An update on clinical care for pregnant women with acromegaly

References

• Melmed S. Medical progress: acromegaly. N Engl J Med. 2006;355(24):2558–2573.
   PubMed Web of Science ®Google Scholar
• Chanson P, Salenave S, Kamenicky P. Acromegaly. Handb Clin Neurol. 2014;124:197–219.
   PubMedGoogle Scholar
• Katznelson L, Laws ER Jr., Melmed S, et al. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2014;99(11):3933–3951.
   PubMed Web of Science ®Google Scholar
• Petrossians P, Daly AF, Natchev E, et al. Acromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) database. Endocr Relat Cancer. 2017;24(10):505–518.
   PubMed Web of Science ®Google Scholar
• Grynberg M, Salenave S, Young J, et al. Female gonadal function before and after treatment of acromegaly. J Clin Endocrinol Metab. 2010;95(10):4518–4525.
   PubMed Web of Science ®Google Scholar
• Esfandiari N, Gotlieb L, Casper RF. Live birth of healthy triplets after in vitro fertilization and embryo transfer in an acromegalic woman with elevated growth hormone. Fertil Steril. 2005;83(4):1041.e1–1041.e3.
   PubMedGoogle Scholar
• Abelove WA, Rupp JJ, Paschkis KE. Acromegaly and pregnancy. J Clin Endocrinol Metab. 1954;14(1):32–44.
   PubMed Web of Science ®Google Scholar
• Assal A, Malcolm J, Lochnan H, et al. Preconception counselling for women with acromegaly: more questions than answers. Obstet Med. 2016;9(1):9–14.
   PubMed Web of Science ®Google Scholar
• Beckers A, Stevenaert A, Foidart JM, et al. Placental and pituitary growth hormone secretion during pregnancy in acromegalic women. J Clin Endocrinol Metab. 1990;71(3):725–731.
   PubMed Web of Science ®Google Scholar
• Ben Salem Hachmi L, Kammoun I, Bouzid C, et al. [Management of acromegaly in pregnant woman]. Ann Endocrinol (Paris). 2010;71(1):60–63.
   PubMed Web of Science ®Google Scholar
• Brian SR, Bidlingmaier M, Wajnrajch MP, et al. Treatment of acromegaly with pegvisomant during pregnancy: maternal and fetal effects. J Clin Endocrinol Metab. 2007;92(9):3374–3377.
   PubMed Web of Science ®Google Scholar
• Espersen T, Ditzel J. Pregnancy and delivery under bromocriptine therapy. Lancet. 1977;2(8045):985–986.
   PubMed Web of Science ®Google Scholar
• Guven S, Durukan T, Berker M, et al. A case of acromegaly in pregnancy: concomitant transsphenoidal adenomectomy and cesarean section. J Matern Fetal Neonatal Med. 2006;19(1):69–71.
   PubMed Web of Science ®Google Scholar
• Haliloglu O, Dogangun B, Ozcabi B, et al. General health status and intelligence scores of children of mothers with acromegaly do not differ from those of healthy mothers. Pituitary. 2016;19(4):391–398.
   PubMed Web of Science ®Google Scholar
• Hisano M, Sakata M, Watanabe N, et al. An acromegalic woman first diagnosed in pregnancy. Arch Gynecol Obstet. 2006;274(3):171–173.
   PubMedGoogle Scholar
• Kasuki L, Neto LV, Takiya CM, et al. Growth of an aggressive tumor during pregnancy in an acromegalic patient. Endocr J. 2012;59(4):313–319.
   PubMed Web of Science ®Google Scholar
• Kupersmith MJ, Rosenberg C, Kleinberg D. Visual loss in pregnant women with pituitary adenomas. Ann Intern Med. 1994;121(7):473–477.
   PubMed Web of Science ®Google Scholar
• Lau SL, McGrath S, Evain-Brion D, et al. Clinical and biochemical improvement in acromegaly during pregnancy. J Endocrinol Invest. 2008;31(3):255–261.
   PubMed Web of Science ®Google Scholar
• Luboshitzky R, Dickstein G, Barzilai D. Bromocriptine-induced pregnancy in an acromegalic patient. Jama. 1980;244(6):584–586.
   PubMed Web of Science ®Google Scholar
• Lunardi P, Rizzo A, Missori P, et al. Pituitary apoplexy in an acromegalic woman operated on during pregnancy by transphenoidal approach. Int J Gynaecol Obstet. 1991;34(1):71–74.
   PubMed Web of Science ®Google Scholar
• O’Herlihy C. Pregnancy in an acromegalic after bromocriptine therapy. Ir J Med Sci. 1980;149(7):281–282.
   PubMed Web of Science ®Google Scholar
• Obuobie K, Mullik V, Jones C, et al. McCune-Albright syndrome: growth hormone dynamics in pregnancy. J Clin Endocrinol Metab. 2001;86(6):2456–2458.
   PubMed Web of Science ®Google Scholar
• Qureshi A, Kalu E, Ramanathan G, et al. IVF/ICSI in a woman with active acromegaly: successful outcome following treatment with pegvisomant. J Assist Reprod Genet. 2006;23(11–12):439–442.
   PubMed Web of Science ®Google Scholar
• Sahli R, Christ E. [Pregnancy in active acromegaly]. Dtsch Med Wochenschr. 2008;133(45):2328–2331.
   PubMed Web of Science ®Google Scholar
• Sanchez R, Boix E, Del Pino Navarro M, et al. [Pregnancy in an acromegalic patient treated with lanreotide and bromocryptin]. Med Clin (Barc). 1999;113(5):198.
   PubMed Web of Science ®Google Scholar
• Serri O, Lanoie G. Successful pregancy in a woman with acromegaly treated with octreotide long-acting release. Endocrinologist. 2003;13:17–19.
   Google Scholar
• Shimatsu A, Usui T, Tagami T, et al. Suppressed levels of growth hormone and insulin-like growth factor-1 during successful pregnancy in persistent acromegaly. Endocr J. 2010;57(6):551–553.
   PubMed Web of Science ®Google Scholar
• Takano T, Saito J, Soyama A, et al. Normal delivery following an uneventful pregnancy in a Japanese acromegalic patient after discontinuation of octreotide long acting release formulation at an early phase of pregnancy. Endocr J. 2006;53(2):209–212.
   PubMed Web of Science ®Google Scholar
• Cundy T, Grundy EN, Melville H, et al. Bromocriptine treatment of acromegaly following spontaneous conception. Fertil Steril. 1984;42(1):134–136.
   PubMed Web of Science ®Google Scholar
• Herman-Bonert V, Seliverstov M, Melmed S. Pregnancy in acromegaly: successful therapeutic outcome. J Clin Endocrinol Metab. 1998;83(3):727–731.
   PubMed Web of Science ®Google Scholar
• Yap AS, Clouston WM, Mortimer RH, et al. Acromegaly first diagnosed in pregnancy: the role of bromocriptine therapy. Am J Obstet Gynecol. 1990;163(2):477–478.
   PubMed Web of Science ®Google Scholar
• Aso T, Goto K, Takeuchi J, et al. A triplet pregnancy after gonadotropin-releasing hormone pulsatile infusion therapy in a postoperative case of growth hormone-producing pituitary macroadenoma. Endocrinol Jpn. 1987;34(3):395–405.
   PubMedGoogle Scholar
• Colao A, Merola B, Ferone D, et al. Acromegaly. J Clin Endocrinol Metab. 1997;82(9):2777–2781.
   PubMed Web of Science ®Google Scholar
• Landolt AM, Schmid J, Wimpfheimer C, et al. Successful pregnancy in a previously infertile woman treated with SMS-201-995 for acromegaly. N Engl J Med. 1989;320(10):671–672.
   PubMed Web of Science ®Google Scholar
• Wiesli P, Zwimpfer C, Zapf J, et al. Pregnancy-induced changes in insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 3 (IGFBP-3), and acid-labile subunit (ALS) in patients with growth hormone (GH) deficiency and excess. Acta Obstet Gynecol Scand. 2006;85(8):900–905.
   PubMed Web of Science ®Google Scholar
• Aono T, Shioji T, Kohno M, et al. Pregnancy following 2-bromo-alpha-ergocryptine (CB-154)-induced ovulation in an acromegalic patient with galactorrhea and amenorrhea. Fertil Steril. 1976;27(3):341–344.
   PubMed Web of Science ®Google Scholar
• Bigazzi M, Ronga R, Lancranjan I, et al. A pregnancy in an acromegalic woman during bromocriptine treatment: effects on growth hormone and prolactin in the maternal, fetal, and amniotic compartments. J Clin Endocrinol Metab. 1979;48(1):9–12.
   PubMed Web of Science ®Google Scholar
• Miyakawa I, Taniyama K, Koike H, et al. Successful pregnancy in an acromegalic patient during 2-Br-alpha-ergocryptine (CB-154) therapy. Acta Endocrinol (Copenh). 1982;101(3):333–338.
   PubMedGoogle Scholar
• Cheng V, Faiman C, Kennedy L, et al. Pregnancy and acromegaly: a review. Pituitary. 2012;15(1):59–63.
   PubMed Web of Science ®Google Scholar
• de Menis E, Billeci D, Marton E, et al. Uneventful pregnancy in an acromegalic patient treated with slow-release lanreotide: a case report. J Clin Endocrinol Metab. 1999;84(4):1489.
   PubMed Web of Science ®Google Scholar
• Edo AE, Eregie A. Pregnancy associated with recurrent acromegaly: a case report. West Afr J Med. 2010;29(2):120–122.
   PubMedGoogle Scholar
• Fassnacht M, Capeller B, Arlt W, et al. Octreotide LAR(R) treatment throughout pregnancy in an acromegalic woman. Clin Endocrinol (Oxf). 2001;55(3):411–415.
   PubMed Web of Science ®Google Scholar
• Hierl T, Ziegler R, Kasperk C. Pregnancy in persistent acromegaly. Clin Endocrinol (Oxf). 2000;53(2):262–263.
   PubMed Web of Science ®Google Scholar
• Maffei P, Tamagno G, Nardelli GB, et al. Effects of octreotide exposure during pregnancy in acromegaly. Clin Endocrinol (Oxf). 2010;72(5):668–677.
   PubMed Web of Science ®Google Scholar
• Mikhail N. Octreotide treatment of acromegaly during pregnancy. Mayo Clin Proc. 2002;77(3):297–298.
   PubMed Web of Science ®Google Scholar
• Montini M, Pagani G, Gianola D, et al. Acromegaly and primary amenorrhea: ovulation and pregnancy induced by SMS 201-995 and bromocriptine. J Endocrinol Invest. 1990;13(2):193.
   PubMed Web of Science ®Google Scholar
• Mozas J, Ocon E, Lopez de la Torre M, et al. Successful pregnancy in a woman with acromegaly treated with somatostatin analog (octreotide) prior to surgical resection. Int J Gynaecol Obstet. 1999;65(1):71–73.
   PubMed Web of Science ®Google Scholar
• Neal JM. Successful pregnancy in a woman with acromegaly treated with octreotide. Endocr Pract. 2000;6:148–150.
   PubMedGoogle Scholar
• Takeuchi K, Funakoshi T, Oomori S, et al. Successful pregnancy in an acromegalic women treated with octreotide. Obstet Gynecol. 1999;93(5 Pt 2):848.
   PubMed Web of Science ®Google Scholar
• Okada Y, Morimoto I, Ejima K, et al. A case of active acromegalic woman with a marked increase in serum insulin-like growth factor-1 levels after delivery. Endocr J. 1997;44(1):117–120.
   PubMed Web of Science ®Google Scholar
• Cozzi R, Attanasio R, Barausse M. Pregnancy in acromegaly: a one-center experience. Eur J Endocrinol. 2006;155(2):279–284.
   PubMed Web of Science ®Google Scholar
• Atmaca A, Dagdelen S, Erbas T. Follow-up of pregnancy in acromegalic women: different presentations and outcomes. Exp Clin Endocrinol Diabetes. 2006;114(3):135–139.
   PubMed Web of Science ®Google Scholar
• Persechini ML, Gennero I, Grunenwald S, et al. [Acromegaly and pregnancy: report of six new cases]. J Gynecol Obstet Biol Reprod (Paris). 2014;43(9):704–712.
   PubMedGoogle Scholar
• Caron P, Broussaud S, Bertherat J, et al. Acromegaly and pregnancy: a retrospective multicenter study of 59 pregnancies in 46 women. J Clin Endocrinol Metab. 2010;95(10):4680–4687.
   PubMed Web of Science ®Google Scholar
• Cheng S, Grasso L, Martinez-Orozco JA, et al. Pregnancy in acromegaly: experience from two referral centers and systematic review of the literature. Clin Endocrinol (Oxf). 2012;76(2):264–271.
   PubMed Web of Science ®Google Scholar
• Karaca Z, Yarman S, Ozbas I, et al. How does pregnancy affect the patients with pituitary adenomas: a study on 113 pregnancies from Turkey. J Endocrinol Invest. 2018;41(1):129–141.
   PubMed Web of Science ®Google Scholar
• Jallad RS, Shimon I, Fraenkel M, et al. Outcome of pregnancies in a large cohort of women with acromegaly. Clin Endocrinol (Oxf). 2018;88(6):896–907.
   PubMed Web of Science ®Google Scholar
• Dias M, Boguszewski C, Gadelha M, et al. Acromegaly and pregnancy: a prospective study. Eur J Endocrinol. 2014;170(2):301–310.
   PubMed Web of Science ®Google Scholar
• Molitch ME. Pituitary disorders during pregnancy. Endocrinol Metab Clin North Am. 2006;35(1):99–116, vi.
   PubMed Web of Science ®Google Scholar
• Karaca Z, Tanriverdi F, Unluhizarci K, et al. Pregnancy and pituitary disorders. Eur J Endocrinol. 2010;162(3):453–475.
   PubMed Web of Science ®Google Scholar
• Bronstein MD, Paraiba DB, Jallad RS. Management of pituitary tumors in pregnancy. Nat Rev Endocrinol. 2011;7(5):301–310.
   PubMed Web of Science ®Google Scholar
• Caron P. Acromegaly and pregnancy. Ann Endocrinol (Paris). 2011;72(4):282–286.
   PubMed Web of Science ®Google Scholar
• Araujo PB, Vieira Neto L, Gadelha MR. Pituitary tumor management in pregnancy. Endocrinol Metab Clin North Am. 2015;44(1):181–197.
   PubMed Web of Science ®Google Scholar
• Abucham J, Bronstein MD, Dias ML. Management of endocrine disease: acromegaly and pregnancy: a contemporary review. Eur J Endocrinol. 2017;177(1):R1–R12.
   PubMedGoogle Scholar
• Muhammad A, Neggers SJ, van der Lely AJ. Pregnancy and acromegaly. Pituitary. 2017;20(1):179–184.
   PubMed Web of Science ®Google Scholar
• Kamenicky P, Mazziotti G, Lombes M, et al. Growth hormone, insulin-like growth factor-1, and the kidney: pathophysiological and clinical implications. Endocr Rev. 2014;35(2):234–281.
   PubMed Web of Science ®Google Scholar
• Melmed S, Bronstein MD, Chanson P, et al. A consensus statement on acromegaly therapeutic outcomes. Nat Rev Endocrinol. 2018;14(9):552–561.
   PubMed Web of Science ®Google Scholar
• Vitale G, Pivonello R, Auriemma RS, et al. Hypertension in acromegaly and in the normal population: prevalence and determinants. Clin Endocrinol (Oxf). 2005;63(4):470–476.
   PubMed Web of Science ®Google Scholar
• Colao A. Improvement of cardiac parameters in patients with acromegaly treated with medical therapies. Pituitary. 2012;15(1):50–58.
   PubMed Web of Science ®Google Scholar
• Herman-Bonert V, Melmed S. Pregnancy in acromegaly. In: Bronstein MD, editor. Pituitary tumors in pregnancy. Norwell (MA): Kluwer Academic Publishers; 1998. p. 109–121.
   Google Scholar
• Alexopoulou O, Bex M, Kamenicky P, et al. Prevalence and risk factors of impaired glucose tolerance and diabetes mellitus at diagnosis of acromegaly: a study in 148 patients. Pituitary. 2014;17(1):81–89.
   PubMed Web of Science ®Google Scholar
• Luo ZC, Nuyt AM, Delvin E, et al. Maternal and fetal IGF-I and IGF-II levels, fetal growth, and gestational diabetes. J Clin Endocrinol Metab. 2012;97(5):1720–1728.
   PubMed Web of Science ®Google Scholar
• Verhaeghe J, Bougoussa M, Van Herck E, et al. Placental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency. Clin Endocrinol (Oxf). 2000;53(5):645–647.
   PubMed Web of Science ®Google Scholar
• Gonzalez JG, Elizondo G, Saldivar D, et al. Pituitary gland growth during normal pregnancy: an in vivo study using magnetic resonance imaging. Am J Med. 1988;85(2):217–220.
   PubMed Web of Science ®Google Scholar
• Scheithauer BW, Sano T, Kovacs KT, et al. The pituitary gland in pregnancy: a clinicopathologic and immunohistochemical study of 69 cases. Mayo Clin Proc. 1990;65(4):461–474.
   PubMed Web of Science ®Google Scholar
• Grand’Maison S, Weber F, Bedard MJ, et al. Pituitary apoplexy in pregnancy: A case series and literature review. Obstet Med. 2015;8(4):177–183.
   PubMed Web of Science ®Google Scholar
• Balinskaite V, Bottle A, Sodhi V, et al. The risk of adverse pregnancy outcomes following nonobstetric surgery during pregnancy: estimates from a retrospective cohort study of 6.5 million pregnancies. Ann Surg. 2017;266(2):260–266.
   PubMed Web of Science ®Google Scholar
• Carvalho P, Lau E, Carvalho D. Surgery induced hypopituitarism in acromegalic patients: a systematic review and meta-analysis of the results. Pituitary. 2015;18(6):844–860.
   PubMed Web of Science ®Google Scholar
• Auriemma RS, Perone Y, Di Sarno A, et al. Results of a single-center observational 10-year survey study on recurrence of hyperprolactinemia after pregnancy and lactation. J Clin Endocrinol Metab. 2013;98(1):372–379.
   PubMed Web of Science ®Google Scholar
• Liao S, Vickers MH, Stanley JL, et al. Human placental growth hormone variant in pathological pregnancies. Endocrinology. 2018;159(5):2186–2198.
   PubMed Web of Science ®Google Scholar
• Frankenne F, Closset J, Gomez F, et al. The physiology of growth hormones (GHs) in pregnant women and partial characterization of the placental GH variant. J Clin Endocrinol Metab. 1988;66(6):1171–1180.
   PubMed Web of Science ®Google Scholar
• Dias ML, Vieira JG, Abucham J. Detecting and solving the interference of pregnancy serum, in a GH immunometric assay. Growth Horm IGF Res. 2013;23(1–2):13–18.
   PubMed Web of Science ®Google Scholar
• Junnila RK, Strasburger CJ, Bidlingmaier M. Pitfalls of insulin-like growth factor-I and growth hormone assays. Endocrinol Metab Clin North Am. 2015;44(1):27–34.
   PubMed Web of Science ®Google Scholar
• Fuglsang J, Ovesen P. Aspects of placental growth hormone physiology. Growth Horm IGF Res. 2006;16(2):67–85.
   PubMed Web of Science ®Google Scholar
• Hennen G, Frankenne F, Closset J, et al. A human placental GH: increasing levels during second half of pregnancy with pituitary GH suppression as revealed by monoclonal antibody radioimmunoassays. Int J Fertil. 1985;30(2):27–33.
   PubMedGoogle Scholar
• Manolopoulou J, Alami Y, Petersenn S, et al. Automated 22-kD growth hormone-specific assay without interference from pegvisomant. Clin Chem. 2012;58(10):1446–1456.
   PubMed Web of Science ®Google Scholar
• Wu Z, Bidlingmaier M, Friess SC, et al. A new nonisotopic, highly sensitive assay for the measurement of human placental growth hormone: development and clinical implications. J Clin Endocrinol Metab. 2003;88(2):804–811.
   PubMed Web of Science ®Google Scholar
• Wu Z, Devany E, Balarini G, et al. Specific monoclonal antibodies and ultrasensitive immunoassays for 20K and 22K human growth hormone. Growth Horm IGF Res. 2010;20(3):239–244.
   PubMed Web of Science ®Google Scholar
• Eriksson L, Frankenne F, Eden S, et al. Growth hormone 24-h serum profiles during pregnancy–lack of pulsatility for the secretion of the placental variant. Br J Obstet Gynaecol. 1989;96(8):949–953.
   PubMedGoogle Scholar
• Caufriez A, Frankenne F, Englert Y, et al. Placental growth hormone as a potential regulator of maternal IGF-I during human pregnancy. Am J Physiol. 1990;258(6 Pt 1):E1014–E1019.
   PubMedGoogle Scholar
• Fuglsang J, Sandager P, Moller N, et al. Kinetics and secretion of placental growth hormone around parturition. Eur J Endocrinol. 2006;154(3):449–457.
   PubMed Web of Science ®Google Scholar
• Fuglsang J, Skjaerbaek C, Espelund U, et al. Ghrelin and its relationship to growth hormones during normal pregnancy. Clin Endocrinol (Oxf). 2005;62(5):554–559.
   PubMed Web of Science ®Google Scholar
• Persechini ML, Gennero I, Grunenwald S, et al. Decreased IGF-1 concentration during the first trimester of pregnancy in women with normal somatotroph function. Pituitary. 2015;18(4):461–464.
   PubMed Web of Science ®Google Scholar
• Chellakooty M, Vangsgaard K, Larsen T, et al. A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth. J Clin Endocrinol Metab. 2004;89(1):384–391.
   PubMed Web of Science ®Google Scholar
• Yang MJ, Tseng JY, Chen CY, et al. Changes in maternal serum insulin-like growth factor-I during pregnancy and its relationship to maternal anthropometry. J Chin Med Assoc. 2013;76(11):635–639.
   PubMed Web of Science ®Google Scholar
• Leung KC, Johannsson G, Leong GM, et al. Estrogen regulation of growth hormone action. Endocr Rev. 2004;25(5):693–721.
   PubMed Web of Science ®Google Scholar
• van der Klaauw AA, Biermasz NR, Zelissen PM, et al. Administration route-dependent effects of estrogens on IGF-I levels during fixed GH replacement in women with hypopituitarism. Eur J Endocrinol. 2007;157(6):709–716.
   PubMed Web of Science ®Google Scholar
• Stone JC, Clark J, Cuneo R, et al. Estrogen and selective estrogen receptor modulators (SERMs) for the treatment of acromegaly: a meta-analysis of published observational studies. Pituitary. 2014;17(3):284–295.
   PubMed Web of Science ®Google Scholar
• Sam S, Molitch ME. Timing and special concerns regarding endocrine surgery during pregnancy. Endocrinol Metab Clin North Am. 2003;32(2):337–354.
   PubMed Web of Science ®Google Scholar
• Cohen-Kerem R, Railton C, Oren D, et al. Pregnancy outcome following non-obstetric surgical intervention. Am J Surg. 2005;190(3):467–473.
   PubMed Web of Science ®Google Scholar
• Chowdhury T, Chowdhury M, Schaller B, et al. Perioperative considerations for neurosurgical procedures in the gravid patient: continuing professional development. Can J Anaesth. 2013;60(11):1139–1155.
   PubMed Web of Science ®Google Scholar
• Kazemi P, Villar G, Flexman AM. Anesthetic management of neurosurgical procedures during pregnancy: a case series. J Neurosurg Anesthesiol. 2014;26(3):234–240.
   PubMed Web of Science ®Google Scholar
• Chanson P. Medical treatment of acromegaly with dopamine agonists or somatostatin analogs. Neuroendocrinology. 2016;103(1):50–58.
   PubMed Web of Science ®Google Scholar
• Sandret L, Maison P, Chanson P. Place of cabergoline in acromegaly: a meta-analysis. J Clin Endocrinol Metab. 2011;96(5):1327–1335.
   PubMed Web of Science ®Google Scholar
• Molitch ME. Endocrinology in pregnancy: management of the pregnant patient with a prolactinoma. Eur J Endocrinol. 2015;172(5):R205–R213.
   PubMed Web of Science ®Google Scholar
• Carmichael JD, Bonert VS, Nuno M, et al. Acromegaly clinical trial methodology impact on reported biochemical efficacy rates of somatostatin receptor ligand treatments: a meta-analysis. J Clin Endocrinol Metab. 2014;99(5):1825–1833.
   PubMed Web of Science ®Google Scholar
• Boulanger C, Vezzosi D, Bennet A, et al. Normal pregnancy in a woman with nesidioblastosis treated with somatostatin analog octreotide. J Endocrinol Invest. 2004;27(5):465–470.
   PubMed Web of Science ®Google Scholar
• Caron P, Gerbeau C, Pradayrol L. Maternal-fetal transfer of octreotide. N Engl J Med. 1995;333(9):601–602.
   PubMed Web of Science ®Google Scholar
• Caron P, Buscail L, Beckers A, et al. Expression of somatostatin receptor SST4 in human placenta and absence of octreotide effect on human placental growth hormone concentration during pregnancy. J Clin Endocrinol Metab. 1997;82(11):3771–3776.
   PubMed Web of Science ®Google Scholar
• Kasuki L, Vieira Neto L, Gadelha MR. Cabergoline treatment in acromegaly: cons. Endocrine. 2014;46(2):220–225.
   PubMed Web of Science ®Google Scholar
• van der Lely AJ, Gomez R, Heissler JF, et al. Pregnancy in acromegaly patients treated with pegvisomant. Endocrine. 2015;49(3):769–773.
   PubMed Web of Science ®Google Scholar