577
Views
1
CrossRef citations to date
0
Altmetric
Original

UHMWPE wear debris upregulates mononuclear cell proinflammatory gene expression in a novel murine model of intramedullary particle disease

, , , , &
Pages 412-420 | Received 02 Jan 2004, Accepted 04 Jun 2004, Published online: 08 Jul 2009

  • Al-Saffar N, Revell P A. Differential expression of transforming growth factor-alpha and macrophage colony-stimulating factor/colony-stimulating factor-1R (c-fins) by multinucleated giant cells involved in pathological bone resorption at the site of orthopaedic implants. J Orthop Res 2000; 18: 800–7
  • Algan S M, Purdon M, Horowitz S M. Role of tumor necrosis factor alpha in particulate-induced bone resorption. J Orthop Res 1996; 14: 30–5
  • Biswas S K, Sodhi A. In vitro activation of murine peritoneal macrophages by monocyte chemoattractant protein-1: upregulation of CD11b, production of proinflammatory cytokines, and the signal transduction pathway. J Interferon Cytokine Res 2002; 22: 527–38
  • Boring L, Gosling J, Chensue S W, Kunkel S L, Farese R V, Jr, Broxmeyer H E, Charo I F. Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C Chemokine receptor knockout mice. J Clin Invest 1997; 100: 2552–61
  • Callaghan J J, Forest E E, Olejniczak J P, Goetz D D, Johnston R C. Charnley total hip arthroplasty in patients less than fifty years old: a twenty to twenty-five-year follow-up. J Bone Joint Surg (Am) 1998; 80: 704–14
  • Chiba J, Rubash H E, Kin K J, Iwaki Y. The characterization of cytokines in the interface tissue obtained from failed cementless total hip arthroplasty with and without femoral osteolysis. Clin Orthop 1994, 300: 304–12
  • Childs L M, Goater J J, O'Keefe R J, Schwarz E M. Effect of antitumor necrosis factor-alpha gene therapy on wear debris-induced osteolysis. J Bone Joint Surg (Am) 2001; 83: 1789–97
  • Clohisy J C, Teitelbaum S, Chen S, Erdmann J M, Abu-Amer Y. Tumor necrosis factor-alpha mediates polymethylmethacrylate particle-induced NF-kappaB activation in osteoclast precursor cells. J Orthop Res 2002; 20: 174–81
  • Goodman S B, Huie P, Song Y, Schurman D, Maloney W, Woolson S, Sibley R. Cellular profile and cytokine production at prosthetic interfaces. Study of tissues retrieved from revised hip and knee replacements. J Bone Joint Surg (Br) 1998; 80: 531–9
  • Green T R, Fisher J, Matthews J B, Stone M H, Ingham E. Effect of size and dose on bone resorption activity of macrophages by in vitro clinically relevant ultra high molecular weight polyethylene particles. J Biomed Mater Res 2000; 53: 490–7
  • Hallab N J, Cunningham B W, Jacobs J J. Spinal implant debris-induced osteolysis. Spine 2003; 28: 125–38
  • Harris W H, Schiller A L, Scholler J M, Freiberg R A, Scott R. Extensive localized bone resorption in the femur following total hip replacement. J Bone Joint Surg (Am) 1976; 58: 612–8
  • Ishimi Y, Miyaura C, Jin C H, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 1990; 145: 3297–303
  • Jilka R L, Hangoc G, Girasole G, Passeri G, Williams D C, Abrams J S, Boyce B, Broxmeyer H, Manolagas S C. Increased osteoclast development after estrogen loss: Mediation by interleukin-6. Science 1992; 257: 88–91
  • Jiranek W A, Machado M, Jasty M, Jevsevar D, Wolfe H J, Goldring S R, Goldberg M J, Harris W H. Production of cytokines around loosened cemented acetabular components: analysis with immunohistochemical techniques and in situ hybridization. J Bone Joint Surg (Br) 1993; 75: 863–79
  • Jones L C, Frondoza C, Hungerford D S. Effect of PMMA particles and movement on an implant interface in a canine model. J Bone Joint Surg (Br) 2001; 83: 448–58
  • Kaar S G, Ragab A A, Kaye S J, Kilic B A, Jinno T, Goldberg V M, Bi Y, Stewart M C, Carter J R, Greenfield E M. Rapid repair of titanium particle-induced osteolysis is dramatically reduced in aged mice. J Orthop Res 2001; 19: 171–8
  • Kim K J, Kobayashi Y, Itoh T. Osteolysis model with continuous infusion of polyethylene particles. Clin Orthop 1998, 352: 46–52
  • Konttinen Y T, Xu J W, Waris E, Li T F, Gomez-Barrena E, Nordsletten L, Santavirta S. Interleukin-6 in aseptic loosening of total hip replacement prostheses. Clin Exp Rheumatol 2002; 20: 485–90
  • Kudo O, Fujikawa Y, Itonaga I, Sabokbar A, Torisu T, Athanasou N A. Proinflammatory cytokine (TNFalpha/IL-1alpha) induction of human osteoclast formation. J Pathol 2002; 198: 220–7
  • Kudo O, Sabokbar A, Pocock A, Itonaga I, Fujikawa Y, Athanasou N A. Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism. Bone 2003; 32: 1–7
  • Livak K J, Schmittgen T D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(Delta Delta C(T)) method. Methods 2001; 25: 402–8
  • Matthews J B, Besong A A, Green T R, Stone M H, Wro-blewski B M, Fisher J, Ingham E. Evaluation of the response of primary human peripheral blood mononuclear phagocytes to challenge with in vitro generated clinically relevant UHMWPE particles of known size and dose. J Biomed Mater Res 2000; 52: 296–307
  • Merkel K D, Erdmann J E, McHugh K P, Abu-Amer Y, Ross F P, Teitelbaum S L. Tumor necrosis factor- mediates implant osteolysis. Am J Pathol 1999; 154: 203–10
  • Millett P J, Allen M J, Bostrom M P. Effects of alendronate on particle-induced osteolysis in a rat model. J Bone Joint Surg (Am) 2002; 84: 236–49
  • Nakashima Y, Sun D, Trindade M C D, Chun L E, Song Y, Goodman S B, Schurman D J, Maloney W J, Smith R L. Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles. J Bone Joint Surg (Br) 1999a; 81: 155–62
  • Nakashima Y, Sun D, Trindade M C D, Maloney W J, Goodman S B, Schurman D J, Smith R L. Signaling pathways for tumor necrosis factor-alpha and interleukin-6 expression in human macrophages exposed to titaniumalloy particulate debris in vitro. J Bone Joint Surg (Br) 1999b; 81: 603–15
  • Neale S D, Sabokbar A, Howie D W, Murray D W, Athanasou N A. Macrophage colony-stimulating factor and interleukin-6 release by periprosthetic cells stimulates osteoclast formation and bone resorption. J Orthop Res 1999; 17: 686–94
  • Niki Y, Matsumoto H, Suda Y, Otani T, Fujikawa K, Toyama Y, Hisamori N, Nozue A. Metal ions induce bone-resorbing cytokine production through the redox pathway in synoviocytes and bone marrow macrophages. Biomaterials 2003; 24: 1447–57
  • Orishimo K F, Claus A M, Sychterz C J, Engh C A. Relationship between polyethylene wear and osteolysis in hips with a second-generation porous-coated cementless cup after seven years of follow-up. Bone Joint Surg (Am) 2003; 85: 1095–9
  • Rahimi P, Wang C Y, Stashenko P, Lee S K, Lorenzo J A, Graves D T. Monocyte chemoattractant protein-1 expression and monocyte recruitment in osseous inflammation in the mouse. Endocrinology 1995; 136: 2752–9
  • Santavirta S, Konttinen Y T, Bergroth V, Eskola A, Tallroth K, Lindholm T. Aggressive granulomatous lesions associated with hip arthroplasty. Immunopathological studies. J Bone Joint Surg (Am) 1990; 72: 252–8
  • Schwarz E M, Lu A P, Goater J J, Benz E B, Kollias G, Rosier R N, Puzas J E, O'Keefe R J. Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis. J Orthop Res 2000; 18: 472–80
  • Shanbhag A S, Hasselman C T, Rubash H E. The John Charnley Award. Inhibition of wear debris mediated osteolysis in a canine total hip arthroplasty model. Clin Orthop 1997, 344: 33–43
  • Shimizu T, Mehdi R, Yoshimura Y, Yoshikawa H, Nomura S, Miyazono K, Takaoka K. Sequential expression of bone morphogenetic protein, tumor necrosis factor, and their receptors in bone-forming reaction after mouse femoral marrow ablation. Bone 1998; 23: 127–33
  • Sud S, Yang S Y, Evans C H, Robbins P D, Wooley P H. Effects of cytokine gene therapy on particulate-induced inflammation in the murine air pouch. Inflammation. 2001; 25: 361–72
  • Sundfeldt M, Widmark M, Johansson C B, Campbell P, Carlsson L V. Effect of submicron polyethylene particles on an osseointegrated implant: an experimental study with a rabbit patello-femoral prosthesis. Acta Orthop Scand. 2002; 73: 416–24
  • Suva L J, Seedor J G, Endo N, Quartuccio H A, Thompson D D, Bab I, Rodan G A. Pattern of gene expression following rat tibial marrow ablation. J Bone Miner Res 1993; 8: 379–88
  • Xing L, Carlson L, Story B, Tai Z, Keng P, Siebenlist U, Boyce B F. Expression of either NF-kappaB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption. J Bone Miner Res 2003; 18: 260–9
  • Yang S, Wu B, Mayton L, Evans C H, Robbins P D, Wooley P H. IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model. Inflamm Res 2002; 51: 342–50

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.