2016. “Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells is Size-Dependent.” Toxicological Sciences: An Official Journal of the Society of Toxicology 150 (2): 473–487. https://doi.org/10.1093/toxsci/kfw011
   PubMed Web of Science ®Google Scholar
• Murphy, A., A. Casey, G. Byrne, G. Chambers, and O. Howe. 2016. “Silver Nanoparticles Induce Pro‐Inflammatory Gene Expression and Inflammasome Activation in Human Monocytes.” Journal of Applied Toxicology: JAT 36 (10): 1311–1320. https://doi.org/10.1002/jat.3315
   PubMed Web of Science ®Google Scholar
• Nallanthighal, S., C. Chan, T. M. Murray, A. P. Mosier, N. C. Cady, and R. Reliene. 2017. “Differential Effects of Silver Nanoparticles on DNA Damage and DNA Repair Gene Expression in Ogg1-Deficient and Wild Type Mice.” Nanotoxicology 11 (8): 996–1011. https://doi.org/10.1080/17435390.2017.1388863
   PubMed Web of Science ®Google Scholar
• Nesargikar, P. N., B. Spiller, and R. Chavez. 2012. “The Complement System: history, Pathways, Cascade and Inhibitors.” European Journal of Microbiology & Immunology 2 (2): 103–111. https://doi.org/10.1556/EuJMI.2.2012.2.2
   PubMedGoogle Scholar
• Neun, B., A. Ilinskaya, and M. Dobrovolskaia. 2020. NCL Method ITA-5.1: Qualitative Analysis of Total complement Activtion by Western Blot. https://ncl.cacner.gov/resources/assay-cascade-protocols https://doi.org/10.17917/HA0Q-5B49
   Google Scholar
• Ng, T. H. S., G. Britton, E. Hill, J. Verhagen, B. Burton, and D. Wraith. 2013. “Regulation of Adaptive Immunity; the Role of Interleukin-10.” Frontiers in Immunology 4: 129. https://doi.org/10.3389/fimmu.2013.00129
   PubMed Web of Science ®Google Scholar
• Ninan, N., N. Goswami, and K. Vasilev. 2020. “The Impact of Engineered Silver Nanomaterials on the Immune System.” Nanomaterials 10 (5): 967. https://doi.org/10.3390/nano10050967
   Web of Science ®Google Scholar
• Orr, S. E., K. Gokulan, M. Boudreau, C. E. Cerniglia, and S. Khare. 2019. “Alteration in the mRNA Expression of Genes Associated with Gastrointestinal Permeability and Ileal TNF-α Secretion Due to the Exposure of Silver Nanoparticles in Sprague–Dawley Rats.” Journal of Nanobiotechnology 17 (1): 63. https://doi.org/10.1186/s12951-019-0499-6
   PubMedGoogle Scholar
• Palta, S., R. Saroa, and A. Palta. 2014. “Overview of the Coagulation System.” Indian Journal of Anaesthesia 58 (5): 515–523. https://doi.org/10.4103/0019-5049.144643
   PubMedGoogle Scholar
• Potter, T., E. Cedrone, S. Skoczen, B. Neun, and M. Dobrovolskaia. 2020. NCL Method ITA-6.3: Leukocyte Proliferation Assay. http://ncl.cancer.gov/resources/assay-cascade-protocols https://doi.org/10.17917/M173-MY22
   Google Scholar
• Pourhoseini, S., R. T. Enos, A. E. Murphy, B. Cai, and J. R. Lead. 2021. “Characterization, Bio-Uptake and Toxicity of Polymer-Coated Silver Nanoparticles and Their Interaction with Human Peripheral Blood Mononuclear Cells.” Beilstein Journal of Nanotechnology 12: 282–294. https://doi.org/10.3762/bjnano.12.23
   PubMed Web of Science ®Google Scholar
• Pratap, U. P., L. Hima, T. Kannan, C. Thyagarajan, H. P. Priyanka, R. Vasantharekha, A. Pushparani, and S. Thyagarajan. 2020. “Sex-Based Differences in the Cytokine Production and Intracellular Signaling Pathways in Patients with Rheumatoid Arthritis.” Archives of Rheumatology 35 (4): 545–557. https://doi.org/10.46497/ArchRheumatol.2020.7481
   PubMed Web of Science ®Google Scholar
• Ray, J. L., and A. Holian. 2019. “Sex Differences in the Inflammatory Immune Response to Multi-Walled Carbon Nanotubes and Crystalline Silica.” Inhalation Toxicology 31 (7): 285–297. https://doi.org/10.1080/08958378.2019.1669743
   PubMed Web of Science ®Google Scholar
• Rettew, J. A., Y. M. Huet-Hudson, and I. Marriott. 2008. “Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity.” Biology of Reproduction 78 (3): 432–437. https://doi.org/10.1095/biolreprod.107.063545
   PubMed Web of Science ®Google Scholar
• Ribeiro, M. J., V. L. Maria, J. J. Scott-Fordsmand, and M. J. Amorim. 2015. “Oxidative Stress Mechanisms Caused by Ag Nanoparticles (NM300K) Are Different from Those of AgNO3: Effects in the Soil Invertebrate Enchytraeus Crypticus.” International Journal of Environmental Research and Public Health 12 (8): 9589–9602. https://doi.org/10.3390/ijerph120809589
   PubMed Web of Science ®Google Scholar
• Royce, S. G., D. Mukherjee, T. Cai, S. S. Xu, J. A. Alexander, Z. Mi, L. Calderon, et al. 2014. “Modeling Population Exposures to Silver Nanoparticles Present in Consumer Products.” Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology 16 (11): 2724. https://doi.org/10.1007/s11051-014-2724-4
   Web of Science ®Google Scholar
• Schroder, K., and J. Tschopp. 2010. “The Inflammasomes.” Cell 140 (6): 821–832. https://doi.org/10.1016/j.cell.2010.01.040
   PubMed Web of Science ®Google Scholar
• Seiffert, J., F. Hussain, C. Wiegman, F. Li, L. Bey, W. Baker, A. Porter, et al. 2015. “Pulmonary Toxicity of Instilled Silver Nanoparticles: influence of Size, Coating and Rat Strain.” PLOS One 10 (3): e0119726. https://doi.org/10.1371/journal.pone.0119726
   PubMed Web of Science ®Google Scholar
• Serpooshan, V., S. Sheibani, P. Pushparaj, M. Wojcik, A. Y. Jang, M. R. Santoso, J. H. Jang, et al. 2018. “Effect of Cell Sex on Uptake of Nanoparticles: The Overlooked Factor at the Nanobio Interface.” ACS Nano 12 (3): 2253–2266. https://doi.org/10.1021/acsnano.7b06212
   PubMed Web of Science ®Google Scholar
• Sharma, B. R., and T. D. Kanneganti. 2021. “NLRP3 Inflammasome in Cancer and Metabolic Diseases.” Nature Immunology 22 (5): 550–559. https://doi.org/10.1038/s41590-021-00886-5
   PubMed Web of Science ®Google Scholar
• Shin, S. H., M. K. Ye, H. S. Kim, and H. S. Kang. 2007. “The Effects of Nano-Silver on the Proliferation and Cytokine Expression by Peripheral Blood Mononuclear Cells.” International Immunopharmacology 7 (13): 1813–1818. https://doi.org/10.1016/j.intimp.2007.08.025
   PubMed Web of Science ®Google Scholar
• Silva, A. L., C. Peres, J. Conniot, A. I. Matos, L. Moura, B. Carreira, V. Sainz, et al. 2017. “Nanoparticle Impact on Innate Immune Cell Pattern-Recognition Receptors and Inflammasomes Activation.” Seminars in Immunology 34: 3–24. https://doi.org/10.1016/j.smim.2017.09.003
   PubMed Web of Science ®Google Scholar
• Simard, J. C., F. Vallieres, R. DE Liz, V. Lavastre, and D. Girard. 2015. “Silver Nanoparticles Induce Degradation of the Endoplasmic Reticulum Stress Sensor Activating Transcription Factor-6 Leading to Activation of the NLRP-3 Inflammasome.” The Journal of Biological Chemistry 290 (9): 5926–5939. https://doi.org/10.1074/jbc.M114.610899
   PubMed Web of Science ®Google Scholar
• Stock, J. B., and M. D. Baker. 2009. “Chemotaxis.” In Encyclopedia of Microbiology (Third Edition), Schaechter, M. (ed.). Oxford: Academic Press.
   Google Scholar
• Szebeni, J. 2014. “Complement Activation-Related Pseudoallergy: A Stress Reaction in Blood Triggered by Nanomedicines and Biologicals.” Molecular Immunology 61 (2): 163–173. https://doi.org/10.1016/j.molimm.2014.06.038
   PubMed Web of Science ®Google Scholar
• Tariba Lovaković, B., R. Barbir, B. Pem, W. Goessler, M. Ćurlin, V. Micek, Ž. Debeljak, et al. 2021. “Sex-Related Response in Mice after Sub-Acute Intraperitoneal Exposure to Silver Nanoparticles.” NanoImpact 23: 100340. https://doi.org/10.1016/j.impact.2021.100340
   PubMed Web of Science ®Google Scholar
• Tran, T. A. T., H. W. Grievink, K. Lipinska, C. Kluft, J. Burggraaf, M. Moerland, D. Tasev, and K. E. Malone. 2019. “Whole Blood Assay as a Model for in Vitro Evaluation of Inflammasome Activation and Subsequent Caspase-Mediated Interleukin-1 Beta Release.” PLOS One 14 (4): e0214999. https://doi.org/10.1371/journal.pone.0214999
   PubMed Web of Science ®Google Scholar
• Traore, K., M. A. Trush, M.,. J. R. George, E. W. Spannhake, W. Anderson, and A. Asseffa. 2005. “Signal Transduction of Phorbol 12-Myristate 13-Acetate (PMA)-Induced Growth Inhibition of Human Monocytic Leukemia THP-1 Cells is Reactive Oxygen Dependent.” Leukemia Research 29 (8): 863–879. https://doi.org/10.1016/j.leukres.2004.12.011
   PubMed Web of Science ®Google Scholar
• Trop, M., M. Novak, S. Rodl, B. Hellbom, W. Kroell, and W. Goessler. 2006. “Silver-Coated Dressing Acticoat Caused Raised Liver Enzymes and Argyria-like Symptoms in Burn Patient.” Journal of Trauma and Acute Care Surgery 60: 648–652.
   Google Scholar
• VON Goetz, N., L. Fabricius, R. Glaus, V. Weitbrecht, D. Günther, and K. Hungerbühler. 2013. “Migration of Silver from Commercial Plastic Food Containers and Implications for Consumer Exposure Assessment.” Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment 30 (3): 612–620. https://doi.org/10.1080/19440049.2012.762693
   PubMed Web of Science ®Google Scholar
• Weldon, B. A., E, M. F. Oberdörster, G. Workman, T. Griffith, W. C. Kneuer, C. Yu, and I. J. 2016. “Occupational Exposure Limit for Silver Nanoparticles: considerations on the Derivation of a General Health-Based Value.” Nanotoxicology 10 (7): 945–956. https://doi.org/10.3109/17435390.2016.1148793
   PubMed Web of Science ®Google Scholar
• Williams, K., J. Milner, M. D. Boudreau, K. Gokulan, C. E. Cerniglia, and S. Khare. 2015. “Effects of Subchronic Exposure of Silver Nanoparticles on Intestinal Microbiota and Gut-Associated Immune Responses in the Ileum of Sprague-Dawley Rats.” Nanotoxicology 9 (3): 279–289. https://doi.org/10.3109/17435390.2014.921346
   PubMed Web of Science ®Google Scholar
• Wu, H., M. Su, H. Jin, X. Li, P. Wang, J. Chen, and J. Chen. 2020. “Rutin-Loaded Silver Nanoparticles with Antithrombotic Function.” Frontiers in Bioengineering and Biotechnology 8: 598977. https://doi.org/10.3389/fbioe.2020.598977
   PubMed Web of Science ®Google Scholar
• Xu, L., Y. Y. Wang, J. Huang, C. Y. Chen, Z. X. Wang, and H. Xie. 2020. “Silver Nanoparticles: Synthesis, Medical Applications and Biosafety.” Theranostics 10 (20): 8996–9031. https://doi.org/10.7150/thno.45413
   PubMed Web of Science ®Google Scholar
• Xue, Y., S. Zhang, Y. Huang, T. Zhang, X. Liu, Y. Hu, Z. Zhang, and M. Tang. 2012. “Acute Toxic Effects and Gender-Related Biokinetics of Silver Nanoparticles following an Intravenous Injection in Mice.” Journal of Applied Toxicology 32 (11): 890–899. https://doi.org/10.1002/jat.2742
   PubMed Web of Science ®Google Scholar
• Yang, E. J., S. Kim, J. S. Kim, and I. H. Choi. 2012. “Inflammasome Formation and IL-1β Release by Human Blood Monocytes in Response to Silver Nanoparticles.” Biomaterials 33 (28): 6858–6867. https://doi.org/10.1016/j.biomaterials.2012.06.016
   PubMed Web of Science ®Google Scholar
• You, D. J., H. Y. Lee, A. J. Taylor-Just, K. E. Linder, and J. C. Bonner. 2020. “Sex Differences in the Acute and Subchronic Lung Inflammatory Responses of Mice to Nickel Nanoparticles.” Nanotoxicology 14 (8): 1058–1081. https://doi.org/10.1080/17435390.2020.1808105
   PubMed Web of Science ®Google Scholar
• Yusuf, A., and A. Casey. 2019. “Surface Modification of Silver Nanoparticle (AgNP) by Liposomal Encapsulation Mitigates AgNP-Induced Inflammation.” Toxicology in Vitro: An International Journal Published in Association with BIBRA 61: 104641. https://doi.org/10.1016/j.tiv.2019.104641
   PubMed Web of Science ®Google Scholar
• Zhang, H., Y. Tang, and J. Tao. 2021a. “Sex-Related Overactivation of NLRP3 Inflammasome Increases Lethality of the Male COVID-19 Patients.” Frontiers in Molecular Biosciences 8: 671363. https://doi.org/10.3389/fmolb.2021.671363
   PubMed Web of Science ®Google Scholar
• Zhang, W., Y. Yao, N. Sullivan, and Y. Chen. 2011. “Modeling the Primary Size Effects of Citrate-Coated Silver Nanoparticles on Their Ion Release Kinetics.” Environmental Science & Technology 45 (10): 4422–4428. https://doi.org/10.1021/es104205a
   PubMed Web of Science ®Google Scholar
• Zhang, X., P. Falagan-Lotsch, and C. J. Murphy. 2021b. “Nanoparticles Interfere with Chemotaxis: An Example of Nanoparticles as Molecular “Knockouts” at the Cellular Level.” ACS Nano 15 (5): 8813–8825. https://doi.org/10.1021/acsnano.1c01262
   PubMed Web of Science ®Google Scholar
• Zhen, Y., and H. Zhang. 2019. “NLRP3 Inflammasome and Inflammatory Bowel Disease.” Frontiers in Immunology 10: 276–276. https://doi.org/10.3389/fimmu.2019.00276
   PubMed Web of Science ®Google Scholar
• Zhu, M., L. Du, R. Zhao, H. Y. Wang, Y. Zhao, G. Nie, and R.-F. Wang. 2020. “Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation.” ACS Nano 14 (3): 3703–3717. https://doi.org/10.1021/acsnano.0c00962
   PubMed Web of Science ®Google Scholar
• Zychlinsky Scharff, A., M. Rousseau, L. Lacerda Mariano, T. Canton, C. R. Consiglio, M. L. Albert, M. Fontes, D. Duffy, and M. A. Ingersoll. 2019. “Sex Differences in IL-17 Contribute to Chronicity in Male versus Female Urinary Tract Infection.” JCI insight 5 (13): 122998. https://doi.org/10.1172/jci.insight.122998
   PubMedGoogle Scholar