Endocrine disrupting chemicals: strategies to protect present and future generations

References

• Zoeller RT, Brown TR, Doan LL, et al. Endocrine-disrupting chemicals and public health protection: a statement of principles from the endocrine society. Endocrinology. 2012;153(9):4097–4110.
   PubMed Web of Science ®Google Scholar
• Zoeller RT, Bergman A, Becher G, et al. A path forward in the debate over health impacts of endocrine disrupting chemicals. Environ Health. 2014;13(1):118.
   PubMedGoogle Scholar
• Schug TT, Abagyan R, Blumberg B, et al. Designing endocrine disruption out of the next generation of chemicals. Green Chem. 2013;15(1):181–198.
   PubMed Web of Science ®Google Scholar
• Collins TJ. Persuasive Communication about matters of great urgency: endocrine disruption. Environ Sci Technol. 2008;42(20):7555–7558.
   PubMed Web of Science ®Google Scholar
• Khetan SK, Collins TJ. Human pharmaceuticals in the aquatic environment:  a challenge to green chemistry. Chem Rev. 2007;107(6):2319–2364.
   PubMed Web of Science ®Google Scholar
• Kolok AS, Ali JM, Rogan EG, et al. The fate of synthetic and endogenous hormones used in the US beef and dairy industries and the potential for human exposure. Curr Environ Health Rep. 2018;5(2):225–232.
   PubMedGoogle Scholar
• Colborn T, Vom Saal FS, Soto AM. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect. 1993;101(5):378–384.
   PubMed Web of Science ®Google Scholar
• Sonnenschein C, Soto AM. An updated review of environmental estrogen and androgen mimics and antagonists. J Steroid Biochem Mol Biol. 1998;65(1–6):143–150.
   PubMed Web of Science ®Google Scholar
• Bigsby R, Chapin RE, Daston GP, et al. Evaluating the effects of endocrine disruptors on endocrine function during development. Environ Health Perspect. 1999;107 Suppl 4(Suppl 4):613–618.
   PubMedGoogle Scholar
• Kavlock RJ, Daston GP, DeRosa C. Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of theU.S. EPA-sponsored workshop. Environ Health Perspect. 1996;104:715–740.
   PubMed Web of Science ®Google Scholar
• Andersen HR, Andersson AM, Arnold SF, et al. Comparison of short-term estrogenicity tests for identification of hormone-disrupting chemicals. Environ Health Perspect. 1999;107(Suppl 1):89–108.
   PubMed Web of Science ®Google Scholar
• Soto AM, Fernandez MF, Luizzi MF, et al. Developing a marker of exposure to xenoestrogen mixtures in human serum. Environ Health Perspect. 1997;105 Suppl 3:647–654.
   PubMed Web of Science ®Google Scholar
• NTP. National toxicology program’s report of the endocrine disruptors low dose peer review. 2001; http://ntp.niehs.nih.gov/ntp/htdocs/liason/LowDosePeerFinalRpt.pdf.
   Google Scholar
• Melnick R, Lucier G, Wolfe M, et al. Summary of the national toxicology program’s report of the endocrine disruptors low-dose peer review. Environ Health Perspect. 2002;110(4):427–431.
   PubMedGoogle Scholar
• Damstra T, Barlow S, Bergman A, et al., eds. Global assessment of the state-of-the-science of endocrine disruptors. Geneva, Switzerland: World Health Organization; 2002.
   Google Scholar
• (IPCS) IPoCS. IPCS risk assessment terminology: world Health Organization. WHO Document Production Services: Geneva; 2004.
   Google Scholar
• Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, et al. Endocrine-disrupting chemicals: an endocrine society scientific statement. Endocr Rev. 2009;30:293–342.
   PubMed Web of Science ®Google Scholar
• Bergman Å, Heindel J, Jobling S, et al., eds. The state-of-the-science of endocrine disrupting chemicals. Geneva: UNEP/WHO; 2012. available from: http://www.who.int/iris/bitstream/10665/78101/1/9789241505031_eng.pdf
   Google Scholar
• Bergman Å, Heindel JJ, Jobling S, et al., Organization WH. State of the science of endocrine disrupting chemicals 2012: summary for decision-makers. 2013;
   Google Scholar
• Gore AC, Chappell VA, Fenton SE, et al. EDC-2: the Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015;36:E1–150.
   PubMed Web of Science ®Google Scholar
• Gore AC, Chappell VA, Fenton SE, et al. Executive summary to EDC-2: the Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015;36(6):593–602.
   PubMed Web of Science ®Google Scholar
• La Merrill MA, Vandenberg LN, Smith MT, et al. Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification. Nat Rev Endocrinol. 2020;16(1):45–57.
   PubMed Web of Science ®Google Scholar
• Smith MT, Guyton KZ, Gibbons CF, et al. Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis. Environ Health Perspect. 2016;124(6):713–721.
   PubMed Web of Science ®Google Scholar
• Smith MT, Guyton KZ, Kleinstreuer N, et al. The key characteristics of carcinogens: relationship to the hallmarks of cancer, relevant biomarkers, and assays to measure them. Cancer Epidemiol Biomarkers Prev. 2020;29(10):1887–1903.
   PubMed Web of Science ®Google Scholar
• Arzuaga X, Smith MT, Gibbons CF, et al. Proposed key characteristics of male reproductive toxicants as an approach for organizing and evaluating mechanistic evidence in human health hazard assessments. Environ Health Perspect. 2019;127(6):65001.
   PubMed Web of Science ®Google Scholar
• Luderer U, Eskenazi B, Hauser R, et al. Proposed key characteristics of female reproductive toxicants as an approach for organizing and evaluating mechanistic data in hazard assessment. Environ Health Perspect. 2019;127(7):75001.
   PubMed Web of Science ®Google Scholar
• Zoeller RT. Challenges confronting risk analysis of potential thyroid toxicants. Risk Anal. 2003;23(1):143–162.
   PubMed Web of Science ®Google Scholar
• Paroder-Belenitsky M, Maestas MJ, Dohán O, et al. Mechanism of anion selectivity and stoichiometry of the Na+/I-symporter (NIS). Proc Nat Acad Sci. 2011;108(44):17933–17938.
   PubMed Web of Science ®Google Scholar
• Niziński P, Błażewicz A, Kończyk J, et al. Perchlorate - properties, toxicity and human health effects: an updated review. Rev Environ Health. 2020. DOI:10.1515/reveh-2020-0006
   PubMedGoogle Scholar
• Leung AM, Pearce EN, Braverman LE. Perchlorate, iodine and the thyroid. Best Pract Res Clin Endocrinol Metab. 2010;24(1):133–141.
   PubMed Web of Science ®Google Scholar
• Vandenberg LN, Hunt PA, Gore AC. Endocrine disruptors and the future of toxicology testing - lessons from CLARITY-BPA. Nat Rev Endocrinol. 2019;15(6):366–374.
   PubMed Web of Science ®Google Scholar
• Myers JP, Zoeller RT, Vom Saal FS. A clash of old and new scientific concepts in toxicity, with important implications for public health. Environ Health Perspect. 2009;117(11):1652–1655.
   PubMed Web of Science ®Google Scholar
• Zoeller RT. Regulation of endocrine-disrupting chemicals insufficient to safeguard public health. J Clin Endocrinol Metab. 2014;99(6):1993–1994.
   PubMed Web of Science ®Google Scholar
• Judson RS, Magpantay FM, Chickarmane V, et al. Integrated model of chemical perturbations of a biological pathway using 18 in vitro high-throughput screening assays for the estrogen receptor. toxicol sci. 2015;148(1):137–154.
   PubMed Web of Science ®Google Scholar
• Judson RS, Houck KA, Watt ED, et al. On selecting a minimal set of in vitro assays to reliably determine estrogen agonist activity. Regul Toxicol Pharmacol. 2017;91:39–49.
   PubMed Web of Science ®Google Scholar
• Cariati F, Carbone L, Conforti A, et al. Bisphenol A-induced epigenetic changes and its effects on the male reproductive system. Front Endocrinol (Lausanne). 2020;11:453.
   PubMed Web of Science ®Google Scholar
• Akash MSH, Sabir S, Rehman K. Bisphenol A-induced metabolic disorders: from exposure to mechanism of action. Environ Toxicol Pharmacol. 2020;77:103373.
   PubMed Web of Science ®Google Scholar
• Cimmino I, Fiory F, Perruolo G, et al. Potential mechanisms of bisphenol A (BPA) contributing to human disease. Int J Mol Sci. 2020;21(16):21.
   Web of Science ®Google Scholar
• Vandenberg LN. Low dose effects challenge the evaluation of endocrine disrupting chemicals. Trends Food SciTechnol. 2019;84:58–61.
   Web of Science ®Google Scholar
• Nohynek GJ, Borgert CJ, Dietrich D, et al. Endocrine disruption: fact or urban legend? Toxicol Lett. 2013;223(3):295–305.
   PubMed Web of Science ®Google Scholar
• Krewski D, Al-Zoughool M, Bird M, et al. Analysis of key characteristics of human carcinogens. Tumour site concordance and mechanisms of carcinogenesis Lyon. IARC Scientific Publication; 2019. p. 257–282.
   Google Scholar
• Kassotis CD, Vandenberg LN, Demeneix B, et al. Endocrine Disrupting Chemicals: economic, regulatory, and policy implications. Lancet Diabetes Endocrinol. 2020;8(8):719–730.
   PubMed Web of Science ®Google Scholar
• Heindel JJ, Vandenberg LN. Developmental origins of health and disease: a paradigm for understanding disease etiology and prevention. Curr Opin Pediatr. 2015;27(2):248–253.
   PubMed Web of Science ®Google Scholar
• McLachlan JA. Environmental signaling: what embryos and evolution teach us about endocrine disrupting chemicals. Endocr Rev. 2001;22(3):319–341.
   PubMed Web of Science ®Google Scholar
• McLachlan JA. Commentary: prenatal exposure to diethylstilbestrol (DES): a continuing story. Int J Epidemiol. 2006;35(4):868–870.
   PubMed Web of Science ®Google Scholar
• Newbold RR. Lessons learned from perinatal exposure to diethylstilbestrol. Toxicol Appl Pharmacol. 2004;199(2):142–150.
   PubMed Web of Science ®Google Scholar
• McLachlan JA, Newbold RR, Burow ME, et al. From malformations to molecular mechanisms in the male: three decades of research on endocrine disrupters. APMIS. 2001;109(4):263–272.
   PubMed Web of Science ®Google Scholar
• Diethylstilbestrol (DES): also harms the third generation. Prescrire international 2016; 25:294–298
   Google Scholar
• Titus L, Hatch EE, Drake KM, et al. Reproductive and hormone-related outcomes in women whose mothers were exposed in utero to diethylstilbestrol (DES): a report from the US National Cancer Institute DES Third Generation Study. Reprod Toxicol. 2019;84:32–38.
   PubMed Web of Science ®Google Scholar
• Newbold RR, Padilla-Banks E, Jefferson WN. Adverse effects of the model environmental estrogen diethylstilbestrol are transmitted to subsequent generations. Endocrinology. 2006;147(6):S11–17.
   PubMed Web of Science ®Google Scholar
• Grandjean P, Barouki R, Bellinger DC, et al. Life-long implications of developmental exposure to environmental stressors: new perspectives. Endocrinology. 2015;156(10):3408–3415.
   PubMed Web of Science ®Google Scholar
• Heindel JJ, Balbus J, Birnbaum L. Developmental origins of health and disease: integrating environmental influences. Endocrinology. 2015;156(10):3416–3421.
   PubMed Web of Science ®Google Scholar
• Heindel JJ, Skalla LA, Joubert BR, et al. Review of developmental origins of health and disease publications in environmental epidemiology. Reprod Toxicol. 2017;68:34–48.
   PubMed Web of Science ®Google Scholar
• Patisaul HB, Adewale HB. Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior. Front Behav Neurosci. 2009;3:10.
   PubMed Web of Science ®Google Scholar
• Vandenberg LN, Najmi A, Mogus JP. Agrochemicals with estrogenic endocrine disrupting properties: lessons Learned? Mol Cell Endocrinol. 2020;518:110860.
   PubMed Web of Science ®Google Scholar
• Cohn BA, La Merrill M, Krigbaum NY, et al. DDT exposure in utero and breast cancer. J Clin Endocrinol Metab. 2015;100(8):2865–2872.
   PubMed Web of Science ®Google Scholar
• Krigbaum NY, Cirillo PM, Flom JD, et al. In utero DDT exposure and breast density before age 50. Reprod Toxicol. 2020;92:85–90.
   Web of Science ®Google Scholar
• La Merrill MA, Krigbaum NY, Cirillo PM, et al. Association between maternal exposure to the pesticide dichlorodiphenyltrichloroethane (DDT) and risk of obesity in middle age. Int J Obes (Lond). 2020;44(8):1723–1732.
   PubMed Web of Science ®Google Scholar
• Wilson JD, George FW, Griffin JE. The hormonal control of sexual development. Science. 1981;211(4488):1278–1284.
   PubMed Web of Science ®Google Scholar
• Siemienowicz KJ, Filis P, Shaw S, et al. Fetal androgen exposure is a determinant of adult male metabolic health. Sci Rep. 2019;9(1):20195.
   PubMedGoogle Scholar
• Recabarren SE, Smith R, Rios R, et al. Metabolic profile in sons of women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2008;93(5):1820–1826.
   PubMed Web of Science ®Google Scholar
• Skakkebaek NE, Rajpert-De Meyts E, Buck Louis GM, et al. Male reproductive disorders and fertility trends: influences of environment and genetic susceptibility. Physiol Rev. 2016;96(1):55–97.
   PubMed Web of Science ®Google Scholar
• Cooper DB, Mahdy H. Oral Contraceptive Pills. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2021, StatPearls Publishing LLC.; 2021.
   Google Scholar
• Mikkelsen EM, Riis AH, Wise LA, et al. Pre-gravid oral contraceptive use and time to pregnancy: a Danish prospective cohort study. Hum Reprod. 2013;28(5):1398–1405.
   PubMed Web of Science ®Google Scholar
• Terry MB, Michels KB, Brody JG, et al. Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research. Breast Cancer Res. 2019;21(1):96.
   PubMed Web of Science ®Google Scholar
• Macon MB, Fenton SE. Endocrine disruptors and the breast: early life effects and later life disease. J Mammary Gland Biol Neoplasia. 2013;18(1):43–61.
   PubMed Web of Science ®Google Scholar
• Paulose T, Speroni L, Sonnenschein C, et al. Estrogens in the wrong place at the wrong time: fetal BPA exposure and mammary cancer. Reprod Toxicol. 2015;54:58–65.
   PubMed Web of Science ®Google Scholar
• Kolla S, Morcos M, Martin B, et al. Low dose bisphenol S or ethinyl estradiol exposures during the perinatal period alter female mouse mammary gland development. Reprod Toxicol. 2018;78:50–59.
   PubMed Web of Science ®Google Scholar
• Matouskova K, Jerry DJ, Vandenberg LN. Exposure to low doses of oxybenzone during perinatal development alters mammary gland morphology in male and female mice. Reprod Toxicol. 2020;92:66–77.
   PubMed Web of Science ®Google Scholar
• Catanese MC, Vandenberg LN. Bisphenol S (BPS) alters maternal behavior and brain in mice exposed during pregnancy/lactation and their daughters. Endocrinology. 2017;158(3):516–530.
   PubMed Web of Science ®Google Scholar
• LaPlante CD, Catanese MC, Bansal R, et al. Bisphenol S alters the lactating mammary gland and nursing behaviors in mice exposed during pregnancy and lactation. Endocrinology. 2017;158(10):3448–3461.
   PubMed Web of Science ®Google Scholar
• LaPlante CD, Bansal R, Dunphy KA, et al. Oxybenzone alters mammary gland morphology in mice exposed during pregnancy and lactation. J Endocr Soc. 2018;2(8):903–921.
   PubMed Web of Science ®Google Scholar
• Garcia-Arevalo M, Alonso-Magdalena P, Rebelo Dos Santos J, et al. Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice. PLoS One. 2014;9(6):e100214.
   PubMed Web of Science ®Google Scholar
• Alonso-Magdalena P, Garcia-Arevalo M, Quesada I, et al. Bisphenol-A treatment during pregnancy in mice: a new window of susceptibility for the development of diabetes in mothers later in life. Endocrinology. 2015;156:1659–1670.
   PubMed Web of Science ®Google Scholar
• Catanese MC, Suvorov A, Vandenberg LN. Beyond a means of exposure: a new view of the mother in toxicology research. Toxicol Res. 2015;4(3):592–612.
   Web of Science ®Google Scholar
• Boardman HM, Hartley L, Eisinga A, et al. Hormone therapy for preventing cardiovascular disease in post‐menopausal women. Cochrane Database Syst Rev. 2015. DOI:10.1002/14651858.CD002229.pub4
   PubMed Web of Science ®Google Scholar
• Writing Group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. Jama. 2002;288(3):321–333.
   PubMed Web of Science ®Google Scholar
• Langer RD, Hodis HN, Lobo RA, et al. Hormone replacement therapy - where are we now? Climacteric. 2021;24(1):3–10.
   PubMed Web of Science ®Google Scholar
• Díaz Santana MV, Hankinson SE, Bigelow C, et al. Urinary concentrations of phthalate biomarkers and weight change among postmenopausal women: a prospective cohort study. Environ Health. 2019;18(1):20.
   PubMedGoogle Scholar
• Lucaccioni L, Trevisani V, Marrozzini L, et al. Endocrine-disrupting chemicals and their effects during female puberty: a review of current evidence. Int J Mol Sci. 2020;21(6):2078.
   Web of Science ®Google Scholar
• Fudvoye J, Lopez-Rodriguez D, Franssen D, et al. Endocrine disrupters and possible contribution to pubertal changes. Best Pract Res Clin Endocrinol Metab. 2019;33(3):101300.
   PubMed Web of Science ®Google Scholar
• Bergman A, Heindel JJ, Kasten T. The impact of endocrine disruption: a consensus statement on the state of the science. Environ Health Perspect. 2013;121(4):A104–A106.
   PubMed Web of Science ®Google Scholar
• Judson RS, Houck KA, Kavlock RJ, et al. In vitro screening of environmental chemicals for targeted testing prioritization: the toxcast project. Environ Health Perspect. 2010;118(4):485–492.
   PubMed Web of Science ®Google Scholar
• Sipes NS, Wambaugh JF, Pearce R, et al. An intuitive approach for predicting potential human health risk with the tox21 10k library. Environ Sci Technol. 2017;51(18):10786–10796.
   PubMed Web of Science ®Google Scholar
• OCDE. General guidance on endocrine assessment: assays and endpoints. https://www.oecd-ilibrary.org/content/component/9789264304741-2-en
   Google Scholar
• Ohta R, Takagi A, Ohmukai H, et al. Ovariectomized mouse uterotrophic assay of 36 chemicals. J Toxicol Sci. 2012;37(5):879–889.
   PubMed Web of Science ®Google Scholar
• Borgert CJ, Mihaich EM, Quill TF, et al. Evaluation of EPA’s Tier 1 Endocrine Screening Battery and recommendations for improving the interpretation of screening results. Regul Toxicol Pharmacol. 2011;59(3):397–411.
   PubMed Web of Science ®Google Scholar
• OCDE. Extended One-Generation Reproductive Toxicity Study (EOGRTS) (OECD TG 443).
   Google Scholar
• Beronius A, Johansson N, Ruden C, et al. The influence of study design and sex-differences on results from developmental neurotoxicity studies of bisphenol A, implications for toxicity testing. Toxicology. 2013;311(1–2):13–26.
   PubMed Web of Science ®Google Scholar
• Gore AC, Martien KM, Gagnidze K, et al. Implications of prenatal steroid perturbations for neurodevelopment, behavior, and autism. Endocr Rev. 2014;35(6):961–991.
   PubMed Web of Science ®Google Scholar
• Rudel RA, Fenton SE, Ackerman JM, et al. Environmental exposures and mammary gland development: state of the science, public health implications, and research recommendations. Environ Health Perspect. 2011;119(8):1053–1061.
   PubMed Web of Science ®Google Scholar
• Birnbaum LS, Bucher JR, Collman GW, et al. Consortium-based science: the NIEHS’s multipronged, collaborative approach to assessing the health effects of Bisphenol A. Environ Health Perspect. 2012;120(12):1640–1644.
   PubMed Web of Science ®Google Scholar
• Schug TT, Heindel JJ, Camacho L, et al. A new approach to synergize academic and guideline-compliant research: the CLARITY-BPA research program. Reprod Toxicol. 2013;40:35–40.
   PubMed Web of Science ®Google Scholar
• Heindel JJ, Newbold RR, Bucher JR, et al. NIEHS/FDA CLARITY-BPA research program update. Reprod Toxicol. 2015;58:33–44.
   PubMed Web of Science ®Google Scholar
• Prins GS, Patisaul HB, Belcher SM, et al. CLARITY-BPA academic laboratory studies identify consistent low-dose Bisphenol A effects on multiple organ systems. Basic Clin Pharmacol Toxicol. 2019;125(Suppl 3):14–31.
   PubMedGoogle Scholar
• Camacho L, Lewis SM, Vanlandingham MM, et al. A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results. Food Chem Toxicol. 2019;132:110728.
   PubMed Web of Science ®Google Scholar
• Vandenberg LN, Prins GS, Patisaul HB, et al. The use and misuse of historical controls in regulatory toxicology: lessons from the CLARITY-BPA Study. Endocrinology. 2020;161(5):bqz014.
   PubMed Web of Science ®Google Scholar
• Vom Saal FS. Flaws in design, execution and interpretation limit CLARITY-BPA’s value for risk assessments of bisphenol A. Basic Clin Pharmacol Toxicol. 2019;125(Suppl 3):32–43.
   PubMedGoogle Scholar
• Vom Saal FS, Vandenberg LN. Update on the health effects of bisphenol A: overwhelming evidence of harm. Endocrinology. 2021162(3):bqaa171.
   PubMed Web of Science ®Google Scholar
• Heindel JJ, Belcher S, Flaws JA, et al. Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies. Reprod Toxicol. 2020;98:29–60; S0890-6238(0820)30150-30157.
   PubMed Web of Science ®Google Scholar
• Rochester JR. Bisphenol A and human health: a review of the literature. Reprod Toxicol. 2013;42:132–155.
   PubMed Web of Science ®Google Scholar
• Bao W, Liu B, Rong S, et al. Association between bisphenol A exposure and risk of all-cause and cause-specific mortality in US adults. JAMA Network Open. 2020;3(8):e2011620.
   PubMed Web of Science ®Google Scholar
• Kassotis CD, Iwanowicz LR, Akob DM, et al. Endocrine disrupting activities of surface water associated with a West Virginia oil and gas industry wastewater disposal site. Sci Total Environ. 2016;557-558:901–910.
   PubMed Web of Science ®Google Scholar
• Kassotis CD, Klemp KC, Vu DC, et al. Endocrine-disrupting activity of hydraulic fracturing chemicals and adverse health outcomes after prenatal exposure in male mice. Endocrinology. 2015;156(12):4458–4473.
   PubMed Web of Science ®Google Scholar
• Kassotis CD, Bromfield JJ, Klemp KC, et al. Adverse reproductive and developmental health outcomes following prenatal exposure to a hydraulic fracturing chemical mixture in female C57Bl/6 Mice. Endocrinology. 2016;157(9):3469–3481.
   PubMed Web of Science ®Google Scholar
• Boule LA, Chapman TJ, Hillman SE, et al. Developmental exposure to a mixture of 23 chemicals associated with unconventional oil and gas operations alters the immune system of mice. Toxicol Sci. 2018;163(2):639–654.
   PubMed Web of Science ®Google Scholar
• Sapouckey SA, Kassotis CD, Nagel SC, et al. Prenatal exposure to unconventional oil and gas operation chemical mixtures altered mammary gland development in adult female mice. Endocrinology. 2018;159(3):1277–1289.
   PubMed Web of Science ®Google Scholar
• Balise VD, Cornelius-Green JN, Kassotis CD, et al. Preconceptional, gestational, and lactational exposure to an unconventional oil and gas chemical mixture alters energy expenditure in adult female mice. Front Endocrinol (Lausanne). 2019;10:323.
   PubMed Web of Science ®Google Scholar
• Balise VD, Cornelius-Green JN, Parmenter B, et al. Developmental exposure to a mixture of unconventional oil and gas chemicals increased risk-taking behavior, activity and energy expenditure in aged female mice after a metabolic challenge. Front Endocrinol (Lausanne). 2019;10:460.
   PubMed Web of Science ®Google Scholar
• Nagel SC, Kassotis CD, Vandenberg LN, et al. Developmental exposure to a mixture of unconventional oil and gas chemicals: a review of experimental effects on adult health, behavior, and disease. Mol Cell Endocrinol. 2020;513:110722.
   PubMed Web of Science ®Google Scholar
• Kortenkamp A, Axelstad M, Baig AH, et al. Removing critical gaps in chemical test methods by developing new assays for the identification of thyroid hormone system-disrupting chemicals-the ATHENA project. Int J Mol Sci. 2020;21(9):3123.
   PubMed Web of Science ®Google Scholar
• Lupu D, Andersson P, Bornehag C-G, et al. The ENDpoiNTs project: novel testing strategies for endocrine disruptors linked to developmental neurotoxicity. Int J Mol Sci. 2020;21(11):21.
   Web of Science ®Google Scholar
• Duursen M, Boberg J, Christiansen S, et al. Safeguarding female reproductive health against endocrine disrupting chemicals-the FREIA Project. Int J Mol Sci. 2020;21(9). DOI:10.3390/ijms21093215
   PubMed Web of Science ®Google Scholar
• Legler J, Zalko D, Jourdan F, et al. The GOLIATH project: towards an internationally harmonised approach for testing metabolism disrupting compounds. Int J Mol Sci. 2020;21(10):3480.
   PubMed Web of Science ®Google Scholar
• Kolatorova Sosvorova L, Vitku J, Dusková M, et al. Endocrine disruptors. Diabetologie Metab Endokrinolog Vyziva. 2018;21:142–149.
   Google Scholar
• Di Renzo GC, Conry JA, Blake J, et al. International federation of gynecology and obstetrics opinion on reproductive health impacts of exposure to toxic environmental chemicals. Int J Gynaecol Obstet. 2015;131(3):219–225.
   PubMed Web of Science ®Google Scholar
• ACOG Committee Opinion, ASRM Committee Opinion, UCSF Program on Reproductive Health and the Environment. Exposure to toxic environmental agents. Fertil Steril. 2013;100(4):931–934.
   PubMed Web of Science ®Google Scholar
• Trasande L, Shaffer RM, Sathyanarayana S. Food Additives and Child Health. Pediatrics. 2018;142(2):e20181408.
   Google Scholar
• Bennett D, Bellinger DC, Birnbaum LS, et al., American College of O, Gynecologists, Child Neurology S, Endocrine S, International Neurotoxicology A, International Society for Children’s H, the E, International Society for Environmental E, National Council of Asian Pacific Islander P, National Hispanic Medical A, National Medical A. Project TENDR: targeting Environmental Neuro-Developmental Risks The TENDR Consensus Statement. Environ Health Perspect. 2016;124(7):A118–A122.
   PubMed Web of Science ®Google Scholar
• Lee MK, Blumberg B. Transgenerational effects of obesogens. Basic Clin Pharmacol Toxicol. 2019;125(Suppl 3):44–57.
   PubMedGoogle Scholar
• Skinner MK. Endocrine disruptor induction of epigenetic transgenerational inheritance of disease. Mol Cell Endocrinol. 2014;398(1–2):4–12.
   PubMed Web of Science ®Google Scholar
• Grandjean P, Abdennebi-Najar L, Barouki R, et al. Timescales of developmental toxicity impacting on research and needs for intervention. Basic Clin Pharmacol Toxicol. 2019;125(Suppl 3):70–80.
   PubMedGoogle Scholar
• Attina TM, Hauser R, Sathyanarayana S, et al. Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis. Lancet Diabetes Endocrinol. 2016;4(12):996–1003.
   PubMed Web of Science ®Google Scholar
• Trasande L, Zoeller RT, Hass U, et al. Burden of disease and costs of exposure to endocrine disrupting chemicals in the European Union: an updated analysis. Andrology. 2016;4(4):565–572.
   PubMed Web of Science ®Google Scholar