1,139
Views
10
CrossRef citations to date
0
Altmetric
SPECIAL ISSUE ARTICLES

Incorporating methods and findings from neuroscience to better understand placebo and nocebo effects in sport

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon

References

  • Abbiss, C. R., & Laursen, P. B. (2005). Models to explain fatigue during prolonged endurance cycling. Sports Medicine, 35(10), 865–898. doi: 10.2165/00007256-200535100-00004
  • Amanzio, M., & Benedetti, F. (1999). Neuropharmacological dissection of placebo analgesia: Expectation-activated opioid systems versus conditioning-activated specific subsystems. The Journal of Neuroscience, 19(1), 484–494.
  • Andani, M., Tinazzi, M., Corsi, N., & Fiorio, M. (2015). Modulation of inhibitory corticospinal circuits induced by a nocebo procedure in motor performance. PLoS One, 10(4), e0125223. doi: 10.1371/journal.pone.0125223
  • Angius, L., Hopker, J., & Mauger, A. R. (2017). The ergogenic effects of transcranial direct current stimulation on exercise performance. Frontiers in Physiology, 8, 90.
  • Ashar, Y. K., Chang, L. J., & Wager, T. D. (2017). Brain mechanisms of the placebo effect: An affective appraisal account. Annual Review of Clinical Psychology, 13(1), 73–98. doi: 10.1146/annurev-clinpsy-021815-093015
  • Atkinson, G., Williamson, P., & Batterham, A. M. (2019). Issues in the determination of ‘responders’ and ‘non-responders’ in physiological research. Experimental Physiology. doi: 10.1113/EP087712
  • Beedie, C. (2010). All in the mind? Pain, placebo effect, and ergogenic effect of caffeine in sports performance. Open Access Journal of Sports Medicine, 1, 87–94.
  • Beedie, C., Benedetti, F., Hurst, P., Coleman, D. A., Foad, A., Cohen, E., … Harvey, S. (2018). Consensus statement on placebo effects in sports and exercise: The need for conceptual clarity, methodological rigour, and the elucidation of neurobiological mechanisms. European Journal of Sport Science, 18(10), 166–175.
  • Beedie, C., Coleman, D. A., & Foad, A. J. (2007). Positive and negative placebo effects resulting from the deceptive administration of an ergogenic aid. International Journal of Sport Nutrition and Exercise Metabolism, 17(3), 259–269.
  • Beedie, C., & Foad, A. (2009). The placebo effect in sports performance: A brief review. Sports Medicine, 39(4), 313–329. doi: 10.2165/00007256-200939040-00004
  • Beedie, C. J., Foad, A. J., & Coleman. (2008). Identification of placebo responsive athletes in 40-km cycling performance. Journal of Sports Science and Medicine, 7, 167–175.
  • Beedie, C., Foad, A., & Hurst, P. (2015). Capitalizing on the placebo component of treatments. Current Sports Medicine Reports, 14(4), 284–287. doi: 10.1249/JSR.0000000000000172
  • Beedie, C., Stuart, E., Coleman, D., & Foad, A. (2006). Placebo effects of caffeine on cycling performance. Medicine & Science in Sports & Exercise, 38(12), 2159–2164. doi: 10.1249/01.mss.0000233805.56315.a9
  • Beedie, C., Terry, P., & Lane, A. (2000). The profile of mood states and athletic performance: Two meta-analyses. Journal of Applied Sport Psychology, 12(1), 49–68. doi: 10.1080/10413200008404213
  • Beedie, C., Whyte, G., Lane, A. M., Cohen, E., Raglin, J., Hurst, P., … Foad, A. (2017). ‘Caution, this treatment is a placebo. It might work, but it might not’: Why emerging mechanistic evidence for placebo effects does not legitimise complementary and alternative medicines in sport. British Journal of Sports Medicine, 52, 817–818.
  • Benedetti, F. (2013). Placebo and the new physiology of the doctor-patient relationship. Physiological Reviews, 93(3), 1207–1246. doi: 10.1152/physrev.00043.2012
  • Benedetti, F., Amanzio, M., Baldi, S., Casadio, C., & Maggi, G. (2008). Inducing placebo respiratory depressant responses in humans via opioid receptors. European Journal of Neuroscience, 11(2), 625–631. doi: 10.1046/j.1460-9568.1999.00465.x
  • Benedetti, F., Amanzio, M., Rosato, R., & Blanchard, C. (2011). Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors. Nature Medicine, 17(10), 1228–1230. doi: 10.1038/nm.2435
  • Benedetti, F., Amanzio, M., Vighetti, S., & Asteggiano, G. (2006). The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. The Journal of Neuroscience, 26(46), 12014. doi: 10.1523/JNEUROSCI.2947-06.2006
  • Benedetti, F., Barbiani, D., & Camerone, E. (2018). Critical life functions: Can placebo replace oxygen? International Review of Neurobiology, 138, 201–218. doi: 10.1016/bs.irn.2018.01.009
  • Benedetti, F., Carlino, E., & Pollo, A. (2011). How placebos change the patient’s brain. Neuropsychopharmacology, 36(1), 339–354. doi: 10.1038/npp.2010.81
  • Benedetti, F., & Dogue, S. (2015). Different placebos, different mechanisms, different outcomes: Lessons for clinical trials. PLoS One, 10(11), e0140967. doi: 10.1371/journal.pone.0140967
  • Benedetti, F., Durando, J., Giudetti, L., Pampallona, A., & Vighetti, S. (2015). High-altitude headache: The effects of real vs sham oxygen administration. Pain, 156(11), 2326–2336. doi: 10.1097/j.pain.0000000000000288
  • Benedetti, F., Lanotte, M., Lopiano, L., & Colloca, L. (2007). When words are painful: Unraveling the mechanisms of the nocebo effect. Neuroscience, 147(2), 260–271.
  • Benedetti, F., Pollo, A., & Colloca, L. (2007). Opioid-mediated placebo responses boost pain endurance and physical performance: Is it doping in sport competitions? The Journal of Neuroscience, 27, 11934–11939.
  • Boecker, H., Sprenger, T., Spilker, M. E., Henriksen, G., Koppenhoefer, M., Wagner, K. J., … Tolle, T. R. (2008). The runner’s high: Opioidergic mechanisms in the human brain. Cerebral Cortex, 18(11), 2523–2531. doi: 10.1093/cercor/bhn013
  • Boto, E., Holmes, N., Leggett, J., Roberts, G., Shah, V., Meyer, S. S., … Brookes, M. J. (2018). Moving magnetoencephalography towards real-world applications with a wearable system. Nature, 555, 657.
  • Bottoms, L., Buscombe, R., & Nicholettos, A. (2014). The placebo and nocebo effects on peak minute power during incremental arm crank ergometry. European Journal of Sport Science, 14(4), 362–367. doi: 10.1080/17461391.2013.822564
  • Broelz, E. K., Enck, P., Niess, A. M., Schneeweiss, P., Wolf, S., & Weimer, K. (2019). The neurobiology of placebo effects in sports: EEG frontal alpha asymmetry increases in response to a placebo ergogenic aid. Scientific Reports, 9(1), 2381–2381. doi: 10.1038/s41598-019-38828-9
  • Colagiuri, B., Schenk, L. A., Kessler, M. D., Dorsey, S. G., & Colloca, L. (2015). The placebo effect: From concepts to genes. Neuroscience, 307, 171–190.
  • Colloca, L., & Miller, F. G. (2011). The nocebo effect and its relevance for clinical practice. Psychosomatic Medicine, 73(7), 598–603. doi: 10.1097/PSY.0b013e3182294a50
  • Davis, J., Alderson, N., & Welsh, R. (2000). Serotonin and central nervous system fatigue: Nutritional considerations. The American Journal of Clinical Nutrition, 72(2), 573S–578S. doi: 10.1093/ajcn/72.2.573S
  • Davis, J., & Bailey, S. (1997). Possible mechanisms of central nervous system fatigue during exercise. Medicine and Science in Sports and Exercise, 29(1), 45–57.
  • Davis, A., Hettinga, F., & Beedie, C. (2019). You don’t need to administer a placebo to elicit a placebo effect: Social factors trigger neurobiological pathways to enhance sports performance. European Journal of Sport Science, doi: 10.1080/17461391.2019.1635212
  • Davis IV, H., Liotti, M., Ngan, E. T., Woodward, T. S., Van Snellenberg, J. X., van Anders, S. M., … Mayberg, H. S. (2008). fMRI BOLD signal changes in elite swimmers while viewing videos of personal failure. Brain Imaging and Behavior, 2(2), 84–93. doi: 10.1007/s11682-007-9016-x
  • De Ataide e Silva, T., Di Cavalcanti Alves de Souza, M., De Amorim, J. F., Stathis, C. G., Leandro, C. G., & Lima-Silva, A. E. (2014). Can carbohydrate mouth rinse improve performance during exercise? A systematic review. Nutrients, 6(1), 1–10. doi: 10.3390/nu6010001
  • de la Fuente-Fernández, R., Ruth, T. J., Sossi, V., Schulzer, M., Calne, D. B., & Stoessl, A. J. (2001). Expectation and dopamine release: Mechanism of the placebo effect in parkinson’s disease. Science, 293(5532), 1164. doi: 10.1126/science.1060937
  • Duncan, M. (2010). Placebo effects of caffeine on anaerobic performance in moderately trained adults. Serbian Journal of Sports Sciences, 4(3), 99–106.
  • Enck, P., Benedetti, F., & Schedlowski, M. (2008). New insights into the placebo and nocebo responses. Neuron, 59(2), 195–206.
  • Enoka, R. M., & Duchateau, J. (2016). Translating fatigue to human performance. Medicine and Science in Sports and Exercise, 48(11), 2228–2238. doi: 10.1249/MSS.0000000000000929
  • Evers, A. W. M., Colloca, L., Blease, C., Annoni, M., Atlas, L. Y., Benedetti, F., … Kelley, J. M. (2018). Implications of placebo and nocebo effects for clinical practice: Expert consensus. Psychotherapy and Psychosomatics, 87(4), 204–210. doi: 10.1159/000490354
  • Fargier, P., Collet, C., Moran, A., & Massarelli, R. (2017). Inter-disciplinarity in sport sciences: The neuroscience example. European Journal of Sport Science, 17(1), 42–50. doi: 10.1080/17461391.2016.1207710
  • Fiorio, M., Emadi Andani, M., Marotta, A., Classen, J., & Tinazzi, M. (2014). Placebo-induced changes in excitatory and inhibitory corticospinal circuits during motor performance. The Journal of Neuroscience, 34(11), 3993. doi: 10.1523/JNEUROSCI.3931-13.2014
  • Foad, A. J., Beedie, C. J., & Coleman, D. A. (2008). Pharmacological and psychological effects of caffeine ingestion in 40-km cycling performance. Medicine & Science in Sports & Exercise, 40(1), 158–165. doi: 10.1249/mss.0b013e3181593e02
  • Foley, T. E., & Fleshner, M. (2008). Neuroplasticity of dopamine circuits after exercise: Implications for central fatigue. NeuroMolecular Medicine, 10(2), 67–80. doi: 10.1007/s12017-008-8032-3
  • Fontes, E. B., Okano, A. H., De Guio, F., Schabort, E. J., Min, L. L., Basset, F. A., … Noakes, T. D. (2013). Brain activity and perceived exertion during cycling exercise: An fMRI study. British Journal of Sports Medicine, 49(8), 556–560.
  • Geuter, S., Koban, L., & Wager, T. D. (2017). The cognitive neuroscience of placebo effects: Concepts, predictions, and physiology. Annual Review of Neuroscience, 40(1), 167–188. doi: 10.1146/annurev-neuro-072116-031132
  • Gibson, A. S. C., Baden, D. A., Lambert, M. I., Lambert, E. V., Harley, Y. X. R., Hampson, D., … Noakes, T. D. (2003). The conscious perception of the sensation of fatigue. Sports Medicine, 33(3), 167–176. doi: 10.2165/00007256-200333030-00001
  • Glaister, M. (2018). The effects of caffeine on time-trial performance and associated physiological responses: A meta-analysis2405 board #241 June 1 1100 AM - 1230 PM. Medicine & Science in Sports & Exercise, 50, 5S.
  • Grgic, J., Grgic, I., Pickering, C., Schoenfeld, B. J., Bishop, D. J., & Pedisic, Z. (2019). Wake up and smell the coffee: Caffeine supplementation and exercise performance—an umbrella review of 21 published meta-analyses. British Journal of Sports Medicine, Bjsports, 2018–100278. doi: 10.1136/bjsports-2018-100278
  • Hall, K. T., Loscalzo, J., & Kaptchuk, T. J. (2015). Genetics and the placebo effect: The placebome. Trends in Molecular Medicine, 21(5), 285–294. doi: 10.1016/j.molmed.2015.02.009
  • Haltia Lauri, T., Rinne Juha, O., Merisaari, H., Maguire Ralph, P., Savontaus, E., Helin, S., … Kaasinen, V. (2007). Effects of intravenous glucose on dopaminergic function in the human brain in vivo. Synapse, 61(9), 748–756. doi: 10.1002/syn.20418
  • Harvey, S., & Beedie, C. (2017). Studying placebo effects in model organisms will help us understand them in humans. Biology Letters, 13, 11.
  • Hurst, P., Foad, A. J., Coleman, D. A., & Beedie, C. (2017). Athletes intending to use sports supplements are more likely to respond to a placebo. Medicine & Science in Sports & Exercise, 40(9), 1877–1883. doi: 10.1249/MSS.0000000000001297
  • Hurst, P., Schiphof-Godart, l., Raglin, J., Coleman, D., Lane, A., Foad, A., & Beedie, C. (2019). Placebo effects on sports performance: A systematic review. European Journal of Sport Science, doi: 10.1080/17461391.2019.1655098
  • Jain, R., Mukherjee, K., & Singh, R. (2004). Influence of sweet tasting solutions on opioid withdrawal. Brain Research Bulletin, 64(4), 319–322. doi: 10.1016/j.brainresbull.2004.08.003
  • Jeukendrup, A. (2013). Oral carbohydrate rinse: Placebo or beneficial? Current Sports Medicine Reports, 12, 4.
  • Jeukendrup, A. E. (2004). Oral carbohydrate rinse: Placebo or beneficial? Medicine & Science in Sports & Exercise, 36(9), 1543–1550.
  • Jeukendrup, A., Rollo, I., & Carter, J. (2013). Carbohydrate mouth rinse: Performance effects and mechanisms. Sports Science Exchange, 26(118), 1–18.
  • Kaasinen, V., Aalto, S., Nagren, K., & Rinne, J. O. (2004). Dopaminergic effects of caffeine in the human striatum and thalamus. NeuroReport, 15(2), 281–285.
  • Kaasinen, V., Aalto, S., Någren, K., & Rinne Juha, O. (2004). Expectation of caffeine induces dopaminergic responses in humans. European Journal of Neuroscience, 19(8), 2352–2356. doi: 10.1111/j.1460-9568.2004.03310.x
  • Kirkendall, D. T. (1990). Mechanisms of peripheral fatigue. Medicine & Science in Sports & Exercise, 22, 4.
  • Levine, J., Gordon, N., & Fields, H. (1978). The mechanism of placebo analgesia. The Lancet, 312(8091), 654–657.
  • Lieberman, M. D. (2006). Social cognitive neuroscience: A review of core processes. Annual Review of Psychology, 58(1), 259–289. doi: 10.1146/annurev.psych.58.110405.085654
  • Lindheimer, J., Szabó, A., Raglin, J., & Beedie, C. (2019). Advancing the understanding of placebo effects in psychological outcomes of exercise: Lessons learned and future research directions. European Journal of Sport Science, doi: 10.1080/17461391.2019.1632937
  • Loy, B. D., & O’Connor, P. J. (2016). The effect of histamine on changes in mental energy and fatigue after a single bout of exercise. Physiology & Behavior, 153, 7–18.
  • Loy, B. D., O’Connor, P. J., Lindheimer, J. B., & Covert, S. F. (2015). Caffeine is ergogenic for adenosine A2A receptor gene (ADORA2A) T allele homozygotes: A pilot study. Journal of Caffeine Research, 5(2), 73–81. doi: 10.1089/jcr.2014.0035
  • Maerlender, A. (2017). The neuropsychology of sport and performance. Developmental Neuropsychology, 42(2), 55–57. doi: 10.1080/87565641.2017.1309656
  • Mauger, A. (2013). Fatigue is a pain—the use of novel neurophysiological techniques to understand the fatigue-pain relationship. Frontiers in Physiology, 4, 104.
  • McCarthy, P. J. (2011). Positive emotion in sport performance: Current status and future directions. International Review of Sport and Exercise Psychology, 4(1), 50–69. doi: 10.1080/1750984X.2011.560955
  • Meeusen, R., & Roelands, B. (2010). Central fatigue and neurotransmitters, can thermoregulation be manipulated? Scandinavian Journal of Medicine & Science in Sports, 20(s3), 19–28. doi: 10.1111/j.1600-0838.2010.01205.x
  • Meeusen, R., & Roelands, B. (2018). Fatigue: Is it all neurochemistry? European Journal of Sport Science, 18(1), 37–46. doi: 10.1080/17461391.2017.1296890
  • Meeusen, R., Roelands, B., & Spriet, L. L. (2013). Caffeine, exercise and the brain. Nestle Nutrition institute Workshop Series, 76, 1–12. doi: 10.1159/000350223
  • Meeusen, R., Watson, P., Hasegawa, H., Roelands, B., & Piacentini, M. F. (2007). Brain neurotransmitters in fatigue and overtraining. Applied Physiology, Nutrition, and Metabolism, 32(5), 857–864. doi: 10.1139/H07-080
  • Meissner, K. (2011). The placebo effect and the autonomic nervous system: Evidence for an intimate relationship. Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1572), 1808–1817. doi: 10.1098/rstb.2010.0403
  • Meissner, K. (2014). Placebo responses on cardiovascular, gastrointestinal, and respiratory organ functions. In F. Benedetti, P. Enck, E. Frisaldi, & M. Schedlowski (Eds.), Placebo (pp. 183–203). Berlin, Heidelberg: Springer Berlin Heidelberg.
  • Micklewright, D., St Clair Gibson, A., Gladwell, V., & Al Salman, A. (2017). Development and validity of the rating-of-fatigue scale. Sports Medicine, 47(11), 2375–2393. doi: 10.1007/s40279-017-0711-5
  • Millet, G. Y. (2011). Can neuromuscular fatigue explain running strategies and performance in ultra-marathons? Sports Medicine, 41(6), 489–506. doi: 10.2165/11588760-000000000-00000
  • Perrey, S., & Besson, P. (2018). Studying brain activity in sports performance: Contributions and issues. Progress in Brain Research, 240, 247–267. doi: 10.1016/bs.pbr.2018.07.004
  • Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002). Placebo and opioid analgesia– imaging a shared neuronal network. Science, 295(5560), 1737. doi: 10.1126/science.1067176
  • Piedimonte, A., Benedetti, F., & Carlino, E. (2015). Placebo-induced decrease in fatigue: Evidence for a central action on the preparatory phase of movement. European Journal of Neuroscience, 41(4), 492–497. doi: 10.1111/ejn.12806
  • Pollo, A., Carlino, E., & Benedetti, F. (2008). The top-down influence of ergogenic placebos on muscle work and fatigue. European Journal of Neuroscience, 28(2), 379–388. doi: 10.1111/j.1460-9568.2008.06344.x
  • Pollo, A., Carlino, E., & Benedetti, F. (2011). Placebo mechanisms across different conditions: From the clinical setting to physical performance. Philosophical Transactions of the Royal Society B: Biological Sciences, 366(1572), 1790–1798. doi: 10.1098/rstb.2010.0381
  • Pollo, A., Carlino, E., Vase, L., & Benedetti, F. (2012). Preventing motor training through nocebo suggestions. European Journal of Applied Physiology, 112(11), 3893–3903.
  • Pollo, A., Vighetti, S., Rainero, I., & Benedetti, F. (2003). Placebo analgesia and the heart. Pain, 102(1), 125–133.
  • Previc, F. H. (2009). The dopaminergic mind in human evolution and history. New York, NY, US: Cambridge University Press.
  • Raichle, M. E. (2015). The brain’s default mode network. Annual Review of Neuroscience, 38(1), 433–447. doi: 10.1146/annurev-neuro-071013-014030
  • Robazza, C., Pellizzari, M., & Hanin, Y. (2004). Emotion self-regulation and athletic performance: An application of the IZOF model. Psychology of Sport and Exercise, 5(4), 379–404.
  • Roelands, B., & Meeusen, R. (2010). Alterations in central fatigue by pharmacological manipulations of neurotransmitters in normal and high ambient temperature. Sports Medicine, 40(3), 229–246. doi: 10.2165/11533670-000000000-00000
  • Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2008). Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. Archives of General Psychiatry, 65(2), 220–231. doi: 10.1001/archgenpsychiatry.2007.34
  • Sedgwick, P. (2012). Placebo run in periods. BMJ: British Medical Journal, 344.
  • Siebenmann, C., Robach, P., Jacobs, R. A., Rasmussen, P., Nordsborg, N., Diaz, V., … Lundby, C. (2011). “Live high–train low” using normobaric hypoxia: A double-blinded, placebo-controlled study. Journal of Applied Physiology, 112(1), 106–117. doi: 10.1152/japplphysiol.00388.2011
  • St Clair Gibson, A., Swart, J., & Tucker, R. (2018). The interaction of psychological and physiological homeostatic drives and role of general control principles in the regulation of physiological systems, exercise and the fatigue process – The integrative governor theory. European Journal of Sport Science, 18(1), 25–36. doi: 10.1080/17461391.2017.1321688
  • Szabó, A., Lindheimer, J., Raglin, J., & Beedie, C. (In Press). Why it is important to understand and study placebo and nocebo effects in sport? A psychological perspective. European Journal of Sport Science.
  • Tracey, I. (2010). Getting the pain you expect: Mechanisms of placebo, nocebo and reappraisal effects in humans. Nature Medicine, 16(11), 1277–1283.
  • Turi, Z., Bjørkedal, E., Gunkel, L., Antal, A., Paulus, W., & Mittner, M. (2018). Evidence for cognitive placebo and nocebo effects in healthy Individuals. Scientific Reports, 8(1), 17443. doi: 10.1038/s41598-018-35124-w
  • Van Cutsem, J., Marcora, S., De Pauw, K., Bailey, S., Meeusen, R., & Roelands, B. (2017). The effects of mental fatigue on physical performance: A systematic review. Sports Medicine, 47(8), 1569–1588. doi: 10.1007/s40279-016-0672-0
  • Völker, I., Kirchner, C., & Bock, O. L. (2016). On the relationship between subjective and objective measures of fatigue. Ergonomics, 59(9), 1259–1263. doi: 10.1080/00140139.2015.1110622
  • Volkow, N. D., Wang, G. J., Logan, J., Alexoff, D., Fowler, J. S., Thanos, P. K., … Tomasi, D. (2015). Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain. Translational Psychiatry, 5, e549. doi: 10.1038/tp.2015.46
  • Wager, T. D., & Atlas, L. Y. (2015). The neuroscience of placebo effects: Connecting context, learning and health. Nature Reviews Neuroscience, 16, 403.
  • Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., … Cohen, J. D. (2004). Placebo-induced changes in fMRI in the anticipation and experience of pain. Science, 303(5661), 1162. doi: 10.1126/science.1093065
  • Wisor, J. P. (2018). Dopamine and wakefulness: Pharmacology, genetics, and circuitry (pp. 115). Berlin, Heidelberg: Springer Berlin Heidelberg.
  • Wright, M. J., Bishop, D. T., Jackson, R. C., & Abernethy, B. (2010). Functional MRI reveals expert-novice differences during sport-related anticipation. NeuroReport, 21, 2.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.