215
Views
4
CrossRef citations to date
0
Altmetric
Review

Prenatal influences on bone health in children

, , &
Pages 193-202 | Received 06 Mar 2019, Accepted 11 Apr 2019, Published online: 26 Apr 2019

References

  • Moon RJ, Harvey NC, Curtis EM, et al. Ethnic and geographic variations in the epidemiology of childhood fractures in the United Kingdom. Bone. 2016;85:9–14.
  • Petrinco M, Di Cuonzo D, Berchialla P, et al. Economic burden of injuries in children: cohort study based on administrative data in a northwestern Italian region. Pediatr Int. 2011;53(6):846–850.
  • Morris MWJ, Bell MJ. The socio-economical impact of paediatric fracture clinic appointments. Injury. 2006;37(5):395–397.
  • Clark EM, Ness AR, Bishop NJ, et al. Association between bone mass and fractures in children: a prospective cohort study. J Bone Miner Res. 2006;21(9):1489–1495.
  • Clark EM, Tobias JH, Ness AR. Association between bone density and fractures in children: a systematic review and meta-analysis. Pediatrics. 2006;117(2):e291–7.
  • Abrahamsen B, van Staa T, Ariely R, et al. Excess mortality following hip fracture: a systematic epidemiological review. Osteoporos Int. 2009;20(10):1633–1650.
  • Kim SM, Moon YW, Lim SJ, et al. Prediction of survival, second fracture, and functional recovery following the first hip fracture surgery in elderly patients. Bone. 2012;50(6):1343–1350.
  • Hernlund E, Svedbom A, Ivergard M, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden: a report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2013;8(1–2):136.
  • Forestier F, Daffos F, Rainaut M, et al. Blood chemistry of normal human fetuses at midtrimester of pregnancy. Pediatr Res. 1987;21(6):579–583.
  • Kovacs CS, Kronenberg HM. Maternal-fetal calcium and bone metabolism during pregnancy, puerperium, and lactation. Endocr Rev. 1997;18(6):832–872.
  • Cross NA, Hillman LS, Allen SH, et al. Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study. Am J Clin Nutr. 1995;61(3):514–523.
  • Koo WW, Walters J, Bush AJ, et al. Dual-energy X-ray absorptiometry studies of bone mineral status in newborn infants. J Bone Miner Res. 1996;11(7):997–1002.
  • Harvey N, Dennison E, Cooper C. Osteoporosis: a lifecourse approach. J Bone Miner Res. 2014;29(9):1917–1925.
  • Kelly TL, Wilson KE, Heymsfield SB. Dual energy X-Ray absorptiometry body composition reference values from NHANES. PLoS One. 2009;4(9):e7038.
  • Hernandez CJ, Beaupre GS, Carter DR. A theoretical analysis of the relative influences of peak BMD, age-related bone loss and menopause on the development of osteoporosis. Osteoporos Int. 2003;14(10):843–847.
  • Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and wales. Lancet. 1986;1(8489):1077–1081.
  • Baird J, Kurshid MA, Kim M, et al. Does birthweight predict bone mass in adulthood? A systematic review and meta-analysis. Osteoporos Int. 2011;22(5):1323–1334.
  • Kuh D, Wills AK, Shah I, et al. Growth from birth to adulthood and bone phenotype in early old age: a British birth cohort study. J Bone Miner Res. 2014;29(1):123–133.
  • Kontulainen SA, Johnston JD, Liu D, et al. Strength indices from pQCT imaging predict up to 85% of variance in bone failure properties at tibial epiphysis and diaphysis. J Musculoskelet Neuronal Interact. 2008;8(4):401–409.
  • Cole ZA, Gale CR, Javaid MK, et al. Maternal dietary patterns during pregnancy and childhood bone mass: a longitudinal study. J Bone Miner Res. 2009;24(4):663–668.
  • Petersen SB, Rasmussen MA, Olsen SF, et al. Maternal dietary patterns during pregnancy in relation to offspring forearm fractures: prospective study from the Danish National Birth Cohort. Nutrients. 2015;7(4):2382–2400.
  • Tobias JH, Steer CD, Emmett PM, et al. Bone mass in childhood is related to maternal diet in pregnancy. Osteoporos Int. 2005;16(12):1731–1741.
  • Harvey N, Dhanwal D, Robinson S, et al. Does maternal long chain polyunsaturated fatty acid status in pregnancy influence the bone health of children? The Southampton Women‘s Survey. Osteoporos Int. 2012;23(9):2359–2367.
  • Handel MN, Moon RJ, Titcombe P, et al. Maternal serum retinol and beta-carotene concentrations and neonatal bone mineralization: results from the Southampton Women‘s Survey cohort. Am J Clin Nutr. 2016;104(4):1183–1188.
  • Ross AC, Taylor CL, Yaktine AL, et al. Dietary reference intakes for calcium and vitamin D. 2011. Washington, DC: The National Academies Press.
  • Hyde NK, Brennan-Olsen SL, Wark JD, et al. Maternal dietary nutrient intake during pregnancy and offspring linear growth and bone: the vitamin D in pregnancy cohort study. Calcif Tissue Int. 2017;100(1):47–54.
  • Heppe DH, Medina-Gomez C, Hofman A, et al. Maternal first-trimester diet and childhood bone mass: the generation r study. Am J Clin Nutr. 2013;98(1):224–232.
  • Ganpule A, Yajnik CS, Fall CH, et al. Bone mass in Indian children–relationships to maternal nutritional status and diet during pregnancy: the Pune maternal nutrition Study. J Clin Endocrinol Metab. 2006;91(8):2994–3001.
  • Jones G, Riley MD, Dwyer T. Maternal diet during pregnancy is associated with bone mineral density in children: a longitudinal study. Eur J Clin Nutr. 2000;54(10):749–756.
  • Yin J, Dwyer T, Riley M, et al. The association between maternal diet during pregnancy and bone mass of the children at age 16. Eur J Clin Nutr. 2010;64(2):131–137.
  • Raman L, Rajalakshmi K, Krishnamachari K, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr. 1978;31(3):466–469.
  • Koo WW, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstetrics Gynecol. 1999;94(4):577–582.
  • Jarjou LM, Prentice A, Sawo Y, et al. Randomized, placebo-controlled, calcium supplementation study in pregnant Gambian women: effects on breast-milk calcium concentrations and infant birth weight, growth, and bone mineral accretion in the first year of life. Am J Clin Nutr. 2006;83(3):657–666.
  • Jarjou LM, Sawo Y, Goldberg GR, et al. Unexpected long-term effects of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake: a follow-up study. Am J Clin Nutr. 2013;98(3):723–730.
  • Ward KA, Jarjou L, Prentice A. Long-term effects of maternal calcium supplementation on childhood growth differ between males and females in a population accustomed to a low calcium intake. Bone. 2017;103:31–38.
  • Prentice A, Ward KA, Nigdikar S, et al. Pregnancy supplementation of Gambian mothers with calcium carbonate alters mid-childhood IGF1 in a sex-specific manner. Bone. 2018;120:314–320.
  • Ward KA, Cole TJ, Laskey MA, et al. The effect of prepubertal calcium carbonate supplementation on skeletal development in Gambian boys – a 12-year follow-up study. J Clin Endocrinol Metab. 2014;99(9):3169–3176.
  • Chevalley T, Bonjour JP, van Rietbergen B, et al. Fractures in healthy females followed from childhood to early adulthood are associated with later menarcheal age and with impaired bone microstructure at peak bone mass. J Clin Endocrinol Metab. 2012;97(11):4174–4181.
  • Moon RJ, Crozier SR, Dennison EM, et al. Tracking of 25-hydroxyvitamin D status during pregnancy: the importance of vitamin D supplementation. Am J Clin Nutr. 2015;102(5):1081–1087.
  • Namgung R, Tsang RC, Lee C, et al. Low total body bone mineral content and high bone resorption in Korean winter-born versus summer-born newborn infants. J Pediatr. 1998;132(3 Pt 1):421–425.
  • Weiler H, Fitzpatrick-Wong S, Veitch R, et al. Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns. Cmaj. 2005;172(6):757–761.
  • Viljakainen H, Korhonen T, Hytinantti T, et al. Maternal vitamin D status affects bone growth in early childhood – a prospective cohort study. Osteoporos Int. 2011;22(3):883–891.
  • Prentice A, Jarjou LM, Goldberg GR, et al. Maternal plasma 25-hydroxyvitamin D concentration and birthweight, growth and bone mineral accretion of Gambian infants. Acta Paediatr. 2009;98(8):1360–1362.
  • Javaid M, Crozier S, Harvey N, et al. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet. 2006;367(9504):36–43.
  • Moon RJ, Harvey NC, Davies JH, et al. D and bone development. Osteoporos Int. 2015;26(4):1449–1451.
  • Zhu K, Aj W, Hart P, et al. Maternal vitamin D status during pregnancy and bone mass in offspring at 20 years of age: a prospective cohort study. J Bone Miner Res. 2014;29(5):1088–1095.
  • Harvey NC, Moon RJ, Sayer AA, et al. Maternal antenatal vitamin D status and offspring muscle development: findings from the Southampton Women’s Survey. J Clin Endocrinol Metab. 2014;99(1):330–337.
  • Sayers A, Tobias JH. Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child. J Clin Endocrinol Metab. 2009;94(3):765–771.
  • Lawlor DA, Wills AK, Fraser A, et al. Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study. Lancet. 2013;381(9884):2176–2183.
  • Garcia AH, Erler NS, Jaddoe VWV, et al. 25-hydroxyvitamin D concentrations during fetal life and bone health in children aged 6 years: a population-based prospective cohort study. Lancet Diabetes Endocrinol. 2017;5(5):367–376.
  • Harvey NC, Moon R, Inskip HM, et al. Gestational vitamin D and childhood bone health. Lancet Diabetes Endocrinol. 2017;5(6):417.
  • Handel MN, Frederiksen P, Cohen A, et al. Neonatal vitamin D status from archived dried blood spots and future risk of fractures in childhood: results from the D-tect study, a population-based case-cohort study. Am J Clin Nutr. 2017;106(1):155–161.
  • Cooper C, Harvey NC, Bishop NJ, et al. Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial. Lancet Diabetes Endocrinol. 2016;4(5):393–402.
  • Harvey NC, Javaid K, Bishop N, et al. MAVIDOS maternal vitamin D osteoporosis study: study protocol for a randomized controlled trial. The MAVIDOS study group. Trials. 2012;13:13.
  • Moon RJ, Harvey NC, Cooper C, et al. Determinants of the maternal 25-hydroxyvitamin D response to vitamin D supplementation during pregnancy. J Clin Endocrinol Metab. 2016;101(12):5012–5020.
  • Moon RJ, Harvey NC, Cooper C, et al. Response to antenatal cholecalciferol supplementation is associated with common vitamin D related genetic variants. J Clin Endocrinol Metab. 2017.
  • Chan GM, McElligott K, McNaught T, et al. Effects of dietary calcium intervention on adolescent mothers and newborns: a randomized controlled trial. Obstetrics Gynecol. 2006;108(3):565–571.
  • De-Regil LM, Palacios C, Lombardo LK, et al. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2016;(1),Cd008873.
  • Harvey NC, Javaid MK, Arden NK, et al. Maternal predictors of neonatal bone size and geometry: the Southampton Women‘s Survey. J Dev Orig Health Dis. 2010;1(1):35–41.
  • Godfrey K, Walker-Bone K, Robinson S, et al. Neonatal bone mass: influence of parental birthweight, maternal smoking, body composition, and activity during pregnancy. J Bone Miner Res. 2001;16(9):1694–1703.
  • Martinez-Mesa J, Menezes AM, Howe LD, et al. Lifecourse relationship between maternal smoking during pregnancy, birth weight, contemporaneous anthropometric measurements and bone mass at 18years old. The 1993 Pelotas birth cohort. Early Hum Dev. 2014;90(12):901–906.
  • Jones G, Riley M, Dwyer T. Maternal smoking during pregnancy, growth, and bone mass in prepubertal children. J Bone Miner Res. 1999;14(1):146–151.
  • Belenchia AM, Jones KL, Will M, et al. Maternal vitamin D deficiency during pregnancy affects expression of adipogenic-regulating genes peroxisome proliferator-activated receptor gamma (PPARgamma) and vitamin D receptor (VDR) in lean male mice offspring. Eur J Nutr. 2016. doi:10.1007/s00394-016-1359-x
  • Parviainen R, Auvinen J, Pokka T, et al. Maternal smoking during pregnancy is associated with childhood bone fractures in offspring – a birth-cohort study of 6718 children. Bone. 2017;101:202–205.
  • Jones G, Hynes KL, Dwyer T. The association between breastfeeding, maternal smoking in utero, and birth weight with bone mass and fractures in adolescena 16-year longitudinal study. Osteoporos Int. 2013;24(5):1605–1611.
  • Martin R, Harvey NC, Crozier SR, et al. Placental calcium transporter (PMCA3) gene expression predicts intrauterine bone mineral accrual. Bone. 2007;40(5):1203–1208.
  • Lillycrop KA, Phillips ES, Jackson AA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005;135(6):1382–1386.
  • Harvey NC, Sheppard A, Godfrey KM, et al. Childhood bone mineral content is associated with methylation status of the RXRA promoter at birth. J Bone Miner Res. 2014;29(3):600–607.
  • Harvey NC, Lillycrop KA, Garratt E, et al. Evaluation of methylation status of the eNOS promoter at birth in relation to childhood bone mineral content. Calcif Tissue Int. 2012;90(2):120–127.
  • Murphy SK, Adigun A, Huang Z, et al. Gender-specific methylation differences in relation to prenatal exposure to cigarette smoke. Gene. 2012;494(1):36–43.
  • Kippler M, Engström K, Jurkovic Mlakar S, et al. Sex-specific effects of early life cadmium exposure on DNA methylation and implications for birth weight [Article]. Epigenetics. 2013;8(5):494–503.
  • Suderman M, Stene LC, Bohlin J, et al. 25-Hydroxyvitamin D in pregnancy and genome wide cord blood DNA methylation in two pregnancy cohorts (MoBa and ALSPAC). J Steroid Biochem Mol Biol. 2016;153:102–109.
  • Curtis EM, Krstic N, Cook E, et al. Gestational vitamin D supplementation leads to reduced perinatal RXRA DNA methylation: results from the MAVIDOS trial. J Bone Miner Res. 2019;34(2):231–240.
  • Baird J, Barker M, Harvey NC, et al. Southampton pregnancy intervention for the next generation (SPRING): protocol for a randomised controlled trial. Trials. 2016;17(1):493.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.