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Review

Salient features and management options of macular telangiectasia type 2: a review and update

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Pages 429-441 | Received 10 Jun 2016, Accepted 27 Sep 2016, Published online: 04 Nov 2016

References

  • Gass JD, Oyakawa RT. Idiopathic juxtafoveolar retinal telangiectasis. Update of classification and follow-up study. Arch Ophthalmol. 1982;100(5):769–780.
  • Gass JD, Blodi BA. Idiopathic juxtafoveolar retinal telangiectasis. Ophthalmology. 1993;100(10):1536–1546.
  • Yannuzzi LA, Bardal AM, Freund KB, et al. Idiopathic macular telangiectasia. Arch Ophthalmol. 2006;124(4):450–460.
  • Charbel Issa P, Gillies MC, Chew EY, et al. Macular telangiectasia type 2. Prog Retin Eye Res. 2013;34:49–77.
  • Klein R, Blodi BA, Meuer SM, et al. The prevalence of macular telangiectasia type 2 in the Beaver Dam eye study. Am J Ophthalmol. 2010;150(1):55–62 e2.
  • Aung KZ, Wickremasinghe SS, Makeyeva G, et al. The prevalence estimates of macular telangiectasia type 2: the melbourne collaborative cohort study. Retina. 2010;30(3):473–478.
  • Sallo FB, Leung I, Mathenge W, et al. The prevalence of type 2 idiopathic macular telangiectasia in two African populations. Ophthalmic Epidemiol. 2012;19(4):185–189.
  • Gillies MC, Zhu M, Chew E, et al. Familial asymptomatic macular telangiectasia type 2. Ophthalmology. 2009;116(12):2422–2429.
  • Clemons TE, Gillies MC, Chew EY, et al. Baseline characteristics of participants in the natural history study of macular telangiectasia (mactel) mactel project report no 2. Ophthalmic Epidemiol. 2010;17(1):66–73.
  • Oh KT, Park DW. Bilateral juxtafoveal telangiectasis in a family. Retina. 1999;19(3):246–247.
  • Hutton WL, Snyder WB, Fuller D, et al. Focal parafoveal retinal telangiectasis. Arch Ophthalmol. 1978;96(8):1362–1367.
  • Chew EY, Murphy RP, Newsome DA, et al. Parafoveal telangiectasis and diabetic retinopathy. Arch Ophthalmol. 1986;104(1):71–75.
  • Siddiqui N, Fekrat S. Group 2A idiopathic juxtafoveolar retinal telangiectasia in monozygotic twins. Am J Ophthalmol. 2005;139(3):568–570.
  • Menchini U, Virgili G, Bandello F, et al. Bilateral juxtafoveolar telangiectasis in monozygotic twins. Am J Ophthalmol. 2000;129(3):401–403.
  • Hannan SR, Madhusudhana KC, Rennie C, et al. Idiopathic juxtafoveolar retinal telangiectasis in monozygotic twins. Br J Ophthalmol. 2007;91(12):1729–1730.
  • Brue C, Tseng JJ, Barbazetto I, et al. Peculiar manifestation of macular telangiectasia type 2. Retin Cases Brief Rep. 2011;5(4):309–312.
  • Abujamra S, Bonanomi MT, Cresta FB, et al. Idiopathic juxtafoveolar retinal telangiectasis: clinical pattern in 19 cases. Ophthalmologica. 2000;214(6):406–411.
  • Sallo FB, Leung I, Chung M, et al. Retinal crystals in type 2 idiopathic macular telangiectasia. Ophthalmology. 2011;118(12):2461–2467.
  • Moisseiev J, Lewis H, Bartov E, et al. Superficial retinal refractile deposits in juxtafoveal telangiectasis. Am J Ophthalmol. 1990;109(5):604–605.
  • Margalit E, Apte RS, Sadda SR. Idiopathic parafoveal telangiectasis associated with a foveal pseudovitelliform lesion. Br J Ophthalmol. 2002;86(12):1455–1456.
  • Albini TA, Benz MS, Coffee RE, et al. Optical coherence tomography of idiopathic juxtafoveolar telangiectasia. Ophthalmic Surg Lasers Imaging. 2006;37(2):120–128.
  • Charbel Issa P, Helb HM, Holz FG, et al. Correlation of macular function with retinal thickness in nonproliferative type 2 idiopathic macular telangiectasia. Am J Ophthalmol. 2008;145(1):169–175.
  • Koizumi H, Slakter JS, Spaide RF. Full-thickness macular hole formation in idiopathic parafoveal telangiectasis. Retina. 2007;27(4):473–476.
  • Engelbrecht NE, Aaberg TM Jr., Sung J, et al. Neovascular membranes associated with idiopathic juxtafoveolar telangiectasis. Arch Ophthalmol. 2002;120(3):320–324.
  • Davidorf FH, Pressman MD, Chambers RB. Juxtafoveal telangiectasis-a name change? Retina. 2004;24(3):474–478.
  • Jindal A, Choudhury H, Pathengay A, et al. A novel clinical sign in macular telangiectasia type 2. Ophthalmic Surg Lasers Imaging Retina. 2015;46(1):134–136.
  • Ablonczy Z, Crosson CE. VEGF modulation of retinal pigment epithelium resistance. Exp Eye Res. 2007;85(6):762–771.
  • Surguch V, Gamulescu MA, Gabel VP. Optical coherence tomography findings in idiopathic juxtafoveal retinal telangiectasis. Graefes Arch Clin Exp Ophthalmol. 2007;245(6):783–788.
  • Powner MB, Gillies MC, Tretiach M, et al. Perifoveal muller cell depletion in a case of macular telangiectasia type 2. Ophthalmology. 2010;117(12):2407–2416.
  • Gaudric A, Ducos De Lahitte G, Cohen SY, et al. Optical coherence tomography in group 2A idiopathic juxtafoveolar retinal telangiectasis. Arch Ophthalmol. 2006;124(10):1410–1419.
  • Sallo FB, Peto T, Egan C, et al. The IS/OS junction layer in the natural history of type 2 idiopathic macular telangiectasia. Invest Ophthalmol Vis Sci. 2012;53(12):7889–7895.
  • Sallo FB, Peto T, Egan C, et al. “En face” OCT imaging of the IS/OS junction line in type 2 idiopathic macular telangiectasia. Invest Ophthalmol Vis Sci. 2012;53(10):6145–6152.
  • Barthelmes D, Gillies MC, Sutter FK. Quantitative OCT analysis of idiopathic perifoveal telangiectasia. Invest Ophthalmol Vis Sci. 2008;49(5):2156–2162.
  • Charbel Issa P, Berendschot TT, Staurenghi G, et al. Confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia. Invest Ophthalmol Vis Sci. 2008;49(3):1172–1177.
  • Charbel Issa P, Finger RP, Helb HM, et al. A new diagnostic approach in patients with type 2 macular telangiectasia: confocal reflectance imaging. Acta Ophthalmol. 2008;86(4):464–465.
  • Bottoni F, Eandi CM, Pedenovi S, et al. Integrated clinical evaluation of type 2A idiopathic juxtafoveolar retinal telangiectasis. Retina. 2010;30(2):317–326.
  • Snodderly DM, Auran JD, Delori FC. The macular pigment. II. Spatial distribution in primate retinas. Invest Ophthalmol Vis Sci. 1984;25(6):674–685.
  • Snodderly DM, Brown PK, Delori FC, et al. The macular pigment. I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate retinas. Invest Ophthalmol Vis Sci. 1984;25(6):660–673.
  • Shen W, Zhang J, Chung SH, et al. Submacular DL-alpha-aminoadipic acid eradicates primate photoreceptors but does not affect luteal pigment or the retinal vasculature. Invest Ophthalmol Vis Sci. 2011;52(1):119–127.
  • Nussbaum JJ, Pruett RC, Delori FC. Historic perspectives macular yellow pigment. The first 200 years. Retina. 1981;1(4):296–310.
  • Whitehead AJ, Mares JA, Danis RP. Macular pigment: a review of current knowledge. Arch Ophthalmol. 2006;124(7):1038–1045.
  • Charbel Issa P, van der Veen RL, Stijfs A, et al. Quantification of reduced macular pigment optical density in the central retina in macular telangiectasia type 2. Exp Eye Res. 2009;89(1):25–31.
  • Helb HM, Issa PC, van der Veen RL, et al. Abnormal macular pigment distribution in type 2 idiopathic macular telangiectasia. Retina. 2008;28(6):808–816.
  • Delori FC, Dorey CK, Staurenghi G, et al. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36(3):718–729.
  • Roorda A, Romero-Borja F, Donnelly Iii W, et al. Adaptive optics scanning laser ophthalmoscopy. Opt Express. 2002;10(9):405–412.
  • Ooto S, Hangai M, Takayama K, et al. High-resolution photoreceptor imaging in idiopathic macular telangiectasia type 2 using adaptive optics scanning laser ophthalmoscopy. Invest Ophthalmol Vis Sci. 2011;52(8):5541–5550.
  • Jacob J, Krivosic V, Paques M, et al. Cone density loss on adaptive optics in early macular telangiectasia type 2. Retina. 2016;36(3):545–551.
  • Huang S, Shen M, Zhu D, et al. In vivo imaging of retinal hemodynamics with OCT angiography and doppler OCT. Biomed Opt Express. 2016;7(2):663–676.
  • Chidambara L, Gadde SG, Yadav NK, et al. Characteristics and quantification of vascular changes in macular telangiectasia type 2 on optical coherence tomography angiography. Br J Ophthalmol. 2016. doi:10.1136/bjophthalmol-2015-307941.
  • Spaide RF, Klancnik JM Jr., Cooney MJ, et al. Volume-rendering optical coherence tomography angiography of macular telangiectasia type 2. Ophthalmology. 2015;122(11):2261–2269.
  • Charbel Issa P, Helb HM, Rohrschneider K, et al. Microperimetric assessment of patients with type 2 idiopathic macular telangiectasia. Invest Ophthalmol Vis Sci. 2007;48(8):3788–3795.
  • Charbel Issa P, Troeger E, Finger R, et al. Structure-function correlation of the human central retina. PLoS One. 2010;5(9):e12864.
  • Clemons TE, Gillies MC, Chew EY, et al. The national eye institute visual function questionnaire in the macular telangiectasia (mactel) project. Invest Ophthalmol Vis Sci. 2008;49(10):4340–4346.
  • Maruko I, Iida T, Sekiryu T, et al. Early morphological changes and functional abnormalities in group 2A idiopathic juxtafoveolar retinal telangiectasis using spectral domain optical coherence tomography and microperimetry. Br J Ophthalmol. 2008;92(11):1488–1491.
  • Schmitz-Valckenberg S, Fan K, Nugent A, et al. Correlation of functional impairment and morphological alterations in patients with group 2A idiopathic juxtafoveal retinal telangiectasia. Arch Ophthalmol. 2008;126(3):330–335.
  • Schmitz-Valckenberg S, Ong EE, Rubin GS, et al. Structural and functional changes over time in mactel patients. Retina. 2009;29(9):1314–1320.
  • Wong WT, Forooghian F, Majumdar Z, et al. Fundus autofluorescence in type 2 idiopathic macular telangiectasia: correlation with optical coherence tomography and microperimetry. Am J Ophthalmol. 2009;148(4):573–583.
  • Bringmann A, Iandiev I, Pannicke T, et al. Cellular signaling and factors involved in muller cell gliosis: neuroprotective and detrimental effects. Prog Retin Eye Res. 2009;28(6):423–451.
  • Bringmann A, Pannicke T, Grosche J, et al. Muller cells in the healthy and diseased retina. Prog Retin Eye Res. 2006;25(4):397–424.
  • Gass JD. Muller cell cone, an overlooked part of the anatomy of the fovea centralis: hypotheses concerning its role in the pathogenesis of macular hole and foveomacualr retinoschisis. Arch Ophthalmol. 1999;117(6):821–823.
  • Chopdar A. Retinal telangiectasis in adults: fluorescein angiographic findings and treatment by argon laser. Br J Ophthalmol. 1978;62(4):243–250.
  • Park DW, Schatz H, McDonald HR, et al. Grid laser photocoagulation for macular edema in bilateral juxtafoveal telangiectasis. Ophthalmology. 1997;104(11):1838–1846.
  • Lowe MA, Akduman L, Olk RJ. Laser photocoagulation and glucose metabolism in idiopathic juxtafoveolar retinal telangiectasis. Ophthalmic Surg Lasers. 1998;29(2):126–139.
  • Kiraly A, Nasemann JE. [idiopathic juxtafoveolar telangiectasis long-term follow-up of visual acuity]. Ophthalmologe. 1995;92(5):698–703.
  • Friedman SM, Mames RN, Stewart MW. Subretinal hemorrhage after grid laser photocoagulation for idiopathic juxtafoveolar retinal telangiectasis. Ophthalmic Surg. 1993;24(8):551–553.
  • De Lahitte GD, Cohen SY, Gaudric A. Lack of apparent short-term benefit of photodynamic therapy in bilateral, acquired, parafoveal telangiectasis without subretinal neovascularization. Am J Ophthalmol. 2004;138(5):892–894.
  • Alldredge CD, Garretson BR. Intravitreal triamcinolone for the treatment of idiopathic juxtafoveal telangiectasis. Retina. 2003;23(1):113–116.
  • Cakir M, Kapran Z, Basar D, et al. Optical coherence tomography evaluation of macular edema after intravitreal triamcinolone acetonide in patients with parafoveal telangiectasis. Eur J Ophthalmol. 2006;16(5):711–717.
  • Martinez JA. Intravitreal triamcinolone acetonide for bilateral acquired parafoveal telangiectasis. Arch Ophthalmol. 2003;121(11):1658–1659.
  • Smithen LM, Spaide RF. Photodynamic therapy and intravitreal triamcinolone for a subretinal neovascularization in bilateral idiopathic juxtafoveal telangiectasis. Am J Ophthalmol. 2004;138(5):884–885.
  • Eandi CM, Ober MD, Freund KB, et al. Anecortave acetate for the treatment of idiopathic perifoveal telangiectasia: a pilot study. Retina. 2006;26(7):780–785.
  • Charbel Issa P, Scholl HP, Holz FG. Short-term effects of intravitreal bevacizumab in type ii idiopathic macular telangiectasia. Retin Cases Brief Rep. 2007;1(4):189–191.
  • Charbel Issa P, Holz FG, Scholl HP. Findings in fluorescein angiography and optical coherence tomography after intravitreal bevacizumab in type 2 idiopathic macular telangiectasia. Ophthalmology. 2007;114(9):1736–1742.
  • Charbel Issa P, Finger RP, Holz FG, et al. Eighteen-month follow-up of intravitreal bevacizumab in type 2 idiopathic macular telangiectasia. Br J Ophthalmol. 2008;92(7):941–945.
  • Charbel IP, Finger RP, Kruse K, et al. Monthly ranibizumab for nonproliferative macular telangiectasia type 2: a 12-month prospective study. Am J Ophthalmol. 2011;151(5):876–86 e1.
  • Toy BC, Koo E, Cukras C, et al. Treatment of nonneovascular idiopathic macular telangiectasia type 2 with intravitreal ranibizumab: results of a phase II clinical trial. Retina. 2012;32(5):996–1006.
  • Yourey PA, Gohari S, Su JL, et al. Vascular endothelial cell growth factors promote the in vitro development of rat photoreceptor cells. J Neurosci. 2000;20(18):6781–6788.
  • Sigler EJ, Randolph JC, Calzada JI, et al. Pars plana vitrectomy with internal limiting membrane removal in type 2 idiopathic macular telangiectasia. Retin Cases Brief Rep. 2013;7(4):380–385.
  • Sigler EJ, Randolph JC, Calzada JI, et al. Comparison of observation, intravitreal bevacizumab, or pars plana vitrectomy for non-proliferative type 2 idiopathic macular telangiectasia. Graefes Arch Clin Exp Ophthalmol. 2013;251(4):1097–1101.
  • Chew EY, Clemons TE, Peto T, et al. Ciliary neurotrophic factor for macular telangiectasia type 2: results from a phase 1 safety trial. Am J Ophthalmol. 2015;159(4):659–66 e1.
  • Park D, Schatz H, McDonald HR, et al. Fibrovascular tissue in bilateral juxtafoveal telangiectasis. Arch Ophthalmol. 1996;114(9):1092–1096.
  • Lee BL. Bilateral subretinal neovascular membrane in idiopathic juxtafoveolar telangiectasis. Retina. 1996;16(4):344–346.
  • Watzke RC, Klein ML, Folk JC, et al. Long-term juxtafoveal retinal telangiectasia. Retina. 2005;25(6):727–735.
  • Potter MJ, Szabo SM, Chan EY, et al. Photodynamic therapy of a subretinal neovascular membrane in type 2A idiopathic juxtafoveolar retinal telangiectasis. Am J Ophthalmol. 2002;133(1):149–151.
  • Potter MJ, Szabo SM, Sarraf D, et al. Photodynamic therapy for subretinal neovascularization in type 2A idiopathic juxtafoveolar telangiectasis. Can J Ophthalmol. 2006;41(1):34–37.
  • Shanmugam MP, Agarwal M. RPE atrophy following photodynamic therapy in type 2A idiopathic parafoveal telangiectasis. Indian J Ophthalmol. 2005;53(1):61–63.
  • Rishi P, Shroff D, Rishi E. Combined photodynamic therapy and intravitreal ranibizumab as primary treatment for subretinal neovascular membrane (SRNVM) associated with type 2 idiopathic macular telangiectasia. Graefes Arch Clin Exp Ophthalmol. 2008;246(4):619–621.
  • Ruys J, De Laey JJ, Vanderhaeghen Y, et al. Intravitreal bevacizumab (Avastin) for the treatment of bilateral acquired juxtafoveal retinal telangiectasis associated with choroidal neovascular membrane. Eye (Lond). 2007;21(11):1433–1434.
  • Shukla D, Singh J, Kolluru CM, et al. Transpupillary thermotherapy for subfoveal neovascularization secondary to group 2A idiopathic juxtafoveolar telangiectasis. Am J Ophthalmol. 2004;138(1):147–149.
  • Maia OO Jr., Bonanomi MT, Takahashi WY, et al. Intravitreal bevacizumab for foveal detachment in idiopathic perifoveal telangiectasia. Am J Ophthalmol. 2007;144(2):296–299.
  • Jorge R, Costa RA, Calucci D, et al. Intravitreal bevacizumab (Avastin) associated with the regression of subretinal neovascularization in idiopathic juxtafoveolar retinal telangiectasis. Graefes Arch Clin Exp Ophthalmol. 2007;245(7):1045–1048.
  • Shanmugam MP, Mythri HM, Shetty NS. Intravitreal bevacizumab for parafoveal telangiectasia-associated choroidal neovascular membrane. Indian J Ophthalmol. 2007;55(6):490–491.
  • Mandal S, Venkatesh P, Abbas Z, et al. Intravitreal bevacizumab (Avastin) for subretinal neovascularization secondary to type 2A idiopathic juxtafoveal telangiectasia. Graefes Arch Clin Exp Ophthalmol. 2007;245(12):1825–1829.
  • Berger AS, McCuen BW 2nd, Brown GC, et al. Surgical removal of subfoveal neovascularization in idiopathic juxtafoveolar retinal telangiectasis. Retina. 1997;17(2):94–98.

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