The role of genetics in food allergy

References

• Lin RY, Anderson AS, Shah SN, et al. Increasing anaphylaxis hospitalizations in the first 2 decades of life: new York State, 1990 −2006. Ann Allergy Asthma Immunol. 2008 Oct;101(4):387–93.
   PubMed Web of Science ®Google Scholar
• Woods RK, Abramson M, Bailey M, et al. International prevalences of reported food allergies and intolerances. Comparisons arising from the European Community Respiratory Health Survey (ECRHS) 1991-1994. Eur J Clin Nutr. 2001 Apr;55(4):298–304.
   PubMed Web of Science ®Google Scholar
• van Odijk J, Ahlstedt S, Bengtsson U, et al. Specific IgE antibodies to peanut in western Sweden–has the occurrence of peanut allergy increased without an increase in consumption? Allergy. 2001 Jun;56:573–577.
   PubMed Web of Science ®Google Scholar
• Grundy J, Matthews S, Bateman B, et al. Rising prevalence of allergy to peanut in children: data from 2 sequential cohorts. J Allergy Clin Immunol. 2002 Nov;110(5):784–789.
   PubMed Web of Science ®Google Scholar
• Tariq SM, Stevens M, Matthews S, et al. Cohort study of peanut and tree nut sensitisation by age of 4 years. BMJ. 1996 Aug 31 313(7056):514–517.
   PubMedGoogle Scholar
• Branum AM, Lukacs SL. Food allergy among children in the United States. Pediatrics. 2009 Dec;124(6):1549–1555.
   PubMed Web of Science ®Google Scholar
• Ben-Shoshan M, Kagan RS, Alizadehfar R, et al. Is the prevalence of peanut allergy increasing? A 5-year follow-up study in children in Montreal. J Allergy Clin Immunol. 2009 Apr;123(4):783–788.
   PubMed Web of Science ®Google Scholar
• Gupta RS, Warren CM, Smith BM, et al. Prevalence and Severity of Food Allergies Among US Adults. JAMA Network Open. 2019 Jan 4 2(1):e185630.
   PubMed Web of Science ®Google Scholar
• Osborne NJ, Koplin JJ, Martin PE, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J Allergy Clin Immunol. 2011 Mar;127(3):668–76 e1-2.
   Web of Science ®Google Scholar
• Shroba J, Rath N, Barnes C. Possible role of environmental factors in the development of food allergies. Clin Rev Allergy Immunol. 2019 Dec;57(3):303–311.
   PubMed Web of Science ®Google Scholar
• Lack G. Update on risk factors for food allergy. J Allergy Clin Immunol. 2012 May;129(5):1187–1197.
   PubMed Web of Science ®Google Scholar
• Koplin JJ, Wake M, Dharmage SC, et al. Cohort Profile: the HealthNuts Study: population prevalence and environmental/genetic predictors of food allergy. Int J Epidemiol. 2015 Aug;44(4):1161–1171.
   PubMed Web of Science ®Google Scholar
• Peters RL, Allen KJ, Dharmage SC, et al. Differential factors associated with challenge-proven food allergy phenotypes in a population cohort of infants: a latent class analysis. Clin Exp Allergy. 2015 May;45(5):953–963.
   PubMed Web of Science ®Google Scholar
• Sampson HA, O’Mahony L, Burks AW, et al. Mechanisms of food allergy. J Allergy Clin Immunol. 2018 Jan;141(1):11–19.
   PubMed Web of Science ®Google Scholar
• Satitsuksanoa P, Jansen K, Globinska A, et al. Regulatory Immune Mechanisms in Tolerance to Food Allergy. Front Immunol. 2018;9:2939.
   PubMed Web of Science ®Google Scholar
• Fazilleau N, Mark L, McHeyzer-Williams LJ, et al. Follicular helper T cells: lineage and location. Immunity. 2009 Mar 20 30(3):324–335.
   PubMed Web of Science ®Google Scholar
• Gowthaman U, Chen JS, Zhang B, et al. Identification of a T follicular helper cell subset that drives anaphylactic IgE. Science. 2019 Aug 30;365(6456). https://doi.org/10.1126/science.aaw6433.
   Google Scholar
• Martin PE, Eckert JK, Koplin JJ, et al. Which infants with eczema are at risk of food allergy? Results from a population-based cohort. Clin Exp Allergy. 2015 Jan;45(1):255–264.
   PubMed Web of Science ®Google Scholar
• Venkataraman D, Soto-Ramirez N, Kurukulaaratchy RJ, et al. Filaggrin loss-of-function mutations are associated with food allergy in childhood and adolescence. J Allergy Clin Immunol. 2014 Oct;134(4):876–82 e4.
   PubMed Web of Science ®Google Scholar
• Eller E, Kjaer HF, Host A, et al. Food allergy and food sensitization in early childhood: results from the DARC cohort. Allergy. 2009 Jul;64(7):1023–1029.
   PubMed Web of Science ®Google Scholar
• Hill DJ, Hosking CS, de Benedictis FM, et al. Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: an international study. Clin Exp Allergy. 2008 Jan;38(1):161–168.
   PubMed Web of Science ®Google Scholar
• Tran MM, Lefebvre DL, Dharma C, et al. Predicting the atopic march: results from the Canadian Healthy Infant Longitudinal Development Study. J Allergy Clin Immunol. 2018 Feb;141(2):601–7 e8.
   PubMed Web of Science ®Google Scholar
• Tsakok T, Marrs T, Mohsin M, et al. Does atopic dermatitis cause food allergy? A systematic review. J Allergy Clin Immunol. 2016 Apr;137(4):1071–1078.
   PubMed Web of Science ®Google Scholar
• Kivisto JE, Clarke A, Dery A, et al. Genetic and environmental susceptibility to food allergy in a registry of twins. J Allergy Clin Immunol Pract. 2019 Nov;7(8):2916–2918.
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang S, Tsai HJ, et al. Genetic and environmental contributions to allergen sensitization in a Chinese twin study. Clin Exp Allergy. 2009 Jul;39(7):991–998.
   PubMed Web of Science ®Google Scholar
• Sicherer SH, Furlong TJ, Maes HH, et al. Genetics of peanut allergy: a twin study. J Allergy Clin Immunol. 2000 Jul;106(1):53–56.
   PubMed Web of Science ®Google Scholar
• Yilmaz-Demirdag Y, Prather B, Bahna SL. Does heredity determine the allergy manifestation or the sensitisation to a specific allergen? Allergol Immunopathol (Madr). 2010 Mar-Apr;38(2):56–59.
   PubMed Web of Science ®Google Scholar
• Tsai HJ, Kumar R, Pongracic J, et al. Familial aggregation of food allergy and sensitization to food allergens: a family-based study. Clin Exp Allergy. 2009 Jan;39(1):101–109.
   PubMed Web of Science ®Google Scholar
• Suaini NHA, Wang Y, Soriano VX, et al. Genetic determinants of paediatric food allergy: a systematic review. Allergy. 2019 Sep;74(9):1631–48.
   Web of Science ®Google Scholar
• Hong X, Hao K, Ladd-Acosta C, et al. Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children. Nat Commun. 2015 Feb 24 6(1):6304.
   PubMedGoogle Scholar
• Madore AM, Vaillancourt VT, Asai Y, et al. HLA-DQB1*02 and DQB1*06:03P are associated with peanut allergy. Eur J Hum Genet. 2013 Oct;21(10):1181–1184.
   PubMed Web of Science ®Google Scholar
• Sandilands A, Sutherland C, Irvine AD, et al. Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci. 2009 May 1 122(9):1285–1294.
   PubMed Web of Science ®Google Scholar
• Irvine AD. Fleshing out filaggrin phenotypes. J Invest Dermatol. 2007 Mar;127(3):504–507.
   PubMed Web of Science ®Google Scholar
• Palmer CN, Irvine AD, Terron-Kwiatkowski A, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet. 2006 Apr;38(4):441–446.
   PubMed Web of Science ®Google Scholar
• Brough HA, Simpson A, Makinson K, et al. Peanut allergy: effect of environmental peanut exposure in children with filaggrin loss-of-function mutations. J Allergy Clin Immunol. 2014 Oct;134(4):867–875.
   PubMed Web of Science ®Google Scholar
• Marenholz I, Grosche S, Kalb B, et al. Genome-wide association study identifies the SERPINB gene cluster as a susceptibility locus for food allergy. Nat Commun. 2017 Oct 20 8(1):1056.
   PubMedGoogle Scholar
• Brown SJ, Asai Y, Cordell HJ, et al. Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy. J Allergy Clin Immunol. 2011 Mar;127(3):661–667.
   PubMed Web of Science ®Google Scholar
• Jansen PR, Petrus NCM, Venema A, et al. Higher Polygenetic Predisposition for Asthma in Cow’s Milk Allergic Children. Nutrients. 2018 Oct 27 10(11):1582.
   Web of Science ®Google Scholar
• Simard M, Madore AM, Girard S, et al. Polygenic risk score for atopic dermatitis in the Canadian population. J Allergy Clin Immunol. 2021 Jan;147(1):406–409.
   PubMed Web of Science ®Google Scholar
• Tangye SG, Al-Herz W, Bousfiha A, et al. Human Inborn Errors of Immunity: 2019 Update on the Classification from the International Union of Immunological Societies Expert Committee. J Clin Immunol. 2020 Jan;40(1):24–64.
   PubMed Web of Science ®Google Scholar
• Siegel AM, Stone KD, Cruse G, et al. Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation. J Allergy Clin Immunol. 2013 Dec;132(6):1388–1396.
   PubMed Web of Science ®Google Scholar
• Kearney CJ, Randall KL, Oliaro J. DOCK8 regulates signal transduction events to control immunity. Cell Mol Immunol. 2017 May;14(5):406–411.
   PubMed Web of Science ®Google Scholar
• Biggs CM, Keles S, Chatila TA. DOCK8 deficiency: insights into pathophysiology, clinical features and management. Clin Immunol. 2017 Aug;181:75–82.
   PubMed Web of Science ®Google Scholar
• Aydin SE, Kilic SS, Aytekin C, et al. DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients. J Clin Immunol. 2015 Feb;35(2):189–198.
   PubMed Web of Science ®Google Scholar
• Jing H, Zhang Q, Zhang Y, et al. Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype. J Allergy Clin Immunol. 2014 Jun;133(6):1667–1675.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Dove CG, Hor JL, et al. DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity. J Exp Med. 2014Dec 15 211(13):2549–2566.
   PubMed Web of Science ®Google Scholar
• Howell MD, Kim BE, Gao P, et al. Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol. 2009 Sep;124(3):R7–R12.
   PubMed Web of Science ®Google Scholar
• Haskologlu S, Kostel Bal S, Islamoglu C, et al. Clinical, immunological features and follow up of 20 patients with dedicator of cytokinesis 8 (DOCK8) deficiency. Pediatr Allergy Immunol. 2020 Jul;31(5):515–527.
   PubMed Web of Science ®Google Scholar
• Aydin SE, Freeman AF, Al-Herz W, et al. Hematopoietic Stem Cell Transplantation as Treatment for Patients with DOCK8 Deficiency. J Allergy Clin Immunol Pract. 2019 Mar;7(3):848–855.
   PubMed Web of Science ®Google Scholar
• Happel CS, Stone KD, Freeman AF, et al. Food allergies can persist after myeloablative hematopoietic stem cell transplantation in dedicator of cytokinesis 8-deficient patients. J Allergy Clin Immunol. 2016 Jun;137(6):1895–8 e5.
   PubMed Web of Science ®Google Scholar
• Sowerwine KJ, Holland SM, Freeman AF. Hyper-IgE syndrome update. Ann N Y Acad Sci. 2012 Feb;1250(1):25–32.
   PubMedGoogle Scholar
• Erlich TH, Yagil Z, Kay G, et al. Mitochondrial STAT3 plays a major role in IgE-antigen-mediated mast cell exocytosis. J Allergy Clin Immunol. 2014 Aug;134(2):460–469.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Davis JC, Lamborn IT, et al. Combined Immunodeficiency Associated with DOCK8 Mutations. N Engl J Med. 2009 Nov 19 361(21):2046–2055.
   PubMed Web of Science ®Google Scholar
• Engelhardt KR, McGhee S, Winkler S, et al. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol. 2009 Dec;124(6):1289–302 e4.
   PubMed Web of Science ®Google Scholar
• Al-Herz W, Ragupathy R, Massaad MJ, et al. Clinical, immunologic and genetic profiles of DOCK8-deficient patients in Kuwait. Clin Immunol. 2012 Jun;143(3):266–272.
   PubMed Web of Science ®Google Scholar
• Alsum Z, Hawwari A, Alsmadi O, et al. Clinical, immunological and molecular characterization of DOCK8 and DOCK8-like deficient patients: single center experience of twenty-five patients. J Clin Immunol. 2013 Jan;33(1):55–67.
   PubMed Web of Science ®Google Scholar
• Sanal O, Jing H, Ozgur T, et al. Additional diverse findings expand the clinical presentation of DOCK8 deficiency. J Clin Immunol. 2012 Aug;32(4):698–708.
   PubMed Web of Science ®Google Scholar
• Chu EY, Freeman AF, Jing H, et al. Cutaneous Manifestations of Deficiency Syndrome. Arch Dermatol. 2012 Jan;148(1):79–84.
   PubMedGoogle Scholar
• Engelhardt KR, Gertz ME, Keles S, et al. The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2015 Aug;136(2):402–412.
   PubMed Web of Science ®Google Scholar
• Chandesris MO, Melki I, Natividad A, et al. Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey. Medicine (Baltimore). 2012 Jul;91(4):e1–e19.
   PubMed Web of Science ®Google Scholar
• Arora M, Bagi P, Strongin A, et al. Gastrointestinal Manifestations of STAT3-Deficient Hyper-IgE Syndrome. J Clin Immunol. 2017 Oct;37(7):695–700.
   PubMed Web of Science ®Google Scholar
• Wu J, Chen J, Tian ZQ, et al. Clinical Manifestations and Genetic Analysis of 17 Patients with Autosomal Dominant Hyper-IgE Syndrome in Mainland China: new Reports and a Literature Review. J Clin Immunol. 2017 Feb;37(2):166–179.
   PubMed Web of Science ®Google Scholar
• Gernez Y, Freeman AF, Holland SM, et al. Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry. J Allergy Clin Immunol Pract. 2018 May;6(3):996–1001.
   PubMed Web of Science ®Google Scholar
• Lin L, Wang Y, Sun B, et al. The clinical, immunological and genetic features of 12 Chinese patients with STAT3 mutations. Allergy Asthma Clin Immunol. 2020;16(1):65.
   PubMed Web of Science ®Google Scholar
• Ferrua F, Cicalese MP, Galimberti S, et al. Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study. Lancet Haematol. 2019 May;6(5):e239–e53.
   PubMed Web of Science ®Google Scholar
• Komatsu N, Saijoh K, Jayakumar A, et al. Correlation between SPINK5 gene mutations and clinical manifestations in Netherton syndrome patients. J Invest Dermatol. 2008 May;128(5):1148–1159.
   PubMed Web of Science ®Google Scholar
• Atschekzei F, Jacobs R, Wetzke M, et al. A Novel CARMIL2 Mutation Resulting in Combined Immunodeficiency Manifesting with Dermatitis, Fungal, and Viral Skin Infections As Well as Selective Antibody Deficiency. J Clin Immunol. 2019 Apr;39(3):274–276.
   PubMed Web of Science ®Google Scholar
• Schober T, Magg T, Laschinger M, et al. A human immunodeficiency syndrome caused by mutations in CARMIL2. Nat Commun. 2017 Jan 23 8(1):14209.
   PubMedGoogle Scholar
• Sorte HS, Osnes LT, Fevang B, et al. A potential founder variant in CARMIL2/RLTPR in three Norwegian families with warts, molluscum contagiosum, and T-cell dysfunction. Mol Genet Genomic Med. 2016 Nov;4(6):604–616.
   PubMed Web of Science ®Google Scholar
• Gambineri E, Ciullini Mannurita S, Hagin D, et al. Clinical, Immunological, and Molecular Heterogeneity of 173 Patients With the Phenotype of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked (IPEX) Syndrome. Front Immunol. 2018;9:2411.
   PubMed Web of Science ®Google Scholar
• Felgentreff K, Siepe M, Kotthoff S, et al. Severe eczema and Hyper-IgE in Loeys-Dietz-syndrome - contribution to new findings of immune dysregulation in connective tissue disorders. Clin Immunol. 2014 Jan;150(1):43–50.
   PubMed Web of Science ®Google Scholar
• Candotti F. Clinical Manifestations and Pathophysiological Mechanisms of the Wiskott-Aldrich Syndrome. J Clin Immunol. 2018 Jan;38(1):13–27.
   PubMed Web of Science ®Google Scholar
• Lexmond WS, Goettel JA, Lyons JJ, et al. FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J Clin Invest. 2016 Oct 3 126(10):4030–4044.
   PubMed Web of Science ®Google Scholar
• Sullivan KE, Mullen CA, Blaese RM, et al. A multiinstitutional survey of the Wiskott-Aldrich syndrome. J Pediatr. 1994 Dec;125(6):876–885.
   PubMed Web of Science ®Google Scholar
• Tuano KS, Orange JS, Sullivan K, et al. Food allergy in patients with primary immunodeficiency diseases: prevalence within the US Immunodeficiency Network (USIDNET). J Allergy Clin Immunol. 2015 Jan;135(1):273–275.
   PubMed Web of Science ®Google Scholar
• Morales-Tirado V, Sojka DK, Katzman SD, et al. Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function. Blood. 2010 Apr 29 115(17):3498–3507.
   PubMed Web of Science ®Google Scholar
• Schneider C, Shen C, Gopal AA, et al. Migration-induced cell shattering due to DOCK8 deficiency causes a type 2-biased helper T cell response. Nat Immunol. 2020 Dec;21(12):1528–1539.
   PubMed Web of Science ®Google Scholar
• Tangye SG, Pillay B, Randall KL, et al. Dedicator of cytokinesis 8-deficient CD4(+) T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells. J Allergy Clin Immunol. 2017 Mar;139(3):933–949.
   PubMed Web of Science ®Google Scholar
• Greil J, Rausch T, Giese T, et al. Whole-exome sequencing links caspase recruitment domain 11 (CARD11) inactivation to severe combined immunodeficiency. J Allergy Clin Immunol. 2013 May;131(5):1376–83 e3.
   PubMed Web of Science ®Google Scholar
• Snow AL, Xiao W, Stinson JR, et al. Congenital B cell lymphocytosis explained by novel germline CARD11 mutations. J Exp Med. 2012 Nov 19 209(12):2247–2261.
   PubMed Web of Science ®Google Scholar
• Dadi H, Jones TA, Merico D, et al. Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11). J Allergy Clin Immunol. 2018 May;141(5):1818–30 e2.
   PubMed Web of Science ®Google Scholar
• Ma CA, Stinson JR, Zhang Y, et al. Germline hypomorphic CARD11 mutations in severe atopic disease. Nat Genet. 2017 Aug;49(8):1192–1201.
   PubMed Web of Science ®Google Scholar
• Dorjbal B, Stinson JR, Ma CA, et al. Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease. J Allergy Clin Immunol. 2019 Apr;143(4):1482–1495.
   PubMed Web of Science ®Google Scholar
• Kim J, Kim MG, Jeong SH, et al. STAT3 maintains skin barrier integrity by modulating SPINK5 and KLK5 expression in keratinocytes. Exp Dermatol 2022 Feb;31(2): 223–232.
   Google Scholar
• Stuvel K, Heeringa JJ, Dalm V, et al. Comel-Netherton syndrome: a local skin barrier defect in the absence of an underlying systemic immunodeficiency. Allergy. 2020 Jul;75(7):1710–1720.
   PubMed Web of Science ®Google Scholar
• Folster-Holst R, Stoll M, Koch WA, et al. Lack of association of SPINK5 polymorphisms with nonsyndromic atopic dermatitis in the population of Northern Germany. Br J Dermatol. 2005 Jun;152(6):1365–1367.
   PubMed Web of Science ®Google Scholar
• Kusunoki T, Okafuji I, Yoshioka T, et al. SPINK5 polymorphism is associated with disease severity and food allergy in children with atopic dermatitis. J Allergy Clin Immunol. 2005 Mar;115(3):636–638.
   PubMed Web of Science ®Google Scholar
• Weidinger S, Baurecht H, Wagenpfeil S, et al. Analysis of the individual and aggregate genetic contributions of previously identified serine peptidase inhibitor Kazal type 5 (SPINK5), kallikrein-related peptidase 7 (KLK7), and filaggrin (FLG) polymorphisms to eczema risk. J Allergy Clin Immunol. 2008 Sep;122(3):560–8 e4.
   PubMed Web of Science ®Google Scholar
• Ashley SE, Tan HT, Vuillermin P, et al. The skin barrierfunction gene SPINK5 is associated with challenge-proven IgE-mediated food allergy in infants. Allergy. 2017 Sep;72(9):1356–1364.
   PubMed Web of Science ®Google Scholar
• Briot A, Deraison C, Lacroix M, et al. Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med. 2009 May 11 206(5):1135–1147.
   PubMed Web of Science ®Google Scholar
• Liang Y, Cucchetti M, Roncagalli R, et al. The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858–866.
   PubMed Web of Science ®Google Scholar
• Wang Y, Ma CS, Ling Y, et al. Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations. J Exp Med. 2016Oct 17 213(11):2413–2435.
   PubMed Web of Science ®Google Scholar
• Kolukisa B, Baser D, Akcam B, et al. Evolution and long-term outcomes of combined immunodeficiency due to CARMIL2 deficiency. Allergy. 2022 Mar;77(3): 1004–1019.
   Web of Science ®Google Scholar
• Alazami AM, Al-Helale M, Alhissi S, et al. Novel CARMIL2 Mutations in Patients with Variable Clinical Dermatitis, Infections, and Combined Immunodeficiency. Front Immunol. 2018;9:203.
   PubMed Web of Science ®Google Scholar
• Krogulska A, Borowiec M, Polakowska E, et al. FOXP3, IL-10, and TGF-beta genes expression in children with IgE-dependent food allergy. J Clin Immunol. 2011 Apr;31(2):205–215.
   PubMed Web of Science ®Google Scholar
• Krogulska A, Polakowska E, Wasowska-Krolikowska K, et al. Decreased FOXP3 mRNA expression in children with atopic asthma and IgE-mediated food allergy. Ann Allergy Asthma Immunol. 2015 Nov;115(5):415–421.
   PubMed Web of Science ®Google Scholar
• Park JH, Lee KH, Jeon B, et al. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome: a systematic review. Autoimmun Rev. 2020 Jun;19(6):102526.
   PubMed Web of Science ®Google Scholar
• Duclaux-Loras R, Charbit-Henrion F, Neven B, et al. Clinical Heterogeneity of Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome: a French Multicenter Retrospective Study. Clin Transl Gastroenterol. 2018 Nov 2 9(10):201.
   PubMedGoogle Scholar
• Rao A, Kamani N, Filipovich A, et al. Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning. Blood. 2007 Jan 1 109(1):383–385.
   PubMed Web of Science ®Google Scholar
• Bottema RW, Kerkhof M, Reijmerink NE, et al. X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts. Allergy. 2010 Jul;65(7):865–874.
   PubMed Web of Science ®Google Scholar
• Frischmeyer-Guerrerio PA, Guerrerio AL, Oswald G, et al. TGFbeta receptor mutations impose a strong predisposition for human allergic disease. Sci Transl Med. 2013 Jul 24 5(195):195ra94.
   PubMed Web of Science ®Google Scholar
• Martino D, Joo JE, Sexton-Oates A, et al. Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy. Epigenetics. 2014 Jul;9(7):998–1006.
   PubMed Web of Science ®Google Scholar
• Paparo L, Nocerino R, Cosenza L, et al., Epigenetic features of FoxP3 in children with cow’s milk allergy. Clin Epigenetics. 8(1): 86. 2016.
   PubMedGoogle Scholar
• Paparo L, Nocerino R, Bruno C, et al. Randomized controlled trial on the influence of dietary intervention on epigenetic mechanisms in children with cow’s milk allergy: the EPICMA study. Sci Rep. 2019 Feb 26 9(1):2828.
   PubMedGoogle Scholar
• Godhwani N, Bahna SL. Antiepilepsy drugs and the immune system. Ann Allergy Asthma Immunol. 2016 Dec;117(6):634–640.
   PubMed Web of Science ®Google Scholar
• Lyons JJ, Milner JD. Primary atopic disorders. J Exp Med. 2018 Apr 2; 215(4):1009–1022.
   PubMed Web of Science ®Google Scholar