Exercise promotes IL-6 release from legs in older men with minor response to unilateral immobilization

References

• Cohen, J. (1988). Statistical power analysis for the behavioural sciences (2nd ed.). Hillsdale, NJ: Lawrence Erlbaum Associates.
   Google Scholar
• Comassi, M., Vitolo, E., Pratali, L., Del, T. S., Dellanoce, C., Rossi, C., … Solini, A. (2015). Acute effects of different degrees of ultra-endurance exercise on systemic inflammatory responses. Internal Medicine Journal, 45(1), 74–79. doi:10.1111/imj.12625
   PubMed Web of Science ®Google Scholar
• Croft, L., Bartlett, J. D., MacLaren, D. P., Reilly, T., Evans, L., Mattey, D. L., … Morton, J. P. (2009). High-intensity interval training attenuates the exercise-induced increase in plasma IL-6 in response to acute exercise. Applied Physiology, Nutrition, and Metabolism, 34, 1098–1107. doi: 10.1139/H09-117
   PubMed Web of Science ®Google Scholar
• Degens, H. (2007). Age-related skeletal muscle dysfunction: Causes and mechanisms. Journal of Musculoskeletal & Neuronal Interactions, 7, 246–252.
   PubMedGoogle Scholar
• Eriksen, L., Gronbaek, M., Helge, J. W., Tolstrup, J. S., & Curtis, T. (2011). The Danish health examination survey 2007–2008 (DANHES 2007–2008). Scandinavian Journal of Public Health, 39, 203–211. doi: 10.1177/1403494810393557
   PubMed Web of Science ®Google Scholar
• Febbraio, M. A., Steensberg, A., Starkie, R. L., McConell, G. K., & Kingwell, B. A. (2003). Skeletal muscle interleukin-6 and tumor necrosis factor-alpha release in healthy subjects and patients with type 2 diabetes at rest and during exercise. Metabolism, 52, 939–944. doi: 10.1016/S0026-0495(03)00105-7
   PubMed Web of Science ®Google Scholar
• Fischer, C. P., Plomgaard, P., Hansen, A. K., Pilegaard, H., Saltin, B., & Pedersen, B. K. (2004). Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle. American Journal of Physiology: Endocrinology and Metabolism, 287, E1189–E1194.
   PubMed Web of Science ®Google Scholar
• Gielen, S., Adams, V., Mobius-Winkler, S., Linke, A., Erbs, S., Yu, J., … Hambrecht, R. (2003). Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. Journal of the American College of Cardiology, 42, 861–868. doi: 10.1016/S0735-1097(03)00848-9
   PubMed Web of Science ®Google Scholar
• Gokhale, R., Chandrashekara, S., & Vasanthakumar, K. C. (2007). Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response. Cytokine, 40, 123–127. doi: 10.1016/j.cyto.2007.08.006
   PubMed Web of Science ®Google Scholar
• Gram, M., Vigelso, A., Yokota, T., Hansen, C. N., Helge, J. W., Hey-Mogensen, M., … Dela, F. (2014). Two weeks of one-leg immobilization decreases skeletal muscle respiratory capacity equally in young and elderly men. Experimental Gerontology, 58, 269–278. doi: 10.1016/j.exger.2014.08.013
   PubMed Web of Science ®Google Scholar
• Gram, M., Vigelso, A., Yokota, T., Helge, J. W., Dela, F., & Hey-Mogensen, M. (2015). Skeletal muscle mitochondrial H2O2 emission increases with immobilization and decreases after aerobic training in young and older men. Journal of Physiology, 593(17), 4011–4027. doi:10.1113/JP270211
   PubMed Web of Science ®Google Scholar
• Grounds, M. D., Radley, H. G., Gebski, B. L., Bogoyevitch, M. A., & Shavlakadze, T. (2008). Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle. Clinical and Experimental Pharmacology and Physiology, 35, 846–851. doi: 10.1111/j.1440-1681.2007.04868.x
   PubMed Web of Science ®Google Scholar
• Haddad, F., Zaldivar, F., Cooper, D. M., & Adams, G. R. (2005). IL-6-induced skeletal muscle atrophy. Journal of Applied Physiology, 98, 911–917. doi: 10.1152/japplphysiol.01026.2004
   PubMed Web of Science ®Google Scholar
• Helge, J. W., Klein, D. K., Andersen, T. M., van, H. G., Calbet, J., Boushel, R., … Saltin, B. (2011). Interleukin-6 release is higher across arm than leg muscles during whole-body exercise. Experimental Physiology, 96, 590–598. doi: 10.1113/expphysiol.2010.056424
   PubMed Web of Science ®Google Scholar
• Helge, J. W., Stallknecht, B., Pedersen, B. K., Galbo, H., Kiens, B., & Richter, E. A. (2003). The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle. The Journal of Physiology, 546, 299–305. doi: 10.1113/jphysiol.2002.030437
   PubMed Web of Science ®Google Scholar
• Howley, E. T., Bassett, D. R.Jr., & Welch, H. G. (1995). Criteria for maximal oxygen uptake: Review and commentary. Medicine & Science in Sports & Exercise, 27, 1292–1301. doi: 10.1249/00005768-199509000-00009
   PubMed Web of Science ®Google Scholar
• Kimura, H., Suzui, M., Nagao, F., & Matsumoto, K. (2001). Highly sensitive determination of plasma cytokines by time-resolved fluoroimmunoassay; effect of bicycle exercise on plasma level of interleukin-1 alpha (IL-1 alpha), tumor necrosis factor alpha (TNF alpha), and interferon gamma (IFN gamma). Analytical Sciences, 17, 593–597. doi: 10.2116/analsci.17.593
   PubMed Web of Science ®Google Scholar
• Kinugawa, T., Kato, M., Ogino, K., Osaki, S., Tomikura, Y., Igawa, O., … Shigemasa, C. (2003). Interleukin-6 and tumor necrosis factor-alpha levels increase in response to maximal exercise in patients with chronic heart failure. International Journal of Cardiology, 87, 83–90. doi: 10.1016/S0167-5273(02)00200-0
   PubMed Web of Science ®Google Scholar
• MacDonald, C., Wojtaszewski, J. F., Pedersen, B. K., Kiens, B., & Richter, E. A. (2003). Interleukin-6 release from human skeletal muscle during exercise: Relation to AMPK activity. Journal of Applied Physiology, 95, 2273–2277. doi: 10.1152/japplphysiol.00242.2003
   PubMed Web of Science ®Google Scholar
• Maestu, J., Jurimae, J., Purge, P., Ramson, R., & Jurimae, T. (2010). Performance improvement is associated with higher postexercise responses in interleukin-6 and tumor necrosis factor concentrations. Journal of Sports Medicine and Physical Fitness, 50, 524–529.
   PubMed Web of Science ®Google Scholar
• Mallinson, J. E., & Murton, A. J. (2013). Mechanisms responsible for disuse muscle atrophy: Potential role of protein provision and exercise as countermeasures. Nutrition, 29, 22–28. doi: 10.1016/j.nut.2012.04.012
   PubMed Web of Science ®Google Scholar
• Narici, M. V., & Maffulli, N. (2010). Sarcopenia: Characteristics, mechanisms and functional significance. British Medical Bulletin, 95, 139–159. doi: 10.1093/bmb/ldq008
   PubMed Web of Science ®Google Scholar
• Norregaard, J., Gram, M., Vigelsoe, A., Wiuff, C., Kuhlman, A. B., Helge, J. W., & Dela, F. (2015). The effect of reduced physical activity and retraining on blood lipids and body composition in young and older adult men. Journal of Aging and Physical Activity, 23(4), 489–495. doi:10.1123/japa.2014-0079
   PubMed Web of Science ®Google Scholar
• Pedersen, M., Steensberg, A., Keller, C., Osada, T., Zacho, M., Saltin, B., … Pedersen, B. K. (2004). Does the aging skeletal muscle maintain its endocrine function? Exercise Immunology Review, 10, 42–55.
   PubMed Web of Science ®Google Scholar
• Reihmane, D., Hansen, A. V., Gram, M., Kuhlman, A. B., Norregaard, J., Pedersen, H. P., … Dela, F. (2013). Immobilization increases interleukin-6, but not tumour necrosis factor-alpha, release from the leg during exercise in humans. Experimental Physiology, 98, 778–783. doi: 10.1113/expphysiol.2012.069211
   PubMed Web of Science ®Google Scholar
• Reihmane, D., Jurka, A., Tretjakovs, P., & Dela, F. (2013). Increase in IL-6, TNF-alpha, and MMP-9, but not sICAM-1, concentrations depends on exercise duration. European Journal of Applied Physiology, 113(4), 851–858. doi:10.1007/s00421-012-2491-9
   PubMed Web of Science ®Google Scholar
• Santos, R. V., Viana, V. A., Boscolo, R. A., Marques, V. G., Santana, M. G., Lira, F. S., … de Mello, M.T. (2012). Moderate exercise training modulates cytokine profile and sleep in elderly people. Cytokine, 60, 731–735. doi: 10.1016/j.cyto.2012.07.028
   PubMed Web of Science ®Google Scholar
• Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardi, M., & Munoz-Canoves, P. (2008). Interleukin-6 is an essential regulator of satellite cell-mediated skeletal muscle hypertrophy. Cell Metabolism, 7, 33–44. doi: 10.1016/j.cmet.2007.11.011
   PubMed Web of Science ®Google Scholar
• Signorelli, S. S., Mazzarino, M. C., Di, P. L., Malaponte, G., Porto, C., Pennisi, G., … Virgilio, V. (2003). High circulating levels of cytokines (IL-6 and TNFalpha), adhesion molecules (VCAM-1 and ICAM-1) and selectins in patients with peripheral arterial disease at rest and after a treadmill test. Vascular Medicine, 8, 15–19. doi: 10.1191/1358863x03vm466oa
   PubMed Web of Science ®Google Scholar
• Steensberg, A., Keller, C., Starkie, R. L., Osada, T., Febbraio, M. A., & Pedersen, B. K. (2002). IL-6 and TNF-alpha expression in, and release from, contracting human skeletal muscle. American Journal of Physiology – Endocrinology and Metabolism, 283, E1272–E1278. doi: 10.1152/ajpendo.00255.2002
   PubMed Web of Science ®Google Scholar
• Toft, A. D., Thorn, M., Ostrowski, K., Asp, S., Moller, K., Iversen, S., … Pedersen, B. K. (2000). N-3 polyunsaturated fatty acids do not affect cytokine response to strenuous exercise. Journal of Applied Physiology, 89, 2401–2406.
   PubMed Web of Science ®Google Scholar
• Trenerry, M. K., Della Gatta, P. A., Larsen, A. E., Garnham, A. P., & Cameron-Smith, D. (2011). Impact of resistance exercise training on interleukin-6 and JAK/STAT in young men. Muscle & Nerve, 43, 385–392. doi: 10.1002/mus.21875
   PubMed Web of Science ®Google Scholar
• Vigelsø, A., Gram, M., Dybboe, R., Kuhlman, A. B., Prats, C., & Grenhaff, P. L. (2015, unpublished results). The effect of 2 weeks’ leg immobilization and aging on substrate utilization and fatty acid mobilization during moderate intensity exercise.
   Google Scholar
• Vigelsø, A., Gram, M., Wiuff, C., Andersen, J. L., Helge, J. W., & Dela, F. (2015). Six weeks’ aerobic retraining after two weeks’ immobilization restores leg lean mass and aerobic capacity but does not fully rehabilitate leg strength in young and older men. Journal of Rehabilitation Medicine, 47(6), 552–560. doi: 10.2340/16501977-1961
   PubMed Web of Science ®Google Scholar
• Washington, T. A., White, J. P., Davis, J. M., Wilson, L. B., Lowe, L. L., Sato, S.,  …  Carson, J. A. (2011). Skeletal muscle mass recovery from atrophy in IL-6 knockout mice. Acta Physiologica (Oxford), 202, 657–669. doi: 10.1111/j.1748-1716.2011.02281.x
   PubMed Web of Science ®Google Scholar
• Winkelman, C. (2004). Inactivity and inflammation: Selected cytokines as biologic mediators in muscle dysfunction during critical illness. AACN Clinical Issues: Advanced Practice in Acute and Critical Care, 15, 74–82. doi: 10.1097/00044067-200401000-00006
   PubMedGoogle Scholar
• Yfanti, C., Fischer, C. P., Nielsen, S., Akerstrom, T., Nielsen, A. R., Veskoukis, A. S., … Pedersen, B. K. (2012). Role of vitamin C and E supplementation on IL-6 in response to training. Journal of Applied Physiology, 112, 990–1000. doi: 10.1152/japplphysiol.01027.2010
   PubMed Web of Science ®Google Scholar