235
Views
32
CrossRef citations to date
0
Altmetric
Original

In vitro cytotoxicity testing of non-thiolated and thiolated chitosan nanoparticles for oral gene delivery

&
Pages 139-148 | Published online: 10 Jul 2009

References

  • Akgun E, Caliskan C, Celik HA, Ozutemiz AO, Tuncyurek M, Aydin HH. Effects of N-acetylcysteine treatment on oxidative stress in acetic acid-induced experimental colitis in rats. J Int Med Res 2005; 33(2)196–206
  • Chambers E, Mitragotri S. Prolonged circulation of large polymeric nanoparticles by non-covalent adsorption on erythrocytes. J Control Release 2004; 100(1)111–119
  • Chen J, Yang WL, Li G, Qian J, Xue JL, Fu SK, Lu DR. Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles. World J Gastroenterol 2004; 10(1)112–116
  • Dekie L, Toncheva V, Dubruel P, Schacht EH, Barrett L, Seymour LW. Poly-L-glutamic acid derivatives as vectors for gene therapy. J Control Release 2000; 65(1–2)187–202
  • Florence AT, Hussain N. Transcytosis of nanoparticle and dendrimer delivery systems: evolving vistas. Adv Drug Deliv Rev 2001; 50(Suppl. 1)S69–89
  • Giles J. Size matters when it comes to safety, report warns. Nature 2004; 430(7000)599
  • Goodman CM, McCusker CD, Yilmaz T, Rotello VM. Toxicity of gold nanoparticles functionalized with cationic and anionic side chains. Bioconjug Chem 2004; 15(4)897–900
  • Guggi D, Langoth N, Hoffer MH, Wirth M, Bernkop-Schnurch A. Comparative evaluation of cytotoxicity of a glucosamine-TBA conjugate and a chitosan-TBA conjugate. Int J Pharm 2004; 278(2)353–360
  • Hoet PH, Bruske-Hohlfeld I, Salata OV. Nanoparticles – known and unknown health risks. J Nanobiotechnology 2004; 2(1)12
  • Hornof MD, Kast CE, Bernkop-Schnurch A. In vitro evaluation of the viscoelastic properties of chitosan-thioglycolic acid conjugates. Eur J Pharm Biopharm 2003; 55(2)185–190
  • Huang M, Khor E, Lim LY. Uptake and cytotoxicity of chitosan molecules and nanoparticles: Effects of molecular weight and degree of deacetylation. Pharm Res 2004; 21(2)344–353
  • Jani P, Halbert GW, Langridge J, Florence AT. Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency. J Pharm Pharmacol 1990; 42(12)821–826
  • Lee D, Zhang W, Shirley SA, Kong X, Hellermann GR, Lockey RF, Mohapatra SS. Thiolated chitosan/DNA nanocomplexes exhibit enhanced and sustained gene delivery. Pharm Res 2007; 24(1)157–167
  • Lee KY, Ha WS, Park WH. Blood compatibility and biodegradability of partially N-acylated chitosan derivatives. Biomaterials 1995; 16(16)1211–1216
  • Leitner VM, Walker GF, Bernkop-Schnurch A. Thiolated polymers: Evidence for the formation of disulphide bonds with mucus glycoproteins. Eur J Pharm Biopharm 2003; 56(2)207–214
  • Loretz B, Thaler M, Bernkop-Schnürch A. 2007. Role of sulfhydryl goups in transfection? A case study with chitosan-NAC nanoparticles. Bioconjug Chem 18(4):1028–1035.
  • MacLaughlin FC, Mumper RJ, Wang J, Tagliaferri JM, Gill I, Hinchcliffe M, Rolland AP. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Control Release 1998; 56(1–3)259–272
  • Martien R, Loretz B, Thaler M, Majzoob S, Bernkop-Schnurch A. Chitosan-thioglycolic acid conjugate: An alternative carrier for oral nonviral gene delivery?. J Biomed Mater Res A 2007; 82A(1)1–9
  • Nimesh S, Kumar R, Chandra R. Novel polyallylamine-dextran sulfate-DNA nanoplexes: Highly efficient non-viral vector for gene delivery. Int J Pharm 2006; 320(1–2)143–149
  • Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, et al. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol 2005; 2: 8
  • Qi L, Xu Z, Jiang X, Li Y, Wang M. Cytotoxic activities of chitosan nanoparticles and copper-loaded nanoparticles. Bioorg Med Chem Lett 2005; 15(5)1397–1399
  • Rejman J, Oberle V, Zuhorn IS, Hoekstra D. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem J 2004; 377(Pt 1)159–169
  • Roy K, Mao HQ, Huang SK, Leong KW. Oral gene delivery with chitosan-DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med 1999; 5(4)387–391
  • Sambruy Y, Ferruzza S, Ranaldi G, De Angelis I. Intestinal cell culture models: Applications in toxicology and pharmacology. Cell Biol Toxicol 2001; 17(4–5)301–317
  • Yin H, Too HP, Chow GM. The effects of particle size and surface coating on the cytotoxicity of nickel ferrite. Biomaterials 2005; 26(29)5818–5826
  • Zheng F, Shi XW, Yang GF, Gong LL, Yuan HY, Cui YJ, Wang Y, Du YM, Li Y. Chitosan nanoparticle as gene therapy vector via gastrointestinal mucosa administration: Results of an in vitro and in vivo study. Life Sci 2007; 80(4)388–396

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.