Effects of obesity on the outcome of pneumonia

References

• Haslam DW, James WP. Obesity. Lancet. 2005;366:1197–1209.
   PubMed Web of Science ®Google Scholar
• Heymsfield SB, Wadden TA. Mechanisms, pathophysiology, and management of obesity. N Engl J Med. 2017;376:254–266.
   PubMed Web of Science ®Google Scholar
• van Baal PH, Polder JJ, de Wit GA, et al. Lifetime medical costs of obesity: prevention no cure for increasing health expenditure. PLoS Med. 2008;5:e29.
   PubMed Web of Science ®Google Scholar
• Popkin BM, Slining MM. New dynamics in global obesity facing low- and middle-income countries. Obes Rev. 2013;14(Suppl 2):11–20.
   PubMed Web of Science ®Google Scholar
• Baik I, Curhan GC, Rimm EB, et al. A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women. Arch Intern Med. 2000;160:3082–3088.
   PubMedGoogle Scholar
• Kwong JC, Campitelli MA, Rosella LC. Obesity and respiratory hospitalizations during influenza seasons in Ontario, Canada: a cohort study. Clin Infect Dis. 2011;53:413–421.
   PubMed Web of Science ®Google Scholar
• Phung DT, Wang Z, Rutherford S, et al. Body mass index and risk of pneumonia: a systematic review and meta-analysis. Obes Rev. 2013;14:839–857.
   PubMed Web of Science ®Google Scholar
• Huttunen R, Karppelin M, Syrjänen J. Obesity and nosocomial infections. J Hosp Infect. 2013;85:8–16.
   PubMed Web of Science ®Google Scholar
• Delle Rose D, Pezzotti P, Fortunato E, et al. Clinical predictors and microbiology of ventilator-associated pneumonia in the intensive care unit: a retrospective analysis in six Italian hospitals. Eur J Clin Microbiol Infect Dis. 2016;35:1531–1539.
   PubMed Web of Science ®Google Scholar
• Dossett LA, Dageforde LA, Swenson BR, et al. Obesity and site-specific nosocomial infection risk in the intensive care unit. Surg Infect (Larchmt). 2009;10:137–142.
   PubMed Web of Science ®Google Scholar
• Bochicchio GV, Joshi M, Bochicchio K, et al. Impact of obesity in the critically ill trauma patient: a prospective study. J Am Coll Surg. 2006;203:533–538.
   PubMed Web of Science ®Google Scholar
• Mica L, Keller C, Vomela J, et al. Obesity and overweight as a risk factor for pneumonia in polytrauma patients: a retrospective cohort study. J Trauma Acute Care Surg. 2013;75:693–698.
   PubMed Web of Science ®Google Scholar
• Serrano PE, Khuder SA, Fath JJ. Obesity as a risk factor for nosocomial infections in trauma patients. J Am Coll Surg. 2010;211:61–67.
   PubMed Web of Science ®Google Scholar
• Kahlon S, Eurich DT, Padwal RS, et al. Obesity and outcomes in patients hospitalized with pneumonia. Clin Microbiol Infect. 2013;19:709–716.
   PubMed Web of Science ®Google Scholar
• Singanayagam A, Singanayagam A, Chalmers JD. Obesity is associated with improved survival in community-acquired pneumonia. Eur Respir J. 2013;42:180–187.
   PubMed Web of Science ®Google Scholar
• Corrales-Medina VF, Valayam J, Serpa JA, et al. The obesity paradox in community-acquired bacterial pneumonia. Int J Infect Dis. 2011;15:e54–57.
   PubMed Web of Science ®Google Scholar
• Braun N, Hoess C, Kutz A, et al. Obesity paradox in patients with community-acquired pneumonia: is inflammation the missing link? Nutrition. 2017;33:304–310.
   PubMed Web of Science ®Google Scholar
• Riquelme R, Jiménez P, Videla AJ, et al. Predicting mortality in hospitalized patients with 2009 H1N1 influenza pneumonia. Int J Tuberc Lung Dis. 2011;15:542–546.
   PubMed Web of Science ®Google Scholar
• Louie JK, Acosta M, Samuel MC, et al. California Pandemic (H1N1) Working Group. A novel risk factor for a novel virus: obesity and 2009 pandemic influenza A (H1N1). Clin Infect Dis. 2011;52:301–312.
   PubMed Web of Science ®Google Scholar
• Braun ES, Crawford FW, Desai MM, et al. Obesity not associated with severity among hospitalized adults with seasonal influenza virus infection. Infection. 2015;43:569–575.
   PubMed Web of Science ®Google Scholar
• Cocoros NM, Lash TL, DeMaria A Jr, et al. Obesity as a risk factor for severe influenza-like illness. Influenza Other Respir Viruses. 2014;8:25–32.
   PubMed Web of Science ®Google Scholar
• King P, Mortensen EM, Bollinger M, et al. Impact of obesity on outcomes for patients hospitalised with pneumonia. Eur Respir J. 2013;41:929–934.
   PubMed Web of Science ®Google Scholar
• Atamna A, Elis A, Gilady E, et al. How obesity impacts outcomes of infectious diseases. Eur J Clin Microbiol Infect Dis. 2017;36:585–591.
   PubMed Web of Science ®Google Scholar
• Nie W, Zhang Y, Jee SH, et al. Obesity survival paradox in pneumonia: a meta-analysis. BMC Med. 2014;12:61.
   PubMed Web of Science ®Google Scholar
• Morgan OW, Bramley A, Fowlkes A, et al. Morbid obesity as a risk factor for hospitalization and death due to 2009 pandemic influenza A(H1N1) disease. PLoS One. 2010;5:e9694.
   PubMed Web of Science ®Google Scholar
• Díaz E, Rodríguez A, Martin-Loeches I, et al. H1N1 SEMICYUC Working Group. Impact of obesity in patients infected with 2009 influenza A(H1N1). Chest. 2011;139:382–386.
   PubMed Web of Science ®Google Scholar
• Myles PR, Semple MG, Lim WS, et al. Influenza Clinical Information Network (FLU-CIN). Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009–2010 in the UK. Thorax. 2012;67:709–717.
   PubMed Web of Science ®Google Scholar
• Kok J, Blyth CC, Foo H, et al. Viral pneumonitis is increased in obese patients during the first wave of pandemic A(H1N1) 2009 virus. PLoS One. 2013;8:e55631.
   PubMed Web of Science ®Google Scholar
• Martin ET, Archer C, McRoberts J, et al. Epidemiology of severe influenza outcomes among adult patients with obesity in Detroit, Michigan, 2011. Influenza Other Respir Viruses. 2013;7:1004–1007.
   PubMed Web of Science ®Google Scholar
• Mertz D, Kim TH, Johnstone J, et al. Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis. Bmj. 2013;347:f5061.
   PubMed Web of Science ®Google Scholar
• Van Kerkhove MD, Cooper MJ, Cost AA, et al. Risk factors for severe outcomes among members of the United States military hospitalized with pneumonia and influenza, 2000–2012. Vaccine. 2015;33:6970–6976.
   PubMed Web of Science ®Google Scholar
• Yang L, Chan KP, Lee RS, et al. Obesity and influenza associated mortality: evidence from an elderly cohort in Hong Kong. Prev Med. 2013;56:118–123.
   PubMed Web of Science ®Google Scholar
• Fisher-Hoch SP, Mathews CE, McCormick JB. Obesity, diabetes and pneumonia: the menacing interface of non-communicable and infectious diseases. Trop Med Int Health. 2013;18:1510–1519.
   PubMed Web of Science ®Google Scholar
• Falagas ME, Kompoti M. Obesity and infection. Lancet Infect Dis. 2006;6:438–446.
   PubMed Web of Science ®Google Scholar
• Almond MH, Edwards MR, Barclay WS, et al. Obesity and susceptibility to severe outcomes following respiratory viral infection. Thorax. 2013;68:684–686.
   PubMed Web of Science ®Google Scholar
• Martí A, Marcos A, Martínez JA. Obesity and immune function relationships. Obes Rev. 2001;2:131–140.
   PubMedGoogle Scholar
• Mancuso P. Obesity and respiratory infections: does excess adiposity weigh down host defense? Pulm Pharmacol Ther. 2013;26:412–419.
   PubMed Web of Science ®Google Scholar
• Stapleton RD, Dixon AE, Parsons PE, et al. NHLBI Acute Respiratory Distress Syndrome Network. The association between BMI and plasma cytokine levels in patients with acute lung injury. Chest. 2010;138:568–577.
   PubMed Web of Science ®Google Scholar
• Kordonowy LL, Burg E, Lenox CC, et al. Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury. Am J Respir Cell Mol Biol. 2012;47:120–127.
   PubMed Web of Science ®Google Scholar
• Mancuso P. Obesity and lung inflammation. J Appl Physiol. 1985;2010(108):722–728.
   Google Scholar
• Ubags ND, Stapleton RD, Vernooy JH, et al. Hyperleptinemia is associated with impaired pulmonary host defense. JCI Insight. 2016;1:e82101.
   PubMed Web of Science ®Google Scholar
• Uji Y, Yamamoto H, Tsuchihashi H, et al. Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality. Surgery. 2009;145:550–557.
   PubMed Web of Science ®Google Scholar
• Athyros VG, Tziomalos K, Karagiannis A, et al. Should adipokines be considered in the choice of the treatment of obesity-related health problems? Curr Drug Targets. 2010;11:122–135.
   PubMed Web of Science ®Google Scholar
• Wu H, Santoni-Rugiu E, Ralfkiaer E, et al. Lipocalin 2 is protective against E. Coli Pneumonia. Respir Res. 2010;11:96.
   PubMed Web of Science ®Google Scholar
• Chan YR, Liu JS, Pociask DA, et al. Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol. 2009;182:4947–4956.
   PubMed Web of Science ®Google Scholar
• Shen J, Obin MS, Zhao L. The gut microbiota, obesity and insulin resistance. Mol Aspects Med. 2013;34:39–58.
   PubMed Web of Science ®Google Scholar
• Puzniak LA, Morrow LE, Huang DB, et al. Impact of weight on treatment efficacy and safety in complicated skin and skin structure infections and nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus. Clin Ther. 2013;35:1557–1570.
   PubMed Web of Science ®Google Scholar
• Sasabuchi Y, Yasunaga H, Matsui H, et al. The dose-response relationship between body mass index and mortality in subjects admitted to the ICU with and without mechanical ventilation. Respir Care. 2015;60:983–991.
   PubMed Web of Science ®Google Scholar
• Al-Dorzi HM, Al Harbi SA, Arabi YM. Antibiotic therapy of pneumonia in the obese patient: dosing and delivery. Curr Opin Infect Dis. 2014;27:165–173.
   PubMed Web of Science ®Google Scholar
• Falagas ME, Karageorgopoulos DE. Adjustment of dosing of antimicrobial agents for bodyweight in adults. Lancet. 2010;375:248–251.
   PubMed Web of Science ®Google Scholar
• Stapleton RD, Suratt BT. Obesity and nutrition in acute respiratory distress syndrome. Clin Chest Med. 2014;35:655–671.
   PubMed Web of Science ®Google Scholar
• Morris AE, Stapleton RD, Rubenfeld GD, et al. The association between body mass index and clinical outcomes in acute lung injury. Chest. 2007;131:342–348.
   PubMed Web of Science ®Google Scholar
• McClean KM, Kee F, Young IS, et al. Obesity and the lung: 1. Epidemiology. Thorax. 2008;63:649–654.
   PubMed Web of Science ®Google Scholar
• Koenig SM. Pulmonary complications of obesity. Am J Med Sci. 2001;321:249–279.
   PubMed Web of Science ®Google Scholar
• Tomlinson DJ, Erskine RM, Morse CI, et al. The impact of obesity on skeletal muscle strength and structure through adolescence to old age. Biogerontology. 2016;17:467–483.
   PubMed Web of Science ®Google Scholar
• Cibella F, Bruno A, Cuttitta G, et al. An elevated body mass index increases lung volume but reduces airflow in Italian schoolchildren. PLoS One. 2015;10:e0127154.
   PubMed Web of Science ®Google Scholar
• O’Donnell DE, Ciavaglia CE, Neder JA. When obesity and chronic obstructive pulmonary disease collide. Physiological and clinical consequences. Ann Am Thorac Soc. 2014;11:635–644.
   PubMedGoogle Scholar
• Murugan AT, Sharma G. Obesity and respiratory diseases. Chron Respir Dis. 2008;5:233–242.
   PubMedGoogle Scholar
• Roth J, Sahota N, Patel P, et al. Obesity paradox, obesity orthodox, and the metabolic syndrome: an approach to unity. Mol Med. 2016 Nov 16;22:873.
   Web of Science ®Google Scholar
• Braun N, Gomes F, Schütz P. “The obesity paradox” in disease – is the protective effect of obesity true? Swiss Med Wkly. 2015;145:w14265.
   PubMed Web of Science ®Google Scholar
• Uppot RN, Sahani DV, Hahn PF, et al. Effect of obesity on image quality: fifteen-year longitudinal study for evaluation of dictated radiology reports. Radiology. 2006;240:435–439.
   PubMed Web of Science ®Google Scholar
• Dobson R, Burgess MI, Sprung VS, et al. Metabolically healthy and unhealthy obesity: differential effects on myocardial function according to metabolic syndrome, rather than obesity. Int J Obes (Lond). 2016;40:153–161.
   PubMed Web of Science ®Google Scholar
• Roberson LL, Aneni EC, Maziak W, et al. Beyond BMI: the “metabolically healthy obese” phenotype & its association with clinical/subclinical cardiovascular disease and all-cause mortality – a systematic review. BMC Public Health. 2014;14:14.
   PubMed Web of Science ®Google Scholar
• Stefan N, Kantartzis K, Machann J, et al. Identification and characterization of metabolically benign obesity in humans. Arch Intern Med. 2008;168:1609–1616.
   PubMed Web of Science ®Google Scholar