The ratio of heart rate to heart rate variability reflects sympathetic activity during incremental cycling exercise

References

• Ahmed, M. W., Kadish, A. H., Parker, M. A., GoldAhmed, M. W., Kadish, A. H., Parker, M. A., & Goldberger, J. J. (1994). Effect of physiologic and pharmacologic adrenergic stimulation on heart rate variability. Journal of the American College of Cardiology, 24(4), 1082–1090. https://doi.org/10.1016/0735-1097(94)90874-5
   PubMed Web of Science ®Google Scholar
• Arai, Y., Saul, J. P., Albrecht, P., Hartley, L. H., Lilly, L. S., Cohen, R. J., & Colucci, W. S. (1989). Modulation of cardiac autonomic activity during and immediately after exercise. American Journal of Physiology, 256(1), H132–H141. https://doi.org/10.1152/ajpheart.1989.256.1.H132
   PubMedGoogle Scholar
• Bailón, R., Laouini, G., Grao, C., Orini, M., Laguna, P., & Meste, O. (2011). The integral pulse frequency modulation model with time-varying threshold: Application to heart rate variability analysis during exercise stress testing. IEEE Transactions on Biomedical Engineering, 58(3 PART 1), 642–652. https://doi.org/10.1109/TBME.2010.2095011
   PubMed Web of Science ®Google Scholar
• Beaver, W. L., Wasserman, K., & Whipp, B. J. (1986). A new method for detecting anaerobic threshold by gas exchange. Journal of Applied Physiology, 60(6), 2020–2027. https://doi.org/10.1152/jappl.1986.60.6.2020
   PubMed Web of Science ®Google Scholar
• Berntson, G. G., Thomas Bigger, J., Eckberg, D. L., Grossman, P., Kaufmann, P. G., Malik, M., … Van Der Molen, M. W. ((1997, November). Heart rate variability: Origins methods, and interpretive caveats. Psychophysiology, 34, 623–648. https://doi.org/10.1111/j.1469-8986.1997.tb02140.x
   PubMed Web of Science ®Google Scholar
• Breuer, H. W. M., Skyschally, A., Schulz, R., Martin, C., Wehr, M., & Heusch, G. (1993). Heart rate viability and circulating catecholamine concentrations during steady state exercise in healthy volunteers. British Heart Journal, 70(2), 144–149. https://doi.org/10.1136/hrt.70.2.144
   PubMedGoogle Scholar
• Cottin, F., Leprêtre, P. M., Lopes, P., Papelier, Y., Médigue, C., & Billat, V. (2006). Assessment of ventilatory thresholds from heart rate variability in well-trained subjects during cycling. International Journal of Sports Medicine, 27(12), 959–967. https://doi.org/10.1055/s-2006-923849
   PubMed Web of Science ®Google Scholar
• Faude, O., Kindermann, W., & Meyer, T. (2009). Lactate threshold concepts: How valid are they? Sports Medicine, 39(6), 469–490. https://doi.org/10.2165/00007256-200939060-00003
   PubMed Web of Science ®Google Scholar
• Gourine, A. V., & Ackland, G. L. (2019). Cardiac vagus and exercise. Physiology, 34(1), 71–80. https://doi.org/10.1152/physiol.00041.2018
   PubMed Web of Science ®Google Scholar
• Hansen, D., Stevens, A., Eijnde, B. O., & Dendale, P. (2012). Endurance exercise intensity determination in the rehabilitation of coronary artery disease patients: A critical re-appraisal of current evidence. Sports Medicine, 42(1), 11–30. https://doi.org/10.2165/11595460-000000000-00000
   PubMed Web of Science ®Google Scholar
• Hayano, J., Sakakibara, Y., Yamada, A., Yamada, M., Mukai, S., Fujinami, T., … Takata, K. (1991). Accuracy of assessment of cardiac vagal tone by heart rate variability in normal subjects. The American Journal of Cardiology, 67(2), 199–204. https://doi.org/10.1016/0002-9149(91)90445-Q
   PubMed Web of Science ®Google Scholar
• Hayano, J., Sakakibara, Y., Yamada, M., Kamiya, T., Fujinami, T., Yokoyama, K., … Takata, K. (1990). Diurnal variations in vagal and sympathetic cardiac control. American Journal of Physiology-Heart and Circulatory Physiology, 258(3), H642–H646. https://doi.org/10.1152/ajpheart.1990.258.3.H642
   Google Scholar
• Hernando, D., Hernando, A., Casajús, J. A., Laguna, P., Garatachea, N., & Bailón, R. (2018). Methodological framework for heart rate variability analysis during exercise: Application to running and cycling stress testing. Medical and Biological Engineering and Computing, 56(5), 781–794. https://doi.org/10.1007/s11517-017-1724-9
   PubMed Web of Science ®Google Scholar
• Hirano, M., Yamada, Y., Hibi, M., Katashima, M., Higaki, Y., Kiyonaga, A., & Tanaka, H. (2014). Simultaneous multiple-subject analysis of respiratory gas exchange in humans. The Journal of Physical Fitness and Sports Medicine, 3(2), 269–279. https://doi.org/10.7600/jpfsm.3.269
   Google Scholar
• Karapetian, G. K., Engels, H. J., & Gretebeck, R. J. (2008). Use of heart rate variability to estimate LT and VT. International Journal of Sports Medicine, 29(8), 652–657. https://doi.org/10.1055/s-2007-989423
   PubMed Web of Science ®Google Scholar
• Kiviniemi, A. M., Hautala, A. J., Kinnunen, H., & Tulppo, M. P. (2007). Endurance training guided individually by daily heart rate variability measurements. European Journal of Applied Physiology, 101(6), 743–751. https://doi.org/10.1007/s00421-007-0552-2
   PubMed Web of Science ®Google Scholar
• Kiyonaga, A., Arakawa, K., Tanaka, H., & Shindo, M. (1985). Blood pressure and hormonal responses to aerobic exercise. Hypertension, 7(1), 125–131.
   PubMed Web of Science ®Google Scholar
• Leicht, A. S., Sinclair, W. H., & Spinks, W. L. (2007). Effect of exercise mode on heart rate variability during steady state exercise. European Journal of Applied Physiology, 102(2), 195–204. https://doi.org/10.1007/s00421-007-0574-9
   PubMed Web of Science ®Google Scholar
• Mazzeo, R. S., & Marshall, P. (1989). Influence of plasma catecholamines on the lactate threshold during graded exercise. Journal of Applied Physiology, 67(4), 1319–1322. https://doi.org/10.1152/jappl.1989.67.4.1319
   PubMed Web of Science ®Google Scholar
• Monfredi, O., Lyashkov, A. E., Johnsen, A. B., Inada, S., Schneider, H., Wang, R., … Boyett, M. R. (2014). Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate. Hypertension, 64(6), 1334–1343. https://doi.org/10.1161/HYPERTENSIONAHA.114.03782
   PubMed Web of Science ®Google Scholar
• Pagani, M., Lombardi, F., Guzzetti, S., Rimoldi, O., Furlan, R., Pizzinelli, P., … Malliani, A. (1986). Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog. Circulation Research, 59(2), 178–193. https://doi.org/10.1161/01.RES.59.2.178
   PubMed Web of Science ®Google Scholar
• Polanczyk, C. A., Rohde, L. E. P., Moraes, R. S., Ferlin, E. L., Leite, C., & Ribeiro, J. P. (1998). Sympathetic nervous system representation in time and frequency domain indices of heart rate variability. European Journal of Applied Physiology, 79(1), 69–73. https://doi.org/10.1007/s004210050475
   Web of Science ®Google Scholar
• Randall, D. C., Brown, D. R., Raisch, R. M., Yingling, J. D., & Randall, W. C. (1991). SA nodal parasympathectomy delineates autonomic control of heart rate power spectrum. American Journal of Physiology-Heart and Circulatory Physiology, 260(3), H985–H988. https://doi.org/10.1152/ajpheart.1991.260.3.H985
   Google Scholar
• Raven, P. B., Fadel, P. J., & Ogoh, S. (2006). Arterial baroreflex resetting during exercise: A current perspective. Experimental Physiology, 91(1), 37–49. https://doi.org/10.1113/expphysiol.2005.032250
   PubMed Web of Science ®Google Scholar
• Robinson, B. F., Epstein, S. E., Beiser, G. D., & Braunwald, E. (1966). Control of heart rate by the autonomic nervous system: Studies in man on the interrelation between baroreceptor mechanisms and exercise. Circulation Research, 19(2), 400–411. https://doi.org/10.1161/01.RES.19.2.400
   PubMed Web of Science ®Google Scholar
• Sacha, J. (2013). Why should one normalize heart rate variability with respect to average heart rate. Frontiers in Physiology, 4(October), 1–2. https://doi.org/10.3389/fphys.2013.00306
   PubMedGoogle Scholar
• Sahara, H., Ezoe, K., Fukuoka, H., Ohtomo, N., Tanaka, Y., Takahashi, N., … Kikudhi, K. (1996). Periodicity of ovarian follicular dynamics in postpartum cows demonstrated using time-series analysis based on the maximum entropy method. Journal of Reproduction and Development, 42(2), 117–124.
   Google Scholar
• Sales, M. M., Sousa, C. V., da Silva Aguiar, S., Knechtle, B., Nikolaidis, P. T., Alves, P. M., & Simões, H. G. (2019). An integrative perspective of the anaerobic threshold. Physiology and Behavior, 205(October 2017), 29–32. https://doi.org/10.1016/j.physbeh.2017.12.015
   PubMedGoogle Scholar
• Sawada, Y., Ohtomo, N., Tanaka, Y., Tanaka, G., Yamakoshi, K., Terachi, S., … Limura, O. (1997). New technique for time series analysis combining the maximum entropy method and non-linear least squares method: Its value in heart rate variability analysis. Medical and Biological Engineering and Computing, 35(4), 318–322.
   PubMed Web of Science ®Google Scholar
• Schneider, D. A., Mclellan, T. M., & Gass, G. C. (2000). Plasma catecholamine and blood lactate responses to incremental arm and leg exercise. Medicine and Science in Sports and Exercise, 32(3), 608–613. https://doi.org/10.1097/00005768-200003000-00009
   PubMed Web of Science ®Google Scholar
• Shiraishi, Y., Katsumata, Y., Sadahiro, T., Azuma, K., Akita, K., Isobe, S., … Takatsuki, S. (2018). Real-time analysis of the heart rate variability during incremental exercise for the detection of the ventilatory threshold. Journal of the American Heart Association, 7(1), 1–12. https://doi.org/10.1161/JAHA.117.006612
   Web of Science ®Google Scholar
• Wasserman, K., Whipp, B. J., Koyal, S. N., & Beaver, W. L. (1973). Anaerobic threshold and respiratory gas exchange during exercise. Journal of Applied Physiology, 35(2), 236–243.
   PubMed Web of Science ®Google Scholar
• White, D. W., & Raven, P. B. (2014). Autonomic neural control of heart rate during dynamic exercise: Revisited. Journal of Physiology, 592(12), 2491–2500. https://doi.org/10.1113/jphysiol.2014.271858
   PubMed Web of Science ®Google Scholar
• Yamamoto, Y., Hughson, R. L., & Peterson, J. C. (1991). Autonomic control of heart rate during exercise studied by heart rate variability spectral analysis. Journal of Applied Physiology, 71(3), 1136–1142. https://doi.org/10.1152/jappl.1991.71.3.1136
   PubMed Web of Science ®Google Scholar