Association of pediatric obesity and asthma, pulmonary physiology, metabolic dysregulation, and atopy; and the role of weight management

References

• Childhood Obesity Facts | overweight & Obesity | CDC. 2018;T04:41:15Z.
   Google Scholar
• Hales CM, Carroll MD, Fryar CD, et al. Prevalence of obesity among adults and youth: United States, 2015-2016. NCHS Data Brief. 2017;288:1–8.
   Google Scholar
• Pi-Sunyer X. The medical risks of obesity. Postgrad Med. 2009 Nov;121(6):21–33.
   PubMed Web of Science ®Google Scholar
• McClean KM, Kee F, Young IS, et al. Obesity and the lung: 1. Epidemiology. Thorax. 2008;63(7):649–654.
   PubMed Web of Science ®Google Scholar
• Mehari A, Afreen S, Ngwa J, et al. Obesity and pulmonary function in African Americans. PLoS ONE. 2015;10(10):e0140610.
   PubMed Web of Science ®Google Scholar
• Deane S, Thomson A. Obesity and the pulmonologist. Arch Dis Child. 2006;91(2):188–191.
   PubMed Web of Science ®Google Scholar
• McCormack MC, Belli AJ, Kaji DA, et al. Obesity as a susceptibility factor to indoor particulate matter health effects in COPD. Eur Respir J. 2015;45(5):1248–1257.
   PubMed Web of Science ®Google Scholar
• Wu TD, Brigham EP, Peng R, et al. Overweight/obesity enhances associations between secondhand smoke exposure and asthma morbidity in children. J Allergy Clin Immunol Pract. 2018;6(6):2157–9.e5.
   PubMed Web of Science ®Google Scholar
• Akinbami LJ, Simon AE, Rossen LM. Changing trends in asthma prevalence among children. Pediatrics. 2016;137(1).
   PubMed Web of Science ®Google Scholar
• Contreras ZA, Chen ZRoumeliotaki T. Does early onset asthma increase childhood obesity risk? a pooled analysis of 16 european cohorts. Eur Respir J. 2018 Sep 27;52(3). pii: 1800504. doi: 10.1183/13993003.00504-2018.
   Web of Science ®Google Scholar
• Chen Z, Salam MT, Alderete TL, et al. Effects of childhood asthma on the development of obesity among school-aged children. Am J Respir Crit Care Med. 2017;195(9):1181–1188.
   PubMed Web of Science ®Google Scholar
• Lang JE, Bunnell HT, Hossain MJ, et al. Being overweight or obese and the development of asthma. Pediatrics. 2018;142(6):1459–1467.
   Web of Science ®Google Scholar
• Gold DR, Damokosh AI, Dockery DW, et al. Body-mass index as a predictor of incident asthma in a prospective cohort of children. Pediatr Pulmonol. 2003;36(6):514–521.
   PubMed Web of Science ®Google Scholar
• Rzehak P, Wijga AH, Keil T, et al. Body mass index trajectory classes and incident asthma in childhood: results from 8 European Birth Cohorts–a global allergy and asthma european network initiative. J Allergy Clin Immunol. 2013;131(6):1528–1536.
   PubMed Web of Science ®Google Scholar
• Gilliland FD, Berhane K, Islam T, et al. Obesity and the risk of newly diagnosed asthma in school-age children. Am J Epidemiol. 2003;158(5):406–415.
   PubMed Web of Science ®Google Scholar
• Chen YC, Dong GH, Lin KC, et al. Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta-analysis. Obes Rev. 2013;14(3):222–231.
   PubMed Web of Science ®Google Scholar
• Egan KB, Ettinger AS, Bracken MB. Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies. BMC Pediatr. 2013;13:121.
   PubMed Web of Science ®Google Scholar
• Lu KD, Billimek J, Bar-Yoseph R, et al. Sex differences in the relationship between fitness and obesity on risk for asthma in adolescents. J Pediatr. 2016;176:36–42.
   PubMed Web of Science ®Google Scholar
• Maltz L, Matz EL, Gordish-Dressman H, et al. Sex differences in the association between neck circumference and asthma. Pediatr Pulmonol. 2016;51(9):893–900.
   PubMed Web of Science ®Google Scholar
• Vlaski E, Stavric K, Seckova L, et al. Influence of physical activity and television-watching time on asthma and allergic rhinitis among young adolescents: preventive or aggravating? Allergol Immunopathol (Madr). 2008;36(5):247–253.
   PubMed Web of Science ®Google Scholar
• Sah PK, Gerald Teague W, Demuth KA, et al. Poor asthma control in obese children may be overestimated because of enhanced perception of dyspnea. J Allergy Clin Immunol Pract. 2013;1(1):39–45.
   PubMed Web of Science ®Google Scholar
• Rastogi D, Khan UI, Isasi CR, et al. Associations of obesity and asthma with functional exercise capacity in urban minority adolescents. Pediatr Pulmonol. 2012;47(11):1061–1069.
   PubMed Web of Science ®Google Scholar
• Borrell LN, Nguyen EA, Roth LA, et al. Childhood obesity and asthma control in the GALA II and SAGE II studies. Am J Respir Crit Care Med. 2013;187(7):697–702.
   PubMed Web of Science ®Google Scholar
• McGarry ME, Castellanos E, Thakur N, et al. Obesity and bronchodilator response in black and Hispanic children and adolescents with asthma. Chest. 2015;147(6):1591–1598.
   PubMed Web of Science ®Google Scholar
• Forno E, Lescher R, Strunk R, et al. Decreased response to inhaled steroids in overweight and obese asthmatic children. J Allergy Clin Immunol. 2011 Mar;127(3):741–749.
   PubMed Web of Science ®Google Scholar
• Forno E, Han -Y-Y, Mullen J, et al. Overweight, obesity, and lung function in children and Adults-A meta-analysis. J Allergy Clin Immunol Pract. 2018;6(2):570–81.e10.
   PubMed Web of Science ®Google Scholar
• Chu Y-T, Chen W-Y, Wang T-N, et al. Extreme BMI predicts higher asthma prevalence and is associated with lung function impairment in school-aged children. Pediatr Pulmonol. 2009;44(5):472–479.
   PubMed Web of Science ®Google Scholar
• Vo P, Makker K, Matta-Arroyo E, et al. The association of overweight and obesity with spirometric values in minority children referred for asthma evaluation. J Asthma. 2013;50(1):56–63.
   PubMed Web of Science ®Google Scholar
• Wang R, Custovic A, Simpson A, et al. Differing associations of BMI and body fat with asthma and lung function in children. Pediatr Pulmonol. 2014 Nov;49(11):1049–1057.
   PubMed Web of Science ®Google Scholar
• Forno E, Weiner DJ, Mullen J, et al. obesity and airway dysanapsis in children with and without asthma. Am J Respir Crit Care Med. 2017;195(3):314–323.
   PubMed Web of Science ®Google Scholar
• Chen Y, Rennie D, Cormier YF, et al. Waist circumference is associated with pulmonary function in normal-weight, overweight, and obese subjects. Am J Clin Nutr. 2007;85(1):35–39.
   PubMed Web of Science ®Google Scholar
• Rastogi D, Canfield SM, Andrade A, et al. Obesity-associated asthma in children: a distinct entity. Chest. 2012;141(4):895–905.
   PubMed Web of Science ®Google Scholar
• Rastogi D, Bhalani K, Hall CB, et al. Association of pulmonary function with adiposity and metabolic abnormalities in urban minority adolescents. Ann Am Thorac Soc. 2014 Jun;11(5):744–752.
   PubMedGoogle Scholar
• Davidson WJ, Mackenzie-Rife KA, Witmans MB, et al. Obesity negatively impacts lung function in children and adolescents. Pediatr Pulmonol. 2014;49(10):1003–1010.
   PubMed Web of Science ®Google Scholar
• Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. J Appl Physiol. 2010;108(1):206–211.
   PubMed Web of Science ®Google Scholar
• Ding DJ, Martin JG, Macklem PT. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J Appl Physiol. 1987;62(3):1324–1330.
   PubMed Web of Science ®Google Scholar
• King GG, Brown NJ, Diba C, et al. The effects of body weight on airway calibre. Eur Respir J. 2005 May;25(5):896–901.
   PubMed Web of Science ®Google Scholar
• Shore SA. Obesity and asthma: possible mechanisms. J Allergy Clin Immunol. 2008;121(5): 1087–1093. quiz 94-95.
   PubMed Web of Science ®Google Scholar
• Boulet L-P, Turcotte H, Boulet G, et al. Deep inspiration avoidance and airway response to methacholine: influence of body mass index. Can Respir J. 2005;12(7):371–376.
   PubMedGoogle Scholar
• Cottrell L, Neal WA, Ice C, et al. Metabolic abnormalities in children with asthma. Am J Respir Crit Care Med. 2011 Feb;183(4):441–448.
   PubMed Web of Science ®Google Scholar
• Del-Rio-Navarro BE, Castro-Rodriguez JA, Garibay Nieto N, et al. Higher metabolic syndrome in obese asthmatic compared to obese nonasthmatic adolescent males. J Asthma. 2010 Jun;47(5):501–506.
   PubMed Web of Science ®Google Scholar
• Rastogi D, Fraser S, Oh J, et al. Inflammation, metabolic dysregulation, and pulmonary function among obese urban adolescents with asthma. Am J Respir Crit Care Med. 2015;191(2):149–160.
   PubMed Web of Science ®Google Scholar
• Singh S, Bodas M, Bhatraju NK, et al. Hyperinsulinemia adversely affects lung structure and function. Am J Physiol Lung Cell Mol Physiol. 2016;310(9):L837–45.
   PubMed Web of Science ®Google Scholar
• Perdue AD, Cottrell LA, Lilly CL, et al. Pediatric metabolic outcome comparisons based on a spectrum of obesity and asthmatic symptoms. J Asthma. 2019 Apr;56(4):388-394.
   Web of Science ®Google Scholar
• Chen YC, Tung KY, Tsai CH, et al. Lipid profiles in children with and without asthma: interaction of asthma and obesity on hyperlipidemia. Diabetes Metab Syndr. 2013 Jan-Mar;7(1):20–25.
   PubMedGoogle Scholar
• Schaafsma D, McNeill KD, Stelmack GL, et al. Insulin increases the expression of contractile phenotypic markers in airway smooth muscle. Am J Physiol Cell Physiol. 2007;293(1):C429–39.
   PubMed Web of Science ®Google Scholar
• Orfanos S, Jude J, Deeney BT, et al. Obesity increases airway smooth muscle responses to contractile agonists. Am J Physiol Lung Cell Mol Physiol. 2018;315(5):L673–L81.
   PubMed Web of Science ®Google Scholar
• Peters MC, McGrath KW, Hawkins GA, et al. Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. Lancet Respir Med. 2016;4(7):574–584.
   PubMed Web of Science ®Google Scholar
• Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med. 2012;18(5):716–725.
   PubMed Web of Science ®Google Scholar
• Vijayakanthi N, Greally JM, Rastogi D. Pediatric obesity-related asthma: the role of metabolic dysregulation. Pediatrics. 2016;137(5).
   PubMed Web of Science ®Google Scholar
• Engin AB. Adipocyte-macrophage cross-talk in obesity. Adv Exp Med Biol. 2017;960:327–343.
   PubMed Web of Science ®Google Scholar
• O’Rourke RW, White AE, Metcalf MD, et al. Hypoxia-induced inflammatory cytokine secretion in human adipose tissue stromovascular cells. Diabetologia. 2011;54(6):1480–1490.
   PubMed Web of Science ®Google Scholar
• Baek H-S, Kim Y-D, Shin J-H, et al. Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma. Ann Allergy Asthma Immunol. 2011;107(1):14–21.
   PubMed Web of Science ®Google Scholar
• Dixon AE, Johnson SE, Griffes LV, et al. Relationship of adipokines with immune response and lung function in obese asthmatic and non-asthmatic women. J Asthma. 2011;48(8):811–817.
   PubMed Web of Science ®Google Scholar
• Nagel G, Koenig W, Rapp K, et al. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Pediatr Allergy Immunol. 2009;20(1):81–88.
   PubMed Web of Science ®Google Scholar
• Guler N, Kirerleri E, Ones U, et al. Leptin: does it have any role in childhood asthma? J Allergy Clin Immunol. 2004;114(2):254–259.
   PubMed Web of Science ®Google Scholar
• von Mutius E, Schwartz J, Neas LM, et al. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax. 2001;56(11):835–838.
   PubMed Web of Science ®Google Scholar
• Huang SL, Shiao G, Chou P. Association between body mass index and allergy in teenage girls in Taiwan. Clin Exp Allergy. 1999;29(3):323–329.
   PubMed Web of Science ®Google Scholar
• Lu KD, Phipatanakul W, Perzanowski MS, et al. Atopy, but not obesity is associated with asthma severity among children with persistent asthma. J Asthma. 2016;53(10):1033–1044.
   PubMed Web of Science ®Google Scholar
• Lord GM, Matarese G, Howard JK, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature. 1998;394(6696):897–901.
   PubMed Web of Science ®Google Scholar
• Matsuda K, Nishi Y, Okamatsu Y, et al. Ghrelin and leptin: a link between obesity and allergy? J Allergy Clin Immunol. 2006;117(3):705–706.
   PubMed Web of Science ®Google Scholar
• Salo PM, Calatroni A, Gergen PJ, et al. Allergy-related outcomes in relation to serum IgE: results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immunol. 2011;127(5):1226–35.e7.
   PubMed Web of Science ®Google Scholar
• Salo PM, Arbes SJ, Jaramillo R, et al. Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. J Allergy Clin Immunol. 2014;134(2):350–359.
   PubMed Web of Science ®Google Scholar
• Santamaria F, Montella S, De Stefano S, et al. Asthma, atopy, and airway inflammation in obese children. J Allergy Clin Immunol. 2007;120(4):965–967.
   PubMed Web of Science ®Google Scholar
• Han -Y-Y, Forno E, Celedón JC. Adiposity, fractional exhaled nitric oxide, and asthma in U.S. Children. Am J Respir Crit Care Med. 2014;190(1):32–39.
   PubMed Web of Science ®Google Scholar
• Kattan M, Kumar R, Bloomberg GR, et al. Asthma control, adiposity, and adipokines among inner-city adolescents. J Allergy Clin Immunol. 2010 Mar;125(3):584–592.
   PubMed Web of Science ®Google Scholar
• Chen Y-C, Fan H-Y, Huang Y-T, et al. Causal relationships between adiposity and childhood asthma: bi-directional Mendelian Randomization analysis. Int J Obes (Lond). 2019;43(1):73–81.
   PubMed Web of Science ®Google Scholar
• Rastogi D, Reddy M, Neugebauer R. Comparison of patterns of allergen sensitization among inner-city Hispanic and African American children with asthma. Ann Allergy Asthma Immunol. 2006;97(5):636–642.
   PubMed Web of Science ®Google Scholar
• Castro-Rodríguez JA, Holberg CJ, Morgan WJ, et al. Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. Am J Respir Crit Care Med. 2001;163(6):1344–1349.
   PubMed Web of Science ®Google Scholar
• Dumas O, Varraso R, Gillman MW, et al. Longitudinal study of maternal body mass index, gestational weight gain, and offspring asthma. Allergy. 2016;71(9):1295–1304.
   PubMed Web of Science ®Google Scholar
• Leermakers ETM, Sonnenschein-van der Voort AMM, Gaillard R, et al. Maternal weight, gestational weight gain and preschool wheezing: the Generation R Study. Eur Respir J. 2013;42(5):1234–1243.
   PubMed Web of Science ®Google Scholar
• Rajappan A, Pearce A, Inskip HM, et al. Maternal body mass index: relation with infant respiratory symptoms and infections. Pediatr Pulmonol. 2017;52(10):1291–1299.
   PubMed Web of Science ®Google Scholar
• Pike KC, Inskip HM, Robinson SM, et al. The relationship between maternal adiposity and infant weight gain, and childhood wheeze and atopy. Thorax. 2013;68(4):372–379.
   PubMed Web of Science ®Google Scholar
• Forno E, Young OM, Kumar R, et al. Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma. Pediatrics. 2014;134(2):e535–46.
   PubMed Web of Science ®Google Scholar
• Halonen M, Lohman IC, Stern DA, et al. Perinatal tumor necrosis factor-α production, influenced by maternal pregnancy weight gain, predicts childhood asthma. Am J Respir Crit Care Med. 2013;188(1):35–41.
   PubMed Web of Science ®Google Scholar
• Azad MB, Becker AB, Kozyrskyj AL. Association of maternal diabetes and child asthma. Pediatr Pulmonol. 2013;48(6):545–552.
   PubMed Web of Science ®Google Scholar
• Popovic M, Pizzi C, Rusconi F, et al. Infant weight trajectories and early childhood wheezing: the NINFEA birth cohort study. Thorax. 2016;71(12):1091–1096.
   PubMed Web of Science ®Google Scholar
• Chen YC, Chih AH, Chen JR, et al. Rapid adiposity growth increases risks of new-onset asthma and airway inflammation in children. Int J Obes (Lond). 2017;41(7):1035–1041.
   PubMed Web of Science ®Google Scholar
• Jackson WM, O’Shea TM, Allred EN, et al. Risk factors for chronic lung disease and asthma differ among children born extremely preterm. Pediatr Pulmonol. 2018;53(11):1533–1540.
   PubMed Web of Science ®Google Scholar
• Ziyab AH, Karmaus W, Kurukulaaratchy RJ, et al. Developmental trajectories of Body Mass Index from infancy to 18 years of age: prenatal determinants and health consequences. J Epidemiol Community Health. 2014;68(10):934–941.
   PubMed Web of Science ®Google Scholar
• Belfort MB, Cohen RT, Rhein LM, et al. Preterm infant growth and asthma at age 8 years. Arch Dis Child Fetal Neonatal Ed. 2016;101(3):F230–4.
   PubMed Web of Science ®Google Scholar
• Renosto LC, Acatauassu C, Andrade I, et al. Growth velocity and weight gain in prepubertal asthmatic children. Rev Assoc Med Bras (1992). 2017;63(3):236–241.
   PubMed Web of Science ®Google Scholar
• Anderson EL, Fraser A, Martin RM, et al. Associations of postnatal growth with asthma and atopy: the PROBIT Study. Pediatr Allergy Immunol. 2013;24(2):122–130.
   PubMed Web of Science ®Google Scholar
• Flexeder C, Thiering E, Brüske I, et al. Growth velocity during infancy and onset of asthma in school-aged children. Allergy. 2012;67(2):257–264.
   PubMed Web of Science ®Google Scholar
• Matos SMA, Jesus SR, Saldiva SRDM, et al. Weight gain in the first two years of life, asthma and atopy: the SCAALA cohort study. Public Health Nutr. 2014;17(11):2537–2545.
   PubMed Web of Science ®Google Scholar
• Sonnenschein-van der Voort AMM, Arends LR, de Jongste JC, et al. Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children. J Allergy Clin Immunol. 2014;133(5):1317–1329.
   PubMed Web of Science ®Google Scholar
• Claudia F, Thiering E, von Berg A, et al. Peak weight velocity in infancy is negatively associated with lung function in adolescence. Pediatr Pulmonol. 2016;51(2):147–156.
   PubMed Web of Science ®Google Scholar
• van der Gugten AC, Koopman M, Evelein AMV, et al. van der Ent CK. Rapid early weight gain is associated with wheeze and reduced lung function in childhood. Eur Respir J. 2012;39(2):403–410.
   PubMed Web of Science ®Google Scholar
• Sonnenschein-van der Voort AMM, Jaddoe VWV, Raat H, et al. Fetal and infant growth and asthma symptoms in preschool children: the Generation R Study. Am J Respir Crit Care Med. 2012;185(7):731–737.
   PubMed Web of Science ®Google Scholar
• Tsai H-J, Wang G, Hong X, et al. Early life weight gain and development of childhood asthma in a prospective birth cohort. Ann Am Thorac Soc. 2018;15(10):1197–1204.
   PubMed Web of Science ®Google Scholar
• Sonnenschein-van der Voort AMM, Howe LD, Granell R, et al. Influence of childhood growth on asthma and lung function in adolescence. J Allergy Clin Immunol. 2015;135(6):1435–43.e7.
   PubMed Web of Science ®Google Scholar
• Hakala K, Stenius-Aarniala B, Sovijärvi A. Effects of weight loss on peak flow variability, airways obstruction, and lung volumes in obese patients with asthma. Chest. 2000;118(5):1315–1321.
   PubMed Web of Science ®Google Scholar
• Stenius-Aarniala B, Poussa T, Kvarnström J, et al. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ. 2000;320(7238):827–832.
   PubMed Web of Science ®Google Scholar
• Aaron SD, Fergusson D, Dent R, et al. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest. 2004;125(6):2046–2052.
   PubMed Web of Science ®Google Scholar
• Johnson JB, Summer W, Cutler RG, et al. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med. 2007;42(5):665–674.
   PubMed Web of Science ®Google Scholar
• Da Silva PL, de Mello MT, Cheik NC, et al. Interdisciplinary therapy improves biomarkers profile and lung function in asthmatic obese adolescents. Pediatr Pulmonol. 2012;47(1):8–17.
   PubMed Web of Science ®Google Scholar
• van de Griendt EJ, van der Baan-Slootweg OH, van Essen-Zandvliet EEM, et al. Gain in lung function after weight reduction in severely obese children. Arch Dis Child. 2012;97(12):1039–1042.
   PubMed Web of Science ®Google Scholar
• Abd El-Kader MS, Al-Jiffri O, Ashmawy EM. Impact of weight loss on markers of systemic inflammation in obese Saudi children with asthma. Afr Health Sci. 2013;13(3):682–688.
   PubMed Web of Science ®Google Scholar
• Scott HA, Gibson PG, Garg ML, et al. Dietary restriction and exercise improve airway inflammation and clinical outcomes in overweight and obese asthma: a randomized trial. Clin Exp Allergy. 2013;43(1):36–49.
   PubMed Web of Science ®Google Scholar
• Jensen ME, Gibson PG, Collins CE, et al. Diet-induced weight loss in obese children with asthma: a randomized controlled trial. Clin Exp Allergy. 2013;43(7):775–784.
   PubMed Web of Science ®Google Scholar
• Dias-Júnior SA, Reis M, de Carvalho-Pinto RM, et al. Effects of weight loss on asthma control in obese patients with severe asthma. Eur Respir J. 2014;43(5):1368–1377.
   PubMed Web of Science ®Google Scholar
• van Leeuwen JC, Hoogstrate M, Duiverman EJ, et al. Effects of dietary induced weight loss on exercise-induced bronchoconstriction in overweight and obese children. Pediatr Pulmonol. 2014;49(12):1155–1161.
   PubMed Web of Science ®Google Scholar
• Ma J, Strub P, Xiao L, et al. Behavioral weight loss and physical activity intervention in obese adults with asthma. A randomized trial. Ann Am Thorac Soc. 2015;12(1):1–11.
   PubMed Web of Science ®Google Scholar
• Luna-Pech JA, Torres-Mendoza BM, Luna-Pech JA, et al. Normocaloric diet improves asthma-related quality of life in obese pubertal adolescents. Int Arch Allergy Immunol. 2014;163(4):252–258.
   PubMed Web of Science ®Google Scholar
• Pakhale S, Baron J, Dent R, et al. Effects of weight loss on airway responsiveness in obese adults with asthma: does weight loss lead to reversibility of asthma? Chest. 2015;147(6):1582–1590.
   PubMed Web of Science ®Google Scholar
• Willeboordse M, van de Kant KDG, Tan FES, et al. A multifactorial weight reduction programme for children with overweight and asthma: a randomized controlled trial. PLoS ONE. 2016;11(6):e0157158.
   PubMed Web of Science ®Google Scholar
• Freitas PD, Ferreira PG, Silva AG, et al. The role of exercise in a weight-loss program on clinical control in obese adults with asthma. A randomized controlled trial. Am J Respir Crit Care Med. 2017;195(1):32–42.
   PubMed Web of Science ®Google Scholar
• Lucas JA, Moonie S, Hogan MB, et al. Efficacy of an exercise intervention among children with comorbid asthma and obesity. Public Health. 2018;159:123–128.
   PubMed Web of Science ®Google Scholar
• Macgregor N, Greenberg N. Effect of surgically induced weight loss on asthma in the morbidly obese. Obes Surg. 1993;3(1):15–21.
   PubMed Web of Science ®Google Scholar
• Dhabuwala A, Cannan RJ, Stubbs RS. Improvement in co-morbidities following weight loss from gastric bypass surgery. Obes Surg. 2000;10(5):428–435.
   PubMed Web of Science ®Google Scholar
• O’Brien PE, Dixon JB, Brown W, et al. The laparoscopic adjustable gastric band (Lap-Band): a prospective study of medium-term effects on weight, health and quality of life. Obes Surg. 2002;12(5):652–660.
   PubMed Web of Science ®Google Scholar
• Simard B, Turcotte H, Marceau P, et al. Asthma and sleep apnea in patients with morbid obesity: outcome after bariatric surgery. Obes Surg. 2004;14(10):1381–1388.
   PubMed Web of Science ®Google Scholar
• Ahroni JH, Montgomery KF, Watkins BM. Laparoscopic adjustable gastric banding: weight loss, co-morbidities, medication usage and quality of life at one year. Obes Surg. 2005;15(5):641–647.
   PubMed Web of Science ®Google Scholar
• Dixon AE, Pratley RE, Forgione PM, et al. Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation. J Allergy Clin Immunol. 2011 Sep;128(3):508-15e1-2.
   PubMed Web of Science ®Google Scholar
• Zerah-Lancner F, Boyer L, Rezaiguia-Delclaux S, et al. Airway responsiveness measured by forced oscillation technique in severely obese patients, before and after bariatric surgery. J Asthma. 2011;48(8):818–823.
   PubMed Web of Science ®Google Scholar
• Boulet L-P, Turcotte H, Martin J, et al. Effect of bariatric surgery on airway response and lung function in obese subjects with asthma. Respir Med. 2012;106(5):651–660.
   PubMed Web of Science ®Google Scholar
• Chapman DG, Irvin CG, Kaminsky DA, et al. Influence of distinct asthma phenotypes on lung function following weight loss in the obese. Respirology. 2014;19(8):1170–1177.
   PubMed Web of Science ®Google Scholar
• van Huisstede A, Rudolphus A, Castro Cabezas M, et al. Effect of bariatric surgery on asthma control, lung function and bronchial and systemic inflammation in morbidly obese subjects with asthma. Thorax. 2015;70(7):659–667.
   PubMed Web of Science ®Google Scholar
• Hasegawa K, Tsugawa Y, Chang Y, et al. Risk of an asthma exacerbation after bariatric surgery in adults. J Allergy Clin Immunol. 2015;136(2):288–94.e8.
   PubMed Web of Science ®Google Scholar
• Maniscalco M, Zamparelli AS, Vitale DF, et al. Long-term effect of weight loss induced by bariatric surgery on asthma control and health related quality of life in asthmatic patients with severe obesity: A pilot study. Respir Med. 2017;130:69–74.
   PubMed Web of Science ®Google Scholar
• Moreno LA, Ochoa MC, Wärnberg J, et al. Treatment of obesity in children and adolescents. How nutrition can work? Int J Pediatr Obes. 2008;3(Suppl 1):72–77.
   PubMed Web of Science ®Google Scholar
• Moreno LA. Effects of diet on growth of children with obesity. J Pediatr Gastroenterol Nutr. 2010;51(Suppl 3):S147–8.
   PubMed Web of Science ®Google Scholar
• Parks EP, Zemel B, Moore RH, et al. Change in body composition during a weight loss trial in obese adolescents. Pediatr Obes. 2014;9(1):26–35.
   PubMed Web of Science ®Google Scholar
• Kalantari N, Mohammadi NK, Rafieifar S, et al. Indicator for success of obesity reduction programs in adolescents: body composition or body mass index? Evaluating a school-based health promotion project after 12 weeks of intervention. Int J Prev Med. 2017;8:73.
   PubMed Web of Science ®Google Scholar
• Jang A-S, Lee JH, Park SW, et al. Severe airway hyperresponsiveness in school-aged boys with a high body mass index. Korean J Intern Med. 2006;21(1):10–14.
   PubMedGoogle Scholar
• Hancox RJ, Milne BJ, Poulton R, et al. Sex differences in the relation between body mass index and asthma and atopy in a birth cohort. Am J Respir Crit Care Med. 2005;171(5):440–445.
   PubMed Web of Science ®Google Scholar
• Mansell AL, Walders N, Wamboldt MZ, et al. Effect of body mass index on response to methacholine bronchial provocation in healthy and asthmatic adolescents. Pediatr Pulmonol. 2006;41(5):434–440.
   PubMed Web of Science ®Google Scholar
• Salome CM, Munoz PA, Berend N, et al. Effect of obesity on breathlessness and airway responsiveness to methacholine in non-asthmatic subjects. Int J Obes (Lond). 2008;32(3):502–509.
   PubMed Web of Science ®Google Scholar
• European Community Respiratory Health S, Chinn S, Jarvis D, Burney P. Relation of bronchial responsiveness to body mass index in the ECRHS. European Community Respiratory Health Survey. Thorax. 2002;57(12):1028–1033.
   PubMed Web of Science ®Google Scholar
• Sood A, Verhulst SJ, Varma A, et al. Association of excess weight and degree of airway responsiveness in asthmatics and non-asthmatics. J Asthma. 2006;43(6):447–452.
   PubMed Web of Science ®Google Scholar
• Bustos P, Amigo H, Oyarzún M, et al. Is there a causal relation between obesity and asthma? Evidence from Chile. Int J Obes (Lond). 2005;29(7):804–809.
   PubMed Web of Science ®Google Scholar
• Consilvio NP, Di Pillo S, Verini M, et al. The reciprocal influences of asthma and obesity on lung function testing, AHR, and airway inflammation in prepubertal children. Pediatr Pulmonol. 2010;45(11):1103–1110.
   PubMed Web of Science ®Google Scholar
• van Veen WJ, Driessen JMM, Kersten ETG, et al. BMI predicts exercise induced bronchoconstriction in asthmatic boys. Pediatr Pulmonol. 2017;52(9):1130–1134.
   PubMed Web of Science ®Google Scholar
• Hansen D, Marinus N, Remans M, et al. Exercise tolerance in obese vs. lean adolescents: a systematic review and meta-analysis. Obes Rev. 2014;15(11):894–904.
   PubMed Web of Science ®Google Scholar
• Arena R, Cahalin LP. Evaluation of cardiorespiratory fitness and respiratory muscle function in the obese population. Prog Cardiovasc Dis. 2014;56(4):457–464.
   PubMed Web of Science ®Google Scholar
• Shim YM, Burnette A, Lucas S, et al. Physical deconditioning as a cause of breathlessness among obese adolescents with a diagnosis of asthma. PLoS ONE. 2013;8(4):e61022.
   PubMed Web of Science ®Google Scholar
• Marinus N, Bervoets L, Massa G, et al. Altered gas-exchange at peak exercise in obese adolescents: implications for verification of effort during cardiopulmonary exercise testing. J Sports Med Phys Fitness. 2017;57(12):1687–1694.
   PubMed Web of Science ®Google Scholar
• Shin YH, Yoon JW, Choi SH, et al. Use of impulse oscillometry system in assessment of asthma severity for preschool children. J Asthma. 2013;50(2):198–203.
   PubMed Web of Science ®Google Scholar
• Komarow HD, Skinner J, Young M, et al. A study of the use of impulse oscillometry in the evaluation of children with asthma: analysis of lung parameters, order effect, and utility compared with spirometry. Pediatr Pulmonol. 2012;47(1):18–26.
   PubMed Web of Science ®Google Scholar
• Galant SP, Komarow HD, Shin H-W, et al. The case for impulse oscillometry in the management of asthma in children and adults. Ann Allergy Asthma Immunol. 2017;118(6):664–671.
   PubMed Web of Science ®Google Scholar
• Ekström S, Hallberg J, Kull I, et al. Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study. Thorax. 2018;73(6):538–545.
   PubMed Web of Science ®Google Scholar
• Lauhkonen E, Koponen P, Nuolivirta K, et al. Obesity and bronchial obstruction in impulse oscillometry at age 5-7 years in a prospective post-bronchiolitis cohort. Pediatr Pulmonol. 2015;50(9):908–914.
   PubMed Web of Science ®Google Scholar
• Jones MH, Roncada C, Fernandes MTC, et al. Asthma and obesity in children are independently associated with airway dysanapsis. Front Pediatr. 2017;5:270.
   PubMed Web of Science ®Google Scholar
• Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011;184(5):602–615.
   PubMed Web of Science ®Google Scholar
• Cardinale F, de Benedictis FM, Muggeo V, et al. Exhaled nitric oxide, total serum IgE and allergic sensitization in childhood asthma and allergic rhinitis. Pediatr Allergy Immunol. 2005;16(3):236–242.
   PubMed Web of Science ®Google Scholar
• Cibella F, Cuttitta G, La Grutta S, et al. Factors that influence exhaled nitric oxide in Italian schoolchildren. Ann Allergy Asthma Immunol. 2008;101(4):407–412.
   PubMed Web of Science ®Google Scholar
• Santamaria F, Montella S, De Stefano S, et al. Relationship between exhaled nitric oxide and body mass index in children and adolescents. J Allergy Clin Immunol. 2005;116(5): 1163–1164. author reply 4-5.
   PubMed Web of Science ®Google Scholar
• Erkoçoğlu M, Kaya A, Ozcan C, et al. The effect of obesity on the level of fractional exhaled nitric oxide in children with asthma. Int Arch Allergy Immunol. 2013;162(2):156–162.
   PubMed Web of Science ®Google Scholar
• Casas M, Den Dekker HT, Kruithof CJ, et al. Early childhood growth patterns and school-age respiratory resistance, fractional exhaled nitric oxide and asthma. Pediatr Allergy Immunol. 2016;27(8):854–860.
   PubMed Web of Science ®Google Scholar
• Yao T-C, Tsai H-J, Chang S-W, et al. Obesity disproportionately impacts lung volumes, airflow and exhaled nitric oxide in children. PLoS ONE. 2017;12(4):e0174691.
   PubMed Web of Science ®Google Scholar
• Leung TF, Li CY, Lam CWK, et al. The relation between obesity and asthmatic airway inflammation. Pediatr Allergy Immunol. 2004;15(4):344–350.
   PubMed Web of Science ®Google Scholar
• Chow JSW, Leung ASM, Li WWS, et al. Airway inflammatory and spirometric measurements in obese children. Hong Kong Med J. 2009;15(5):346–352.
   PubMedGoogle Scholar
• Linn WS, Rappaport EB, Berhane KT, et al. Exhaled nitric oxide in a population-based study of southern California schoolchildren. Respir Res. 2009;10:28.
   PubMed Web of Science ®Google Scholar
• Jensen ME, Gibson PG, Collins CE, et al. Airway and systemic inflammation in obese children with asthma. Eur Respir J. 2013;42(4):1012–1019.
   PubMed Web of Science ®Google Scholar
• Szefler SJ, Mitchell H, Sorkness CA, et al. Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet. 2008;372(9643):1065–1072.
   PubMed Web of Science ®Google Scholar
• Cibella F, Cuttitta G, La Grutta S, et al. A cross-sectional study assessing the relationship between BMI, asthma, atopy, and eNO among schoolchildren. Ann Allergy Asthma Immunol. 2011 Oct;107(4):330–336.
   PubMed Web of Science ®Google Scholar
• Kim C-K, Koh YY, Callaway Z. The validity of induced sputum and bronchoalveolar lavage in childhood asthma. J Asthma. 2009;46(2):105–112.
   PubMed Web of Science ®Google Scholar
• Murugan A, Prys-Picard C, Calhoun WJ. Biomarkers in asthma. Curr Opin Pulm Med. 2009;15(1):12–18.
   PubMed Web of Science ®Google Scholar
• Busse WW. Biological treatments for severe asthma: where do we stand? Curr Opin Allergy Clin Immunol. 2018;18(6):509–518.
   PubMed Web of Science ®Google Scholar
• Marques P, Limbert C, Oliveira L, et al. Metformin effectiveness and safety in the management of overweight/obese nondiabetic children and adolescents: metabolic benefits of the continuous exposure to metformin at 12 and 24 months. Int J Adolesc Med Health. 2016;29(5).
   PubMedGoogle Scholar
• Calixto MC, Lintomen L, André DM, et al. Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. PLoS ONE. 2013;8(10):e76786.
   PubMed Web of Science ®Google Scholar