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Acta Orthopaedica Volume 88, 2017 - Issue 3
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Original Articles

No effect of teriparatide on migration in total knee replacement

A randomized controlled trial involving 50 patients

Håkan LedinOrthopedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linköping University, Linköping; ;Department of Orthopedics, Aleris Specialist Care Motala AB, Motala; Correspondence[email protected]
,
Lars GoodDepartment of Orthopedics, Hospital of Oskarshamn, Oskarshamn;
,
Torsten JohanssonOrthopedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linköping University, Norrköping, Sweden
&
Per AspenbergOrthopedics, Department of Clinical and Experimental Medicine, Faculty of Medicine, Linköping University, Linköping;
Pages 259-262 | Received 26 Aug 2016, Accepted 19 Jan 2017, Published online: 13 Mar 2017

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  • Aspenberg P. Special Review: Accelerating fracture repair in humans: a reading of old experiments and recent clinical trials. BoneKEy reports 2013; 2: 244.
  • Aspenberg P, Johansson T. Teriparatide improves early callus formation in distal radial fractures. Acta Orthop 2010; 81(2):234–6.
  • Aspenberg P, Sandberg O. Distal radial fractures heal by direct woven bone formation. Acta Orthop 2013; 84(3): 297–300.
  • Aspenberg P, Wermelin K, Tengwall P, Fahlgren A. Additive effects of PTH and bisphosphonates on the bone healing response to metaphyseal implants in rats. Acta Orthop 2008; 79(1): 111–5.
  • Aspenberg P, Genant H K, Johansson T, Nino A J, See K, Krohn K, Garcia-Hernandez P A, Recknor C P, Einhorn T A, Dalsky G P, Mitlak B H, Fierlinger A, Lakshmanan M C. Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures. J Bone Miner Res 2010; 25(2): 404–14.
  • Aspenberg P, Malouf J, Tarantino U, Garcia-Hernandez PA, Corradini C, Overgaard S, Stepan JJ, Borris L, Lespessailles E, Frihagen F, Papavasiliou K, Petto H, Caeiro JR, Marin F. Effects of teriparatide compared with risedronate on recovery after pertrochanteric hip fracture: results of a randomized, active-controlled, double-blind clinical trial at 26 weeks. J Bone Joint Surg Am 2016; 98(22): 1868–78
  • Bernhardsson M, Sandberg O, Aspenberg P. Experimental models for cancellous bone healing in the rat. Acta Orthop 2015; 86(6): 745–50.
  • Gabet Y, Muller R, Levy J, Dimarchi R, Chorev M, Bab I, Kohavi D. Parathyroid hormone 1-34 enhances titanium implant anchorage in low-density trabecular bone: a correlative micro-computed tomographic and biomechanical analysis. Bone 2006; 39(2): 276–82.
  • Hilding M, Aspenberg P. Postoperative clodronate decreases prosthetic migration: 4-year follow-up of a randomized radiostereometric study of 50 total knee patients. Acta Orthop 2006; 77(6): 912–6.
  • Hilding M, Ryd L, Toksvig-Larsen S, Aspenberg P. Clodronate prevents prosthetic migration: a randomized radiostereometric study of 50 total knee patients. Acta Orthop Scand 2000; 71(6): 553–7.
  • Huang T W, Yang T Y, Huang K C, Peng K T, Lee M S, Hsu R W. Effect of teriparatide on unstable pertrochanteric fractures. BioMed research international 2015; 2015: 568390.
  • Johansson T. PTH 1-34 (teriparatide) may not improve healing in proximal humerus fractures. A randomized, controlled study of 40 patients. Acta Orthop 2016; 87(1): 79–82.
  • Ledin H, Aspenberg P, Good L. Tourniquet use in total knee replacement does not improve fixation, but appears to reduce final range of motion. Acta Orthop 2012; 83(5): 499–503.
  • Ledin H, Good L, Aspenberg P. Denosumab reduces early migration in total knee replacement: a randomized controlled trial in 50 patients. Acta Orthop 2017. [Ahead of print]
  • Namba R S, Inacio M C, Cheetham T C, Dell R M, Paxton E W, Khatod M X. Lower total knee arthroplasty revision risk associated with bisphosphonate use, even in patients with normal bone density. J Arthroplasty 2016; 31(2): 537–41.
  • Pijls B G, Valstar E R, Nouta K A, Plevier J W, Fiocco M, Middeldorp S, Nelissen R G. Early migration of tibial components is associated with late revision: a systematic review and meta-analysis of 21,000 knee arthroplasties. Acta Orthop 2012; 83(6): 614–24.
  • Ryd L, Albrektsson B E, Carlsson L, Dansgard F, Herberts P, Lindstrand A, Regner L, Toksvig-Larsen S. Roentgen stereophotogrammetric analysis as a predictor of mechanical loosening of knee prostheses. J Bone Joint Surg Br 1995; 77(3): 377–83.
  • Sandberg O H, Aspenberg P. Inter-trabecular bone formation: a specific mechanism for healing of cancellous bone. Acta Orthop 2016; 87(5): 459–65.
  • Skripitz R, Aspenberg P. Early effect of parathyroid hormone (1-34) on implant fixation. Clin Orthop Rel Res 2001a; (392): 427–32.
  • Skripitz R, Aspenberg P. Implant fixation enhanced by intermittent treatment with parathyroid hormone. J Bone Joint Surg Br 2001b; 83(3): 437–40.
  • Teng S, Yi C, Krettek C, Jagodzinski M. Bisphosphonate use and risk of implant revision after total hip/knee arthroplasty: a meta-analysis of observational studies. PloS one. 2015; 10(10):e 0139927.

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