Can artificial intelligence be used to improve the quality of vision in patients with amblyopia? The first digital pill in medicine administered under AI

References

• Batra S, Baker R, Wang T, et al. Digital health technology for use in patients with serious mental illness: a systematic review of the literature. Med Devices. 2017;10:237–251. doi: 10.2147/MDER.S144158
   Google Scholar
• Hess RF, Thompson B. New insights into amblyopia: binocular therapy and noninvasive brain stimulation. J Aapos. 2013;17(1):89–93. doi: 10.1016/j.jaapos.2012.10.018
   PubMed Web of Science ®Google Scholar
• Hou C, Kim YJ, Lai XJ, et al. Degraded attentional modulation of cortical neural populations in strabismic amblyopia. J Vis. 2016;16(3):16. doi: 10.1167/16.3.16
   PubMed Web of Science ®Google Scholar
• Verghese P, McKee SP, Levi DM. Attention deficits in amblyopia. Curr Opin Psychol. 2019;29:199–204. doi: 10.1016/j.copsyc.2019.03.011
   PubMed Web of Science ®Google Scholar
• Wong SP, Baldwin AS, Hess RF, et al. Shifting eye balance using monocularly directed attention in normal vision. J Vis. 2021;21(5):4. doi: 10.1167/jov.21.5.4
   PubMed Web of Science ®Google Scholar
• De Buffon C. Disseration sur la cause du strabisme ou des yeux louches. Hist Acad R Sci. 1743.
   Google Scholar
• Hess RF, Thompson B. Amblyopia and the binocular approach to its therapy. Vision Res. 2015;114:4–16. doi: 10.1016/j.visres.2015.02.009
   PubMed Web of Science ®Google Scholar
• Hess RF. Reasons why we might want to question the use of patching to treat amblyopia as well as the reliance on visual acuity as the primary outcome measure. Br Med J. 2022;7(1):e000914. doi: 10.1136/bmjophth-2021-000914
   Web of Science ®Google Scholar
• Mansouri B, Thompson B, Hess RF. Measurement of suprathreshold binocular interactions in amblyopia. Vision Res. 2008;48(28):2775–2784. doi: 10.1016/j.visres.2008.09.002
   PubMed Web of Science ®Google Scholar
• Clavagnier S, Thompson B, Hess RF Long lasting effects of daily theta burst rTMS sessions in the human amblyopic cortex. J Brain Stimulation. 2012;6(6):860–867. in submission. doi: 10.1016/j.brs.2013.04.002
   Web of Science ®Google Scholar
• Thompson B, Mansouri B, Koski L, et al. Brain plasticity in the adult: restoration of function in amblyopia using rTMS. Current Biology. 2008;18(14):1067–1071. submitted 09/01/08. doi: 10.1016/j.cub.2008.06.052
   PubMed Web of Science ®Google Scholar
• Hess RF, Mansouri B, Thompson B. A new binocular approach to the treatment of amblyopia in adults well beyond the critical period of visual development. Restorat Neurol Neurosci. 2010;28(6):1–10. doi: 10.3233/RNN-2010-0550
   PubMed Web of Science ®Google Scholar
• Hess RF, Mansouri B, Thompson B. Restoration of binocular vision in amblyopia. Strabismus. 2011;19(3):110–118. doi: 10.3109/09273972.2011.600418
   PubMedGoogle Scholar
• Li J, Thompson B, Deng D, et al. Dichoptic training enables the adult amblyopic brain to learn. Curr Biol. 2013;23(8):R308–R309. doi: 10.1016/j.cub.2013.01.059
   PubMed Web of Science ®Google Scholar
• Mansouri B, Singh P, Globa A, et al. Binocular training reduces amblyopic visual acuity impairment. Strabismus. 2014;22(1):1–6. doi: 10.3109/09273972.2013.877945
   PubMedGoogle Scholar
• Spiegel DP, Li J, Hess RF, et al. Transcranial direct current stimulation enhances recovery of stereopsis in adults with amblyopia. Neurotherapeutics. 2013;10(4):831–839. doi: 10.1007/s13311-013-0200-y
   PubMed Web of Science ®Google Scholar
• To L, Thompson B, Blum J, et al. A game platform for treatment of amblyopia. IEEE Trans Neural Syst Rehabil Eng. 2011;19(30):280–289. doi: 10.1109/TNSRE.2011.2115255
   PubMedGoogle Scholar
• Li J, Spiegel DP, Hess RF, et al. Dichoptic training improves contrast sensitivity in adults with amblyopia. Vision Res. 2015;114:161–172. doi: 10.1016/j.visres.2015.01.017
   PubMed Web of Science ®Google Scholar
• Epelbaum M, Milleret C, Buisseret P, et al. The sensitive period for strabismic amblyopia in humans. Ophthalmol. 1993;100(3):323–327. doi: 10.1016/S0161-6420(13)32170-8
   PubMed Web of Science ®Google Scholar
• Birch EE, Li S, Jost RM, et al. Binocular iPad treatment for amblyopia in preschool children. J Am Assoc Pediatr Ophthalmol Strabismus. 2014;18(4):e1–e2. doi: 10.1016/j.jaapos.2014.07.004
   Google Scholar
• Knox PJ, Simmers AJ, Gray LS, et al. An exploratory study: prolonged periods of binocular stimulation can provide an effective treatment for childhood amblyopia. Invest Ophthalmol Vis Sci. 2012;53(2):817–824. doi: 10.1167/iovs.11-8219
   PubMed Web of Science ®Google Scholar
• Li J, Yu M, Hess RF, et al. Author reply: To PMID 23622875. Ophthalmol. 2014;121(3):e14–15. doi: 10.1016/j.ophtha.2013.10.038
   PubMedGoogle Scholar
• Li SL, Jost RM, Morale SE, et al. A binocular iPad treatment for amblyopic children. Eye. 2014;28(10):1246–1253. doi: 10.1038/eye.2014.165
   PubMed Web of Science ®Google Scholar
• Li SL, Jost RM, Morale SE, et al. Binocular ipad treatment of amblyopia for lasting improvements in visual acuity. JAMA Ophthalmol. 2015;133(4):479–480. doi: 10.1001/jamaophthalmol.2014.5515
   PubMed Web of Science ®Google Scholar
• Holmes JM, Beck RW, Kraker RT, et al. Risk of amblyopia recurrence after cessation of treatment. J AAPOS. 2004;8(5):420–428.
   PubMed Web of Science ®Google Scholar
• Hess RF, Babu RJ, Clavagnier S, et al. The IPOD binocular home-based treatment for amblyopia in adults: Efficacy and compliance. Clin And Exp Optom. 2014;97(5):389–398. doi: 10.1111/cxo.12192
   PubMed Web of Science ®Google Scholar
• Birch EE, Jost RM, Kelly KR, et al. Baseline and clinical Factors Associated with Response to amblyopia treatment in a Randomized clinical Trial. Optom Vis Sci. 2020;97(5):316–323. doi: 10.1097/OPX.0000000000001514
   PubMed Web of Science ®Google Scholar
• Jost RM, Kelly KR, Hunter JS, et al. A randomized clinical trial of contrast increment protocols for binocular amblyopia treatment. J AAPOS. 2020;24(5):e282 281–e282 287. doi: 10.1016/j.jaapos.2020.06.009
   Web of Science ®Google Scholar
• Kelly KR, Jost RM, Dao L, et al. Binocular iPad game vs patching for treatment of amblyopia in children: a randomized clinical trial. JAMA Ophthalmol. 2016;134(12):1402–1408. doi: 10.1001/jamaophthalmol.2016.4224
   PubMed Web of Science ®Google Scholar
• Kelly KR, Jost RM, Wang YZ, et al. Improved binocular outcomes following binocular treatment for childhood amblyopia. Invest Ophthalmol Vis Sci. 2018;59(3):1221–1228. doi: 10.1167/iovs.17-23235
   PubMed Web of Science ®Google Scholar
• Webber AL, Wood JM, Thompson B. Fine Motor Skills of children with amblyopia improve following binocular treatment. Invest Ophthalmol Vis Sci. 2016;57(11):4713–4720. doi: 10.1167/iovs.16-19797
   PubMed Web of Science ®Google Scholar
• Gao TY, Guo CX, Babu RJ, et al. Effectiveness of a binocular video game vs placebo video game for improving visual functions in older children, Teenagers, and adults with amblyopia: a randomized clinical trial. JAMA Ophthalmol. 2018;136(2):172–181. doi: 10.1001/jamaophthalmol.2017.6090
   PubMed Web of Science ®Google Scholar
• Holmes JM, Manh VM, Lazar EL, et al. Effect of a binocular iPad game vs part-time patching in children aged 5 to 12 Years with amblyopia: a randomized clinical trial. JAMA Ophthalmol. 2016;134(12):1391–1400. doi: 10.1001/jamaophthalmol.2016.4262
   PubMed Web of Science ®Google Scholar
• Manh VM, Holmes JM, Lazar EL, et al. A randomized trial of a binocular iPad game versus part-time patching in children aged 13 to 16 years with amblyopia. Am J Ophthalmol. 2018;186:104–115. doi: 10.1016/j.ajo.2017.11.017
   PubMed Web of Science ®Google Scholar
• Gao TY, Black JM, Babu RJ, et al. Adherence to home-based videogame treatment for amblyopia in children and adults. Clin Exp Optom. 2021;104(7):773–779. doi: 10.1080/08164622.2021.1878834
   PubMed Web of Science ®Google Scholar
• Li SL, Reynaud A, Hess RF, et al. Dichoptic movie viewing treats childhood amblyopia. J AAPOS. 2015;19(5):401–405. doi: 10.1016/j.jaapos.2015.08.003
   PubMed Web of Science ®Google Scholar
• Sauvan L, Stolowy N, Denis D, et al. Contribution of short-time occlusion of the amblyopic eye to a passive dichoptic video treatment for amblyopia beyond the critical period. Neural Plast. 2019;2019:1–12. doi: 10.1155/2019/6208414
   Web of Science ®Google Scholar
• Xiao S, Gaier ED, Mazow ML, et al. Improved adherence and treatment outcomes with an engaging, personalized digital therapeutic in amblyopia. Sci Rep. 2020;10(1):8328. doi: 10.1038/s41598-020-65234-3
   PubMed Web of Science ®Google Scholar
• Lunghi C, Burr DC, Morrone C. Brief periods of monocular deprivation disrupt ocular balance in human adult visual cortex. Curr Biol. 2011;21(14):R538–539. doi: 10.1016/j.cub.2011.06.004
   PubMed Web of Science ®Google Scholar
• Zhou J, Clavagnier S, Hess RF. Short-term monocular deprivation strengthens the patched eye’s contribution to binocular combination. J Vis. 2013;13(5). doi: 10.1167/13.5.12
   Web of Science ®Google Scholar