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Review

Early post-transplant hyperglycemia and post-transplant diabetes mellitus following heart transplantation

ORCID Icon, & ORCID Icon
Pages 129-140 | Received 07 Aug 2023, Accepted 15 Jan 2024, Published online: 22 Jan 2024

References

  • Newman JD, Schlendorf KH, Cox ZL, et al. Post-transplant diabetes mellitus following heart transplantation. J Heart Lung Transplant. 2022;41(11):1537–46. doi: 10.1016/j.healun.2022.07.011
  • Vest AR, Cherikh WS, Noreen SM, et al. New-onset diabetes mellitus after adult heart transplantation and the risk of renal dysfunction or mortality. Transplantation. 2022;106(1):178–187. doi: 10.1097/TP.0000000000003647
  • Kim HJ, Jung SH, Kim JJ, et al. New-onset diabetes mellitus after heart transplantation – incidence, risk factors and impact on clinical outcome. Circulation. 2017;81(6):806–814. doi: 10.1253/circj.CJ-16-0963
  • Zhang M, Han Y, Yuan Y, et al. Risk factors for new-onset diabetes mellitus after heart transplantation in Chinese patients: a single center experience. Ann Nutr Metab. 2019;74(4):331–8. doi: 10.1159/000500138
  • Sharif A, Hecking M, De Vries AP, et al. Proceedings from an international consensus meeting on posttransplantation diabetes mellitus: recommendations and future directions. Am J Transplant. 2014;14(9):1992–2000. doi: 10.1111/ajt.12850
  • Lund LH, Edwards LB, Dipchand AI, et al. The registry of the international society for heart and lung transplantation: thirty-third adult heart transplantation report—2016; focus theme: primary diagnostic indications for transplant. J Heart Lung Transplant. 2016;35(10):1158–1169. doi: 10.1016/j.healun.2016.08.017
  • Shah KS, Kittleson MM, Kobashigawa JA. Updates on heart transplantation. Curr Heart Fail Rep. 2019;16(5):150–156. doi: 10.1007/s11897-019-00432-3
  • ANZOD Registry. Section 12: deceased organ transplant outcome data. 2019 annual report. Adelaide (SA): Australia and New Zealand Dialysis and Transplant Registry; 2019.
  • ANZOD Registry. Section 7: deceased donor heart donation. 2022 annual report. Adelaide (SA): Australia and New Zealand Dialysis and Transplant Registry; 2022.
  • Munshi VN, Saghafian S, Cook CB, et al. Incidence, risk factors, and trends for postheart transplantation diabetes mellitus. Am J Cardiol. 2020;125(3):436–40. doi: 10.1016/j.amjcard.2019.10.054
  • Cehic MG, Nundall N, Greenfield JR, et al. Management strategies for posttransplant diabetes mellitus after heart transplantation: A review. J Transplant. 2018;2018:1–14. doi: 10.1155/2018/1025893
  • Zielińska K, Kukulski L, Wróbel M, et al. Prevalence and risk factors of new-onset diabetes after transplantation (NODAT). Ann Transplant. 2020;25:e926556. doi: 10.12659/AOT.926556
  • Chowdhury TA, Wahba M, Mallik R, et al. Association of British clinical diabetologists and renal association guidelines on the detection and management of diabetes post solid organ transplantation. Diabetic Med. 2021;38(6):e14523. doi: 10.1111/dme.14523
  • Iqbal A, Zhou K, Kashyap SR, et al. Early post-renal transplant hyperglycemia. J Clin Endocrinol Metab. 2021;107(2):549–562. doi: 10.1210/clinem/dgab697
  • Eide IA, Halden TAS, Hartmann A, et al. Limitations of hemoglobin A1c for the diagnosis of posttransplant diabetes mellitus. Transplantation. 2015;99(3):629–35. doi: 10.1097/TP.0000000000000376
  • Chakkera HA, Weil EJ, Castro J, et al. Hyperglycemia during the immediate period after kidney transplantation. Clin J Am Soc Nephrol. 2009;4(4):853–9. doi: 10.2215/CJN.05471008
  • Gupta S, Bansal S, Böckerman P. Does a rise in BMI cause an increased risk of diabetes?: evidence from India. PloS One. 2020;15(4):e0229716. doi: 10.1371/journal.pone.0229716
  • Park SC, Yoon YD, Jung HY, et al. Effect of transient post-transplantation hyperglycemia on the development of diabetes mellitus and transplantation outcomes in kidney transplant recipients. Transplant Proc. 2015;47(3):666–671. doi: 10.1016/j.transproceed.2014.11.053
  • Ling Q, Xu X, Xie H, et al. New-onset diabetes after liver transplantation: a national report from China liver transplant registry. Liver Int. 2016;36(5):705–12. doi: 10.1111/liv.13042
  • Kgosidialwa O, Blake K, O’Connell O, et al. Post-transplant diabetes mellitus associated with heart and lung transplant. Ir J Med Sci. 2020;189(1):185–189. doi: 10.1007/s11845-019-02068-7
  • Zhao T, Zhao Y, Zong A, et al. Association of body mass index and fasting plasma glucose concentration with post-transplantation diabetes mellitus in Chinese heart transplant recipients. J Int Med Res. 2020;48(3):1–13. doi: 10.1177/0300060520910629
  • Porrini EL, Díaz JM, Moreso F, et al. Clinical evolution of post-transplant diabetes mellitus. Nephrol Dialysis Transplantation. 2016;31(3):495–505. doi: 10.1093/ndt/gfv368
  • Feng KY, Henricksen EJ, Wayda B, et al. Impact of diabetes mellitus on clinical outcomes after heart transplantation. Clin Transplant. 2021;35(11):e14460. doi: 10.1111/ctr.14460
  • Raven LM, Muir CA, Macdonald PS, et al. Diabetes medication following heart transplantation: a focus on novel cardioprotective therapies—A joint review from endocrinologists and cardiologists. Acta Diabetol. 2022;60(4):471–80. doi: 10.1007/s00592-022-02018-3
  • Aouad LJ, Clayton P, Wyburn KR, et al. Evolution of glycemic control and variability after kidney transplant. Transplantation. 2018;102(9):1563–8. doi: 10.1097/TP.0000000000002155
  • Wang R, Zhang Y, Fan J, et al. Risk factors for new-onset diabetes mellitus after heart transplantation: a nomogram approach. Transplant Proc. 2022;54(3):762–768. doi: 10.1016/j.transproceed.2022.01.030
  • Sparks JD, Cantor RS, Pruitt E, et al. New‐onset diabetes after pediatric heart transplantation: a review of the pediatric heart transplant study. Pediatr Transplant. 2019;23(5):e13476. doi: 10.1111/petr.13476
  • Sehgal S, Bock MJ, Louks Palac H, et al. New-onset diabetes mellitus after heart transplantation in children – incidence and risk factors. Pediatr Transplant. 2016;20(7):963–969. doi: 10.1111/petr.12759
  • Xie L, Tang W, Wang X, et al. Pretransplantation risk factors associated with new-onset diabetes after living-donor kidney transplantation. Transplant Proc. 2016;48(10):3299–3302. doi: 10.1016/j.transproceed.2016.10.026
  • Shaked A, Loza B-L, Van Loon E, et al. Donor and recipient polygenic risk scores influence the risk of post-transplant diabetes. Nature Med. 2022;28(5):999–1005. doi: 10.1038/s41591-022-01758-7
  • McCaughan JA, McKnight AJ, Maxwell AP. Genetics of new-onset diabetes after transplantation. J Am Soc Nephrol. 2014;25(5):1037–49. doi: 10.1681/ASN.2013040383
  • Hsu WC, Araneta MRG, Kanaya AM, et al. BMI cut points to identify at-risk Asian Americans for type 2 diabetes screening. Diabetes Care. 2015;38(1):150–8. doi: 10.2337/dc14-2391
  • Ferrannini E, Natali A, Bell P, et al. Insulin resistance and hypersecretion in obesity. European group for the study of insulin resistance (EGIR). J Clin Investig. 1997;100(5):1166–73. doi: 10.1172/JCI119628
  • Lee MJ, Park JT, Park KS, et al. Normal body mass index with central obesity has increased risk of coronary artery calcification in Korean patients with chronic kidney disease. Kidney Int. 2016;90(6):1368–76. doi: 10.1016/j.kint.2016.09.011
  • Cao Q, Yu S, Xiong W, et al. Waist-hip ratio as a predictor of myocardial infarction risk: a systematic review and meta-analysis. Medicine. 2018;97(30):e11639. doi: 10.1097/MD.0000000000011639
  • Gwon JG, Choi J, Jung CW, et al. Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes. Sci Rep. 2021;11(1):783. doi: 10.1038/s41598-020-80266-5
  • Pinar U, Rod X, Mageau A, et al. Surgical complications risk in obese and overweight recipients for kidney transplantation: a predictive morphometric model based on sarcopenia and vessel-to-skin distance. World J Urol. 2021;39(6):2223–2230. doi: 10.1007/s00345-020-03407-5
  • Oniscu GC, Abramowicz D, Bolignano D, et al. Management of obesity in kidney transplant candidates and recipients: a clinical practice guideline by the DESCARTES working group of ERA. Nephrol Dialysis Transplantation. 2021;37(Supplement_1):1–15. doi: 10.1093/ndt/gfab310
  • Tamez-Pérez HE. Steroid hyperglycemia: prevalence, early detection and therapeutic recommendations: a narrative review. World J Diabetes. 2015;6(8):1073. doi: 10.4239/wjd.v6.i8.1073
  • BioRender. Created with BioRender.com. Toronto (ON): BioRender; 2023.
  • Hecking M, Sharif A, Eller K, et al. Management of post‐transplant diabetes: immunosuppression, early prevention, and novel antidiabetics. Transplant Int. 2021;34(1):27–48. doi: 10.1111/tri.13783
  • Haller MC, Royuela A, Nagler EV, et al. Steroid avoidance or withdrawal for kidney transplant recipients. Cochrane Database Syst Rev. 2016;2016(8):CD005632. doi: 10.1002/14651858.CD005632.pub3
  • Thomusch O, Wiesener M, Opgenoorth M, et al. Rabbit-ATG or basiliximab induction for rapid steroid withdrawal after renal transplantation (harmony): an open-label, multicentre, randomised controlled trial. Lancet. 2016;388(10063):3006–16. doi: 10.1016/S0140-6736(16)32187-0
  • Midtvedt K, Hjelmesaeth J, Hartmann A, et al. Insulin resistance after renal transplantation: the effect of steroid dose reduction and withdrawal. J Am Soc Nephrol. 2004;15(12):3233–9. doi: 10.1097/01.ASN.0000145435.80005.1E
  • Dai C, Walker JT, Shostak A, et al. Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable. JCI Insight. 2020;5(1):e130770. doi: 10.1172/jci.insight.130770
  • Triñanes J, Rodriguez-Rodriguez AE, Brito-Casillas Y, et al. Deciphering tacrolimus-induced toxicity in pancreatic β cells. Am J Transplant. 2017;17(11):2829–40. doi: 10.1111/ajt.14323
  • Torres A, Hernández D, Moreso F, et al. Randomized controlled trial assessing the impact of tacrolimus versus cyclosporine on the incidence of posttransplant diabetes mellitus. Kidney Int Rep. 2018;3(6):1304–15. doi: 10.1016/j.ekir.2018.07.009
  • Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease. Cell. 2017;168(6):960–976. doi: 10.1016/j.cell.2017.02.004
  • Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, et al. Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing. Nat Commun. 2017;8(1):16014. doi: 10.1038/ncomms16014
  • Raven LM, Muir CA, Pouliopoulos J, et al. Metabolic sequelae of everolimus treatment after cardiac transplant: a hypothesis-generating study. Heart Lung & Circulation. 2023;32(9):1076–1079. doi: 10.1016/j.hlc.2023.05.014
  • Shivaswamy V, Boerner B, Larsen J. Post-transplant diabetes mellitus: causes, treatment, and impact on outcomes. Endocrine Reviews. 2016;37(1):37–61. doi: 10.1210/er.2015-1084
  • Schweer T, Gwinner W, Scheffner I, et al. High impact of rejection therapy on the incidence of post-transplant diabetes mellitus after kidney transplantation. Clin Transplant. 2014;28(4):512–9. doi: 10.1111/ctr.12329
  • Einollahi B, Motalebi M, Salesi M, et al. The impact of cytomegalovirus infection on new-onset diabetes mellitus after kidney transplantation: a review on current findings. J Nephropathol. 2014;3(4):139–148. doi: 10.12860/jnp.2014.27
  • Montefusco L, Ben Nasr M, D’Addio F, et al. Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection. Nat Metab. 2021;3(6):774–85. doi: 10.1038/s42255-021-00407-6
  • Xie Y, Xu E, Bowe B, et al. Long-term cardiovascular outcomes of COVID-19. Nature Med. 2022;28(3):583–90. doi: 10.1038/s41591-022-01689-3
  • Rizvi AA, Kathuria A, Al Mahmeed W, et al. Post-COVID syndrome, inflammation, and diabetes. J Diabetes Complications. 2022;36(11):108336. doi: 10.1016/j.jdiacomp.2022.108336
  • Peled Y, Ram E, Lavee J, et al. Hypomagnesemia is associated with new-onset diabetes mellitus following heart transplantation. Cardiovasc Diabetol. 2019;18(1):132. doi: 10.1186/s12933-019-0939-5
  • Han T, Lan L, Qu R, et al. Temporal relationship between hyperuricemia and insulin resistance and its impact on future risk of hypertension. Hypertension. 2017;70(4):703–11. doi: 10.1161/HYPERTENSIONAHA.117.09508
  • Chakkera HA, Knowler WC, Devarapalli Y, et al. Relationship between inpatient hyperglycemia and insulin treatment after kidney transplantation and future new onset diabetes mellitus. Clin J Am Soc Nephrol. 2010;5(9):1669–75. doi: 10.2215/CJN.09481209
  • Nagaraja P, Ravindran V, Morris-Stiff G, et al. Role of insulin resistance indices in predicting new-onset diabetes after kidney transplantation. Transplant Int. 2013;26(3):273–80. doi: 10.1111/tri.12026
  • Leon BM, Maddox TM. Diabetes and cardiovascular disease: epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015;6(13):1246–1258. doi: 10.4239/wjd.v6.i13.1246
  • Ram E, Lavee J, Tenenbaum A, et al. Metformin therapy in patients with diabetes mellitus is associated with a reduced risk of vasculopathy and cardiovascular mortality after heart transplantation. Cardiovasc Diabetol. 2019;18(1):118. doi: 10.1186/s12933-019-0925-y
  • Hahr AJ, Molitch ME. Management of diabetes mellitus in patients with chronic kidney disease. Clin Diabetes Endocrinol. 2015;1(1):2. doi: 10.1186/s40842-015-0001-9
  • Wallia A, Schmidt K, Oakes DJ, et al. Glycemic control reduces infections in post-liver transplant patients: results of a prospective, randomized study. J Clin Endocrinol Metab. 2017;102(2):451–459. doi: 10.1210/jc.2016-3279
  • Londero TM, Giaretta LS, Farenzena LP, et al. Microvascular complications of posttransplant diabetes mellitus in kidney transplant recipients: a longitudinal study. J Clin Endocrinol Metab. 2019;104(2):557–67. doi: 10.1210/jc.2018-01521
  • Burroughs TE, Swindle J, Takemoto S, et al. Diabetic complications associated with new-onset diabetes mellitus in renal transplant recipients. Transplantation. 2007;83(8):1027–34. doi: 10.1097/01.tp.0000259617.21741.95
  • Zinman B, Lachin JM, Empagliflozin IS. Cardiovascular Outcomes, and Mortality in Type 2 Diabetes. N Engl J Med. 2016;374(11):1094.
  • Marso SP, Bain SC, Consoli A, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016;375(19):1834–44. doi: 10.1056/NEJMoa1607141
  • American Diabetes Association. Introduction: standards of medical care in diabetes—2022. Diabetes Care. 2021;45(Supplement_1):S1–2. doi: 10.2337/dc22-Sint
  • Gosmanov AR, Dagogo-Jack S. Predicting, managing and preventing new-onset diabetes after transplantation. Minerva Endocrinol. 2012;37(3):233–246.
  • Hecking M, Haidinger M, Döller D, et al. Early basal insulin therapy decreases new-onset diabetes after renal transplantation. J Am Soc Nephrol. 2012;23(4):739–49. doi: 10.1681/ASN.2011080835
  • Schwaiger E, Krenn S, Kurnikowski A, et al. Early postoperative basal insulin therapy versus standard of care for the prevention of diabetes mellitus after kidney transplantation: a multicenter randomized trial. J Am Soc Nephrol. 2021;32(8):2083–98. doi: 10.1681/ASN.2021010127
  • Lo C, Toyama T, Oshima M, et al. Glucose-lowering agents for treating pre-existing and new-onset diabetes in kidney transplant recipients. Cochrane Database Syst Rev. 2020;2020(8): CD009966. doi: 10.1002/14651858.CD009966.pub3
  • Kuningas K, Driscoll J, Mair R, et al. Comparing glycaemic benefits of active versus passive lifestyle intervention in kidney allograft recipients: a randomized controlled trial. Transplantation. 2020;104(7):1491–99. doi: 10.1097/TP.0000000000002969
  • Squires RW, Bonikowske AR. Cardiac rehabilitation for heart transplant patients: considerations for exercise training. Prog Cardiovasc Dis. 2022;70:40–8. doi: 10.1016/j.pcad.2021.12.003
  • Costa R, Moreira E, Silva Cardoso J, et al. Effectiveness of exercise-based cardiac rehabilitation for heart transplant recipients: a systematic review and meta-analysis. Health Serv Insights. 2023;16:11786329231161482. doi: 10.1177/11786329231161482
  • Li J, Chong A, Carey S. Dietary interventions on the prevention and management of diabetes in post‐kidney transplantation – a systematic review. Nephrology. 2022;27(3):269–80. doi: 10.1111/nep.13982
  • Peled Y, Lavee J, Raichlin E, et al. Metformin therapy reduces the risk of malignancy after heart transplantation. J Heart Lung Transplant. 2017;36(12):1350–57. doi: 10.1016/j.healun.2017.06.009
  • Lipska KJ, Bailey CJ, Inzucchi SE. Use of metformin in the setting of mild-to-moderate renal insufficiency. Diabetes Care. 2011;34(6):1431–7. doi: 10.2337/dc10-2361
  • Muir CA, Greenfield JR, MacDonald PS. Empagliflozin in the management of diabetes mellitus after cardiac transplantation. J Heart Lung Transplant. 2017;36(8):914–6. doi: 10.1016/j.healun.2017.05.005
  • Cehic MG, Muir CA, Greenfield JR, et al. Efficacy and safety of Empagliflozin in the management of diabetes mellitus in heart transplant recipients. Transplant Direct. 2019;5(5):e450. doi: 10.1097/TXD.0000000000000885
  • Sammour Y, Nassif M, Magwire M, et al. Effects of GLP-1 receptor agonists and SGLT-2 inhibitors in heart transplant patients with type 2 diabetes: initial report from a cardiometabolic center of excellence. J Heart Lung Transplant. 2021;40(6):426–9. doi: 10.1016/j.healun.2021.02.012
  • Halden TAS, Kvitne KE, Midtvedt K, et al. Efficacy and safety of Empagliflozin in renal transplant recipients with posttransplant diabetes mellitus. Diabetes Care. 2019;42(6):1067–74. doi: 10.2337/dc19-0093
  • Zelniker TA, Braunwald E. Mechanisms of cardiorenal effects of sodium-glucose cotransporter 2 inhibitors: JACC state-of-the-art review. J Am Coll Cardiol. 2020;75(4):422–34. doi: 10.1016/j.jacc.2019.11.031
  • Azoulay L, Suissa S. Sulfonylureas and the risks of cardiovascular events and death: a methodological meta-regression analysis of the observational studies. Diabetes Care. 2017;40(5):706–14. doi: 10.2337/dc16-1943
  • Dalem J, Brouwers MCGJ, Stehouwer CDA, et al. Risk of hypoglycaemia in users of sulphonylureas compared with metformin in relation to renal function and sulphonylurea metabolite group: population based cohort study. BMJ. 2016;354:i3625. doi: 10.1136/bmj.i3625
  • Attallah N, Yassine L. Linagliptin in the management of type 2 diabetes mellitus after kidney transplant. Transplant Proc. 2021;53(7):2234–2237. doi: 10.1016/j.transproceed.2021.07.035
  • Haidinger M, Werzowa J, Hecking M, et al. Efficacy and safety of vildagliptin in new-onset diabetes after kidney transplantation—A randomized, double-blind, placebo-controlled trial. Am J Transplant. 2014;14(1):115–23. doi: 10.1111/ajt.12518
  • Raven LM, Muir CA, Kessler Iglesias C, et al. Sodium glucose co-transporter 2 inhibition with empagliflozin on metabolic, cardiac and renal outcomes in recent cardiac transplant recipients (EMPA-HTx): protocol for a randomised controlled trial. BMJ Open. 2023;13(3):e069641. doi: 10.1136/bmjopen-2022-069641

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