1,561
Views
10
CrossRef citations to date
0
Altmetric
Editorial

How can we improve the design of small molecules to target thioredoxin reductase for treating cancer?

&
Pages 331-333 | Received 28 Sep 2020, Accepted 18 Nov 2020, Published online: 14 Dec 2020

References

  • Zhang J, Li X, Han X, et al. Targeting the thioredoxin system for cancer therapy. Trends Pharmacol Sci. 2017;38(9):794–808.
  • Dagnell M, Schmidt EE, Arner ESJ. The A to Z of modulated cell patterning by mammalian thioredoxin reductases. Free Radic Biol Med. 2018;115:484–496.
  • Cai W, Zhang L, Song Y, et al. Small molecule inhibitors of mammalian thioredoxin reductase. Free Radic Biol Med. 2012;52(2):257–265.
  • Arnér ESJ. Targeting the selenoprotein thioredoxin reductase 1 for anticancer therapy. Adv Cancer Res. 2017;136:139–151.
  • Zhang B, Zhang J, Peng S, et al. Thioredoxin reductase inhibitors: a patent review. Expert Opin Ther Pat. 2017;27(5):547–556.
  • Bian M, Fan R, Zhao S, et al. Targeting the thioredoxin system as a strategy for cancer therapy. J Med Chem. 2019;62(16):7309–7321.
  • Zhang J, Zhang B, Li X, et al. Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: an update. Med Res Rev. 2019;39(1):5–39.
  • Anestal K, Prast-Nielsen S, Cenas N, et al. Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells. PloS One. 2008;3(4):e1846.
  • Xu J, Cheng Q, Arner ES. Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities. Free Radic Biol Med. 2016;94:110–120.
  • Canon J, Rex K, Saiki AY, et al. The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity. Nature. 2019;575(7781):217–223. .
  • Zhang B, Ge C, Yao J. et al. Selective selenol fluorescent probes: design, synthesis, structural determinants, and biological applications. J Am Chen Soc. 2015;137(2):757–769.
  • Arkin MR, Tang Y, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. Chem Biol. 2014;21(9):1102–1114.
  • Fritz-Wolf K, Kehr S, Stumpf M, et al. Crystal structure of the human thioredoxin reductase-thioredoxin complex. Nat Commun. 2011;2:383.
  • Xu J, Eriksson SE, Cebula M, et al. The conserved Trp114 residue of thioredoxin reductase 1 has a redox sensor-like function triggering oligomerization and crosslinking upon oxidative stress related to cell death. Cell Death Dis. 2015;6:e1616.
  • Zhang L, Duan D, Liu Y, et al. Highly selective off-on fluorescent probe for imaging thioredoxin reductase in living cells. J Am Chem Soc. 2014;136(1):226–233.
  • Li X, Zhang B, Yan C, et al. A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage. Nat Commun. 2019;10:2745.
  • Li X, Hou Y, Meng X, et al. Selective activation of a prodrug by thioredoxin reductase providing a strategy to target cancer cells. Angew Chem Int Ed Engl. 2018;57(21):6141–6145.
  • Prast-Nielsen S, Dexheimer TS, Schultz L, et al. Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay. Free Radic Biol Med. 2011;50(9):1114–1123.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.