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Review

Biologics for chronic spontaneous urticaria: toward a personalized treatment

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Pages 1297-1305 | Received 30 Aug 2022, Accepted 17 Oct 2022, Published online: 26 Oct 2022

References

  • Grattan CEH, Francis DM, Hide M, et al. Detection of circulating histamine releasing autoantibodies with functional properties of anti-IgE in chronic urticaria. Clin Exp Allergy. 1991;21:695–704.
  • Hide M, Francis DM, Grattan CEH, et al. Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med. 1993;328:1599–1604.
  • Fiebiger E, Maurer D, Holub H, et al. Serum IgG autoantibodies directed against the alpha chain of FcεRI: a selective marker and pathogenetic factor for a distinct subset of chronic urticaria patients? J Clin Invest. 1995;96:2606–2612.
  • Ferrer M, Kinet JP, Kaplan AP. Comparative studies of functional and binding assays for IgG anti-FcεRIα (α-subunit). J Allergy Clin Immunol. 1998;101:672–676.
  • Greaves MW. Chronic urticaria. J Allergy Clin Immunol. 2000;105:664–672.
  • Asero R, Tedeschi A, Lorini M, et al. Chronic urticaria: novel clinical and serological aspects. Clin Exp Allergy. 2001;31:1105–1110.
  • Sabroe RA, Fiebiger E, Francis DM, et al. Classification of anti-FcepsilonRI and anti-IgE autoantibodies in chronic idiopathic urticaria and correlation with disease severity. J Allergy Clin Immunol. 2002;110:492–499.
  • Altrichter S, Peter HJ, Pisarevskaja D, et al. IgE mediated autoallergy against thyroid peroxidase—a novel pathomechanism of chronic spontaneous urticaria? PLoS One. 2011;6(4):e14794.
  • Schmetzer O, Lakin E, Topal FA, et al. IL‐24 is a common and specific autoantigen of IgE in patients with chronic spontaneous urticaria. J Allergy Clin Immunol. 2018;142:876‐82.
  • Asero R, Marzano AV, Ferrucci S, et al. Co-occurrence of IgE and IgG autoantibodies in patients with chronic spontaneous urticaria. Clin Exp Immunol. 2020;200:242–249.
  • Sanchez J, Sanchez A, Cardona R. Causal relationship between anti-TPO IgE and chronic urticaria by in-vitro and in-vivo tests. Allergy Asthma Immunoll Res. 2019;11:29–42.
  • Kolkhir P, Kovalkova E, Chernov A, et al. Autoimmune chronic spontaneous urticaria detection with IgG-anti-TPO and total IgE. J Allergy Clin Immunol Pract. 2021;9:4138–4146.
  • Asero R. Clinical variables of severe chronic spontaneous urticaria from total IgE standpoint: a retrospective study. Eur Ann Allergy Clin Immunol. 2022;50:30–33.
  • Bossi F, Frossi B, Radillo O, et al. Mast cells are critically involved in serum mediated vascular leakage in chronic urticaria beyond high-affinity IgE receptor stimulation. Allergy. 2011;66:1538–1545.
  • Cugno M, Marzano AV, Tedeschi A, et al. Expression of tissue factor by eosinophils in patients with chronic urticaria. Int Arch Allergy Immunol. 2009;148:170–174.
  • Yanase Y, Takahagi S, Hide M. Chronic spontaneous urticaria and the extrinsic coagulation system. Allergol Int. 2018;67:191–194.
  • Saito R, Yanase Y, Kamegashira A, et al. Increase of tissue factor expression on the surface of peripheral monocytes of patients with chronic spontaneous urticaria. Allergy. 2020;75:971–974.
  • Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al. The international EAACI/GA2LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria. Allergy. 2022;77:734–766.
  • Tharp MD, Bernstein JA, Kavati A, et al. Benefits and harms of omalizumab treatment in adolescent and adult patients with chronic idiopathic (Spontaneous) urticaria: a meta-analysis of “Real-world” Evidence. JAMA Dermatol. 2019;155:29–38.
  • Zhao ZT, Ji CM, Yu WJ, et al. Omalizumab for the treatment of chronic spontaneous urticaria: a meta-analysis of randomized clinical trials. J Allergy Clin Immunol. 2016;137:1742–1750.
  • Marzano AV, Genovese G, Casazza G, et al. Predictors of response to omalizumab and relapse in chronic spontaneous urticaria: a study of 470 patients. J Eur Acad Dermatol Venereol. 2019;33:918–924.
  • Ertas R, Ozyurt K, Atasoy M, et al. The clinical response to omalizumab in chronic spontaneous urticaria patients is linked to and predicted by IgE levels and their change. Allergy. 2018;73:705–712.
  • Weller K, Ohanyan T, Hawro T, et al. Total IgE levels are linked to the response of chronic spontaneous urticaria patients to omalizumab. Allergy. 2018;73:2406–2408.
  • Straesser MD, Oliver E, Palacios T, et al. Serum IgE as an immunological marker to predict response to omalizumab treatment in symptomatic chronic urticaria. J Allergy Clin Immunol Pract. 2018;6:1386–1388.
  • Nettis E, Cegolon L, Di Leo E, et al. Omalizumab in chronic spontaneous urticaria: efficacy, safety, predictors of treatment outcome, and time to response. Ann Allergy Asthma Immunol. 2018;121:474–478.
  • Asero R. Chronic spontaneous urticaria treated with Omalizumab: what differentiates early from late responders? Eur Ann Allergy Clin Immunol. 2021;53(1):47–48.
  • Palacios T, Stillman L, Borish L, et al. Lack of basophil CD203c-upregulating activity as an immunological marker to predict response to treatment with omalizumab in patients with symptomatic chronic urticaria. J Allergy Clin Immunol Pract. 2016;4:529–530.
  • Deza G, Bertolín-Colilla M, Pujol RM, et al. Basophil FcεRI expression in chronic spontaneous urticaria: a potential immunological predictor of response to omalizumab therapy. Acta Derm Venereol. 2017;97:698–704.
  • Asero R. Clinical variables of severe chronic spontaneous urticaria from total IgE standpoint: a retrospective study. Eur Ann Allergy Clin Immunol. 2022;54:30–33.
  • Gericke J, Metz M, Ohanyan T, et al. Serum autoreactivity predicts time to response to omalizumab therapy in chronic spontaneous urticaria. J Allergy Clin Immunol. 2017;139:1059–1061.
  • Endo T, Toyoshima S, Hayama K, et al. Relationship between changes in the 7-day urticaria activity score after treatment with omalizumab and the responsiveness of basophils to FcεRI stimulation in patients with chronic spontaneous urticaria Asia Pac Allergy. Asia Pac Allergy. 2020;10:e12.
  • Ertaş R, Hawro T, Altrichter S, et al. Antinuclear antibodies are common and linked to poor response to omalizumab treatment in patients with CSU. Allergy. 2020;75:468–470.
  • Schoepke N, Asero R, Ellrich A, et al. Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria: results of the PURIST Study. Allergy. 2019;74:2427–2436.
  • Asero R. Omalizumab in severe chronic urticaria: are slow and non-responders different? Eur Ann Allergy Clin Immunol. 2021;53:263–266.
  • Maggi L, Rossettini B, Montaini G, et al. Omalizumab dampens type 2 inflammation in a group of long-term treated asthma patients and detaches IgE from FcεRI. Eur J Immunol. 2018;48:2005–2014.
  • Kaplan AP, Gimenez-Arnau AM, Saini SS. Mechanisms of action that contribute to efficacy of omalizumab in chronic spontaneous urticaria. Allergy. 2017;72:519–533.
  • Maurer M, Khan DA, Komi DEA, et al. Biologics for the use in chronic spontaneous urticaria: when and which. J Allergy Clin Immunol Pract. 2021;9:1067–1078.
  • Tedeschi A, Kolkhir P, Asero R, et al. Chronic urticaria and coagulation: pathophysiological and clinical aspects. Allergy. 2014;69:683–691.
  • Yanase Y, Matsuo Y, Takahagi S, et al. Coagulation factors induce human skin mast cell and basophil degranulation via the activation of complement 5 and the C5a receptor. J Allergy Clin Immunol. 2021;147:1101–1104.
  • Shtessel M, Limjunyawong N, Oliver ET, et al. MRGPRX2 activation causes increased skin reactivity in patients with chronic spontaneous urticaria. J Invest Dermatol. 2021;141:678–681.
  • Cao TBT, Cha HY, Yang EM, et al. Elevated MRGPRX2 levels related to disease severity in patients with chronic spontaneous urticaria. Allergy Asthma Immunol Res. 2021;13:498–506.
  • Maurer M, Gimenez-Arnau AM, Sussman G, et al. Ligelizumab for chronic spontaneous urticaria. N Engl J Med. 2019;381:1321–1332.
  • Gasser P, Tarchevskaya SS, Guntern P, et al. The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. Nat Commun. 2020;11:165.
  • Wedi B. Emerging treatments for chronic urticaria. Expert Opin Investig Drugs. 2022;31:281–290.
  • Harris JM, Cabanski CR, Scheerens H, et al. A randomized trial of quilizumab in adults with refractory chronic spontaneous urticaria. J Allergy Clin Immunol. 2016;138:1730–1732.
  • Asero R, Cugno M, Tedeschi A. Eosinophils in chronic urticaria: supporting or leading actors? World Allergy Organ J. 2009;2:213–217.
  • Giménez-Arnau AM, DeMontojoye L, Asero R, et al. The pathogenesis of chronic spontaneous urticaria: the role of infiltrating cells. J Allergy Clin Immunol Pract. 2021;9:2195–2208.
  • Bernstein JA, Singh U, Rao MB, et al. Benralizumab for chronic spontaneous urticaria. N Engl J Med. 2020;383:1389–1391.
  • Magerl M, Terhorst D, Metz M, et al. Benefit of mepolizumab treatment in a patient with chronic spontaneous urticaria. J Dtsch Dermatol Ges. 2018;16:477–478.
  • Antonicelli L, Tontini C, Garritani MS, et al. Efficacy of mepolizumab in patients with concomitant severe eosinophilic asthma and severe chronic urticaria: an example of personalized medicine? J Investig Allergol Clin Immunol. 2021 Nov;29. Online ahead of print
  • Maurer M, Altrichter S, Metz M, et al. Benefit from reslizumab treatment in a patient with chronic spontaneous urticaria and cold urticaria. J Eur Acad Dermatol Venereol. 2018;32:e112–3.
  • Sanchez J, Sanchez A, Muner M, et al. Presence of IgE autoantibodies against eosinophil peroxidase and eosinophil cationic protein in severe chronic spontaneous urticaria and atopic dermatitis. Allergy Asthma Immunol Res. 2021;13:746–761.
  • Maurer M, Casale T, Saini S, et al. Dupilumab significantly reduces itch and hives in patients with chronic spontaneous urticaria: results from a phase III trial (LIBERTY-CSU CUPID Study A). J Allergy Clin Immunol. 2022 ;149:AB312.
  • Hamilton JD, Harel S, Swanson BN, et al. Dupilumab suppresses type 2 inflammatory biomarkers across multiple atopic, allergic diseases. Clin Exp Allergy. 2021;51:915–931.
  • Alvarado D, Maurer M, Gedrich R, et al. Anti-KIT monoclonal antibody CDX-0159 induces profound and durable mast cell suppression in a healthy volunteer study. Allergy. 2022 Feb 19;77(8):2393–2403. Online ahead of print.
  • Terhorst-Molawi D, Hawro T, Grekowitz E, et al. The anti-KIT antibody, CDX-0159, reduces mast cell numbers and circulating tryptase and improves disease control in patients with chronic inducible urticaria (CIndU). J Allergy Clin Immunol. 2022;149(2):AB178. AB178.
  • Altrichter S, Staubach P, Pasha M, et al. An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria. J Allergy Clin Immunol. 2022;149:1683–1690.
  • Combalia A, Losno RA, Prieto-Gonzàlez S, et al. Rituximab in chronic spontaneous urticaria: an encouraging therapeutic approach. Skin Pharmacol Physiol. 2018;31:184–187.
  • Sabag DA, Matanes L, Bejar J, et al. Interleukin-17 is a potential player and treatment target in severe chronic spontaneous urticaria. Clin Exp Allergy. 2020;50:799–804.
  • Maul JT, Distler M, Kolios A, et al. Canakinumab lacks efficacy in treating adult patients with moderate to severe chronic spontaneous urticaria in a phase II randomized double-Blind placebo-Controlled single-center study. J Allergy Clin Immunol Pract. 2021;9:463–468.
  • Krause K, Weller K, Stefaniak R, et al. Efficacy and safety of the interleukin-1 antagonist rilonacept in Schnitzler syndrome: an open-label study. Allergy. 2012;67:943–950.
  • Kay AB, Clark P, Maurer M, et al. Elevations in T-helper-2-initiating cytokines (interleukin-33, interleukin-25 and thymic stromal lymphopoietin) in lesional skin from chronic spontaneous (‘idiopathic’) urticaria. Br J Dermatol. 2015;172:1294–1302.
  • Sand FI, Thomsen SF. Off-label use of TNF-alpha inhibitors in a dermatological university department: retrospective evaluation of 118 patients. Dermatol Ther. 2015;28:158–165.
  • Wilson LH, Eliason MJ, Leiferman KM, et al. Treatment of refractory chronic urticaria with tumor necrosis factor-alfa inhibitors. J Am Acad Dermatol. 2011;64:1221–1222.
  • Metz M, Sussman G, Gagnon R, et al. Fenebrutinib in H1 antihistamine-refractory chronic spontaneous urticaria: a randomized phase II trial. Nat Med. 2021;27:1961–1969.
  • Kolkhir P, Munoz M, Asero R, et al. Autoimmune chronic spontaneous urticaria. J Allergy Clin Immunol. 2022;149:1819–1831.
  • Maurer M, Berger W, Gimenez-Arnau A, et al. Remibrutinib, a novel BTK inhibitor, demonstrates promising efficacy and safety in chronic spontaneous urticaria. J Allergy Clin Immunol. In press;2022. DOI: 10.1016/j.jaci.2022.08.027.
  • Asero R, Tedeschi A. Usefulness of a short course of oral prednisone in antihistamine-resistant chronic urticaria: a retrospective analysis. J Investig Allergol Clin Immunol. 2010;20:386–390.
  • Grattan CE, O’Donnell BF, Francis DM, et al. Randomized double-blind study of cyclosporin in chronic ‘idiopathic’ urticaria. Br J Dermatol. 2000;143:365–372.
  • Zhou B, Li J, Liu R, et al. The role of crosstalk of immune cells in pathogenesis of chronic spontaneous urticaria. Front Immunol. 2022;13:879754.

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