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Systematic Review

Impact of resolvin mediators in the immunopathology of diabetes and wound healing

, , , & ORCID Icon
Pages 681-690 | Received 04 Jan 2021, Accepted 31 Mar 2021, Published online: 22 Apr 2021

References

  • Tsalamandris S, Antonopoulos AS, Oikonomou E, et al. The role of inflammation in diabetes: current concepts and future perspectives. Eur Cardiol. 2019;14(1):50–59.
  • Hellmann J, Tang Y, Spite M, et al. Proresolving lipid mediators and diabetic wound healing. Curr Opin Endocrinol Diabetes Obes. 2012;19(2):104–108.
  • Freire MO, Dalli J, Serhan CN, et al. Neutrophil resolvin E1 receptor expression and function in type 2 diabetes. J Immunol. 2017;198(2):718–728.
  • Pal A, Al‐Shaer AE, Guesdon W, et al. Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner. Faseb J. 2020;34(8):10640–10656.
  • Tang Y, Zhang MJ, Hellmann J, et al. Proresolution therapy for the treatment of delayed healing of diabetic wounds. Diabetes. 2013;62(2):618–627.
  • Sima C, Paster B, Van Dyke TE, et al. Function of pro-resolving lipid mediator resolvin E1 in type 2 diabetes. Crit Rev Immunol. 2018;38(5):343–365.
  • Spite M, Clària J, Serhan C, et al. Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab. 2014;19(1):21–36.
  • Thankam FG, Ayoub JG, Ahmed MMR, et al. Association of hypoxia and mitochondrial damage associated molecular patterns in the pathogenesis of vein graft failure: a pilot study. Transl Res. 2021;229:38–52.
  • Satish M, Agrawal DK. Atherothrombosis and the NLRP3 inflammasome - endogenous mechanisms of inhibition. Transl Res. 2020;215:75–85.
  • Satish M, Gunasekar P, Agrawal DK. Pro-inflammatory and pro-resolving mechanisms in the immunopathology of arteriovenous fistula maturation. Expert Rev Cardiovasc Ther. 2019;17(5):369–376.
  • Satish M, Agrawal DK. Pro-resolving lipid mediators in the resolution of neointimal hyperplasia pathogenesis in atherosclerotic diseases. Expert Rev Cardiovasc Ther. 2019;17(3):177–184.
  • Wallace HA, Basehore BM, Zito PM. Wound healing phases. StatPearls. 2020;29.
  • Patel S, Srivastava S, Singh MR, et al. Mechanistic insight into diabetic wounds: pathogenesis, molecular targets and treatment strategies to pace wound healing. Biomed Pharmacothe. 2019;112:108615.
  • Pradhan L, Nabzdyk C, Andersen ND, et al. Inflammation and neuropeptides: the connection in diabetic wound healing. Expert Rev Mol Med. 2009;11. DOI:10.1017/S1462399409000945.
  • Zhang MJ, Spite M. Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids. Annu Rev Nutr. 2012;32:203–227.
  • Chandrasekharan JA, Sharma-Walia N. Lipoxins: nature’s way to resolve inflammation. J Inflamm Res. 2015;8:181–192.
  • Fu T, Mohan M, Brennan EP, et al. Therapeutic potential of lipoxin A4 in chronic inflammation: focus on cardiometabolic disease. ACS Pharmacol Transl Sci. 2020;3,1:43–55.
  • Hellmann J, Tang Y, Kosuri M, et al. Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. Faseb J. 2011;25(7):2399–2407.
  • Serhan CN, Levy BD. Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators. J Clin Invest. 2018;128(7):2657–2669.
  • Arita M, Ohira T, Sun YP, et al. Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J immunol. 1950;178(6):2007.
  • Dinh T, Tecilazich F, Kafanas A, et al. Mechanisms involved in the development and healing of diabetic foot ulceration. Diabetes. 2012;61(11):2937–2947.
  • Hoke GD, Ramos C, Hoke NN, et al. Atypical diabetic foot ulcer keratinocyte protein signaling correlates with impaired wound healing. J Diabetes Res. 2016;2016:1586927.
  • Jere SW, Houreld NN, Abrahamse H, et al. Role of the PI3K/AKT (mTOR and GSK3β) signalling pathway and photobiomodulation in diabetic wound healing. Cytokine Growth Factor Rev. 2019;50:52–59.
  • Zubair M, Ahmad J. Role of growth factors and cytokines in diabetic foot ulcer healing: a detailed review. Rev Endocr Metab Disord. 2019;20(2):207–217.
  • Li C, Wu X, Liu S, et al. Role of resolvins in the inflammatory resolution of neurological diseases. Front Pharmacol. 2020;11:612.
  • Pakyari M, Farrokhi A, Maharlooei MK, et al. Critical role of transforming growth factor beta in different phases of wound healing. Adv Wound Care. 2013;2(5):215–224.
  • Al-Mulla F, Leibovich SJ, Francis IM, et al. Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes. Mol Biosyst. 2011;7(11):3006–3020.
  • Khaled M, Shibani N-A, Labban N, et al. Effects of resolvin D1 on cell survival and cytokine expression of human gingival fibroblasts. J Periodontol. 2013;84(12):1838–1846.
  • El Gazaerly H, Elbardisey DM, Eltokhy HM, et al. Effect of transforming growth factor Beta 1 on wound healing in induced diabetic rats. Int J Health Sci (Qassim). 2013;7(2):160–172.
  • Luo B, Han F, Xu K, et al. Resolvin D1 programs inflammation resolution by increasing TGF- expression induced by dying cell clearance in experimental autoimmune neuritis. J Neurosci. 2016;36(37):9590–9603.
  • Zheng S, Wang Q, D’Souza V, et al. Resolvin D1 stimulates epithelial wound repair and inhibits TGF-β-induced EMT whilst reducing fibroproliferation and collagen production. Lab Invest. 2018;98(1):130–140.
  • Shu Y, Liu Y, Li X, et al. Aspirin-triggered resolvin D1 inhibits TGF-β1-induced EndMT through increasing the expression of smad7 and is closely related to oxidative stress. Biomol Ther (Seoul). 2016;24(2):132–139.
  • Qu X, Zhang X, Yao J, et al. Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation. J Pathol. 2012;228(4):506–519.
  • Lee H-N, Kundu JK, Cha YN, et al. Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-α expression. J Cell Sci. 2013;126(Pt 17):4037–4047.
  • Kourtzelis I, Hajishengallis G, Chavakis T, et al. Phagocytosis of apoptotic cells in resolution of inflammation. Front Immunol. 2020;11(553):31.
  • Ortega-Gómez A, Perretti M, Soehnlein O, et al. Resolution of inflammation: an integrated view. EMBO Mol Med. 2013;5(5):661–674.
  • Serhan CN, Chiang N, Dalli J, et al. Lipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol. 2014;7(2):a016311. 30.
  • Pirault J, Magnus B. Lipoxin and resolvin receptors transducing the resolution of inflammation in cardiovascular disease. Front Pharmacol. 2018;9:1273.
  • Krishnamoorthy S, Recchiuti A, Chiang N, et al. Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012;180(5):2018–2027.
  • Sima C, Montero E, Nguyen D, et al. ERV1 overexpression in myeloid cells protects against high fat diet induced obesity and glucose intolerance. Sci Rep. 2017;7(1):12848.
  • Oehler B, Mohammadi M, Perpina Viciano C, et al. Peripheral interaction of resolvin D1 and E1 with opioid receptor antagonists for antinociception in inflammatory pain in rats. Front Mol Neurosci. 2017;10(242):3.
  • Hansen TV, Vik A, Serhan CN, et al. The protectin family of specialized pro-resolving mediators: potent immunoresolvents enabling innovative approaches to target obesity and diabetes. Front Pharmacol. 2019;9:1582.
  • Chiang N, Libreros S, Norris PC, et al. Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions. J Clin Invest. 2019;129(12):5294–5311.
  • Albuquerque-Souza E, Schulte F, Chen T, et al. Maresin-1 and resolvin E1 promote regenerative properties of periodontal ligament stem cells under inflammatory conditions. Front Immunol. 2020;11:585530.
  • Hong S, Tian H, Lu Y, et al. Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes. Am J Physiol Cell Physiol. 2014;307(11):C1058-C1067.
  • Narasimha Das U. Lipoxins, resolvins, protectins, maresins and nitrolipids, and their clinical implications with specific reference to diabetes mellitus and other diseases: part II. Clin Lipidol. 2013;9(4):465–480.
  • Das UN. Arachidonic acid and lipoxin A4 as possible endogenous anti-diabetic molecules. Prostaglandins Leukot Essent Fatty Acids. 2013;88(3):201–210.
  • Herrera BS, Hasturk H, Kantarci A, et al. Impact of resolvin E1 on murine neutrophil phagocytosis in type 2 diabetes. Infect Immun. 2014;83(2):792–801.
  • Dinh T, Veves A. Microcirculation of the diabetic foot. Curr Pharm Des. 2005;11(18):2301–2309.
  • Zhang MJ, Sansbury BE, Hellmann J, et al. Resolvin D2 enhances postischemic revascularization while resolving inflammation. Circulation. 2016;134(9):666–680.
  • Menon R, Krzyszczyk P, Berthiaume F, et al. Pro-resolution potency of resolvins D1, D2 and E1 on neutrophil migration and in dermal wound healing. Nano LIFE. 2017;7(1):1750002.
  • Felemban B. Impact of resolvin D1 on RAGE and NF-kB gene expression in human monocytes. Boston Univ. 2013:1–62.
  • Liua,b T, Xianga A, Peng T, et al. HMGB1–C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis. Proc Nat Acad Sci. 2019;116(46):23254–23263. .
  • Geraldes P, King GL. Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res. 2010;106(8):1319–1331.
  • Mitchell S, Thomas G, Harvey K, et al. Lipoxins, aspirin-triggered epi-lipoxins, lipoxin stable analogues, and the resolution of inflammation: stimulation of macrophage phagocytosis of apoptotic neutrophils in vivo. J Am Soc Nephrol. 2002;13(10):2497–2507.
  • Quiros M, Feier D, Birkl D, et al. Resolvin E1 is a pro-repair molecule that promotes intestinal epithelial wound healing. Proc Nat Acad Sci. 2020;117(17):9477–9482.
  • Zhang Z, Hu X, Qi X, et al. Resolvin D1 promotes corneal epithelial wound healing and restoration of mechanical sensation in diabetic mice. Mol Vis. 2018;24:274–285.
  • Pham TL, Kakazu AH, He J, et al. Novel RvD6 stereoisomer induces corneal nerve regeneration and wound healing post-injury by modulating trigeminal transcriptomic signature. Sci Rep. 2020;10(1):4582.
  • Bohr S, Patel SJ, Sarin D, et al. Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. Wound Repair Regen. 2013;21(1):35–43.
  • Hellmann J, Sansbury BE, Wong B, et al. Biosynthesis of D-series resolvins in skin provides insights into their role in tissue repair. J Invest Dermatol. 2018;138(9):2051–2060.
  • Abdolmaleki F, Kovanen PT, Mardani R, et al. Resolvins: emerging players in autoimmune and inflammatory diseases. Clin Rev Allergy Immunol. 2020;58(1):82–91.

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