Advanced search
Publication Cover
Expert Opinion on Drug Discovery Volume 19, 2024 - Issue 2
Submit an article Journal homepage
556
Views
0
CrossRef citations to date
0
Altmetric
Editorial

How can we unlock the full potential of marine biological resources for novel drug discovery in an effective and ethical way?

Hidayat HussainDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), GermanyCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-8654-8127View further author information
ORCID Icon
Pages 125-130 | Received 08 Jun 2023, Accepted 15 Nov 2023, Published online: 23 Nov 2023

References

  • Sigwart JD, Blasiak R, Jaspars M, et al. Unlocking the potential of marine biodiscovery. Nat Prod Rep. 2021;38(7):1235–1242. doi: 10.1039/D0NP00067A
  • Cappello E, Nieri P. From life in the sea to the clinic: the marine drugs approved and under clinical trial. Life. 2021;11(12):1390. doi: 10.3390/life11121390
  • The global marine pharmaceuticals pipeline. USA: Midwestern University. Available from: https://www.marinepharmacology.org/
  • Almaliti J, Gerwick WH. Methods in marine natural product drug discovery: what’s new? Expert Opin Drug Discov. 2023;18(7):687–691. doi: 10.1080/17460441.2023.2214360
  • Mayer AMS, Pierce M, Reji M, et al. J Pharmacol Exp Ther 2023;385(S3):299. doi:10.1124/jpet.122.527010
  • Guo FW, Zhang Q, Gu YC, et al. Sulfur-containing marine natural products as leads for drug discovery and development. Curr Opin Chem Biol. 2023;75:102330. doi: 10.1016/j.cbpa.2023.102330
  • Gupta R, Srivastava D, Sahu M, et al. Artificial intelligence to deep learning: machine intelligence approach for drug discovery. Mol Divers. 2021;25(3):1315–1360. doi: 10.1007/s11030-021-10217-3
  • Farghali H, Canová NK, Arora M. The potential applications of artificial intelligence in drug discovery and development. Physiol Res. 2021;70:S715–S722. doi: 10.33549/physiolres.934765
  • Chu L, Huang J, Muhammad M, et al. Genome mining as a biotechnological tool for the discovery of novel marine natural products. Crit Rev Biotechnol. 2020;40(5):571–589. doi: 10.1080/07388551.2020.1751056
  • Gomez-Escribano J, Alt S, Bibb M. Next generation sequencing of actinobacteria for the discovery of novel natural products. Mar Drugs. 2016;14(4):78. doi: 10.3390/md14040078
  • Joern P, Dequan H, Gaiping W. Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge theonella swinhoei. Proc Natl Acad Sci USA. 2004;101(46):16222–16227. doi: 10.1073/pnas.0405976101
  • Bauman KD, Butler KS, Moore BS, et al. Genome mining methods to discover bioactive natural products. Nat Prod Rep. 2021;38(11):2100–2129. doi: 10.1039/d1np00032b
  • Eustaquio AS, Nam SJ, Penn K, et al. The discovery of salinosporamide K from the marine bacterium “Salinispora pacifica” by genome mining gives insight into pathway evolution. Chembiochem. 2011;12(1):61–64. doi: 10.1002/cbic.201000564
  • Vestola J, Shishido TK, Jokela J, et al. Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway. Proc Natl Acad Sci USA. 2014;111(18):E1909–E1917. doi: 10.1073/pnas.1320913111
  • Saha S, Zhang W, Zhang G, et al. Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams. Chem Sci. 2017;8(2):1607–1612. doi: 10.1039/c6sc03875a
  • Zhao N, Song Y, Xie X, et al. Synthetic biology-inspired cell engineering in diagnosis, treatment, and drug development. Signal Transduct Target Ther. 2023;8(1):112. doi: 10.1038/s41392-023-01375-x
  • Subramanian M, Marudhamuthu M. Hitherto unknown terpene synthase organization in taxol‑producing endophytic bacteria isolated from marine macroalgae. Curr Microbiol. 2020;77(6):918–923. doi: 10.1007/s00284-020-01878-8
  • Wang C, Kim JH, Kim SW. Synthetic biology and metabolic engineering for marine carotenoids: nNew opportunities and future prospects. Mar Drugs. 2014;12(9):4810–4832. doi: 10.3390/md12094810
  • Sherman B, Henry RJ. The Nagoya Protocol and historical collections of plants. Nat Plants. 2020;6(5):430–432. doi: 10.1038/s41477-020-0657-8
  • Dey P, Kundu A, Chakraborty HJ, et al. Therapeutic value of steroidal alkaloids in cancer: current trends and future perspectives. Int J Cancer. 2019;145(7):1731–1744. doi: 10.1002/ijc.31965
  • Coley CW, Green WH, Jensen KF. Machine learning in computer-aided synthesis planning. Acc Chem Res. 2018;51(5):1281–1289. doi: 10.1021/acs.accounts.8b00087
  • Szymkuc S, Gajewska EP, Klucznik T, et al. Computer-assisted synthetic planning: the end of the beginning. Angew Chem Int Ed. 2016;55(20):5904–5937. doi: 10.1002/anie.201506101
  • Pereira F, Aires-de-Sousa J. Computational methodologies in the exploration of marine natural product leads. Mar Drugs. 2018;16(7):236. doi: 10.3390/md16070236
  • Ng J, Bandeira N, Liu WT, et al. Dereplication and de novo sequencing of nonribosomal peptides. Nat Methods. 2009;6(8):596–599. doi: 10.1038/nmeth.1350
  • Bai L, Romanova EV, Sweedler JV. Distinguishing endogenous D-amino acid-containing neuropeptides in individual neurons using tandem mass spectrometry. Anal Chem. 2011;83(7):2794–2800. doi: 10.1021/ac200142m

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.