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Review

New insights into the progression from cutaneous lupus to systemic lupus erythematosus

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Pages 829-837 | Received 21 Jun 2020, Accepted 31 Jul 2020, Published online: 29 Sep 2020

References

  • Kuhn A, Schuppe HC, Ruzicka T, et al. Rare cutaneous manifestaions of lupus erythematosus. A clinical overview. Hautarzt. 2000;51(11):818–825.
  • Jin H, Zhang G, Zhou Y, et al. Old lines tell new tales: blaschko linear lupus erythematosis. Autoimmun Rev. 2016;15(4):291–306.
  • Kuhn A, Landmann A. The classification and diagnosis of cutaneous lupus erythematosus. J Autoimmun. 2014 Feb-Mar;48-49:14–19.
  • Wenzel J. Cutaneous lupus erythematosus: new insights into pathogenesis and therapeutic strategies. Nat Rev Rheumatol. 2019;15(9):519–532.
  • Baek YS, Park SH, Baek J, et al. Cutaneous lupus erythematosus and its association with systemic lupus erythematosus: a nationwide population-based cohort study in Korea. J Dermatol. 2020 Feb;47(2):163–165. • The latest retrospective study reported the incidence of progression from CLE to SLE.
  • Durosaro O, Davis MDP, Reed KB, et al. Incidence of cutaneous lupus erythematosus, 1965–2005: a population-based study. Arch Dermatol. 2009;145(3):249–253.• The latest retrospective study reported the incidence of progression from CLE to SLE.An origional article reported the incidence of CLE and disease progression to SLE.
  • Grönhagen CM, Fored CM, Granath F, et al. Cutaneous lupus erythematosus and the association with systemic lupus erythematosus: a population-based cohort of 1088 patients in Sweden. Br J Dermatol. 2011;164(6):1335–1341. • The latest retrospective study reported the incidence of progression from CLE to SLE.This is the first nationwide epidemiological study on CLE.
  • Ribero S, Sciascia S, Borradori L, et al. The cutaneous spectrum of lupus erythematosus. Clin Rev Allergy Immunol. 2017;53(3):291–305.
  • Gilliam JN, Sontheimer RD. Skin manifestations of SLE. Clin Rheum Dis. 1982;8(1):207–218.
  • Saurit V, Campana R, Ruiz Lascano A, et al. Mucocutaneous lesions in patients with systemic lupus erythematosus [Manifestaciones mucocutáneas en pacientes con lupus eritematoso sistémico]. Medicina (B Aires). 2003;63(4):283–287.
  • Grönhagen CM, Gunnarsson I, Svenungsson E, et al. Cutaneous manifestations and serological findings in 260 patients with systemic lupus erythematosus. Lupus. 2010;19(10):1187–1194.
  • Ng PP, Tan SH, Koh ET, et al. Epidemiology of cutaneous lupus erythematosus in a tertiary referral centre in Singapore. Australas J Dermatol. 2000;41(4):229–233.
  • Crowson AN, Magro C. The cutaneous pathology of lupus erythematosus: a review. J Cutan Pathol. 2001;28:1.
  • Dickey BZ, Holland KE, Drolet BA, et al. Demographic and clinical characteristics of cutaneous lupus erythematosus at a paediatric dermatology referral centre. Br J Dermatol. 2013;169(2):428–433.
  • Moises‐Alfaro C, Berrón‐Pérez R, Carrasco‐Daza D, et al. Discoid lupus erythematosus in children: clinical, histopathologic, and follow-up features in 27 cases. Pediatr Dermatol. 2003 Mar–Apr;20(2):103–107.
  • MCdA S, ZNP DO, MCdMR M, et al. Discoid lupus erythematosus in children–a retrospective study of 34 patients. Pediatr Dermatol. 2008 Mar–Apr;25(2):163–167.
  • Arkin LM, Buhr K, Brandling-Bennett H, et al. Practice-based differences in paediatric discoid lupus erythematosus. Br J Dermatol. 2019;181(4):805–810.
  • Arkin LM, Ansell L, Rademaker A, et al. The natural history of pediatric-onset discoid lupus erythematosus. J Am Acad Dermatol. 2015;72(4):628–633.
  • Cherif F, Mebazaa A, Mokni M, et al. Childhood discoid lupus erythematosus: a Tunisian retrospective study of 16 cases. Pediatr Dermatol. 2003;20(4):295–298.
  • Okon LG, Werth VP. Cutaneous lupus erythematosus: diagnosis and treatment. Best Pract Res Clin Rheumatol. 2013;27(3):391–404.
  • Rothfield N, Sontheimer RD, Bernstein M. Lupus erythematosus: systemic and cutaneous manifestations. Clin Dermatol. 2006 Sep-Oct;24(5):348–362.
  • O’Brien JC, Chong BF. Not just skin deep: systemic disease involvement in patients with cutaneous lupus. J Investig Dermatol Symp Proc. 2017;18(2):S69–S74.
  • Healy E, Kieran E, Rogers S. Cutaneous lupus erythematosus–a study of clinical and laboratory prognostic factors in 65 patients. Ir J Med Sci. 1995 Apr-Jun;164(2):113–115.
  • Chong BF, Song J, Olsen NJ. Determining risk factors for developing systemic lupus erythematosus in patients with discoid lupus erythematosus. Br J Dermatol. 2012;166(1):29–35. •• The latest retrospective study reported the incidence of progression from CLE to SLE.This study identified clinical and laboratory indicators, which are associated with disease progression.
  • Tebbe B, Orfanos CE. Epidemiology and socioeconomic impact of skin disease in lupus erythematosus. Lupus. 1997;6(2):96–104.
  • Elman SA, Joyce C, Costenbader KH, et al. Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study. Clin Exp Dermatol. 2020;45(1):89–91.
  • Wieczorek IT, Propert KJ, Okawa J, et al. Systemic symptoms in the progression of cutaneous to systemic lupus erythematosus. JAMA Dermatol. 2014;150(3):291–296.•• This study reported the severity of systemic symptoms developed by patients who experience a transition from CLE to SLE.
  • Callen JP. Systemic lupus erythematosus in patients with chronic cutaneous (discoid) lupus erythematosus. Clinical and laboratory findings in seventeen patients. J Am Acad Dermatol. 1985;12(2 Pt 1):278–288.
  • Maloney KC, Ferguson TS, Stewart HD, et al. Clinical and immunological characteristics of 150 systemic lupus erythematosus patients in Jamaica: a comparative analysis. Lupus. 2017;26(13):1448–1456.
  • Sontheimer RD. Subacute cutaneous lupus erythematosus. J Invest Dermatol. 1993;100(1):2S–8S.
  • Tebbe B, Hoffmann S, Orfanos CE. Course and prognosis of subacute cutaneous lupus erythematosus. A prospective study of 34 patients [Verlauf und Prognose des subakut-kutanen Lupus erythematodes. Eine prospektive Studie an 34 Patienten]. Hautarzt. 1994;45(10):690–695.
  • Vera-Recabarren MA, García-Carrasco M, Ramos-Casals M, et al. Comparative analysis of subacute cutaneous lupus erythematosus and chronic cutaneous lupus erythematosus: clinical and immunological study of 270 patients. Br J Dermatol. 2010;162(1):91–101.
  • Tebbe B, Mansmann U, Wollina U, et al. Markers in cutaneous lupus erythematosus indicating systemic involvement. A multicenter study on 296 patients. Acta Derm Venereol. 1997;77(4):305–308.
  • Aringer M, Costenbader K, Daikh D, et al. 2019 European league against rheumatism/American college of rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019 Sep;78(9):1151–1159.
  • Merola JF, Chang CA, Sanchez MR, et al. Is chronic cutaneous discoid lupus protective against severe renal disease in patients with systemic lupus erythematosus? J Drugs Dermatol. 2011;10(12):1413–1420.
  • Yavuz GO, Yavuz IH, Bayram I, et al. Clinic experience in discoid lupus erythematosus: a retrospective study of 132 cases. Postepy Dermatologii I Alergologii. 2019;36(6):739–743.
  • Tarazi M, Gaffney RG, Kushner CJ, et al. Cutaneous lupus erythematosus patients with a negative antinuclear antibody meeting the American college of rheumatology and/or systemic lupus international collaborating clinics criteria for systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2019;71(11):1404–1409.
  • MS D, Mbengue B, Seck A, et al. Evolution of autoantibodies profile in systemic lupus erythematosus according to age and clinical manifestations. Ann Biol Clin (Paris). 2014;72(3):351–358.
  • Walocko F, Black S, Anderson S, et al. Worsening skin damage in patients with cutaneous lupus erythematosus may predict development of systemic lupus erythematosus. J Am Acad Dermatol. 2020 May 11;S0190-9622(20)30848-3.
  • Callen JP. Chronic cutaneous lupus erythematosus. Clinical, laboratory, therapeutic, and prognostic examination of 62 patients. Arch Dermatol. 1982;118(6):412–416.
  • Patel P, Werth V. Cutaneous lupus erythematosus: a review. Dermatol Clin. 2002;20(3):373–v.
  • Watanabe T, Tsuchida T. Classification of lupus erythematosus based upon cutaneous manifestations. Dermatological, systemic and laboratory findings in 191 patients. Dermatology. 1995;190(4):277–283.
  • Tebbe B, Orfanos CE. [Lupus erythematosus of the skin. An analysis of 97 patients]. Z Hautkr. 1987;62(22):1563–72, 1577–8, 1583–4.
  • Cardinali C, Caproni M, Bernacchi E, et al. The spectrum of cutaneous manifestations in lupus erythematosus–the Italian experience. Lupus. 2000;9(6):417–423.
  • Patsinakidis N, Gambichler T, Lahner N, et al. Cutaneous characteristics and association with antinuclear antibodies in 402 patients with different subtypes of lupus erythematosus. J Eur Acad Dermatol Venereol JEADV. 2016;30(12):2097–2104.
  • Black DR, Hornung CA, Schneider PD, et al. Frequency and severity of systemic disease in patients with subacute cutaneous lupus erythematosus. Arch Dermatol. 2002;138(9):1175–1178.
  • Biazar C, Sigges J, Patsinakidis N, et al. Cutaneous lupus erythematosus: first multicenter database analysis of 1002 patients from the European Society of Cutaneous Lupus Erythematosus (EUSCLE). Autoimmun Rev. 2013;12(3):444–454.
  • Zian Z, Maamar M, Aouni ME, et al. Immunological and clinical characteristics of systemic lupus erythematosus: a series from morocco. Biomed Res Int. 2018;2018:3139404.
  • Kuhn A, Sticherling M, Bonsmann G. Clinical manifestations of cutaneous lupus erythematosus. J Dtsch Dermatol Ges. 2007;5(12):1124–1137.
  • Arbuckle MR, McClain MT, Rubertone MV, et al. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med. 2003;349(16):1526–1533.
  • Scott A, Rees EG. The relationship of systemic lupus erythematosus and discoid lupus erythematosus; a clinical and hematological study. AMA Arch Derm. 1959;79(4):422–435.
  • Millard LG, Rowell NR. Abnormal laboratory test results and their relationship to prognosis in discoid lupus erythematosus. A long-term follow-up study of 92 patients. Arch Dermatol. 1979;115(9):1055–1058.
  • Rowell NR. Laboratory abnormalities in the diagnosis and management of lupus erythematosus. Br J Dermatol. 1971;84(3):210–216.
  • Vlachiotis S, Andreakos E. Lambda interferons in immunity and autoimmunity. J Autoimmun. 2019 Nov;104:102319.
  • Lambers WM, de Leeuw K, Doornbos-van der Meer B, et al. Interferon score is increased in incomplete systemic lupus erythematosus and correlates with myxovirus-resistance protein A in blood and skin. Arthritis Res Ther. 2019 Dec 2;21(1):260.
  • Rodero MP, Decalf J, Bondet V, et al. Detection of interferon alpha protein reveals differential levels and cellular sources in disease. J Exp Med. 2017 May 1;214(5):1547–1555.
  • Farkas L, Beiske K, Lund-Johansen F, et al. Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions. Am J Pathol. 2001 Jul;159(1):237–243.
  • Chyuan IT, Tzeng HT, Chen JY. Signaling pathways of type i and type iii interferons and targeted therapies in systemic lupus erythematosus. Cells. 2019 Aug 23;8:9.
  • Zahn S, Rehkämper C, Kümmerer BM, et al. Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFNλ) in cutaneous lupus erythematosus. J Invest Dermatol. 2011 Jan;131(1):133–140.
  • Goel RR, Wang X, O’Neil LJ, et al. Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5409–5419.
  • Li Q, Wu H, Zhou S, et al. An update on the pathogenesis of skin damage in lupus. Curr Rheumatol Rep. 2020 May 12;22(5):16.
  • Achtman JC, Werth VP. Pathophysiology of cutaneous lupus erythematosus. Arthritis Res Ther. 2015 Aug 10;17(1):182.
  • Niewold TB, Kelly JA, Kariuki SN, et al. IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Ann Rheum Dis. 2012 Mar;71(3):463–468.
  • Barbhaiya M, Costenbader KH. Environmental exposures and the development of systemic lupus erythematosus. Curr Opin Rheumatol. 2016;28(5):497–505.
  • MDP A-B, Paradela S, Balboa-Barreiro V, et al. Cutaneous lupus erythematosus: factors related to cutaneous activity and damage in a cohort of 260 patients from A Coruña, Spain. Lupus. 2020;15:961203320930094.
  • Freemer MM, King TE, Criswell LA. Association of smoking with dsDNA autoantibody production in systemic lupus erythematosus. Ann Rheum Dis. 2006;65(5):581–584.
  • Rubin RL. Drug-induced lupus. Expert Opin Drug Saf. 2015;14(3):361–378.
  • Rubin RL. Drug-induced lupus. Toxicology. 2005;209(2):135–147.
  • Chang C, Gershwin ME. Drug-induced lupus erythematosus: incidence, management and prevention. Drug Saf. 2011;34(5):357–374.
  • He Y, Sawalha AH. Drug-induced lupus erythematosus: an update on drugs and mechanisms. Curr Opin Rheumatol. 2018;30(5):490–497.
  • Agudelo CA, Wise CM, Lyles MF. Pure red cell aplasia in procainamide induced systemic lupus erythematosus. Report and review of the literature. J Rheumatol. 1988;15(9):1431–1432.
  • Sheldon PJ, Williams WR. Procainamide-induced systemic lupus erythematosus. Ann Rheum Dis. 1970;29(3):236–243.
  • Timlin H, Wu M, Crespo-Bosque M, et al. Clinical characteristics of hydralazine-induced lupus. Cureus. 2019;11(6):e4996–e4996.
  • Schlienger RG, Bircher AJ, Meier CR. Minocycline-induced lupus. A systematic review. Dermatology. 2000;200(3):223–231.
  • Jarukitsopa S, Hoganson DD, Crowson CS, et al. Epidemiology of systemic lupus erythematosus and cutaneous lupus erythematosus in a predominantly white population in the United States. Arthritis Care Res (Hoboken). 2015 May;67(6):817–828.
  • Baek YS, Park SH, Baek J, et al. Cutaneous lupus erythematosus and its association with systemic lupus erythematosus: a nationwide population-based cohort study in Korea. J Dermatol. 2020 Feb;47(2):163–165.
  • Kuhn A, Herrmann M, Kleber S, et al. Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis Rheum. 2006 Mar;54(3):939–950.
  • Baima B, Sticherling M. Apoptosis in different cutaneous manifestations of lupus erythematosus. Br J Dermatol. 2001 May;144(5):958–966.
  • Ma C, Xia Y, Yang Q, et al. The contribution of macrophages to systemic lupus erythematosus. Clin Immunol. 2019 Oct;207:1–9.
  • Baumann I, Kolowos W, Voll RE, et al. Impaired uptake of apoptotic cells into tingible body macrophages in germinal centers of patients with systemic lupus erythematosus. Arthritis Rheum. 2002 Jan;46(1):191–201.
  • Fiore N, Castellano G, Blasi A, et al. Immature myeloid and plasmacytoid dendritic cells infiltrate renal tubulointerstitium in patients with lupus nephritis. Mol Immunol. 2008 Jan;45(1):259–265.
  • Tsokos GC, Lo MS, Costa Reis P, et al. New insights into the immunopathogenesis of systemic lupus erythematosus. Nat Rev Rheumatol. 2016;12(12):716–730.
  • Quelhas da Costa R, ME A-A, DA I, et al. Assessment of response to B-cell depletion using rituximab in cutaneous lupus erythematosus. JAMA Dermatol. 2018 Dec 1;154(12):1432–1440.
  • Li QZ, Zhou J, Wandstrat AE, et al. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes. Clin Exp Immunol. 2007 Jan;147(1):60–70.
  • Chong BF, Tseng LC, Lee T, et al. IgG and IgM autoantibody differences in discoid and systemic lupus patients. J Invest Dermatol. 2012 Dec;132(12):2770–2779.
  • Kuhn A, Aberer E, Bata-Csörgő Z, et al. S2k guideline for treatment of cutaneous lupus erythematosus - guided by the European dermatology forum (EDF) in cooperation with the European academy of dermatology and venereology (EADV). J Eur Acad Dermatol Venereol JEADV. 2017;31(3):389–404.
  • James JA, Kim-Howard XR, Bruner BF, et al. Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus. Lupus. 2007;16(6):401–409.
  • Vital EM, Wittmann M, Edward S, et al. Brief report: responses to rituximab suggest B cell-independent inflammation in cutaneous systemic lupus erythematosus. Arthritis Rheumatol. 2015 Jun;67(6):1586–1591.
  • Hofmann SC, Leandro MJ, Morris SD, et al. Effects of rituximab-based B-cell depletion therapy on skin manifestations of lupus erythematosus–report of 17 cases and review of the literature. Lupus. 2013 Aug;22(9):932–939.
  • Md Yusof MY, Shaw D, El-Sherbiny YM, et al. Predicting and managing primary and secondary non-response to rituximab using B-cell biomarkers in systemic lupus erythematosus. Ann Rheum Dis. 2017 Nov;76(11):1829–1836.
  • Salle R, Chasset F, Kottler D, et al. Belimumab for refractory manifestations of cutaneous lupus: a multicenter, retrospective observational study of 16 patients. J Am Acad Dermatol. 2020 May 18;S0190-9622(20)30923-3.
  • Zhao M, Zhou Y, Zhu B, et al. IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus. Ann Rheum Dis. 2016 Nov;75(11):1998–2006.
  • Renauer P, Coit P, Jeffries MA, et al. DNA methylation patterns in naïve CD4+ T cells identify epigenetic susceptibility loci for malar rash and discoid rash in systemic lupus erythematosus. Lupus Sci Med. 2015;2(1):e000101.
  • Moore E, Putterman C. Are lupus animal models useful for understanding and developing new therapies for human SLE? J Autoimmun. 2020 Jun;10:102490.

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