Breast implant illness: scientific evidence of its existence

References

• Cohen Tervaert JW, Colaris M, van der Hulst RR, et al. Silicone breast implants and autoimmune rheumatic diseases: myth or reality. Curr Opin Rheumatol. 2017 Jul;29(4):348–354.
   PubMed Web of Science ®Google Scholar
• Deva AK, Cuss A, Magnusson M, et al. The “Game of Implants”: a perspective on the crisis-prone history of breast implants. Aesth Surg J. 2019;39(S1):S55–S65.
   PubMedGoogle Scholar
• [cited 2021 Jul 8]. Available from: www.natrelle.ca/en/qualitty
   Google Scholar
• [cited 2021 Jul 8]. Available from: https://www.fda.gov/medical-devices/breast-implants/medical-device-reports-systemic-symptoms-women-breast-implants
   Google Scholar
• [cited 2021 Jul 8]. Available from: https://www.fda.gov/consumers/consumer-updates/what-know-about-breast-implants
   Google Scholar
• Edworthy SM, Martin L, Barr SG, et al. A clinical study of the relationship between silicone breast implants and connective tissue disease. J Rheumatol. 1998 Feb;25(2):254–260.
   PubMed Web of Science ®Google Scholar
• de Boer M, Colaris M, van der Hulst RR, et al. Is explantation of silicone breast implants useful in patients with complaints? Immunol Res. 2017 Feb;65(1):25–36.
   PubMed Web of Science ®Google Scholar
• Colaris MJ, de Boer M, van der Hulst RR, et al. Two hundreds cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature. Immunol Res. 2017 Feb;65(1):120–128.
   PubMed Web of Science ®Google Scholar
• Meijs J, de Vries-Bouwstra JK, Cohen Tervaert JW, et al. A case of late-onset systemic sclerosis with ruptured silicone breast implants. Neth J Med. 2018 Jul;76(5):243–248.
   PubMed Web of Science ®Google Scholar
• Carruthers BM, van de Sande MI, De Meirleir KL, et al. Myalgic encephalomyelitis: international consensus criteria: review: ME: intl. Consensus criteria. J Intern Med. 2011;270(4):327–338.
   PubMed Web of Science ®Google Scholar
• Cohen Tervaert JW. Autoinflammatory/autoimmunity syndrome induced by adjuvants (ASIA; Shoenfeld’s syndrome): a new flame. Autoimmun Rev. 2018;17(12):1259–1264.
   PubMed Web of Science ®Google Scholar
• Colaris MJL, Cohen Tervaert JW, Ponds RWHM, et al. Subjective cognitive functioning in silicone breast implant patients: a cohort study. Plast Reconstr Surg Glob Open. 2021 Feb 17;9(2):e3394.
   PubMedGoogle Scholar
• Wolfe F, Clauw DJ, Fitzcharles MA, et al. Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46(3):319–329.
   PubMed Web of Science ®Google Scholar
• Meier LG, Barthel HR, Seidl C. Development of polyarthritis after insertion of silicone breast implants followed by remission after implant removal in 2 HLA-identical sisters bearing rheumatoid arthritis susceptibility genes. J Rheumatol. 1997;24(9):1838–1841.
   PubMed Web of Science ®Google Scholar
• Balk EM, Earley A, Avendano EA, et al. Long-term health outcomes in women with silicone gel breast implants: a systematic review. Ann Intern Med. 2016;164(3):164–175.
   PubMed Web of Science ®Google Scholar
• Shoaib BO, Patten BM, Calkins DS. Adjuvant breast disease: an evaluation of 100 symptomatic women with breast implants or silicone fluid injections. Keio J Med. 1994;43(2):79–87.
   PubMedGoogle Scholar
• Dagan A, Kogan M, Shoenfeld Y, et al. When uncommon and common coalesce: adult onset Still’s disease associated with breast augmentation as part of autoimmune syndrome induced by adjuvants (ASIA). Clin Rheumatol. 2016;35(6):1643–1648.
   PubMed Web of Science ®Google Scholar
• Freundlich B, Altman C, Snadorfi N, et al. A profile of symptomatic patients with silicone breast implants: a Sjögrens-like syndrome. Semin Arthritis Rheum. 1994;24(1 Suppl 1):44–53.
   PubMed Web of Science ®Google Scholar
• Mavromatis BH, Tzioufas AG, Moutsopoulos HM. Sjögren-like disease and silicone implants: a Greek experience. J Clin Rheumatol. 1998;4(3):147–150.
   PubMed Web of Science ®Google Scholar
• Nayfe R, Uthman I, Aoun J, et al. Seronegative antiphospholipid syndrome. Rheumatology (Oxford). 2013;52(8):1358–1367.
   PubMed Web of Science ®Google Scholar
• Maijers MC, de Blok CJ, Niessen FB, et al. Women with silicone breast implants and unexplained systemic symptoms: a descriptive cohort study. Neth J Med. 2013;71(10):534–540.
   PubMed Web of Science ®Google Scholar
• Frieri M, Patel R, Celestin J. Mast cell activation syndrome: a review. Curr Allergy Asthma Rep. 2013;13(1):27–32.
   PubMed Web of Science ®Google Scholar
• Maharaj S. An atypical immune-inflammatory disorder secondary to breast implant exposure. J Long Term Eff Med Implants. 2012;22(1):33–48.
   PubMedGoogle Scholar
• Spencer TR, Schur PM. The challenge of multiple chemical sensitivity. J Environ Health. 2008;70(10):24–27.
   PubMed Web of Science ®Google Scholar
• David PR, Dagan A, Colaris M, et al. Churg-Strauss syndrome: singulair or silicone (or both?). Isr Med Assoc J. 2016;18(3–4):168–170.
   PubMed Web of Science ®Google Scholar
• Dragu A, Theegarten D, Bach AD, et al. Intrapulmonary and cutaneous siliconomas after silent silicone breast implant failure. Breast J. 2009;15(5):496–499.
   PubMed Web of Science ®Google Scholar
• Gopinath PP, Ali A, Van Tornout F, et al. Chronic silicone embolism syndrome due to PIP breast implant leakage: a new entity? Histopathology. 2015;66(6):904–906.
   PubMed Web of Science ®Google Scholar
• Bois MC, Hu X, Roden AC, et al. Increasing pulmonary infiltrates in a 72-year-old woman with metastatic breast cancer. Chest. 2014 Dec;146(6):e208–e211.
   PubMed Web of Science ®Google Scholar
• Cohen Tervaert JW, Kappel RM. Silicone implant incompatibility syndrome (SIIS): a frequent cause of ASIA (Shoenfeld’s syndrome). Immunol Res. 2013;56(2–3):293–298.
   PubMed Web of Science ®Google Scholar
• Grahame R, Bird HA, Child A. The revised (Brighton 1998) criteria for the diagnosis of benign joi hypermobility syndrome (BJHS). J Rheumatol. 2000;27(7):1777–1779.
   PubMed Web of Science ®Google Scholar
• Watad A, Rosenberg V, Tiosano S, et al. Silicone breast implants and the risk of autoimmune/rheumatic disorders: a real-world analysis. Int J Epidemiol. 2018 Dec 1;47(6):1846–1854.
   PubMed Web of Science ®Google Scholar
• Martins F, Sofiya L, Sykiotis GP, et al. Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance. Nat Rev Clin Oncol. 2019 Sep;16(9):563–580.
   PubMed Web of Science ®Google Scholar
• Quagliariello V, Passariello M, Coppola C, et al. Cardiotoxicity and pro-inflammatory effects of the immune checkpoint inhibitor Pembrolizumab associated to Trastuzumab. Int J Cardiol. 2019 Oct 1;292:171–179.
   PubMed Web of Science ®Google Scholar
• Quagliariello V, De Laurentiis M, Cocco S, et al. NLRP3 as putative marker of ipilimumab-induced cardiotoxicity in the presence of hyperglycemia in estrogen-responsive and triple-negative breast cancer cells. Int J Mol Sci. 2020 Oct 21;21(20):7802.
   Web of Science ®Google Scholar
• Clauw DJ. What is the meaning of ‘small fiber neuropathy’ in fibromyalgia? Pain. 2015;156(11):2115–2116.
   PubMed Web of Science ®Google Scholar
• Teuber SS, Reilly DA, Howell L, et al. Severe migratory granulomatous reactions to silicone gel in 3 patients. J Rheumatol. 1999;26(3):699–704.
   PubMed Web of Science ®Google Scholar
• Wolfram D, Oberreiter B, Mayerl C, et al. Altered systemic serologic parameters in patients with silicone mammary implants. Immunol Lett. 2008;118(1):96–100.
   PubMed Web of Science ®Google Scholar
• Colaris MJL, van der Hulst RR, Tervaert JWC. Vitamin D deficiency as a risk factor for the development of autoantibodies in patients with ASIA and silicone breast implants: a cohort study and review of the literature. Clin Rheumatol. 2017 May;36(5):981–993.
   PubMed Web of Science ®Google Scholar
• Halpert G, Watad A, Tsur AM, et al. Autoimmune dysautonomia in women with silicone breast implants. J Autoimmun. 2021 Jun;120:102631. Epub 2021 Mar 31.
   PubMed Web of Science ®Google Scholar
• Castro C, Fernandes D, Mendonça M, et al. Silicone-induced granuloma of breast implant capsule mimicking anaplastic large cell lymphoma. Breast J. 2020;26(5):1028–1030.
   PubMed Web of Science ®Google Scholar
• Kim JR, Chang M-C, Kim YM, et al. Usefulness of sonography for diagnosis of siliconomas mimicking metastatic lymphadenopathy on computed tomography. J Ultrasound Med. 2015;34(1):167–169.
   PubMed Web of Science ®Google Scholar
• Vermeulen RC, Kurk RM, Visser FC, et al. Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. J Transl Med. 2010 Oct 11;8(1):93.
   PubMedGoogle Scholar
• Centeno JA, Mullick FG, Panos RG, et al. Laser-Raman microprobe identification of inclusions in capsules associated with silicone gel breast implants. Mod Pathol. 1999 Jul;12(7):714–721.
   PubMed Web of Science ®Google Scholar
• Kappel RM, Boer LL, Dijkman H. Gel bleed and rupture of silicone breast implants investigated by light-, electron microscopy and energy dispersive X-ray analysis of internal organs and nervous tissue. Clin Med Rev Case Rep. 2016;3(3):087.
   Google Scholar
• Shoenfeld Y, Agmon-Levin N. ASIA’-autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmun. 2011;36(1):4–8.
   PubMed Web of Science ®Google Scholar
• Miseré RML, Colaris MJL, Tervaert JWC, et al. The prevalence of self-reported health complaints and health-related quality of life in women with breast implants. Aesthet Surg J. 2021 May 18;41(6):661–668.
   PubMed Web of Science ®Google Scholar
• Giltay EJ, Bernelot Moens HJ, Riley AH, et al. Silicone breast prostheses and rheumatic symptoms: a retrospective follow up study. Ann Rheum Dis. 1994;53(3):194–196.
   PubMed Web of Science ®Google Scholar
• Sunnquist M, Jason LA, Nehrke P, et al. A comparison of case definitions for myalgic encephalomyelitis and chronic fatigue syndrome. J Chronic Dis Manag. 2017;2(2):1013.
   PubMedGoogle Scholar
• Hughes GR, Khamashta MA. Seronegative antiphospholipid syndrome. Ann Rheum Dis. 2003;62(12):1127.
   PubMed Web of Science ®Google Scholar
• Coroneos CJ, Selber JC, Offodile AC 2nd, Butler CE, Clemens MW. US FDA breast implant postapproval studies: long-term outcomes in 99,993 patients. Ann Surg. 2019 Jan;269(1):30–36.
   PubMed Web of Science ®Google Scholar
• Cooper GS, Bynum ML, Somers EC. Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases. J Autoimmun. 2009 Nov-Dec;33(3–4):197–207.
   PubMed Web of Science ®Google Scholar
• Miranda RN, Medeiros LJ, Ferrufino-Schmidt MC, et al. Pioneers of breast implant–associated anaplastic large cell lymphoma: history from case report to global recognition. Plast Reconstr Surg. 2019 Mar;143(3S):7S–14S.
   PubMedGoogle Scholar
• de Boer M, van Leeuwen FE, Hauptmann M, et al. Breast implants and the risk of anaplastic large-cell lymphoma in the breast. JAMA Oncol. 2018 Mar 1;4(3):335–341.
   PubMed Web of Science ®Google Scholar
• Keech JA Jr, Creech BJ. Anaplastic T-cell lymphoma in proximity to a saline-filled breast implant. Plast Reconstr Surg. 1997;100(2):554–555.
   PubMed Web of Science ®Google Scholar
• de Jong D, Vasmel WLE, de Boer JP, et al. Anaplastic large-cell lymphoma in women with breast implants. JAMA. 2008 Nov 5;300(17):2030.
   PubMed Web of Science ®Google Scholar
• Los-de Vries GT, de Boer M, van Dijk E, et al. Chromosome 20 loss is characteristic for breast implant-associated anaplastic large cell lymphoma. Blood. 2020 Sep 8;136(25):2927–2932. blood.2020005372. blood.2020005372.
   PubMed Web of Science ®Google Scholar
• Collett DJ, Rakhorst H, Lennox P, et al. Current risk estimate of breast implant-associated anaplastic large cell lymphoma in textured breast implants. Plast Reconstr Surg. 2019 March;143(3S):30S–40S.
   PubMedGoogle Scholar
• Segal Y, Dahan S, Sharif K, et al. The value of Autoimmune Syndrome Induced by Adjuvant (ASIA) - Shedding light on orphan diseases in autoimmunity. Autoimmun Rev. 2018 May;17(5):440–448.
   PubMed Web of Science ®Google Scholar
• Coffman R, Sher A, Seder R. Vaccine adjuvants: putting innate immunity to work. Immunity. 2010;33(4):492–503.
   PubMed Web of Science ®Google Scholar
• Ruiz JT, Lujan L, Blank M, et al. Adjuvants-and vaccines-induced autoimmunity: animal models. Immunol Res. 2017;65(1):55–65.
   PubMed Web of Science ®Google Scholar
• See FDA report on breast implant special topics from advisory panel, March 25th and 26th, 2019. [cited 2021 Jul 8]. Available from: https://www.fda.gov/media/122956/download
   Google Scholar
• Cohen Tervaert JW. Autoinflammatory/autoimmunity syndrome induced by adjuvants (Shoenfeld’s syndrome) in patients after a polypropylene mesh implantation. Best Prac Res Clin Rheumatol. 2018 Aug;32(4):511–520.
   PubMed Web of Science ®Google Scholar
• Caravantes-Cortes MI, Roldan-Valadez E, Zwojewski-Martinez RD, et al. Breast prosthesis syndrome: pathophysiology and management algorithm. Aesthetic Plast Surg. 2020 Oct;44(5):1423–1437.
   PubMed Web of Science ®Google Scholar
• Major MR, Wong VW, Nelson ER, et al. The foreign body response: at the interface of surgery and bioengineering. Plast Reconstr Surg. 2015 May;135(5):1489–1498.
   PubMed Web of Science ®Google Scholar
• Anderson M, Rodriguez A, Chang DT. Foreign body reaction to biomaterials. Semin Immunol. 2008 Apr;20(2):86–100.
   PubMed Web of Science ®Google Scholar
• Ajdic D, Zoghbi Y, Gerth D, et al. The relationship of bacterial biofilms and capsular contracture in breast implants. Aesthet Surg J. 2016 Mar;36(3):297–309.
   PubMed Web of Science ®Google Scholar
• Langbach O, Kristoffersen AK, Abesha-Belay E, et al. Oral, intestinal, and skin bacteria in ventral hernia mesh implants. J Oral Microbiol. 2016 Jul 29;8(1):31854.
   PubMed Web of Science ®Google Scholar
• Lee M, Ponraja G, McLeod K, et al. Breast Implant Illness: a Biofilm Hypothesis. Plast Reconstr Surg Glob Open. 2020 Apr 30;8(4):e2755.
   PubMedGoogle Scholar
• Babensee JE. Interaction of dendritic cells with biomaterials. Semin Immunol. 2008;20(2):101–108.
   PubMed Web of Science ®Google Scholar
• Nolfi AL, Brown BN, Liang R, et al. Host response to synthetic mesh in women with mesh complications. Am J Obstet Gynecol. 2016 Aug;215(2):206.e1–206.e8.
   PubMed Web of Science ®Google Scholar
• Zdolsek JWE, Tang L, Tang L. Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans. J Transl Med. 2007;5(1):31.
   PubMedGoogle Scholar
• Wouters MM, Balemans D, Van Wanrooy S, et al. Histamine receptor H1-mediated sensitization of TRPV1 mediates visceral hypersensitivity and symptoms in patients with irritable bowel syndrome. Gastroenterology. 2016 Apr;150(4):875–887.
   PubMed Web of Science ®Google Scholar
• Junge K, Binnebösel M, Von Trotha KT, et al. Mesh biocompatibility: effects of cellular inflammation and tissue remodelling. Langenbecks Arch Surg. 2012 Feb;397(2):255–270.
   PubMed Web of Science ®Google Scholar
• Matzelle MM, Babensee JE. Humoral immune responses to model antigen co-delivered with biomaterials used in tissue engineering. Biomaterials. 2004 Jan;25(2):295–304.
   PubMed Web of Science ®Google Scholar
• Bennewitz NL, Babensee JE. The effect of the physical form of poly(lactic-co-glycolic acid) carriers on the humoral immune response to co-delivered antigen. Biomaterials. 2005 Jun;26(16):2991–2999.
   PubMed Web of Science ®Google Scholar
• Kool M, Pétrilli V, De Smedt T. Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome. J Immunol. 2008 Sep 15;181(6):3755–3759.
   PubMed Web of Science ®Google Scholar
• [cited 2021 Jul 8]. Available from: https://radiopaedia.org/articles/metal-on-metal-pseudotumour?lang=us
   Google Scholar
• Cobelli N, Scharf B, et al. Mediators of the inflammatory response to joint replacement devices. Nat Rev Rheumatol. 2011 Sep 6;7(10):600–608.
   PubMed Web of Science ®Google Scholar
• Dowling J, Mansell A. Toll‐like receptors: the Swiss army knife of immunity and vaccine development. Clin Transl Immunology. 2016;5(5):e85.
   PubMed Web of Science ®Google Scholar
• Grammatopoulos G, Munemoto M, Inagaki Y, et al. The diagnosis of infection in metal-on-metal hip arthroplasties. J Arthroplasty. 2016 Nov;31(11):2569–2573.
   PubMed Web of Science ®Google Scholar
• McDonald AH, Sanger JR, Schneider M, et al. Silicone gel enhances the development of autoimmune disease in New Zealand black mice but fails to induce it in BALB/cAnPt mice. Clin Immunol Immunopathol. 1998;87(3):248–255.
   PubMedGoogle Scholar
• Wolfram D, Rabensteiner E, Grundtman C, et al. T regulatory cells and TH17 cells in peri-silicone implant capsular fibrosis. Plast Reconstr Surg. 2012 Feb;129(2):327e–337e.
   PubMed Web of Science ®Google Scholar
• Campbell A, Brautbar N, Vojdani A. Suppressed natural killer cell activity in patients with silicone breast implants: reversal upon explantation. Toxicol Ind Health. 1994 May-Jun;10(3):149–154.
   PubMed Web of Science ®Google Scholar
• Onnekink C, Kappel RM, Boelens WC, et al. Low molecular weight silicones induce cell death in cultured cells. Sci Rep. 2020 Jun 12;10(1):9558.
   PubMed Web of Science ®Google Scholar
• Todorov TI, de Bakker E, Smith D, et al. A case of silicone and sarcoid granulomas in a patient with “Highly Cohesive” silicone breast implants: a histopathologic and Laser Raman microprobe analysis. Int J Environ Res Public Health. 2021 Apr 24;18(9):4526.
   PubMed Web of Science ®Google Scholar
• Dijkman HBPM, Slaats I, Bult P. Assessment of silicone particle migration among women undergoing removal or revision of silicone breast implants in the Netherlands. JAMA Network Open. 2021 Sep 1;4(9):e2125381.
   PubMed Web of Science ®Google Scholar
• Lykissa ED, Maharaj SV. Total platinum concentration and platinum oxidation states in body fluids, tissue, and explants from women exposed to silicone and saline breast implants by IC-ICPMS. Anal Chem. 2006 May 1;78(9):2925–2933.
   PubMed Web of Science ®Google Scholar
• Wee CE, Younis J, Isbester K, et al. Understanding breast implant illness, before and after explantation: a patient-reported outcomes study. Ann Plast Surg. 2020 Jul;85(S1 Suppl 1):S82–S86.
   PubMedGoogle Scholar
• See FDA Report: Biological Responses to Metal Implants September 2019. [cited 2021 Jul 8]. Available from: https://www.fda.gov/media/131150/download
   Google Scholar
• Healy D, Mangin D. Clinical Judgments, not algorithms, are key to patient safety. BMJ. 2019;367:5777.
   PubMedGoogle Scholar
• Lucas R, Rodney Harris R. On the nature of evidence and ‘Proving’ causality: smoking and lung cancer vs. sun exposure, vitamin D and multiple sclerosis. Int J Environ Res Public Health. 2018 Aug 12;15(8):ii: E1726.
   PubMed Web of Science ®Google Scholar
• Damoiseaux JGMC, Cohen Tervaert JW. The definition of autoimmune disease: are Koch’s postulates applicable? Netherlands J Med. 2002 Aug;60(7):266–268.
   PubMed Web of Science ®Google Scholar
• Fedak KM, Bernal A, et al. Applying the Bradford Hill criteria in the 21st century: how data integration has changed causal inference in molecular epidemiology. Emerg Themes Epidemiol. 2015 Sep 30;12(1):14. eCollection 2015.
   PubMedGoogle Scholar
• Davidovici BB, Wolf R. The challenge of drug-rechallenge: Facts and controversies. Clinics Derm. 2010;28(3):349–353 .
   Web of Science ®Google Scholar
• Song JW, Chung KC. Observational studies: cohort and case-control studies. Plast Reconstr Surg. 2010;126(6):2234–2242.
   PubMed Web of Science ®Google Scholar
• Cuellar ML, Gluck O, Molina JF, et al. Silicone breast implant–associated musculoskeletal manifestations. Clin Rheumatol. 1995;14(6):667–672.
   PubMed Web of Science ®Google Scholar
• Contant CM, Swaak AJ, Obdeijn AI, et al. A prospective study on silicone breast implants and the silicone-related symptom complex. Clin Rheumatol. 2002;21(3):215–219.
   PubMed Web of Science ®Google Scholar
• Shoaib BO, Patten BM. Human adjuvant disease: presentation as a multiple sclerosis-like syndrome. South Med J. 1996;89(2):179–188.
   PubMed Web of Science ®Google Scholar
• Gaubitz M, Jackisch C, Domschke W, et al. Silicone breast implants: correlation between implant ruptures, magnetic resonance spectroscopically estimated silicone presence in the liver, antibody status and clinical symptoms. Rheumatol (Oxford). 2002;41(2):129–135.
   PubMedGoogle Scholar
• De Jong WH, Goldhoorn CA, Kallewaard M, et al. Study to determine the presence of antipolymer antibodies in a group of Dutch women with a silicone breast implant. Clin Exp Rheumatol. 2002;20(2):151–160.
   PubMed Web of Science ®Google Scholar
• Englert H, Joyner E, Thompson M, et al. Augmentation mammoplasty and “silicone-osis. Intern Med J. 2004;34(12):668–676.
   PubMed Web of Science ®Google Scholar
• Vasey FB, Havice DL, Bocanegra TS, et al. Clinical findings in symptomatic women with silicone breast implants. Semin Arthritis Rheum. 1994;24(1 Suppl 1):22–28.
   PubMed Web of Science ®Google Scholar
• Vermeulen RC, Scholte HR. Rupture of silicone gel breast implants and symptoms of pain and fatigue. J Rheumatol. 2003;30(10):2263–2267.
   PubMed Web of Science ®Google Scholar
• Bridges AJ, Conley C, Wang G, et al. A clinical and immunologic evaluation of women with silicone breast implants and symptoms of rheumatic disease. Ann Intern Med. 1993;118(12):929–936.
   PubMed Web of Science ®Google Scholar
• Freundlich B, Altman C, Snadorfi N, et al. A profile of symptomatic patients with silicone breast implants: a Sjögrens-like syndrome. Semin Arthritis Rheum. 1994;24(1 Suppl 1):44–53.
   PubMed Web of Science ®Google Scholar
• Solomon G. A clinical and laboratory profile of symptomatic women with silicone breast implants. Semin Arthritis Rheum. 1994;24(1 Suppl 1):29–37.
   PubMed Web of Science ®Google Scholar
• Peters W, Smith D, Fornasier V, et al. An outcome analysis of 100 women after explantation of silicone gel breast implants. Ann Plast Surg. 1997;39(1):9–19.
   PubMed Web of Science ®Google Scholar
• Melmed EP. A review of explantation in 240 symptomatic women: a description of explantation and capsulectomy with reconstruction using a periareolar technique. Plast Reconstr Surg. 1998;101(5):1364–1373.
   PubMed Web of Science ®Google Scholar
• Wells KE, Roberts C, Daniels SM, et al. Psychological and rheumatic symptoms of women requesting silicone breast implant removal. Ann Plast Surg. 1995;34(6):572–577.
   PubMed Web of Science ®Google Scholar
• Kiene H, Hamre HJ, Kienle GS, et al. In support of clinical case reports: a system of causality assessment. Glob Adv Health Med. 2013 Mar;2(2):64–75.
   PubMedGoogle Scholar
• Schaefer CJ, Lawrence WD, Wooley PH. Influence of long term silicone implantation on type II collagen induced arthritis in mice. Ann Rheum Dis. 1999;58(8):503–509.
   PubMed Web of Science ®Google Scholar
• Schaefer CJ, Wooley PH. The influence of silicone implantation on murine lupus in MRL lpr/lpr mice. J Rheumatol. 1999 Oct;26(10):2215–2221.
   PubMed Web of Science ®Google Scholar