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Global Public Health
An International Journal for Research, Policy and Practice
Volume 18, 2023 - Issue 1
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Understanding how PrEP is made successful: Implementation science needs an evidence-making approach

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Article: 2250426 | Received 27 Sep 2022, Accepted 16 Aug 2023, Published online: 24 Aug 2023

References

  • Auerbach, J. D., & Hoppe, T. A. (2015). Beyond “getting drugs into bodies”: Social science perspectives on pre-exposure prophylaxis for HIV. Journal of the International AIDS Society, 18(4), https://doi.org/10.7448/IAS.18.4.19983
  • Bavinton, B. R., Vaccher, S., Jin, F., Prestage, G. P., Holt, M., Zablotska-Manos, I. B., Guy, R., Amin, J., Templeton, D. J., Yeung, B., Hammoud, M. A., Lewis, D., Baker, D., Dharan, N., McNulty, A. M., & Grulich, A. E. (2021). High levels of prevention-effective adherence to HIV PrEP: An analysis of substudy data from the EPIC-NSW trial. JAIDS Journal of Acquired Immune Deficiency Syndromes, 87(4), 1040–1047. https://doi.org/10.1097/QAI.0000000000002691
  • Bekker, L., Pike, C., & Hillier, S. L. (2022). HIV prevention: Better choice for better coverage. Journal of the International AIDS Society, 25), https://doi.org/10.1002/jia2.25872
  • Bernays, S., Bourne, A., Kippax, S., Aggleton, P., & Parker, R. (Eds.). (2021). Remaking HIV Prevention in the 21st Century: The Promise of TasP, U = U and PrEP (Vol. 5). Springer International. https://doi.org/10.1007/978-3-030-69819-5
  • Beymer, M. R., Holloway, I. W., Pulsipher, C., & Landovitz, R. J. (2019). Current and future PrEP medications and modalities: On-demand, injectables, and topicals. Current HIV/AIDS Reports, 16(4), 349–358. https://doi.org/10.1007/s11904-019-00450-9
  • Blackstock, O. J. (2021). Ensuring progress toward ending the HIV epidemic while confronting the dual pandemics of COVID-19 and systemic racism. American Journal of Public Health, 111(8), 1462–1464. https://doi.org/10.2105/AJPH.2021.306196
  • Brown, G., & Di Feliciantonio, C. (2022). Geographies of PrEP, TasP and undetectability: Reconceptualising HIV assemblages to explore what else matters in the lives of gay and bisexual men. Dialogues in Human Geography, 12(1), 100–118. https://doi.org/10.1177/2043820621989574
  • Cáceres, C. F., O’Reilly, K. R., Mayer, K. H., & Baggaley, R. (2015). PrEP implementation: Moving from trials to policy and practice. Journal of the International AIDS Society, 18, 20222. https://doi.org/10.7448/IAS.18.4.20222
  • Calabrese, S. K., Tekeste, M., Mayer, K. H., Magnus, M., Krakower, D. S., Kershaw, T. S., Eldahan, A. I., Hawkins, G., Underhill, L. A., Hansen, K., Betancourt, N. B., Dovidio, J. R., & F, J. (2019). Considering stigma in the provision of HIV Pre-exposure prophylaxis: Reflections from current prescribers. AIDS Patient Care and STDs, 33(2), 79–88. https://doi.org/10.1089/apc.2018.0166
  • Callander, D., Thilani Singham Goodwin, A., Duncan, D. T., Grov, C., El-Sadr, W., Grant, M., Thompson, R. J., Simmons, M., Oshiro-Brantly, J. L., Bhatt, K. J., & Meunier, É. (2022). “What will we do if we get infected?”: An interview-based study of the COVID-19 pandemic and its effects on the health and safety of sex workers in the United States. SSM - Qualitative Research in Health, 2, 100027. https://doi.org/10.1016/j.ssmqr.2021.100027
  • Celum, C., Hosek, S., Tsholwana, M., Kassim, S., Mukaka, S., Dye, B. J., Pathak, S., Mgodi, N., Bekker, L.-G., Donnell, D. J., Wilson, E., Yuha, K., Anderson, P. L., Agyei, Y., Noble, H., Rose, S. M., Baeten, J. M., Fogel, J. M., Adeyeye, A., … Delany-Moretlwe, S. (2021). PrEP uptake, persistence, adherence, and effect of retrospective drug level feedback on PrEP adherence among young women in Southern Africa: Results from HPTN 082, a randomized controlled trial. PLOS Medicine, 18(6), e1003670. https://doi.org/10.1371/journal.pmed.1003670
  • Coy, K. C., Hazen, R. J., Kirkham, H. S., Delpino, A., & Siegler, A. J. (2019). Persistence on HIV preexposure prophylaxis medication over a 2-year period among a national sample of 7148 PrEP users, United States, 2015 to 2017. Journal of the International AIDS Society, 22(2), e25252. https://doi.org/10.1002/jia2.25252
  • Feldstein, A. C., & Glasgow, R. E. (2008). A practical, robust implementation and sustainability model (PRISM) for integrating research findings into practice. The Joint Commission Journal on Quality and Patient Safety, 34(4), 228–243. https://doi.org/10.1016/S1553-7250(08)34030-6
  • García-Iglesias, J. (2022). ‘PrEP is like an adult using floaties’: meanings and new identities of PrEP among a niche sample of gay men. Culture, Health & Sexuality, 24(2), 153–166. https://doi.org/10.1080/13691058.2020.1821096
  • Gaspar, M., Grey, C., Wells, A., Hull, M., Tan, D. H. S., Lachowsky, N., & Grace, D. (2022). Public health morality, sex, and COVID-19: Sexual minority men’s HIV pre-exposure prophylaxis (PrEP) decision-making during Ontario’s first COVID-19 lockdown. Critical Public Health, 116–126. https://doi.org/10.1080/09581596.2021.1970720
  • Geng, E. H., Nash, D., Phanuphak, N., Green, K., Solomon, S., Grimsrud, A., Sohn, A. H., Mayer, K. H., Bärnighausen, T., & Bekker, L. (2022). The question ofthe question: impactful implementation science to address the HIV epidemic. Journal of the International AIDS Society, 25), https://doi.org/10.1002/jia2.25898
  • Girard, G., Patten, S., LeBlanc, M.-A., Adam, B. D., & Jackson, E. (2019). Is HIV prevention creating new biosocialities among gay men? Treatment as prevention and pre-exposure prophylaxis in Canada. Sociology of Health & Illness, 41(3), 484–501. https://doi.org/10.1111/1467-9566.12826
  • Glasgow, R. E., Vogt, T. M., & Boles, S. M. (1999). Evaluating the public health impact of health promotion interventions: The RE-AIM framework. American Journal of Public Health, 89(9), 1322–1327. https://doi.org/10.2105/AJPH.89.9.1322
  • Grulich, A. E., Jin, F., Bavinton, B. R., Yeung, B., Hammoud, M. A., Amin, J., Cabrera, G., Clackett, S., Ogilvie, E., Vaccher, S., Vickers, T., McNulty, A., Smith, D. J., Dharan, N. J., Selvey, C., Power, C., Price, K., Zablotska, I., Baker, D. A., … Guy, R. (2021). Long-term protection from HIV infection with oral HIV pre-exposure prophylaxis in gay and bisexual men: Findings from the expanded and extended EPIC-NSW prospective implementation study. The Lancet HIV, 8(8), e486–e494. https://doi.org/10.1016/S2352-3018(21)00074-6
  • Haberer, J. E., Bangsberg, D. R., Baeten, J. M., Curran, K., Koechlin, F., Amico, K. R., Anderson, P., Mugo, N., Venter, F., Goicochea, P., Caceres, C., & O’Reilly, K. (2015). Defining success with HIV pre-exposure prophylaxis. Aids (london, England), 29(11), 1277–1285. https://doi.org/10.1097/QAD.0000000000000647
  • Haire, B., Murphy, D., Maher, L., Zablotska-Manos, I., Vaccher, S., & Kaldor, J. (2021). What does PrEP mean for ‘safe sex’ norms? A qualitative study. PLOS ONE, 16(8), e0255731. https://doi.org/10.1371/journal.pone.0255731
  • Hammoud, M. A., Grulich, A., Holt, M., Maher, L., Murphy, D., Jin, F., Bavinton, B., Haire, B., Ellard, J., Vaccher, S., Saxton, P., Bourne, A., Degenhardt, L., Storer, D., & Prestage, G. (2021). Substantial decline in Use of HIV preexposure prophylaxis following introduction of COVID-19 physical distancing restrictions in Australia: Results from a prospective observational study of Gay and bisexual Men. JAIDS Journal of Acquired Immune Deficiency Syndromes, 86(1), 22–30. https://doi.org/10.1097/QAI.0000000000002514
  • Hardon, A., & Sanabria, E. (2017). Fluid drugs: Revisiting the anthropology of pharmaceuticals. Annual Review of Anthropology, 46(1), 117–132. https://doi.org/10.1146/annurev-anthro-102116-041539
  • Holt, M. (2015). Configuring the users of new HIV-prevention technologies: The case of HIV pre-exposure prophylaxis. Culture, Health & Sexuality, 17(4), 428–439. https://doi.org/10.1080/13691058.2014.960003
  • Holt, M. (2021). Imagined futures and unintended consequences in the making of PrEP: An evidence-making intervention perspective. In S. Bernays, A. Bourne, S. Kippax, P. Aggleton, & R. Parker (Eds.), Remaking HIV Prevention in the 21st Century (Vol. 5, pp. 249–264). Springer International.
  • Holt, M., Newman, C. E., Lancaster, K., Smith, A. K., Hughes, S., & Truong, H.-H. M. (2019). HIV pre-exposure prophylaxis and the ‘problems’ of reduced condom use and sexually transmitted infections in Australia: a critical analysis from an evidence-making intervention perspective. Sociology of Health & Illness, 41(8), 1535–1548. https://doi.org/10.1111/1467-9566.12967
  • Hughes, S. D., Sheon, N., Andrew, E. V. W., Cohen, S. E., Doblecki-Lewis, S., & Liu, A. Y. (2018). Body/selves and beyond: Men’s narratives of sexual behavior on PrEP. Medical Anthropology, 37(5), 387–400. https://doi.org/10.1080/01459740.2017.1416608
  • Laborde, N. D., Kinley, P. M., Spinelli, M., Vittinghoff, E., Whitacre, R., Scott, H. M., & Buchbinder, S. P. (2020). Understanding PrEP persistence: Provider and patient perspectives. AIDS and Behavior, https://doi.org/10.1007/s10461-020-02807-3
  • Lampland, M., & Star, S. L.2009). Standards and their stories: How quantifying, classifying, and formalizing practices shape everyday life. Cornell Univ. Press.
  • Latour, B. (2005). Reassembling the social: An introduction to actor-network-theory. Oxford University Press.
  • Law, J. (2009). Seeing like a survey. Cultural Sociology, 3(2), 239–256. https://doi.org/10.1177/1749975509105533
  • Lazarus, L., Lorway, R., & Reza-Paul, S. (2021). Entangled bodies in a PrEP demonstration project. In S. Bernays, A. Bourne, S. Kippax, P. Aggleton, & R. Parker (Eds.), Remaking HIV Prevention in the 21st Century (Vol. 5, pp. 277–288). Springer International Publishing. https://doi.org/10.1007/978-3-030-69819-5_20
  • Lobb, R., & Colditz, G. A. (2013). Implementation science and Its application to population health. Annual Review of Public Health, 34(1), 235–251. https://doi.org/10.1146/annurev-publhealth-031912-114444
  • Lock, M. M., & Nguyen, V.-K. (2018). An anthropology of biomedicine. John Wiley & Sons, Inc.
  • Maine, A. (2020). Bareback sex, PrEP,National AIDS TrustvNHS Englandand the reality of gay sex. Sexualities, 23(8), 1362–1377. https://doi.org/10.1177/1363460719886733
  • Marcus, J. L., & Krakower, D. S. (2022). Making PrEP easy. The Lancet HIV, 9(4), e226–e228. https://doi.org/10.1016/S2352-3018(22)00036-4
  • Martinez-Lacabe, A. (2019). The non-positive antiretroviral gay body: The biomedicalisation of gay sex in England. Culture, Health & Sexuality, 21(10), 1117–1130. https://doi.org/10.1080/13691058.2018.1539772
  • Matambanadzo, P., Busza, J., Mafaune, H., Chinyanganya, L., Machingura, F., Ncube, G., Steen, R., Phillips, A., & Cowan, F. M. (2021). “It went through the roof”: an observation study exploring the rise in PrEP uptake among Zimbabwean female sex workers in response to adaptations during COVID-19. Journal of the International AIDS Society, 24), https://doi.org/10.1002/jia2.25813
  • May, C., & Finch, T. (2009). Implementing, embedding, and integrating practices: An outline of normalization process theory. Sociology, 43(3), 535–554. https://doi.org/10.1177/0038038509103208
  • May, C. R., Johnson, M., & Finch, T. (2016). Implementation, context and complexity. Implementation Science, 11), https://doi.org/10.1186/s13012-016-0506-3
  • Mol, A. (2002). The body multiple: Ontology in medical practice. Duke University Press.
  • Molina, J.-M., Charreau, I., Spire, B., Cotte, L., Chas, J., Capitant, C., Tremblay, C., Rojas-Castro, D., Cua, E., Pasquet, A., Bernaud, C., Pintado, C., Delaugerre, C., Sagaon-Teyssier, L., Mestre, S. L., Chidiac, C., Pialoux, G., Ponscarme, D., Fonsart, J., … Rabian, C. (2017). Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: An observational cohort study. The Lancet HIV, 4(9), e402–e410. https://doi.org/10.1016/S2352-3018(17)30089-9
  • Møller, K., & Ledin, C. (2021). Viral hauntology: Specters of AIDS in infrastructures of Gay sexual sociability. In B. M. S. Thomsen (Ed.), Affects, interfaces, events (pp. 147–162). Imbricate! Press. https://doi.org/10.22387/IMBAIE.06
  • Murphy, D. (2021). Factors influencing coverage of HIV pre-exposure prophylaxis (PrEP) in Australia. HIV Australia. https://www.afao.org.au/article/factors-influencing-coverage-of-hiv-pre-exposure-prophylaxis-prep-in-australia/.
  • Murphy, D., Ellard, J., Maher, L., Saxton, P., Holt, M., Haire, B., Grulich, A., Bavinton, B., Philpot, S., Bourne, A., Storer, D., Jin, F., Hammoud, M., & Prestage, G. (2023). How to have sex in a pandemic: The development of strategies to prevent COVID-19 transmission in sexual encounters among gay and bisexual men in Australia. Culture, Health & Sexuality, 271–286. https://doi.org/10.1080/13691058.2022.2037717
  • Nagington, M., & Sandset, T. (2020). Putting the NHS England on trial: Uncertainty-as-power, evidence and the controversy of PrEP in England. Medical Humanities, 46(3), 176–179. https://doi.org/10.1136/medhum-2019-011780
  • Nwokolo, N., Hill, A., McOwan, A., & Pozniak, A. (2017). Rapidly declining HIV infection in MSM in central London. The Lancet HIV, 4(11), e482–e483. https://doi.org/10.1016/S2352-3018(17)30181-9
  • Orne, J., & Gall, J. (2019). Converting, monitoring, and policing PrEP citizenship: Biosexual citizenship and the PrEP surveillance regime. Surveillance & Society, 17(5), 641–661. https://doi.org/10.24908/ss.v17i5.12945
  • Paparini, S. (2021). The political life of PrEP in England: An ethnographic account. In S. Bernays, A. Bourne, S. Kippax, P. Aggleton, & R. Parker (Eds.), Remaking HIV Prevention in the 21st Century (Vol. 5, pp. 145–158). Springer International Publishing. https://doi.org/10.1007/978-3-030-69819-5_11
  • Paparini, S., Nutland, W., Rhodes, T., Nguyen, V.-K., & Anderson, J. (2018). DIY HIV prevention: Formative qualitative research with men who have sex with men who source PrEP outside of clinical trials. PLOS ONE, 13(8), e0202830. https://doi.org/10.1371/journal.pone.0202830
  • Peters, D., Tran, N., & Adam, T. (2013). Implementation research in health: A practical guide. Alliance for Health Policy and Systems Research, World Health Organization. https://apps.who.int/iris/handle/10665/91758.
  • Philbin, M. M., & Perez-Brumer, A. (2022). Promise, perils and cautious optimism: The next frontier in long-acting modalities for the treatment and prevention of HIV. Current Opinion in HIV and AIDS, 17(2), 72–88. https://doi.org/10.1097/COH.0000000000000723
  • Pillay, D., Stankevitz, K., Lanham, M., Ridgeway, K., Murire, M., Briedenhann, E., Jenkins, S., Subedar, H., Hoke, T., & Mullick, S. (2020). Factors influencing uptake, continuation, and discontinuation of oral PrEP among clients at sex worker and MSM facilities in South Africa. PLOS ONE, 15(4), e0228620. https://doi.org/10.1371/journal.pone.0228620
  • Proctor, E., Silmere, H., Raghavan, R., Hovmand, P., Aarons, G., Bunger, A., Griffey, R., & Hensley, M. (2011). Outcomes for implementation research: Conceptual distinctions, measurement challenges, and research agenda. Administration and Policy in Mental Health and Mental Health Services Research, 38(2), 65–76. https://doi.org/10.1007/s10488-010-0319-7
  • Race, K. (2016). Reluctant objects. GLQ: A Journal of Lesbian and Gay Studies, 22(1), 1–31. https://doi.org/10.1215/10642684-3315217
  • Rhodes, T., Harris, M., Sanín, F. G., & Lancaster, K. (2021). Ecologies of drug war and more-than-human health: The case of a chemical at war with a plant. International Journal of Drug Policy, 89, 103067. https://doi.org/10.1016/j.drugpo.2020.103067
  • Rhodes, T., & Lancaster, K. (2019). Evidence-making interventions in health: A conceptual framing. Social Science & Medicine, 238, 112488. https://doi.org/10.1016/j.socscimed.2019.112488
  • Rosengarten, M., & Michael, M. (2009). The performative function of expectations in translating treatment to prevention: The case of HIV pre-exposure prophylaxis, or PrEP. Social Science & Medicine, 69(7), 1049–1055. https://doi.org/10.1016/j.socscimed.2009.07.039
  • Scott, H. M., Spinelli, M., Vittinghoff, E., Morehead-Gee, A., Hirozawa, A., James, C., Hammer, H., Liu, A., Gandhi, M., & Buchbinder, S. (2019). Racial/ethnic and HIV risk category disparities in preexposure prophylaxis discontinuation among patients in publicly funded primary care clinics. Aids (london, England), 33(14), 2189–2195. https://doi.org/10.1097/QAD.0000000000002347
  • Shangani, S., Bhaskar, N., Richmond, N., Operario, D., & Van Den Berg, J. J. (2021). A systematic review of early adoption of implementation science for HIV prevention or treatment in the United States. Aids (london, England), 35(2), 177–191. https://doi.org/10.1097/QAD.0000000000002713
  • Smith, A. K. J., Haire, B., Newman, C. E., & Holt, M. (2021). Challenges of providing HIV pre-exposure prophylaxis across Australian clinics: Qualitative insights of clinicians. Sexual Health, 18(2), 187–194. https://doi.org/10.1071/SH20208
  • Smith, A. K. J., Lancaster, K., Rhodes, T., & Holt, M. (2023). Dosing practices made mundane: Enacting HIV pre-exposure prophylaxis adherence in domestic routines. Sociology of Health & Illness, https://doi.org/10.1111/1467-9566.13687
  • Smith, A. K. J., Newman, C. E., Haire, B., & Holt, M. (2022a). Clinician imaginaries of HIV PrEP users in and beyond the gay community in Australia. Culture, Health & Sexuality, 24(10), 1423–1437. https://doi.org/10.1080/13691058.2021.1957152
  • Smith, A. K. J., Newman, C. E., Haire, B., & Holt, M. (2022b). Prescribing as affective clinical practice: Transformations in sexual health consultations through HIV pre-exposure prophylaxis. Sociology of Health & Illness, 44(7), 1182–1200. https://doi.org/10.1111/1467-9566.13502
  • Spieldenner, A. (2016). Prep whores and HIV prevention: The queer communication of HIV Pre-exposure prophylaxis (PrEP). Journal of Homosexuality, 63(12), 1685–1697. https://doi.org/10.1080/00918369.2016.1158012
  • Thomann, M. (2018). ‘On December 1, 2015, sex changes. Forever’: Pre-exposure prophylaxis and the pharmaceuticalisation of the neoliberal sexual subject. Global Public Health, 13(8), 997–1006. https://doi.org/10.1080/17441692.2018.1427275
  • Torres, T. S., Hoagland, B., Bezerra, D. R. B., Garner, A., Jalil, E. M., Coelho, L. E., Benedetti, M., Pimenta, C., Grinsztejn, B., & Veloso, V. G. (2021). Impact of COVID-19 pandemic on sexual minority populations in Brazil: An analysis of social/racial disparities in maintaining social distancing and a description of sexual behavior. AIDS and Behavior, 25(1), 73–84. https://doi.org/10.1007/s10461-020-02984-1
  • van Hoek, A. J., Reitsema, M., Xiridou, M., van Sighem, A., van Benthem, B., Wallinga, J., van Duijnhoven, Y., van der Loeff, M. S., Prins, M., & Hoornenborg, E. (2021). Offering a choice of daily and event-driven preexposure prophylaxis for men who have sex with men in The Netherlands: A cost-effectiveness analysis. Aids (london, England), 35(10), 1677–1682. https://doi.org/10.1097/QAD.0000000000002913
  • Whyte, S. R., Geest, S. v. d., & Hardon, A. (2002). Social lives of medicines. Cambridge University Press.
  • World Health Organization. (2019). What’s the 2 + 1 + 1? Event-driven oral pre-exposure prophylaxis to prevent HIV for men who have sex with men: Update to WHO’s recommendation on oral PrEP: Technical brief. https://www.who.int/hiv/pub/prep/211/en/.
  • Young, I., Boydell, N., Patterson, C., Hilton, S., & McDaid, L. (2021). Configuring the PrEP user: Framing pre-exposure prophylaxis in UK newsprint 2012–2016. Culture, Health & Sexuality, 23(6), 772–787. https://doi.org/10.1080/13691058.2020.1729420