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Orignal papers

In vitro testing of chitosan in gentamicin-loaded bone cement No antimicrobial effect and reduced mechanical performance

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Pages 851-860 | Received 29 Aug 2007, Accepted 20 May 2008, Published online: 08 Jul 2009

References

  • Arciola C, Campoccia D, Gamberini S, Rizzi S, Donati M, Baldassarri L, Montanaro L. Search for the insertion element IS256 within ica locus of Staphylococcus epidermidis clinical isolates collected from biomaterial-associated infections. Biomaterials. 2004; 25(18)4117–25
  • Arciola C, Gamberini S, Campoccia D, Visai L, Speziale P, Baldassarri L, Montanaro L. A multiplex PCR method for the detection of all five individual genes of ica locus in Staphylococcus epidermidis. A survey of 400 clinical isolates from prosthesis-associated infections. J Biomed Mat Res A 2005; 75(2)408–13
  • Askew M, Kufel M, Fleissner P, Grasdisar I, Salstrom S, Tan S. Effect of vacuum mixing on the mechanical properties of antibiotic-impregnated polymethyl methacrylate bone cement. J Biomed Mat Res 1990; 24(1)73–580
  • ASTM F 451-99ae1: Standard Specification for Acrylic Bone Cement 1999
  • Bertazzoni Minelli E, Benini A, Magnan B, Bartolozzi P. Release of gentamicin and vancomycin from temporary human hip spacers in two-stage revision of infected arthroplasty. J Antimicrob Chemother 2004; 53(1)329–34
  • Burtanapanitkit B, Srinilta V, Ingiviga N, Oungbho K, Geater A, Ovatlarnporn C. The efficacy of hydroxyapatite composite as a biodegradable antibiotic delivery system. Clin Orthop. 2004; 424: 244–52
  • Dunne N, Leonard D, Daly C, Buchanan F, Orr J. Small punch testing technique to characterise the mechanical properties of self-curing acrylic bone cement. Proceedings of the Institution of Mechanical Engineers. Journal of Engineering in Medicine Part H6 2006; 220(1)11–21
  • Dunne N, Hill J, McAfee P, Todd K, Kirkpatrick R, Tunney M, Patrick S. In vitro study of the efficacy of acrylic bone cement loaded with supplementary amounts of gentamicin. Effect on mechanical properties, antibiotic release, and biofilm formation. Acta Orthop 2007; 78(6)774–85
  • Ensing G, Hendriks J, Jongsma J, vanHorn J, van der Mei H, Busscher H. The influence of ultrasound on the release of gentamicin from antibiotic-loaded acrylic beads and bone cements. J Biomed Mat Res B 2005; 75(1)1–5
  • Espehaug B, Engesaeter L, Vollset S, Havelin L, Langeland N. Antibiotic prophylaxis in total hip arthroplasty. Review of 10905 primary cemented total hip replacements reported to the Norwegian arthroplasty register 1987 to 1995. J Bone Joint Surg (Br) 1997; 79: 590–5
  • Garcia-Saenaz M, Arias-Puente A, Fresnadillo-Martinez M, Matillia-Rodriguez A. In vitro adhesion of Staphylococcus epidermidis to intraocular lenses. J Cataract Refract Surg 2000; 26(11)1673–9
  • Ge Z, Baguenard L, Wee A, Khor E. Hydroxyapatite-chitin materials as potential tissue engineered bone substitutes. Biomaterials 2004; 25(6)1049–58
  • Hendriks J, van Horn H, van der Mei H, Busscher H. Backgrounds of antibiotic-loaded bone cement and prosthetic related infection. Biomaterials 2004; 25(1)545–56
  • Hope P, Kristinsson K, Norman P, Elson R. Deep infection of cemented total hip arthroplasty caused by coagulase-negative staphylococci. J Bone Jt Surg (Br) 1989; 71: 851–5
  • International Standard Organisation 5833: Implants for surgery. Acrylic resin cement 2002
  • Keevil B, Lockhart S, Cooper D. Determination of tobramycin in serum using liquid chromatography–tandem mass spectrometry and comparison with a fluorescence polarisation assay. J Chromatography B 2003; 794: 329–35
  • Khor E, Lim L. Implantable applications of chitin and chitosan. Biomaterials 2003; 24(1)2339–49
  • Kim S, Kim Y, Yoon T, Park S, Cho I, Kim E, Kim I, Shin J. The characteristics of a hydroxyapatite-chitosan-PMMA bone cement. Biomaterials 2004; 25(1)5715–23
  • Klekamp J, Dawson J, Haas D, DeBoer D, Christie M. The use of vancomycin and tobramycin in acrylic bone cement: biomechanical effects and elution kinetics for use in joint arthroplasty. J Arthroplasty 1999; 14(1)339–46
  • Kuechle D, Landon G, Musher D, Noble P. Elution of vancomycin, daptomycin and amikacin from acrylic bone cement. Clin Orthop 1991; 264: 302–8
  • McLaren A, Nelson C, McLaren S, DeClerk G. The effect of glycine filler on the elution rate of gentamicin from acrylic bone cement: A pilot study. Clin Orthop 2004; 427: 25–7
  • McLaren A, Nelson C, McLaren S, Smeltzer M. Xylitol and glycine fillers increase permeability of PMMA to enhance elution of daptomycin. Clin Orthop 2006; 451(1)22–8
  • McLaren A, McLaren S, McLemore R, Vernon B. Particle Size of fillers affects permeability of polymethylmethacrylate. Clin Orthop 2007; 461: 64–7
  • Passuti N, Gouin F. Antibiotic-loaded bone cement in orthopaedic surgery. J Bone Spine 2003; 70(1)169–74
  • Risbud M, Bhonde R. Polyacrylamide-chitosan hydrogels: in vitro biocompatibility and sustained antibiotic release studies. Drug Deliv 2000; 1(1)61–l7
  • Shi Z, Neoh K, Kang E, Wang W. Antibacterial and mechanical properties of bone cement impregnated with chitosan nanoparticles. Biomaterials 2006; 27(1)2440–9
  • Sterling G J, Crawford S, Potter J H, Koerbin G, Crawford R. The pharmacokinetics of simplex-tobramycin bone cement. J Bone Joint Surg (Br) 2003; 85: 646–9
  • Thornes B, Murray P, Bouchier-Hayes D. Development of resistant strains of Staphylococcus epidermidis on genta-micin-loaded bone cement in vivo. J Bone Joint Surg (Br) 2002; 84(5)758–60
  • Tunney M, Patrick S, Gorman S, Nixon J, Anderson N, Davis R, Hanna D, Ramage G. Improved detection of infection in hip replacements. A currently underestimated problem. J Bone Joint Surg (Br) 1998a; 80 568–72
  • Tunney M, Ramage G, Patrick S, Murphy P, Gorman S. Antimicrobial susceptibility of bacteria isolated from orthopaedic implants following revision hip surgery. Antimicrob Agents Chemother. 1998b; 42(11)3002–5
  • Tunney M, Dunne N, Einarsson G, McDowell A, Kerr A, Patrick S. Bacterial biofilm formation by bacteria isolated from retrieved failed prosthetic hip implants in an in vitro model of hip arthroplasty antibiotic prophylaxis. J Orthop Res 2007; 25(10)2–10

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