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Original Articles

Empathizing with basic emotions: Common and discrete neural substrates

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Pages 364-384 | Published online: 24 Feb 2007

References

  • Adolphs , R. , Tranel , D. , Damasio , H. and Damasio , A. 1994 . Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala . Nature , 372 : 669 – 672 .
  • Baron-Cohen , S. 2001 . Theory of mind and autism: A review . International Review of Mental Retardation , 23 : 169
  • Baron-Cohen , S. 2002 . The extreme male brain theory of autism . Trends in Cognitive Sciences , 6 : 248 – 254 .
  • Baron-Cohen , S. , Ring , H. , Bullmore , E. , Wheelwright , S. , Ashwin , C. and Williams , S. 2000 . The amygdala theory of autism . Neuroscience and Behavioural Reviews , 24 : 355 – 364 .
  • Baron-Cohen , S. , Spitz , A. and Cross , P. 1993 . Can children with autism recognize surprise? . Cognition and Emotion , 7 : 507 – 516 .
  • Baron-Cohen , S. and Wheelwright , S. 2004 . The Empathy Quotient (EQ). An investigation of adults with Asperger syndrome or high functioning autism, and normal sex differences . Journal of Autism and Developmental Disorders , 34 : 163 – 175 .
  • Baron-Cohen , S. , Wheelwright , S. and Jolliffe , T. 1997 . Is there a “language of the eyes”? Evidence from normal adults and adults with autism or Asperger syndrome . Visual Cognition , 4 : 311 – 331 .
  • Blanchard , D. and Blanchard , R. 1989 . “ Experimental animal models of aggression: What they say about human behaviour ” . In Human aggression: Naturalistic approaches ). London: Routledge Edited by: Archer , J. and Browne , K. 94 – 121 .
  • Bowlby , J. 1969 . Attachment , London : Hogarth Press .
  • Buccino , G. , Binkofski , F. , Fink , G. , Fadiga , L. , Fogassi , L. Gallese , V. 2001 . Action observation activates premotor and parietal areas in a somatotopic manner: An fMRI study . European Journal of Neuroscience , 13 : 400 – 404 .
  • Bullmore , E. T. , Suckling , J. , Overmeyer , S. , Rabe-Hesketh , S. , Taylor , E. and Brammer , M. J. 1999 . Global, voxel and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain . IEEE Transactions on Medical Imaging , 18 : 32 – 42 .
  • Calder , A. J. , Keane , J. , Lawrence , A. D. and Manes , F. 2004 . Impaired recognition of anger following damage to the ventral striatum . Brain , 127 : 1958 – 1969 .
  • Calder , A. J. , Lawrence , A. D. and Young , A. W. 2001 . Neuropsychology of fear and loathing . Nature Reviews Neuroscience , 2 : 352 – 363 .
  • Carr , L. , Iacoboni , M. , Dubeau , M.-C. , Mazziotta , J. and Lenzi , G. 2003 . Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas . Proceedings for the National Academy of Sciences of the USA , 100 : 5497 – 5502 .
  • Celani , G. , Battacchi , M. W. and Arcidiacono , L. 1999 . The understanding of the emotional meaning of facial expressions in people with autism . Journal of Autism and Developmental Disorders , 29 : 57 – 66 .
  • Chakrabarti , B. , Kent , L. , Suckling , J. , Bullmore , E. T. and Baron-Cohen , S. 2006 . Variations in human cannabinoid receptor (CNR1) gene modulate striatal response to happy faces . European Journal of Neuroscience , 23 : 1944 – 1948 .
  • Chakrabarti , B. , & Lawrence , A. D. ( 2004 ). Trait extraversion predicts amygdala response to neutral faces . Presented at British Psychological Society Annual Conference , London .
  • Chaminade , T. , Meltzoff , A. and Decety , J. 2002 . Does the end justify the means? A PET exploration of the mechanisms involved in human imitation . NeuroImage , 15 : 318 – 328 .
  • Chapman , E. , Baron- Cohen , S. , Auyeung , B. , Knickmeyer , R. , Taylor , K. and Hackett , G. 2006 . Fetal testosterone and empathy: Evidence from the Empathy Quotient (EQ) and the “Reading the Mind in the Eyes” Test . Social Neuroscience , 1 : 135 – 148 .
  • Cusack , R. 2004 . Automatic analysis for neuroimaging , Cambridge, , UK : MRC Cognition and Brain Sciences Unit .
  • Damasio , A. R. , Grabowski , T. J. , Bechara , A. , Damasio , H. , Ponto , L. L. B. Parvizi , J. 2000 . Subcortical and cortical brain activity during the feeling of self-generated emotions . Nature Neuroscience , 3 : 1049 – 1056 .
  • Dapretto , M. , Davies , M. , Pfeifer , J. , Scott , A. , Sigman , M. Bookheimer , S. 2006 . Understanding emotions in others: Mirror neuron dysfunction in children with autism spectrum disorders . Nature Neuroscience , 9 : 28 – 30 .
  • Darwin , C. ( 1998 ). The expression of emotions in man and animals . London : HarperCollins . (Originally published in 1872)
  • Decety , J. , Chaminade , T. , Grezes , J. and Meltzoff , A. 2002 . A PET exploration of the neural mechanisms involved in reciprocal imitation . NeuroImage , 15 : 265 – 272 .
  • Delancey , C. 2001 . Passionate engines: What emotions reveal about mind , New York : Oxford University Press .
  • den Ouden , H. , Frith , U. , Frith , C. and Blakemore , S. J. 2005 . Thinking about intentions . NeuroImage , 28 : 787 – 796 .
  • Deruelle , C. , Rondan , C. , Gepner , B. and Tardiff , C. 2004 . Spatial frequency and face processing in children with autism and Asperger syndrome . Journal of Autism and Developmental Disorders , 34 : 199 – 210 .
  • Ekman , P. and Friesen , W. 1971 . Constants across cultures in the face and emotion . Journal of Personality and Social Psychology , 17 : 124 – 129 .
  • Ekman , P. and Keltner , D. 2000 . “ Facial expression of emotion ” . In Handbook of emotion , Edited by: Haviland-Jones , J. and Lewis , G. 236 – 249 . New York : Guilford Press .
  • Eugene , F. , Levesque , J. , Mensour , B. , Leroux , J.-M. , Beaudoin , G. Bourgouin , P. 2003 . The impact of individual differences on the neural circuitry underlying sadness . NeuroImage , 19 : 354 – 364 .
  • Fletcher , P. C. , Happé , F. , Frith , U. , Baker , S. C. Dolan , R. J. 1995 . Other minds in the brain: A functional imaging study of “theory of mind” in story comprehension . Cognition , 57 : 109 – 128 .
  • Forster , K. and Forster , J. 2003 . DMDX: A Windows display program with millisecond accuracy. Behavior Research Methods . Instruments and Computers , 35 : 116 – 124 .
  • Friston , K. , Harrison , L. and Penny , W. 2003 . Dynamic causal modelling . NeuroImage , 19 : 1273 – 1302 .
  • Frith , U. 2001 . Mind blindness and the brain in autism . Neuron , 32 : 969 – 979 .
  • Frith , U. and Frith , C. 2003 . Development and neurophysiology of mentalizing . Philosophical Transactions of the Royal Society, Series B, Biological Sciences , 358 : 459 – 473 .
  • Gallese , V. 2003 . The roots of empathy: The shared manifold hypothesis and the neural basis of intersubjectivity . Psychopathology , 36 : 171 – 180 .
  • Gallese , V. , Fadiga , L. , Fogassi , L. and Rizzolatti , G. 1996 . Action recognition in the premotor cortex . Brain , 119 : 593 – 609 .
  • Gallese , V. , Fadiga , L. , Fogassi , L. and Rizzolatti , G. 2002 . “ Action representation and the inferior parietal lobule ” . In Common mechanisms in perception and action: Attention and performance , Edited by: Prinz , W. and Hommel , B. 247 – 266 . Oxford, , UK : Oxford University Press .
  • Golan , O. and Baron-Cohen , S. 2006 . Systemizing empathy: Teaching adults with Asperger's syndrome/high functioning autism to recognize emotions using interactive multimedia . Development and Psychopathology , 18 : 591 – 617 .
  • Golan , O. , Baron-Cohen , S. and Hill , J. J. 2006 . The Cambridge Mindreading (CAM) Face–Voice Battery: Testing complex emotion recognition in adults with and without Asperger syndrome . Journal of Autism and Developmental Disorders , 36 : 169 – 183 .
  • Gottesman , I. , Psych , H. and Gould , T. 2003 . The endophenotype concept in psychiatry: Etymology and strategic intentions . American Journal of Psychiatry , 160 : 636 – 645 .
  • Grosbras , M.-H. and Paus , T. 2006 . Brain networks involved in viewing angry hands or faces . Cerebral Cortex , 16 : 1087 – 1096 .
  • Gusnard , D. , Akbudak , E. , Shulman , G. and Raichle , M. 2001 . Medial prefrontal cortex and self-referential mental activity: Relation to a default mode of brain function . Proceedings for the National Academy of Sciences of the USA , 98 : 4259 – 4264 .
  • Haidt , J. , McCauley , C. and Rozin , P. 1994 . Individual differences in sensitivity to disgust: A scale sampling seven domains of disgust elicitors . Personality and Individual Differences , 16 : 701 – 713 .
  • Hall , G. B. C. , Szechtman , H. and Nahmias , C. 2003 . Enhanced salience and emotion recognition in Autism: A PET study . American Journal of Psychiatry , 160 : 1439 – 1441 .
  • Hamzei , F. , Rijntjes , M. , Dettmers , C. , Glauche , V. , Weiller , C. and Buchel , C. 2003 . The human action recognition system and its relationship to Broca's area: An fMRI study . NeuroImage , 19 : 637 – 644 .
  • Hariri , A. R. , Mattay , V. S. , Tessitore , A. , Fera , F. and Weinberger , D. R. 2003 . Neocortical modulation of the amygdala response to fearful stimuli . Biological Psychiatry , 53 : 494 – 501 .
  • Haxby , J. V. , Hoffman , E. A. and Gobbini , M. I. 2000 . The distributed human neural system for face perception . Trends in Cognitive Sciences , 4 : 223 – 233 .
  • Haxby , J. V. , Hoffman , E. A. and Gobbini , M. I. 2002 . Human neural systems for face recognition and social communication . Biological Psychiatry , 51 : 59 – 67 .
  • Hejmadi , A. , Davidson , R. and Rozin , P. 2000 . Exploring Hindu Indian emotion expressions: Evidence for accurate recognition by Americans and Indians . Psychological Science , 11 : 183 – 187 .
  • Hobson , R. P. 1986 . The autistic child's appraisal of expressions of emotion . Journal of Child Psychology and Psychiatry , 27 : 321 – 342 .
  • Hurley , S. L. 2005 . “ Active perception and perceiving action: The shared circuits hypothesis ” . In Perceptual experience , Edited by: Gendler , T. and Hawthorne , J. 205 – 259 . New York : Oxford University Press .
  • Hynes , C. , Baird , A. and Grafton , S. 2006 . Differential role of the orbital frontal lobe in emotional versus cognitive perspective-taking . Neuropsychologia , 44 : 374 – 383 .
  • Iacoboni , M. , Koski , L. , Brass , M. , Bekkering , H. , Woods , R. Dubeau , M. 2001 . Reafferent copies of imitated actions in the right superior temporal cortex . Proceedings of the National Academy of Sciences of the USA , 98 : 13995 – 13999 .
  • Izard , C. and Ackerman , B. 2000 . “ Motivational, organizational, and regulatory functions of discrete emotions ” . In Handbook of emotions , Edited by: Haviland-Jones , J. and Lewis , M. 253 – 264 . New York : Guilford Press .
  • Johnson-Frey , S. , Maloof , F. , Newman-Norlund , R. , Farrer , C. , Inati , S. and Grafton , S. 2003 . Actions or hand–object interactions? Human inferior frontal cortex and action observation . Neuron , 39 : 1053 – 1058 .
  • Kanwisher , N. , McDermott , J. and Chun , M. 1997 . The fusiform face area: A module in human extrastriate cortex specialized for face perception . Journal of Neuroscience , 17 : 4302 – 4311 .
  • Keysers , C. and Perrett , D. I. 2004 . Demystifying social cognition: A Hebbian perspective . Trends in Cognitive Science , 8 : 501 – 507 .
  • Knickmeyer , R. , Baron-Cohen , S. , Raggatt , P. and Taylor , K. 2005 . Foetal testosterone, social cognition, and restricted interests in children . Journal of Child Psychology and Psychiatry , 46 : 198 – 210 .
  • Koski , L. , Iacoboni , M. , Dubeau , M.-C. , Woods , R. and Mazziotta , J. 2003 . Modulation of cortical activity during different imitative behaviors . Journal of Neurophysiology , 89 : 460 – 471 .
  • Krolak-Salmon , P. , Henaff , M.-A. , Vighetto , A. , Bauchet , F. , Bertrand , O. Mauguiere , F. 2006 . Experiencing and detecting happiness in humans: The role of the supplementary motor area . Annals of Neurology , 59 : 196 – 199 .
  • Lawrence , A. D. and Calder , A. J. 2003 . “ Homologizing human emotions ” . In Emotions, evolution and rationality , Edited by: Evans , D. and Cruse , P. 15 – 47 . Oxford, , UK : Oxford University Press .
  • Lawrence , A. D. , Chakrabarti , B. , & Calder , A. J. ( 2004 ). Looking at happy and sad faces: An fMRI study . Presented at Annual meeting of the Cognitive Neuroscience Society , San Diego , USA .
  • LeDoux , J. 2000 . Emotion circuits in the brain . Annual Review of Neuroscience , 23 : 155 – 184 .
  • Leslie , K. , Johnson-Frey , S. and Grafton , S. 2004 . Functional imaging of face and hand imitation: Toward a motor theory of empathy . NeuroImage , 21 : 601 – 607 .
  • Liotti , M. , Mayberg , H. , Brannan , S. , McGinnis , S. , Jerabek , P. and Fox , P. 2000 . Differential limbic-cortical correlates of sadness and anxiety in healthy subjects: Implications for affective disorders . Biological Psychiatry , 48 : 30 – 42 .
  • Lord , C. , Rutter , M. , Goode , S. , Heemsbergen , J. , Jordan , H. Mawhood , L. 1989 . Autism Diagnostic Observation Schedule: A standard observation of communicative and social behaviour . Journal of Autism and Developmental Disorders , 19 : 185 – 212 .
  • Lord , C. , Rutter , M. and Le Couteur , A. 1994 . Autism Diagnostic Interview—Revised . Journal of Autism and Developmental Disorders , 24 : 659 – 686 .
  • Macdonald , H. , Rutter , M. , Howlin , P. , Rios , P. , Le Couteur , A. Evered , C. 1989 . Recognition and expression of emotional cues by autistic and normal adults . Journal of Child Psychology and Psychiatry , 30 : 865 – 877 .
  • Malhi , G. , Lagopoulos , J. , Ward , P. , Kumari , V. , Mitchell , D. Parker , G. 2004 . Cognitive generation of affect in bipolar depression: An fMRI study . European Journal of Neuroscience , 19 : 741 – 754 .
  • Mayberg , H. , Liotti , M. , Brannan , S. , McGinnis , M. Y. , Mahurin , R. Jerabek , P. 1999 . Reciprocal limbic-cortical function and negative mood: Converging PET findings in depression and normal sadness . American Journal of Psychiatry , 156 : 675 – 682 .
  • McGuinness , E. , Siverstsen , D. and Allman , J. 1980 . Organization of the face representation in macaque motor cortex . Journal of Comparative Neurology , 193 : 591 – 608 .
  • Mobbs , D. , Greicius , M. D. , Abdel-Azim , E. , Menon , V. and Reiss , A. L. 2003 . Humor modulates the mesolimbic reward centers . Neuron , 40 : 1041 – 1048 .
  • Molnar-Szakacs , I. , Iacoboni , M. , Koski , L. and Mazziotta , J. C. 2004 . Functional segregation within pars opercularis of the inferior frontal gyrus: Evidence from fMRI studies of imitation and action observation . Cerebral Cortex , 15 : 986 – 994 .
  • Murphy , F. C. , Nimmo-Smith , I. and Lawrence , A. D. 2003 . Functional neuroanatomy of emotions: A meta-analysis. Cognitive . Affective & Behavioral Neuroscience , 3 : 207 – 233 .
  • Nichols , T. and Holmes , A. 2002 . Nonparametric permutation tests for functional neuroimaging: A primer with examples . Human Brain Mapping , 15 : 1 – 25 .
  • Nishitani , N. , Avikainen , S. and Hari , R. 2004 . Abnormal imitation-related cortical activation sequences in Asperger's syndrome . Annals of Neurology , 55 : 558 – 562 .
  • O'Doherty , J. 2004 . Reward representations and reward-related learning in the human brain: Insights from neuroimaging . Current Opinion in Neurobiology , 14 : 796 – 776 .
  • O'Doherty , J. , Deichmann , R. , Critchley , H. D. and Dolan , R. J. 2002 . Neural responses during anticipation of a primary taste reward . Neuron , 33 : 815 – 826 .
  • Panksepp , J. 1998 . Affective neuroscience: The foundations of human and animal emotions , New York : Oxford University Press .
  • Phan , K. L. , Wager , T. , Taylor , S. F. and Liberzon , I. 2002 . Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI . NeuroImage , 16 : 331 – 348 .
  • Phillips , M. , Young , A. , Senior , C. , Brammer , M. , Andrew , C. Calder , A. 1997 . A specific neural substrate for perceiving facial expressions of disgust . Nature , 389 : 495 – 498 .
  • Phillips , M. L. , Bullmore , E. T. , Howard , R. , Woodruff , P. W. R. , Wright , I. C. Williams , S. R. C. 1998a . Investigation of facial recognition memory and happy and sad facial expression perception: An fMRI study . Psychiatry Research Neuroimaging , 83 : 127 – 138 .
  • Phillips , M. L. , Young , A. W. , Scott , S. , Calder , A. J. , Andrew , C. Giampetro , V. 1998b . Neural responses to facial and vocal expressions of fear and disgust. Proceedings of the Royal Society London, Series B . Biological Sciences , 265 : 1809 – 1817 .
  • Power , M. and Dalgleish , T. 1997 . Cognition and emotion: From order to disorder , Hove, , UK : Psychology Press .
  • Prather , M. , Lavenex , P. , Mauldin-Jourdain , M. , Mason , W. , Capitanio , J. Mendoza , S. 2001 . Increased social fear and decreased fear of objects in monkeys with neonatal amygdala lesions . Neuroscience , 106 : 653 – 658 .
  • Preston , S. D. and de Waal , F. B. M. 2002 . Empathy: Its ultimate and proximate bases . Behavioural and Brain Sciences , 25 : 1 – 72 .
  • Prinz , J. 2004 . “ Which emotions are basic? ” . In Emotions, evolution and rationality , Edited by: Evans , D. and Cruse , P. 69 – 88 . Oxford, , UK : Oxford University Press .
  • Rabe-Hesketh , S. , Bullmore , E. and Brammer , M. 1997 . The analysis of functional magnetic resonance images . Statistical Methods in Medical Research , 6 : 215 – 237 .
  • Rahm , B. , Opwis , K. , Kaller , C. , Spreer , J. , Schwarzvald , R. Seifritz , E. 2006 . Tracking the subprocesses of decision-based action in the human frontal lobes . NeuroImage , 30 : 656 – 667 .
  • Ridderinkhof , K. , van den Wildenberg , W. , Segalowitz , S. and Carter , C. 2004 . Neural mechanisms of cognitive control: The role of prefrontal cortex in action selection, response inhibition, performance monitoring and reward-based learning . Brain and Cognition , 56 : 129 – 140 .
  • Rizzolatti , G. and Craighero , L. 2004 . The mirror-neuron system . Annual Review of Neuroscience , 27 : 169 – 192 .
  • Rizzolatti , G. , Fadiga , L. , Gallese , V. and Fogassi , L. 1996 . Premotor cortex and the recognition of motor actions . Cognitive Brain Research , 3 : 131 – 141 .
  • Rolls , E. 2000 . On the brain and emotion . Behavioral and Brain Sciences , 23 : 219 – 228 .
  • Saxe , R. and Kanwisher , N. 2003 . People thinking about thinking people. The role of the temporo-parietal junction in “theory of mind . NeuroImage , 19 : 1835 – 1842 .
  • Schultz , W. , Tremblay , L. and Hollerman , J. R. 2000 . Reward processing in primate orbitofrontal cortex and basal ganglia . Cerebral Cortex , 10 : 272 – 283 .
  • Shumake , J. , Edwards , E. and Gonzalez-Lima , F. 2001 . Hypermetabolism of paraventricular hypothalamus in the congenitally helpless rat . Neuroscience Letters , 311 : 45 – 48 .
  • Singer , T. , Seymour , B. , O'Doherty , J. , Kaube , H. , Dolan , R. and Frith , C. 2004 . Empathy for pain involves the affective but not sensory components of pain . Science , 303 : 1157 – 1167 .
  • Suckling , J. and Bullmore , E. 2004 . Permutation tests for factorially designed neuroimaging experiments . Human Brain Mapping , 22 : 193 – 205 .
  • Swaab , D. F. , Bao , A. M. and Lucassen , P. J. 2005 . The stress system in the human brain in depression and neurodegeneration . Ageing Research Reviews , 4 : 141 – 194 .
  • Vogt , B. 2005 . Pain and emotion interactions in subregions of the cingulate gyrus . Nature Reviews Neuroscience , 6 : 533 – 544 .
  • Walden , T. and Ogan , T. 1988 . The development of social referencing . Child Development , 59 : 1230 – 1240 .
  • Wicker , B. , Keysers , C. , Plailly , J. , Royet , J.-P. , Gallese , V. and Rizzolatti , G. 2003 . Both of us disgusted in my insula: The common neural basis of seeing and feeling disgust . Neuron , 40 : 655 – 664 .
  • Worsley , K. , Marrett , S. , Neelin , P. , Vandal , A. , Friston , K. and Evans , A. 1996 . A unified statistical approach for determining significant signals in images of cerebral activation . Human Brain Mapping , 4 : 58 – 73 .
  • Yirmiya , N. , Sigman , M. , Kasari , C. and Mundy , P. 1992 . Empathy and cognition in high functioning children with autism . Child Development , 63 : 150 – 160 .

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