Male circumcision to prevent syphilis in 1855 and HIV in 1986 is supported by the accumulated scientific evidence to 2015: Response to Darby

References

• Abdool Karim, Q., Abdool Karim, S. S., Frohlich, J. A., Grobler, A. C., Baxter, C., Mansoor, L. E., … Taylor, D. (2010). Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science, 329, 1168–1174. doi:10.1126/science.1193748
   PubMed Web of Science ®Google Scholar
• American Academy of Pediatrics. (2012). Circumcision policy statement. Task force on Circumcision. Pediatrics, 130(3), e756–e785. doi:10.1542/peds.103.3.686
   PubMed Web of Science ®Google Scholar
• Auvert, B., Taljaard, D., Lagarde, E., Sobngwi-Tambekou, J., Sitta, R., & Puren, A. (2005). Randomized, controlled intervention trial of male circumcision for reduction of HIV infection risk: The ANRS 1265 Trial. PLoS Medicine, 2(e298), 1112–1122. doi:10.1371/journal.pmed.0020298
   Web of Science ®Google Scholar
• Auvert, B., Taljaard, D., Rech, D., Lissouba, P., Singh, B., Bouscaillou, J., … Lewis, D. (2013). Association of the ANRS-12126 male circumcision project with HIV levels among men in a South African township: Evaluation of effectiveness using cross-sectional surveys. PLoS Medicine, 10 (article no. e1001509), 1–12. doi:10.1371/journal.pmed.1001509
   Web of Science ®Google Scholar
• Baeten, J. M., Donnell, D., Kapiga, S. H., Ronald, A., John-Stewart, G., Inambao, M., … Celum, C. (2010). Male circumcision and risk of male-to-female HIV-1 transmission: A multinational prospective study in African HIV-1-serodiscordant couples. AIDS, 24, 737–744. doi:10.1097/QAD.0b013e32833616e0
   PubMed Web of Science ®Google Scholar
• Bailey, R. C., Moses, S., Parker, C. B., Agot, K., Maclean, I., Krieger, J. N., … Ndinya-Achola, J. O. (2007). Male circumcision for HIV prevention in young men in Kisumu, Kenya: A randomised controlled trial. The Lancet, 369, 643–656. doi:10.1016/S0140-6736(07)60312-2
   PubMed Web of Science ®Google Scholar
• Bailey, R. C., Moses, S., Parker, C. B., Agot, K., MacLean, I., Krieger, J. N., … Ndinya-Achola, J. O. (2010, July 18–23). The protective effect of adult male circumcision against HIV acquisition is sustained for at least 54 months: Results from the Kisumu, Kenya trial. XVIII International AIDS Conference, Vienna, Abstract#FRLBC1. Retrieved August 16, 2015, from http://pag.aids2010.org/Abstracts.aspx?AID=17707
   Google Scholar
• Bailey, R. C., Neema, S., & Othieno, R. (1999). Sexual behaviors and other HIV risk factors in circumcised and uncircumcised men in Uganda. Journal of Acquired Immune Deficiency Syndrome, 22, 294–301.
   PubMed Web of Science ®Google Scholar
• Bailis, S., & Halperin, D. (2006). Reviews ‘a surgical temptation: The demonisation of the foreskin and the rise of circumcision in Britain’ by Robert Darby. British Medical Journal, 332, 183. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1336783/pdf/bmj33200183.pdf
   Google Scholar
• Banerjee, J., Klausner, J. D., Halperin, D. T., Wamai, R., Schoen, E. J., Moses, S., … Bowa, K. (2011). Circumcision denialism unfounded and unscientific. [Critique of Green et al., ‘Male circumcision and HIV prevention: Insufficient evidence and neglected external validity’]. American Journal of Preventive Medicine, 40, e11–e12. doi:10.1016/j.amepre.2010.12.005
   PubMed Web of Science ®Google Scholar
• Bärnighausen, T., Bloom, D. E., & Humair, S. (2012). Economics of antiretroviral treatment vs. circumcision for HIV prevention. Proceedings of the National Academy of Sciences USA, 109, 21271–21276.
   PubMed Web of Science ®Google Scholar
• Butler, D. (2009). Jury still out on HIV vaccine results. Nature, 461, 1187. doi:10.1038/4611187a
   PubMed Web of Science ®Google Scholar
• Buvé, A., Weiss, H. A., Laga, M., Van Dyck, E., Musonda, R., Zekeng, L., … Hayes, R. J. (2001). The epidemiology of gonorrhoea, chlamydial infection and syphilis in four African cities. AIDS, 15(Suppl. 4), S79–S88.
   PubMedGoogle Scholar
• Bwayo, J., Plummer, F., Omari, M., Mutere, A., Moses, S., Ndinya-Achola, J., … Kreiss, J. (1994). Human immunodeficiency virus infection in long-distance truck drivers in east Africa. Archives of Internal Medicine, 154, 1391–1396.
   PubMed Web of Science ®Google Scholar
• Byakika-Tusiime, J. (2008). Circumcision and HIV infection: Assessment of causality. AIDS and Behavior, 12, 835–841. doi:10.1007/s10461-008-9453-6
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention. (2010). Monitoring selected national HIV prevention and care objectives by using HIV surveillance data—United States and 6 U.S. dependent areas—2010. HIV Surveillance Supplemental Report, 17(3), Part A. Atlanta, GA: US Department of Health and Human Services, CDC; 2012. Retrieved April 20, 2014, from http://www.cdc.gov/hiv/topics/surveillance/resources/reports
   Google Scholar
• Centers for Disease Control and Prevention. (2011). HIV surveillance report: Diagnoses of HIV infection in the United States and dependent areas, 23. Retrieved July 25, 2015, from http://www.cdc.gov/hiv/pdf/statistics_2011_HIV_Surveillance_Report_vol_23.pdf
   Google Scholar
• Centers for Disease Control and Prevention. (2013). Male circumcision. Retrieved March 14, 2015, from http://www.cdc.gov/hiv/prevention/research/malecircumcision/
   Google Scholar
• Centers for Disease Control and Prevention. (2014). Recommendations for providers counseling male patients and parents regarding male circumcision and the prevention of HIV infection, STIs, and other health outcomes. Docket No. CDC-2014-0012. Retrieved July 7, 2015, from http://www.gpo.gov/fdsys/pkg/FR-2014-12-02/pdf/2014-27814.pdf
   Google Scholar
• Chemtob, D., Op De Coul, E., Van Sighem, A., Mor, Z., Cazein, F., & Semaille, C. (2015). Impact of male circumcision among heterosexual HIV cases: Comparisons between three low HIV prevalence countries. Israel Journal of Health Policy Research 4, article no. 36, 1–8. doi:10.1186/s13584-015-0033-8
   PubMed Web of Science ®Google Scholar
• Cook, L. S., Koutsky, L. A., & Holmes, K. K. (1994). Circumcision and sexually transmitted diseases. American Journal of Public Health, 84, 197–201.
   PubMed Web of Science ®Google Scholar
• Cox, G., & Morris, B. J. (2012). Why circumcision: From pre-history to the twenty-first century. In D. A. Bolnick, M. A. Koyle, & A. Yosha (Eds.), Surgical guide to circumcision (pp. 243–259). London: Springer. Retrieved from http://www.springer.com/us/book/9781447128571
   Google Scholar
• Darby, R. (2005). A surgical temptation: The demonization of the foreskin and the rise in circumcision in Britain. Chicago, IL: University of Chicago Press. Retrieved from http://press.uchicago.edu/ucp/books/book/chicago/S/bo3534612.html
   Google Scholar
• Darby, R. (2015). Syphilis 1855 and HIV-AIDS 2007: Historical reflections on the tendency to blame human anatomy for the action of micro-organisms. Global Public Health, 10, 573–588. doi:10.1080/17441692.2014.957231
   PubMed Web of Science ®Google Scholar
• Dave, S. S., Johnson, A. M., Fenton, K. A., Mercer, C. H., Erens, B., & Wellings, K. (2003). Male circumcision in Britain: Findings from a national probability sample survey. Sexually Transmitted Infections, 79, 499–500. doi:10.1136/sti.79.6.499
   PubMed Web of Science ®Google Scholar
• Deeks, S. G., Autran, B., Berkhout, B., Benkirane, M., Cairns, S., Chomont, N., … Barré-Sinoussi, F. (2012). International AIDS Society scientific working group on HIV cure. Towards an HIV cure: A global scientific strategy. Nature Reviews Immunology, 12, 607–614. doi:10.1038/nri3262
   PubMed Web of Science ®Google Scholar
• Deeks, S. G., Lewin, S. R., & Havlir, D. V. (2013). The end of AIDS: HIV infection as a chronic disease. The Lancet, 382, 1525–1533. doi:10.1016/S0140-6736(13)61809-7
   PubMed Web of Science ®Google Scholar
• Diseker, R. A., Peterman, T. A., Kamb, M. L., Kent, C., Zenilman, J. M., Douglas, J. M., … Iatesta, M. (2000). Circumcision and STD in the United States: Cross sectional and cohort analysis. Sexually Transmitted Infections, 76, 474–479. doi:10.1136/sti.76.6.474
   PubMed Web of Science ®Google Scholar
• Donovan, B., Basset, I., & Bodsworth, N. J. (1994). Male circumcision and common sexually transmissible diseases in a developed nation setting. Genitourinary Medicine, 70, 317–320.
   PubMedGoogle Scholar
• Eke, N., & Nkanginieme, K. E. (2006). Female genital mutilation. The Lancet, 367, 1799–1800.
   PubMed Web of Science ®Google Scholar
• El Bcheraoui, C., Zhang, X., Cooper, C. S., Rose, C. E., Kilmarx, P. H., & Chen, R. T. (2014). Rates of adverse events associated with male circumcision in US medical settings, 2001 to 2010. JAMA Pediatrics, 168, 625–634. doi:10.1001/jamapediatrics.2013.5414
   PubMed Web of Science ®Google Scholar
• El-Sadr, W. M., Mayer, K. H., & Hodder, S. L. (2010). AIDS in America – forgotten but not gone. New England Journal of Medicine, 362, 967–970. doi:10.1056/NEJMp1000069
   PubMed Web of Science ®Google Scholar
• European Centre for Disease Prevention and Control/WHO Regional Office for Europe. (2013). HIV/AIDS surveillance in Europe 2012. Stockholm: Author. Retrieved April 20, 2015, from, http://www.euro.who.int/__data/assets/pdf_file/0018/235440/e96953.pdf
   Google Scholar
• Faria, N. R., Rambaut, A., Suchard, M. A., Baele, G., Bedford, T., Ward, M. J., … Lemey, P. (2014). HIV epidemiology. The early spread and epidemic ignition of HIV-1 in human populations. Science, 346, 56–61. doi:10.1126/science.1256739
   PubMed Web of Science ®Google Scholar
• Fink, A. J. (1986). A possible explanation for heterosexual male infection with AIDS. New England Journal of Medicine, 314, 1167.
   Google Scholar
• Freeland, E. H. (1900). Circumcision as a preventative of syphilis and other disorders. The Lancet, 156, 1869–1871.
   Google Scholar
• Frith, J. (2012). Syphilis – Its early history and treatment until penicillin, and the debate on its origins. Journal of Military and Veterans’ Health, 20, 49–58. Retrieved from http://jmvh.org/article/syphilis-its-early-history-and-treatment-until-penicillin-and-the-debate-on-its-origins/
   Google Scholar
• Ganor, Y., & Bomsel, M. (2011). HIV-1 transmission in the male genital tract. American Journal of Reproductive Immunology, 65, 284–291. doi:10.1111/j.1600-0897.2010.00933.x
   PubMed Web of Science ®Google Scholar
• Ganor, Y., Zhou, Z., Tudor, D., Schmitt, A., Vacher-Lavenu, M. C., Gibault, L., … Bomsel, M. (2010). Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates. Mucosal Immunology, 3, 506–522. doi:10.1038/mi.2010.32
   PubMed Web of Science ®Google Scholar
• Garenne, M. (2008). Long-term population effect of male circumcision in generalised HIV epidemics in sub-Saharan Africa. African Journal of AIDS Research, 7, 1–8. doi:10.2989/AJAR.2008.7.1.1.429
   PubMed Web of Science ®Google Scholar
• Gebremedhin, S. (2010). Assessment of the protective effect of male circumcision from HIV infection and sexually transmitted diseases: Evidence from 18 demographic and health surveys in sub-Saharan Africa. African Journal of Reproductive Health, 14, 105–113. doi:10.4314/eajph.v7i4.64746
   PubMedGoogle Scholar
• Gottlieb, S. L., Low, N., Newman, L. M., Bolan, G., Kamb, M., & Broutet, N. (2014). Toward global prevention of sexually transmitted infections (STIs): The need for STI vaccines. Vaccine, 32, 1527–1535. doi:10.1016/j.vaccine.2013.07.087
   PubMed Web of Science ®Google Scholar
• Gouws, E., White, P. J., Stover, J., & Brown, T. (2006). Short term estimates of adult HIV incidence by mode of transmission: Kenya and Thailand as examples. Sexually Transmitted Infections, 82(Suppl. 3), iii51–iii55. doi:10.1136/sti.2006.020164
   PubMed Web of Science ®Google Scholar
• Grant, R. M., Lama, J. R., Anderson, P. L., McMahan, V., Liu, A. Y., Vargas, L., … Glidden, D. V. (2010). Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. New England Journal of Medicine, 363, 2587–2599. doi:10.1056/NEJMoa1011205
   PubMed Web of Science ®Google Scholar
• Gray, R., Azire, J., Serwadda, D., Kiwanuka, N., Kigozi, G., Kiddugavu, M., … Wawer, M. (2004). Male circumcision and the risk of sexually transmitted infections and HIV in Rakai, Uganda. AIDS, 18, 2428–2430.
   PubMed Web of Science ®Google Scholar
• Gray, R., Kigozi, G., Kong, X., Ssempiija, V., Makumbi, F., Wattya, S., … Wawer, M. J. (2012). The effectiveness of male circumcision for HIV prevention and effects on risk behaviors in a post-trial follow up study in Rakai, Uganda. AIDS, 26, 609–615. doi:10.1097/QAD.0b013e3283504a3f
   PubMed Web of Science ®Google Scholar
• Gray, R. H., Kigozi, G., Serwadda, D., Makumbi, F., Watya, S., Nalugoda, F., … Wawer, M. J. (2007). Male circumcision for HIV prevention in men in Rakai, Uganda: A randomised trial. The Lancet, 369, 657–666. doi:10.1016/S0140-6736(07)60313-4
   PubMed Web of Science ®Google Scholar
• Gray, R. H., Kiwanuka, N., Quinn, T. C., Sewankambo, N. K., Serwadda, D., Mangen, F. W., … Wawer, M. J. (2000). Male circumcision and HIV aquisition and transmission: Cohort studies in Rakai, Uganda. AIDS, 14, 2371–2381.
   PubMed Web of Science ®Google Scholar
• Gust, D. A., Wiegand, R. E., Kretsinger, K., Sansom, S., Kilmarx, P. H., Bartholow, B. N., … Chen, R. T. (2010). Circumcision status and HIV infection among MSM: Reanalysis of a Phase III HIV vaccine clinical trial. AIDS, 24(8), 1135–1143. doi:10.1097/QAD.0b013e328337b8bd
   PubMed Web of Science ®Google Scholar
• Hallett, T. B., Alsallaq, R. A., Baeten, J. M., Weiss, H., Celum, C., Gray, R., … Abu-Raddad, L. (2011). Will circumcision provide even more protection from HIV to women and men? New estimates of the population impact of circumcision interventions. Sexually Transmitted Infections, 87, 88–93. doi:10.1136/sti.2010.043372
   PubMed Web of Science ®Google Scholar
• Halperin, D. T., Weiss, H. A., Hayes, R., Auvert, B., Bailey, R. C., Caldwell, J., … Klausner, J. (2002). Response to Ronald Gray, Male circumcision and HIV acquisition and transmission: Cohort studies in Rakai, Uganda (AIDS 2000,14:2371–2381). AIDS, 16, 810–812.
   PubMed Web of Science ®Google Scholar
• Hand, E. A. (1949). Circumcision and venereal disease. Archives of Dermatology and Syphilology, 60, 341–346.
   PubMedGoogle Scholar
• Hauri, A. M., Armstrong, G. L., & Hutin, Y. J. (2004). The global burden of disease attributable to contaminated injections given in health care settings. International Journal of STD & AIDS, 15, 7–16. doi:10.1258/095646204322637182
   PubMed Web of Science ®Google Scholar
• Hutchinson, J. (1855). On the influence of circumcision in preventing syphilis. Medical Times and Gazette, II, 542–543.
   Google Scholar
• Iliffe, J. (2006). The African AIDS epidemic: A history. Athens: Ohio University Press. Retrieved from http://www.ohioswallow.com/book/The+African+AIDS+Epidemic
   Google Scholar
• Jameson, D. R., Celum, C. L., Manhart, L., Menza, T. W., & Golden, M. R. (2010). The association between lack of circumcision and HIV, HSV-2, and other sexually transmitted infections among men who have sex with men. Sexually Transmitted Diseases, 37, 147–152. doi:10.1097/OLQ.0b013e3181bd0ff0
   PubMed Web of Science ®Google Scholar
• Jayathunge, P. H., McBride, W. J., MacLaren, D., Kaldor, J., Vallely, A., & Turville, S. (2014). Male circumcision and HIV transmission; what do we know? The Open AIDS Journal, 8, 31–44. doi:10.2174/1874613601408010031
   PubMedGoogle Scholar
• Kent, S. J., Reece, J. C., Petravic, J., Martyushev, A., Kramski, M., De Rose, R., … Davenport, M. P. (2013). The search for an HIV cure: Tackling latent infection. The Lancet Infectious Diseases, 13, 614–621. doi:10.1016/S1473-3099(13)70043-4
   PubMed Web of Science ®Google Scholar
• Kenyon, C. R., Osbak, K., & Buyze, J. (2014). The prevalence of HIV by ethnic group is correlated with HSV-2 and syphilis prevalence in Kenya, South Africa, the United Kingdom, and the United States. Interdisciplinary Perspectives on Infectious Diseases, 2014, article no. 284317, 1–11. doi:10.1155/2014/284317
   Google Scholar
• Kigozi, G., Lukabwe, I., Kagaayi, J., Wawer, M. J., Nantume, B., Kigozi, G., … Gray, R. H. (2009). Sexual satisfaction of women partners of circumcised men in a randomized trial of male circumcision in Rakai, Uganda. BJU International, 104, 1698–1701. doi:10.1111/j.1464-410X.2009.08683.x
   PubMed Web of Science ®Google Scholar
• Kigozi, G., Watya, S., Polis, C. B., Buwembo, D., Kiggundu, V., Wawer, M. J., … Gray, R. H. (2008). The effect of male circumcision on sexual satisfaction and function, results from a randomized trial of male circumcision for human immunodeficiency virus prevention, Rakai, Uganda. BJU International, 101, 65–70. doi:10.1111/j.1464-410X.2007.07369.x
   PubMed Web of Science ®Google Scholar
• Klausner, J. D. (2013). Faulty analysis leads to erroneous conclusions. Journal of Sexual Medicine, 10, 613–614. doi:10.1111/j.1743-6109.2012.02986.x
   PubMed Web of Science ®Google Scholar
• Krieger, J. N., Mehta, S. D., Bailey, R. C., Agot, K., Ndinya-Achola, J. O., Parker, C., … Moses, S. (2008). Adult male circumcision: Effects on sexual function and sexual satisfaction in Kisumu, Kenya. Journal of Sexual Medicine, 5, 2610–2622. doi:10.1111/j.1743-6109.2008.00979.x
   PubMed Web of Science ®Google Scholar
• Laumann, E. O., Masi, C. M., & Zuckerman, E. W. (1997). Circumcision in the United States. Prevalence, prophyactic effects, and sexual practice. Journal of American Medical Association, 277, 1052–1057.
   PubMed Web of Science ®Google Scholar
• Lavreys, L., Rakwar, J. P., Thompson, M. L., Kackson, D. J., Mandaliya, K., Chohan, B. H., … Kreiss, J. K. (1999). Effect of circumcision on incidence of human immunodeficiency virus type 1 and other sexually transmitted diseases: A prospective cohort study of trucking company employees in Kenya. The Journal of Infectious Diseases, 180, 330–336.
   PubMed Web of Science ®Google Scholar
• Lemos, M. P., Lama, J. R., Karuna, S. T., Fong, Y., Montano, S. M., Ganoza, C., … McElrath, M. J. (2014). The inner foreskin of healthy males at risk of HIV infection harbors epithelial CD4+ CCR5+ cells and has features of an inflamed epidermal barrier. PLoS One, 9, article no. e108954, 1–11. doi:10.1371/journal.pone.0108954
   Web of Science ®Google Scholar
• Lloyd, V. E., & Lloyd, N. L. (1934). Circumcision and syphilis. British Medical Journal, 1, 144–146.
   PubMedGoogle Scholar
• Lopez, L. M., Otterness, C., Chen, M., Steiner, M., & Gallo, M. F. (2013). Behavioral interventions for improving condom use for dual protection. Cochrane Database System Review, 10, article no. CD010662, 1–42. doi:10.1002/14651858.CD010662.pub2
   Web of Science ®Google Scholar
• Mahoney, J. F., Arnold, R. C., & Harris, A. (1943). Penicillin treatment of early syphilis – a preliminary report. American Journal of Public Health Nations Health, 33, 1387–1391.
   Google Scholar
• Manda, S. O., Lombard, C. J., & Mosala, T. (2012). Divergent spatial patterns in the prevalence of the human immunodeficiency virus (HIV) and syphilis in South African pregnant women. Geospatial Health, 6, 221–231.
   PubMed Web of Science ®Google Scholar
• Masters, W. H., & Johnson, V. E. (1966). Human sexual response. Boston, MA: Little Brown.
   Google Scholar
• McCoombe, S. G., & Short, R. V. (2006). Potential HIV-1 target cells in the human penis. AIDS, 20, 1491–1495. doi:10.1097/01.aids.0000237364.11123.98
   PubMed Web of Science ®Google Scholar
• Mehta, S. D., Moses, S., Parker, C. B., Agot, K., Maclean, I., & Bailey, R. C. (2012). Circumcision status and incident herpes simplex virus type 2 infection, genital ulcer disease, and HIV infection. AIDS, 26, 1141–1149. doi:10.1097/QAD.0b013e328352d116
   PubMed Web of Science ®Google Scholar
• Millett, G. A., Flores, S. A., Marks, G., Reed, J. B., & Herbst, J. H. (2008). Circumcision status and risk of HIV and sexually transmitted infections among men who have sex with men: A meta-analysis. Journal of the American Medical Association, 300, 1674–1684. doi:10.1001/jama.300.14.1674
   PubMed Web of Science ®Google Scholar
• Mills, E., Cooper, C., Anema, A., & Guyatt, G. (2008). Male circumcision for the prevention of heterosexually acquired HIV infection: A meta-analysis of randomized trials involving 11,050 men. HIV Medicine, 9, 332–335. doi:10.1111/j.1468-1293.2008.00596.x
   PubMed Web of Science ®Google Scholar
• Mishra, V., & Bignami-Van Assche, S. (2009). Concurrent sexual partnerships and HIV infection: Evidence from national population based surveys (DHS Working Paper 62). Retrieved April 21, 2015, from http://pdf.usaid.gov/pdf_docs/Pnado191.pdf
   Google Scholar
• Mishra, V., Khan, S., Liu, L., & Kottiri, B. (2008). Medical injection use and HIV in sub-Saharan Africa. DHS comparative studies no. 21. Calverton: Macro International. Retrieved April 20, 2015, from http://dhsprogram.com/pubs/pdf/CR21/CR21.pdf
   Google Scholar
• Mmbaga, E. J., Leonard, F., & Leyna, G. H. (2012). Incidence and predictors of adolescent's early sexual debut after three decades of HIV interventions in Tanzania: A time to debut analysis. PLoS One, 7, article no. e41700, 1–9. doi:10.1371/journal.pone.0041700
   Web of Science ®Google Scholar
• Mor, Z., Kent, C. K., Kohn, R. P., & Klausner, J. D. (2007). Declining rates in male circumcision amidst increasing evidence of its public health benefit. PLoS One, 2, e861 (4 pages). doi:10.1371/journal.pone.0000861
   PubMed Web of Science ®Google Scholar
• Morris, B. J. (2012). Boyle and Hill's circumcision ‘Phallusies’. BJU International, 110, E153–E154. doi:10.1111/j.1464-410X.2012.10674_2.x
   PubMed Web of Science ®Google Scholar
• Morris, B. J., Bailey, R. C., Klausner, J. D., Leibowitz, A., Wamai, R. G., Waskett, J. H., … Hankins, C. A. (2012). Review: A critical evaluation of arguments opposing male circumcision for HIV prevention in developed countries. AIDS Care, 24, 1565–1575. doi:10.1080/09540121.2012.661836
   PubMed Web of Science ®Google Scholar
• Morris, B. J., Bailis, S. A., & Wiswell, T. E. (2014). Circumcision rates in the United States: Rising or falling? What effect might the new affirmative pediatric policy statement have? Mayo Clinic Proceedings, 89, 677–686. doi:10.1016/j.mayocp.2014.01.001
   PubMed Web of Science ®Google Scholar
• Morris, B. J., Hankins, C. A., Tobian, A. A., Krieger, J. N., & Klausner, J. D. (2014). Does male circumcision protect against sexually transmitted infections? Arguments and meta-analyses to the contrary fail to withstand scrutiny. ISRN Urology, 2014, article no. 684706, 1–23. doi:10.1155/2014/684706
   Google Scholar
• Morris, B. J., & Krieger, J. N. (2013). Does male circumcision affect sexual function, sensitivity or satisfaction? A systematic review. Journal of Sexual Medicine, 10, 2644–2657. doi:10.1111/jsm.12293
   PubMed Web of Science ®Google Scholar
• Morris, B. J., & Wamai, R. G. (2012). Biological basis for the protective effect conferred by male circumcision against HIV infection. International Journal of STD & AIDS, 23, 153–159. doi:10.1258/ijsa.2011.011228
   PubMed Web of Science ®Google Scholar
• Morris, B. J., Waskett, J. H., Banerjee, J., Wamai, R. G., Tobian, A. A. R., Gray, R. H., … Mindel, A. (2012). A ‘snip’ in time: What is the best age to circumcise? BMC Pediatrics, 12, article no. 20, 1–15. doi:10.1186/1471-2431-12-20
   PubMed Web of Science ®Google Scholar
• Morris, B. J., Waskett, J. H., Gray, R. H., Halperin, D. T., Wamai, R., Auvert, B., & Klausner, J. D. (2011). Exposé of misleading claims that male circumcision will increase HIV infections in Africa. Journal of Public Health in Africa, 2, article no. e281, 28–122. Retrieved from https://www.researchgate.net/publication/268285464_Expos_of_misleading_claims_that_male_circumcision_will_increase_HIV_infections_in_Africa
   Google Scholar
• National AIDS and STI Control Programme. (2014, June). Kenya AIDS indicator survey 2012: Final report. Nairobi: Author. Retrieved October 20, 2014, from http://www.nacc.or.ke/attachments/article/403/KAIS_II_2014_Final_Report.pdf
   Google Scholar
• Newell, J., Senkoro, K., Mosha, F., Grosskurth, H., Nicoll, A., Barongo, L., … Killewo, J. (1993). A population-based study of syphilis and sexually transmitted disease syndromes in north-western Tanzania. 2. Risk factors and health seeking behaviour. Genitourinary Medicine, 69, 421–426.
   PubMedGoogle Scholar
• Njeuhmeli, E., Forsythe, S., Reed, J., Opuni, M., Bollinger, L., Heard, N., … Hankins, C. (2011). Voluntary medical male circumcision: Modeling the impact and cost of expanding male circumcision for HIV prevention in eastern and southern Africa. PLoS Medicine, 8, article no. e1001132, 1–15. doi:10.1371/journal.pmed.1001132
   Web of Science ®Google Scholar
• Otieno-Nyunya, B., Bennett, E., Bunnell, R., Dadabhai, S., Gichangi, A. A., Mugo, N., … Kaiser, R. (2011). Epidemiology of syphilis in Kenya: Results from a nationally representative serological survey. Sexually Transmitted Infections, 87(6), 521–525.
   PubMed Web of Science ®Google Scholar
• Parker, S. W., Stewart, A. J., Wren, M. N., Gollow, M. M., & Straton, J. A. (1983). Circumcision and sexually transmissible diseases. Medical Journal of Australia, 2, 288–290.
   PubMed Web of Science ®Google Scholar
• Parkhurst, J. O. (2010). Understanding the correlations between wealth, poverty and human immunodeficiency virus infection in African countries. Bulletin of the World Health Organization, 88, 519–526. doi:10.2471/BLT.09.070185
   PubMed Web of Science ®Google Scholar
• Patterson, B. K., Landy, A., Siegel, J. N., Flener, Z., Pessis, D., Chaviano, A., … Bailey, R. C. (2002). Susceptibility to human immunodeficiency virus-1 infection of human foreskin and cervical tissue grown in explant culture. American Journal of Pathology, 161, 867–873. doi:10.1016/S0002-9440(10)64247-2
   PubMed Web of Science ®Google Scholar
• Perry, L., Rech, D., Mavhu, W., Frade, S., Machaku, M. D., Onyango, M., … Bertrand, J. T. (2014). Work experience, job-fulfillment and burnout among VMMC providers in Kenya, South Africa, Tanzania and Zimbabwe. PLoS One, 9, article no. e84215, 1–9. doi:10.1371/journal.pone.0084215
   Web of Science ®Google Scholar
• Pintye, J., Baeten, J. M., Manhart, L. E., Celum, C., Ronald, A., Mugo, N., … Hefron, R. (2014). Association between male circumcision and incidence of syphilis in men and women: A prospective study in HIV-1 serodiscordant heterosexual African couples. The Lancet Global Health, 2, e664–e671. doi:10.1016/S2214-109X(14)70315-8
   PubMed Web of Science ®Google Scholar
• Pollard, R. B., Rockstroh, J. K., Pantaleo, G., Asmuth, D. M., Peters, B., Lazzarin, A., … Sørensen, B. (2014). Safety and efficacy of the peptide-based therapeutic vaccine for HIV-1, Vacc-4x: A phase 2 randomised, double-blind, placebo-controlled trial. Lancet Infectious Diseases, 14, 291–300. doi:10.1016/S1473-3099(13)70343-8
   PubMed Web of Science ®Google Scholar
• Rerks-Ngarm, S., Pitisuttithum, P., Nitayaphan, S., Kaewkungwal, J., Chiu, J., Paris, R., … Kim, J. H. (2009). Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. New England Journal of Medicine, 361, 2209–2220. doi:10.1056/NEJMoa0908492
   PubMed Web of Science ®Google Scholar
• Reynolds, S. J., Shepherd, M. E., Risbud, A. R., Gangakhedkar, R. R., Brookmeyer, R. S., Divekar, A. D., … Bollinger, R. C. (2004). Male circumcision and risk of HIV-1 and other sexually transmitted infections in India. The Lancet, 363, 1039–1040. doi:10.1016/S0140-6736(04)15840-6
   PubMed Web of Science ®Google Scholar
• Rodriguez-Diaz, C. E., Clatts, M. C., Jovet-Toledo, G. G., Vargas-Molina, R. L., Goldsamt, L. A., & Garcia, H. (2012). More than foreskin: Circumcision status, history of HIV/STI, and sexual risk in a clinic-based sample of men in Puerto Rico. Journal of Sexual Medicine, 9, 2933–2937. doi:10.1111/j.1743-6109.2012.02871.x
   PubMed Web of Science ®Google Scholar
• Sansom, S. L., Prabhu, V. S., Hutchinson, A. B., An, Q., Hall, H. I., Shrestha, R. K., … Taylor, A. W. (2010). Cost-effectiveness of newborn circumcision in reducing lifetime HIV risk among U.S. males. PLoS One, 5, article no. e8723, 1–8. doi:10.1371/journal.pone.0008723
   Web of Science ®Google Scholar
• Schmid, G. P., Buve, A., Mugyeny, P., Garnett, G. P., Hayes, R. J., Williams, B. G., … Boerma, J. T. (2004). Transmission of HIV-1 infection in sub-Saharan Africa and effect of elimination of unsafe injections. The Lancet, 363, 482–488. doi:10.1016/S0140-6736(04)15497-4
   PubMed Web of Science ®Google Scholar
• Schneider, J. A., Dandona, R., Pasupneti, S., Lakshmi, V., Liao, C., Yeldandi, V., & Mayer, K. H. (2010). Initial commitment to pre-exposure prophylaxis and circumcision for HIV prevention amongst Indian truck drivers. PLoS One, 5, article no. e11922, 1–10. doi:10.1371/journal.pone.0011922
   Web of Science ®Google Scholar
• Schrek, R., & Lenowitz, H. (1947). Etiologic factors in carcinoma of the penis. Cancer Research, 7(3), 180–187.
   PubMed Web of Science ®Google Scholar
• Seed, J., Allen, S., Mertens, T., Hudes, E., Serufilira, A., Carael, M., … & Nsengumuremyi, F. (1995). Male circumcision, sexually transmitted disease, and risk of HIV. Journal of Acquired Immune Deficiciency Syndrome and Human Retrovirolology, 8, 83–90.
   PubMedGoogle Scholar
• Sgaier, S. K., Reed, J. B., Thomas, A., & Njeuhmeli, E. (2014). Achieving the HIV prevention impact of voluntary medical male circumcision: Lessons and challenges for managing programs. PLoS Medicine, 11, article no. e1001641, 1–9. doi:10.1371/journal.pmed.1001641
   Web of Science ®Google Scholar
• Siegfried, N., Muller, M., Deeks, J. J., & Volmink, J. (2009). Male circumcision for prevention of heterosexual acquisition of HIV in men. Cochrane Database Systemetic Reviews, 2, article no. CD003362, 1–38. doi:10.1002/14651858.CD003362.pub2
   Web of Science ®Google Scholar
• Silby, F. A. (1913). Part II: Boys. In M. Scharlieb & F.A. Silby (Eds.), Youth and sex. Dangers and safeguards for girls and boys (pp. 44–92). London: Dodge Publishing.
   Google Scholar
• Tabet, S., Sanchez, J., Lama, J., Goicochea, P., Campos, P., Rouillon, M., … Holmes, K. K. (2002). HIV, syphilis and heterosexual bridging among Peruvian men who have sex with men. AIDS, 16, 1271–1277.
   PubMed Web of Science ®Google Scholar
• Talukdar, A., Khandokar, M. R., Bandopadhyay, S. K., & Detels, R. (2007). Risk of HIV infection but not other sexually transmitted diseases is lower among homeless Muslim men in Kolkata. AIDS, 21, 2231–2235. doi:10.1097/QAD.0b013e3282e9a718
   PubMed Web of Science ®Google Scholar
• Tarkang, E. E. (2013). Age at sexual debut and associated factors among high school female learners in Limbe urban area of Camaroon. Global Advanced Research Journal of Social Science, 2, 163–168. Retrieved from http://garj.org/garjss/7/2013/2/7/age-at-sexual-debut-and-associated-factors-among-high-school-female-learners-in-limbe-urban-area-of-cameroon
   Google Scholar
• Templeton, D. J., Jin, F., Mao, L., Prestage, G. P., Donovan, B., Imrie, J., … Grulich, A. E. (2009). Circumcision and risk of HIV infection in Australian homosexual men. AIDS, 23, 2347–2351. doi:10.1097/QAD.0b013e32833202b8
   PubMed Web of Science ®Google Scholar
• Templeton, D. J., Jin, F., Prestage, G. P., Donovan, B., Imrie, J. C., Kippax, S. C., … Grulich, A. E. (2009). Circumcision and risk of sexually transmissible infections in a community-based cohort of HIV-negative homosexual men in Sydney, Australia. Journal of Infectious Diseases, 200, 1813–1819. doi:10.1086/648376
   PubMed Web of Science ®Google Scholar
• Tian, Y., Liu, W., Wang, J. Z., Wazir, R., Yue, X., & Wang, K. J. (2013). Effects of circumcision on male sexual functions: A systematic review and meta-analysis. Asian Journal of Andrology, 15, 662–666. doi:10.1038/aja.2013.47
   PubMed Web of Science ®Google Scholar
• Tobian, A. A., & Quinn, T. C. (2009). Herpes simplex virus type 2 and syphilis infections with HIV: An evolving synergy in transmission and prevention. Current Opinion in HIV & AIDS, 4, 294–299. doi:10.1097/COH.0b013e32832c1881
   PubMed Web of Science ®Google Scholar
• Tobian, A. A. R., Serwadda, D., Quinn, T. C., Kigozi, G., Gravitt, P. E., Laeyendecker, O., … Gray, R. H. (2009). Male circumcision for the prevention of HSV-2 and HPV infections and syphilis. New England Journal of Medicine, 360, 1298–1309. doi:10.1056/NEJMoa0802556
   PubMed Web of Science ®Google Scholar
• Todd, J., Munguti, K., Grosskurth, H., Mngara, J., Changalucha, J., Mayaud, P., … Hayes, R. (2001). Risk factors for active syphilis and TPHA seroconversion in a rural African population. Sexually Transmitted Infections, 77, 37–45.
   PubMed Web of Science ®Google Scholar
• Uganda Ministry of Health and ICF International. (2012). 2011 Uganda AIDS indicator survey: Key findings. Calverton, MD: MOH and ICF International. Retrieved September 30, 2015, from http://health.go.ug/docs/UAIS_2011_KEY_FINDINGS.pdf
   Google Scholar
• UNAIDS. (2008). Safe, voluntary, informed male circumcision and comprehensive HIV prevention programming: Guidance for decision-makers on human rights, ethical & legal considerations. Retrieved April 21, 2015, from http://data.unaids.org/pub/Report/2008/JC1552_Circumcision_en.pdf
   Google Scholar
• UNAIDS. (2013). UNAIDS report on the global AIDS epidemic 2013. Retrieved April 21, 2015, from http://www.unaids.org/en/media/unaids/contentassets/documents/epidemiology/2013/gr2013/UNAIDS_Global_Report_2013_en.pdf
   Google Scholar
• Urassa, M., Todd, J., Boerma, J. T., Hayes, R., & Islingo, R. (1997). Male circumcision and susceptibility to HIV infection among men in Tanzania. AIDS, 11, 73–80.
   PubMed Web of Science ®Google Scholar
• Van Howe, R. S. (2013). Sexually transmitted infections and male circumcision: A systematic review and meta-analysis. ISRN Urology, 2013, article no. 109846, 1–42. doi:10.1155/2013/109846
   Google Scholar
• Vaz, R. G., Gloyd, S., Folgosa, E., & Kreiss, J. (1995). Syphilis and HIV infection among prisoners in Maputo, Mozambique. International Journal of STD & AIDS, 6, 42–46.
   PubMed Web of Science ®Google Scholar
• Wabwire-Mangen, F., Odiit, M., Kirungi, W., Kisitu, D. K., & Wanyama, J. O. (2009). Uganda: HIV modes of transmission and prevention response analysis. Kampala: National AIDS Commission. Retrieved November 3, 2014, from http://numat.jsi.com/Resources/Docs/UnaidsUgandaCountryReport_09.pdf
   Google Scholar
• Wamai, R., & Morris, B. J. (2011). ‘How to contain generalized HIV epidemics’ article misconstrues the evidence. International Journal of STD & AIDS, 22, 415–416. doi:10.1258/ijsa.2010.010460
   PubMed Web of Science ®Google Scholar
• Wamai, R. G., Morris, B. J., Bailey, R. C., Klausner, J. D., & Boedickere, M. N. (2015). Male circumcision for protection against HIV infection in sub-Saharan Africa: The evidence in favour justifies the implementation now in progress. Global Public Health, 10, 639–666. doi:10.1080/17441692.2014.989532
   PubMed Web of Science ®Google Scholar
• Wamai, R. G., Morris, B. J., Bailis, S. A., Sokal, D., Klausner, J. D., Appleton, R., … Banerjee, J. (2011). Male circumcision for HIV prevention: Current evidence and implementation in sub-Saharan Africa. Journal of the International AIDS Society, 14, article no. 49, 1–17. doi:10.1186/1758-2652-14-49
   PubMed Web of Science ®Google Scholar
• Wamai, R. G., Morris, B. J., Waskett, J. H., Green, E. C., Banerjee, J., Bailey, R. C., … Hankins, C. A. (2012). Criticisms of African trials fail to withstand scrutiny: Male circumcision does prevent HIV infection. Journal of Law and Medicine, 20, 93–123.
   PubMedGoogle Scholar
• Wamai, R. G., Weiss, H. A., Hankins, C., Agot, K., Karim, Q. A., Shisana, O., … Halperin, D. T. (2008). Male circumcision is an efficacious, lasting and cost-effective strategy for combating HIV in high-prevalence AIDS epidemics: Time to move beyond debating the science. Future HIV Therapy, 2, 399–405. Retrieved from http://www.futuremedicine.com/doi/pdf/10.2217/17469600.2.5.399
   Google Scholar
• Wand, H., & Ramjee, G. (2012). The relationship between age of coital debut and HIV seroprevalence among women in Durban, South Africa: A cohort study. BMJ Open, 2, article no. e000285, 1–8. doi:10.1136/bmjopen-2011-000285
   Web of Science ®Google Scholar
• Waskett, J. H., Morris, B. J., & Weiss, H. A. (2009). Errors in meta-analysis by Van Howe. International Journal of STD & AIDS, 20, 216–218. doi:10.1258/ijsa.2009.008126
   PubMed Web of Science ®Google Scholar
• Wawer, M. J., Makumbi, F., Kigozi, G., Serwadda, D., Watya, S., Nalugoda, F., … Gray, R. H. (2009). Circumcision in HIV-infected men and its effect on HIV transmission to female partners in Rakai, Uganda: A randomised controlled trial. The Lancet, 374, 229–237. doi:10.1016/S0140-6736(09)60998-3
   PubMed Web of Science ®Google Scholar
• Weiss, H. A., Halperin, D., Bailey, R. C., Hayes, R. J., Schmid, G., & Hankins, C. A. (2008). Male circumcision for HIV prevention: From evidence to action? AIDS, 22, 567–574. doi:10.1097/QAD.0b013e3282f3f406
   PubMed Web of Science ®Google Scholar
• Weiss, H. A., Hankins, C. A., & Dickson, K. (2009). Male circumcision and risk of HIV infection in women: A systematic review and meta-analysis. Lancet Infectetctious Diseases, 9, 669–677. doi:10.1016/S1473-3099(09)70235-X
   PubMed Web of Science ®Google Scholar
• Weiss, H. A., Plummer, M. L., Changalucha, J., Mshana, G., Shigongo, Z. S., Todd, J., … Ross, D. A. (2008). Circumcision among adolescent boys in rural northwestern Tanzania. Tropical Medicine & International Health, 13, 1054–1061. doi:10.1111/j.1365-3156.2008.02107.x
   PubMed Web of Science ®Google Scholar
• Weiss, H. A., Thomas, S. L., Munabi, S. K., & Hayes, R. J. (2006). Male circumcision and risk of syphilis, chancroid, and genital herpes: A systematic review and meta-analysis. Sexually Transmitted Infections, 82, 101–110. doi:10.1136/sti.2005.017442
   PubMed Web of Science ®Google Scholar
• Weller, S., & Davis-Beaty, K. (2002). Condom effectiveness in reducing heterosexual HIV transmission. Cochrane Database Systematic Reviews, article no. CD003255, 1–25. doi:10.1002/14651858.CD003255
   Google Scholar
• Whitla, W. (1912). A dictionary of treatment – including medical and surgical therapeutics. London: Bailli'ere, Tindall and Cox.
   Google Scholar
• Wilson, R. A. (1947). Circumcision and venereal disease. Canadian Medical Association Journal, 56, 54–56.
   PubMed Web of Science ®Google Scholar
• de Witte, L., Nabatov, A., Pion, M., Fluitsma, D., de Jong, M. A., de Gruijl, T., … Geijtenbeek, T. B. (2007). Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. Nature Medicine, 13, 367–371. doi:10.1038/nm1541
   PubMed Web of Science ®Google Scholar
• Wiysonge, C. S., Kongnyuy, E. J., Shey, M., Muula, A. S., Navti, O. B., Akl, E. A., & Lo, Y. R. (2011). Male circumcision for prevention of homosexual acquisition of HIV in men. Cochrane Database Systemetic Reviews, 6, article no. CD007496, 1–46. doi:10.1002/14651858.CD007496.pub2
   Web of Science ®Google Scholar
• Wolbarst, A. L. (1914). Universal circumcision as a sanitary measure. Journal of the American Medical Association, 62, 92–97.
   Google Scholar
• World Health Organization. (2012). Global incidence and prevalence of selected curable sexually transmitted infections – 2008. Retrieved April 21, 2015, from http://apps.who.int/iris/bitstream/10665/43749/1/9789241596169_eng.pdf
   Google Scholar
• World Health Organization. (2014a). Female genital mutilation. Fact sheet no. 241. Retrieved April 27, 2015, from http://www.who.int/mediacentre/factsheets/fs241/en/
   Google Scholar
• World Health Organization. (2014b). HIV/AIDS. Fact sheet no. 360. Retrieved April 27, 2015, from http://www.who.int/mediacentre/factsheets/fs360/en/
   Google Scholar
• World Health Organization and Joint United Nations Program on HIV/AIDS. (2007a). Male circumcision: Global trends and determinants of prevalence, safety and acceptability. Geneva: World Health Organization. Retrieved June 3, 2015, from http://whqlibdoc.who.int/publications/2007/9789241596169_eng.pdf
   Google Scholar
• World Health Organization and Joint United Nations Program on HIV/AIDS. (2007b). New data on male circumcision and HIV prevention: Policy and programme implications. Retrieved April 21, 2015, from http://apps.who.int/iris/bitstream/10665/43751/1/9789241595988_eng.pdf
   Google Scholar
• Zuma, K., Setswe, G., Ketye, T., Mzolo, T., Rehle, T., & Mbelle, N. (2010). Age at sexual debut: A determinant of multiple partnerships among South African youth. African Journal of Reproductive Health, 14, 47–54.
   PubMedGoogle Scholar