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Expert Review of Clinical Immunology Volume 17, 2021 - Issue 7
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Editorial

Vitamin D as disease-modifying therapy for multiple sclerosis?

Matthew R Lincolna Department of Neurology, Yale School of Medicine, New Haven, CT, USA;b Broad Institute of Harvard and MIT, Cambridge, MA, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2962-6253View further author information
ORCID Icon,
Raphael Schneiderc Division of Neurology, University of Toronto, Toronto, Ontario, Canada;d Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Toronto, Ontario, CanadaView further author information
&
Jiwon Ohc Division of Neurology, University of Toronto, Toronto, Ontario, Canada;d Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Toronto, Ontario, CanadaView further author information
Pages 691-693 | Received 02 Mar 2021, Accepted 08 Apr 2021, Published online: 15 Apr 2021

References

  • Orton S-M, Wald L, Confavreux C, et al. Association of UV radiation with multiple sclerosis prevalence and sex ratio in France. Neurology. 2011;76:425–431.
  • Munger KL, Zhang SM, O’Reilly E, et al. Vitamin D intake and incidence of multiple sclerosis. Neurology. 2004;62:60–65.
  • Munger KL, Levin LI, Hollis BW, et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006;296:2832–2838.
  • Kampman MT, Wilsgaard T, Mellgren SI. Outdoor activities and diet in childhood and adolescence relate to MS risk above the Arctic circle. J Neurol. 2007;254:471–477.
  • Dean G, Elian M. Age at immigration to England of Asian and Caribbean immigrants and the risk of developing multiple sclerosis. J Neurol Neurosurg Psychiatry. 1997;63:565–568.
  • Willer CJ, Dyment DA, Sadovnick AD, et al. Timing of birth and risk of multiple sclerosis: population based study. BMJ. 2005;330:120.
  • Munger KL, Åivo J, Hongell K, et al. Vitamin D status during pregnancy and risk of multiple sclerosis in offspring of women in the Finnish maternity cohort. JAMA Neurol. 2016;73:515–519.
  • Nielsen NM, Munger KL, Koch-Henriksen N, et al. Neonatal vitamin D status and risk of multiple sclerosis: a population-based case-control study. Neurology. 2017;88:44–51.
  • Mokry LE, Ross S, Ahmad OS, et al. Vitamin D and risk of multiple sclerosis: a Mendelian randomization study. PLOS Med. 2015;12:e1001866.
  • Gianfrancesco MA, Stridh P, Rhead B, et al. Evidence for a causal relationship between low vitamin D, high BMI, and pediatric-onset MS. Neurology. 2017;88:1623–1629.
  • Clarke J, Yaqubi M, Futhey NC, et al. Vitamin D regulates MerTK-dependent phagocytosis in human myeloid cells. J Immunol Baltim Md 1950. 2020;205:398–406.
  • Da Costa DSMM, Hygino J, Ferreira TB, et al. Vitamin D modulates different IL-17-secreting T cell subsets in multiple sclerosis patients. J Neuroimmunol. 2016;299:8–18.
  • Smolders J, Peelen E, Thewissen M, et al. Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis. PloS One. 2010;5:e15235.
  • Sotirchos ES, Bhargava P, Eckstein C, et al. Safety and immunologic effects of high- vs low-dose cholecalciferol in multiple sclerosis. Neurology. 2016;86:382–390.
  • Haas J, Schwarz A, Korporal-Kuhnke M, et al. Hypovitaminosis D upscales B-cell immunoreactivity in multiple sclerosis. J Neuroimmunol. 2016;294:18–26.
  • Häusler D, Torke S, Peelen E, et al. High dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium. Brain J Neurol. 2019;142:2737–2755.
  • Ascherio A, Munger KL, White R, et al. Vitamin D as an early predictor of multiple sclerosis activity and progression. JAMA Neurol. 2014;71:306–314.
  • Soilu-Hänninen M, Laaksonen M, Laitinen I, et al. A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2008;79:152–157.
  • Jagannath VA, Filippini G, Di Pietrantonj C, et al. Vitamin D for the management of multiple sclerosis. Cochrane Database Syst Rev. 2018;9:CD008422.
  • Atkinson SA, Fleet JC. Canadian recommendations for vitamin D intake for persons affected by multiple sclerosis. J Steroid Biochem Mol Biol. 2020;199:105606.

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