Preliminary in vitro investigation of the potential health effects of Optisol™, a nanoparticulate manganese modified titanium dioxide UV-filter used in certain sunscreen products

References

• American Conference of Governmental Industrial Hygienists. 2000. 2000 TLVs and BEIs. Based on the documentations of the threshold limit values and biological exposure indices. Cincinnati, , OH: ACGIH.
   Google Scholar
• Boffetta P, Soutar A, Cherrie JW, Granath F, Andersen A, Anttila A, Blettner M, Gaborieau V, Klug SJ, Langard S, Luce D, Merletti F, Miller B, Mirabelli D, Pukkala E, Adami H-O, Weiderpass E. Mortality among workers employed in the titanium dioxide production industry in Europe. Cancer Causes Control 2004; 15: 697–706
   PubMed Web of Science ®Google Scholar
• Boots (UK) Ltd. 2008. Measurement of UVa:UVb ratios according to the Boots Star rating System (2008 Revision). NottinghamUK: Boots (UK) Ltd.
   Google Scholar
• D Briggs, Seah, MP, 1990. Practical surface analysis. Vol. 1, 2nd ed. New York: Wiley.
   Google Scholar
• BS EN ISO 10993-5. 1999. Biological evaluation of medical devices. Tests for in vitro cytotoxicity.
   Google Scholar
• Cancer Research UK. 2008. UK Skin cancer incidence statistics. Accessed from the website: http://info.cancerresearchuk.org/cancerstats/types/skin/incidence.
   Google Scholar
• Cerutti PA. Prooxidant states and tumour promotion. Science 1985; 227: 375–381
   PubMed Web of Science ®Google Scholar
• Cerutti PA. Oxy-radicals and cancer. Lancet 1994; 344: 862–863
   PubMed Web of Science ®Google Scholar
• Colvin V. Point of impact: Where technology collides with society, business, and personal lives. Technol Rev 2003; 106: 71–73
   Google Scholar
• De Silva O, Rougier A, Dossou KG. The HET-CAM test: A study of the irritation potential of chemicals and formulations. ATLA 1992; 20: 432–437
   Google Scholar
• Diffey BL, Robson J. A new substrate to measure sunscreen protection factors throughout the ultraviolet spectrum. J Soc Cosmet Chem 1989; 40: 127–133
   Web of Science ®Google Scholar
• Donaldson K, Tran C. Inflammation caused by particles and fibres. Inhal Toxicol 2002; 14: 5–27
   PubMed Web of Science ®Google Scholar
• Donawho CK, Wolf P. Sunburn. sunscreen and melanoma Curr Opin Oncol 1996; 8: 159
   PubMedGoogle Scholar
• EEC Council Directive. 1976. 76/768/EEC of the 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products. Official Journal L262 27/9/1976. pp. 169–200.
   Google Scholar
• Fallerl C, Barcher M, Dami N, Roguet R. Predictive ability of reconstructed human epidermis equivalents for the assessment of skin irritation of cosmetics. Toxicol in Vitro 2002; 16: 557–572
   PubMed Web of Science ®Google Scholar
• Fryzek JP, Chadda B, Marano D, White K, Schweitzer S, McLaughlin JK, Blot WJ. A cohort mortality study among titanium dioxide manufacturing workers in the United States. J Occup Environ Med 2003; 45: 400–409
   PubMed Web of Science ®Google Scholar
• Greiter F. Sun protection factor – origin and methods. Sonderdr Parfum Kosmet 1974; 55: 70–75
   Google Scholar
• Greiter F. What is light protection? Sun protection factor and problems in determining it. Apotheker J 1981; 4/5: 58–61
   Google Scholar
• Gulleron L, Coecke S, Sysmans M, Hansen E, van Oproy S, Marzin D, van Cauteren H, Vanparys Ph. Evaluation of the HET-CAM-TSA method as an alternative to the Draize eye irritation test. Toxicol in vitro 1997; 11(5)641–644
   PubMed Web of Science ®Google Scholar
• Hartung, T. 2007. Statement on the validity of in vitro tests for skin irritation. ECVAM 27 April.
   Google Scholar
• Hecht E, Zajac A. Optics2nd edn. Addison Wesley. Reading, Mass. 1987
   Google Scholar
• Heinrich U, Fuhst R, Rittinghausen S, Creutzenberg O, Bellman B, Koch W, Levsen K. Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel-engine exhaust, carbon black and titanium dioxide. Inhal Tox 1995; 7(4)533–556
   Web of Science ®Google Scholar
• Institute for Environment and Health. 1999. IEH report on approaches to predicting toxicity from occupational exposure to dusts. An appraisal of low toxicity dusts. Report R11. MRC.
   Google Scholar
• International Agency for Research on Cancer (IARC). 1989. Monographs on the evaluation of carcinogenic risks to humans: Some organic solvents, resin monomers and related compounds, pigments and occupational exposures in paint manufacture and painting. 47. LyonFrance: IARC.
   Google Scholar
• International Agency for Research on Cancer (IARC). 2006. Monographs on the evaluation of carcinogenic risks to humans: Carbon black, titanium dioxide and non-asbestiform talc. 93. In Preparation. Meeting Feb.
   Google Scholar
• International Agency for Research on Cancer. 2001. IARC Handbooks of Cancer Prevention. Sunscreens. 5.
   Google Scholar
• ISD Online. 2007. Cancer mortality in Scotland; 2006.
   Google Scholar
• IUCLID CD-ROM. 2000. Public data on high volume chemicals. European Commission Joint Research Centre, European Chemicals Bureau. EUR 19559 EN.
   Google Scholar
• DJ Kirkland. 1989. Statistical evaluation of mutagenicity test data UKEMS sub-committee on guidelines for mutagenicity testing. Report Part III. Cambridge University Press.
   Google Scholar
• La Vecchia C, Lucchini F, Negri E, Levi F, La Vecchia C, et al. Recent declines in worldwide mortality from cutaneous melanoma in youth and middle age. Int J Cancer 1999; 81(1)62–66
   PubMed Web of Science ®Google Scholar
• Lee KP, Trochimowicz HJ, Reinhardt CF. Pulmonary reponse of rats exposed to titanium dioxide (TiO2) by inhalation for two years. Toxicol Appl Pharmacol 1985; 79: 179–192
   PubMed Web of Science ®Google Scholar
• Luepke NP. Hen's egg chorionallantoic membrane test for irritation potential. Food Chem Toxicol 1985; 23(2)287–291
   PubMed Web of Science ®Google Scholar
• Maron DM, Ames BN. Revised methods for the Salmonella mutagenicity test. Mutat Res 1983; 113: 173–215
   PubMed Web of Science ®Google Scholar
• Miller DL, Weinstock MA. Nonmelanoma skin cancer in the United States: Incidence. J Am Acad Dermatol 1994; 30: 774–778
   PubMed Web of Science ®Google Scholar
• Mitchell DL. DNA damage and repair. A handbook of organic photochemistry and photobiology2nd edn, W Horspool, F Lenci. CRC Press, London 2003
   Google Scholar
• Muhle H, Bellman B, Creutzenberg O, Dasenbrock C, Ernst H, Kilpper R, Mackenzie JC, Morrow P, Mohr U, Takenaka S, Mermelstein R. Pulmonary response to toner upon chronic inhalation exposure in rats. Fund Appl Toxicol 1991; 17: 280–299
   PubMedGoogle Scholar
• NANODERM. 2007. Quality of skin as a barrier to ultra-fine particles. QLK4-CT-2002-02678. Final Report.
   Google Scholar
• Northern Ireland Cancer Registry. 2008. Cancer mortality in Northern Ireland; 2005.
   Google Scholar
• Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 2005; 113(7)823–839
   PubMed Web of Science ®Google Scholar
• Oberdörster, G. 1994. Extrapolation of results from animal inhalation studies with particles to humans. In: Dungworth, Mohr, Mauderly, Oberdörster. Toxic and carcinogenic effects of solid particles in the respiratory tract. ILSI Press. Washington DCUSA.
   Google Scholar
• Oberdörster G. Lung particle overload: Implications for occupational exposures to particles. Regul Toxicol Pharmacol 1995; 21: 123–135
   PubMed Web of Science ®Google Scholar
• Office for National Statistics. 2006. Mortality statistics: Cause, England and Wales 2006. London TSO 2007.
   Google Scholar
• Organisation for Economic Co-operation and Development (OECD). 1997. Test Guideline 471 Bacterial Reverse mutation test. Adopted 21 July, 1997.
   Google Scholar
• Organisation for Economic Co-operation and Development (OECD). 2004. Test Guideline 432 In vitro 3T3 NRU Photoxicity test. Adopted 13 April 2004.
   Google Scholar
• Organisation for Economic Co-operation and Development (OECD). 2002. Test Guideline 404 Acute dermal irritation/corrosion. Adopted 24 April 2002.
   Google Scholar
• Rampaul A, Parkin IP, Cramer LP. Damaging and protecting properties of inorganic components of sunscreens applied to cultured human skin cells. J Photochem Photobiol 2007; 191: 138–148
   Web of Science ®Google Scholar
• Sayes CM, Wahi R, Kurian PA, Liu Y, West JL, Ausman KD, Warheit DB, Colvin VL. Correlating nanoscale titania structure with toxicity: A cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicol Sci 2006; 92(1)174–185
   PubMed Web of Science ®Google Scholar
• Scharffetter-Kochanek K, Wlaschek M, Brenneisen P, Schauen M, Blaudschun R, Wenk J. UV-induced reactive oxygen species in photocarcinogenesis and photoaging. Biol Chem 1997; 378: 1247–1257
   PubMed Web of Science ®Google Scholar
• Schulze R. Some tests and remarks regarding the problem of sunscreens that are found on the market. Parfum Kosmet 1956a; 37: 310–316
   Google Scholar
• Schulze R. Some tests and remarks regarding the problem of sunscreens that are found on the market. Parfum Kosmet 1956b; 37: 365–372
   Google Scholar
• Severi G, Giles GG, Robertson C, Boyle CP, Autier P. Mortality from cutaneous melanoma: Evidence for contrasting trends between populations. Br J Cancer 2000; 82(11)1887–1891
   PubMed Web of Science ®Google Scholar
• Shirley DA. High-resolution X-Ray photoemission spectrum of the valence bands of gold. Phys Rev B 1972; 5: 4709
   Web of Science ®Google Scholar
• UK Health & Safety Executive. 1998. Occupational exposure limits 1998 (EH40/98). SudburyUK: HSE Books.
   Google Scholar
• US National Institute for Occupational Safety & Health (NIOSH). 2005. Current Intelligence Bulletin: Evaluation of health hazard and recommendations for Occupational Exposure to titanium dioxide. Draft Nov. 2005.
   Google Scholar
• Wakefield G, Green M, Lipscomb S, Flutter B. Modified titania nanomaterials for sunscreen applications – reducing free radical generation and DNA damage. Materials Sci Technol 2004a; 20(8)985–988
   Web of Science ®Google Scholar
• Wakefield G, Lipscomb S, Holland E, Knowland J. The effects of manganese doping on UVA absorption and free radical generation of micronised titanium dioxide and its consequences for the photostability of UVA absorbing organic sunscreen components. Photochem Photobiol Sci 2004b; 3: 648–652
   PubMed Web of Science ®Google Scholar
• Wakefield G, Stott J, Hock J. Sunscreens and cosmetics containing manganese doped titanium dioxide nanoparticles. SOFW-J 2005; 131: 46–51
   Google Scholar
• Wakefield G, Stott J. Photostabilisation of organic UV-absorbing and anti-oxidant cosmetic components in formulations containing micronised manganese-doped titanium dioxide. J Cosmet Sci 2006; 57: 385–395
   PubMed Web of Science ®Google Scholar
• World Health Organization (WHO). 2000. Accessed from the internet website: www.who.int/mediacentre/factsheets.
   Google Scholar