Oxytocin increases empathy to pain when adopting the other- but not the self-perspective

REFERENCES

• Abu-Akel, A., Fischer-Shofty, M., Levkovitz, Y., Decety, J., & Shamay-Tsoory, S. (2014). The role of oxytocin in empathy to the pain of conflictual out-group members among patients with schizophrenia. Psychological Medicine. Advance online publication. doi:10.1017/S003329171400097X
   PubMedGoogle Scholar
• Abu-Akel, A., & Shamay-Tsoory, S. (2011). Neuroanatomical and neurochemical bases of theory of mind. Neuropsychologia, 49(11), 2971–2984. doi:10.1016/j.neuropsychologia.2011.07.012
   PubMed Web of Science ®Google Scholar
• Bartz, J. A., Zaki, J., Bolger, N., Hollander, E., Ludwig, N. N., Kolevzon, A., & Ochsner, K. N. (2010). Oxytocin selectively improves empathic accuracy. Psychological Science, 21(10), 1426–1428. doi:10.1177/0956797610383439
   PubMed Web of Science ®Google Scholar
• Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011). Social effects of oxytocin in humans: Context and person matter. Trends in Cognitive Science, 15(7), 301–309.
   PubMed Web of Science ®Google Scholar
• Batson, C. D. (2009a). Empathy-induced altruistic motivation. In P. R. Shaver & M. Mikulincer (Eds.), Prosocial motives, emotions, and behavior (pp. 15–34). Washington, DC: American Psychological Association.
   Google Scholar
• Batson, C. D. (2009b). These things called empathy: Eight related but distinct phenomena. In J. Decety & W. Ickes (Eds.), The Social Neuroscience of Empathy (pp. 3–15). Cambridge, MA: MIT Press.
   Google Scholar
• Batson, C. D., Early, S., & Salvarani, G. (1997). Perspective taking: Imagining how another feels versus imaging how you would feel. Personality and Social Psychology Bulletin, 23, 751–758. doi:10.1177/0146167297237008
   Web of Science ®Google Scholar
• Batson, C. D., Sager, K., Garst, E., Kang, M., Rubchinsky, K., & Dawson, K. (1997). Is empathy-induced helping due to self–other merging? Journal of Personality and Social Psychology, 73, 495–509. doi:10.1037/0022-3514.73.3.495
   Web of Science ®Google Scholar
• Bethlehem, R. A., Van Honk, J., Auyeung, B., & Baron-Cohen, S. (2013). Oxytocin, brain physiology, and functional connectivity: A review of intranasal oxytocin fMRI studies. Psychoneuroendocrinology, 38(7), 962–974. doi:10.1016/j.psyneuen.2012.10.011
   PubMed Web of Science ®Google Scholar
• Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002). Sniffing neuropeptides: A transnasal approach to the human brain. Nature Neuroscience, 5(6), 514–516. doi:10.1038/nn0602-849
   PubMed Web of Science ®Google Scholar
• Brown, L. M., Bradley, M. M., & Lang, P. J. (2006). Affective reactions to pictures of ingroup and outgroup members. Biological Psychology, 71(3), 303–311. doi:10.1016/j.biopsycho.2005.06.003
   PubMed Web of Science ®Google Scholar
• Bruneau, E. G., Dufour, N., & Saxe, R. (2012). Social cognition in members of conflict groups: Behavioural and neural responses in Arabs, Israelis and South Americans to each other’s misfortunes. Philosophical Transactions of the Royal Society, London, B Biological Sciences, 367(1589), 717–730.
   PubMed Web of Science ®Google Scholar
• Cheng, Y., Chen, C., Lin, C. P., Chou, K. H., & Decety, J. (2010). Love hurts: An fMRI study. Neuroimage, 51(2), 923–929. doi:10.1016/j.neuroimage.2010.02.047
   PubMed Web of Science ®Google Scholar
• Cohen, J. (1998). Statistical power analysis for the behavioral sciences (2nd ed.). Hillsdale, NJ: Erlbaum.
   Google Scholar
• Colonnello, V., Chen, F. S., Panksepp, J., & Heinrichs, M. (2013). Oxytocin sharpens self-other perceptual boundary. Psychoneuroendocrinology, 38(12), 2996–3002. doi:10.1016/j.psyneuen.2013.08.010
   PubMed Web of Science ®Google Scholar
• Danziger, N., Faillenot, I., & Peyron, R. (2009). Can we share a pain we never felt? Neural correlates of empathy in patients with congenital insensitivity to pain. Neuron, 61(2), 203–212. doi:10.1016/j.neuron.2008.11.023
   PubMed Web of Science ®Google Scholar
• De Dreu, C. K., Greer, L. L., Van Kleef, G. A., Shalvi, S., & Handgraaf, M. J. (2011). Oxytocin promotes human ethnocentrism. Proceedings of the National Academy of Sciences USA, 108(4), 1262–1266. doi:10.1073/pnas.1015316108
   PubMed Web of Science ®Google Scholar
• Decety, J., Chen, C., Harenski, C., & Kiehl, K. A. (2013). An fMRI study of affective perspective taking in individuals with psychopathy: Imagining another in pain does not evoke empathy. Frontiers in Human Neuroscience, 7, 489. doi:10.3389/fnhum.2013.00489
   PubMed Web of Science ®Google Scholar
• Decety, J., & Jackson, P. L. (2004). The functional architecture of human empathy. Behavioral and Cognitive Neuroscience Reviews, 3(2), 71–100. doi:10.1177/1534582304267187
   PubMedGoogle Scholar
• Decety, J., & Lamm, C. (2007). The role of the right temporoparietal junction in social interaction: How low-level computational processes contribute to meta-cognition. The Neuroscientist, 13(6), 580–593. doi:10.1177/1073858407304654
   PubMed Web of Science ®Google Scholar
• Decety, J., & Sommerville, J. A. (2003). Shared representations between self and other: A social cognitive neuroscience view. Trends in Cognitive Sciences, 7(12), 527–533. doi:10.1016/j.tics.2003.10.004
   PubMed Web of Science ®Google Scholar
• Decety, J., & Svetlova, M. (2012). Putting together phylogenetic and ontogenetic perspectives on empathy. Developmental Cognitive Neuroscience, 2(1), 1–24. doi:10.1016/j.dcn.2011.05.003
   PubMed Web of Science ®Google Scholar
• Di Simplicio, M., Massey-Chase, R., Cowen, P. J., & Harmer, C. J. (2009). Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers. Journal of Psychopharmacology, 23(3), 241–248. doi:10.1177/0269881108095705
   PubMed Web of Science ®Google Scholar
• Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007). Oxytocin improves “mind-reading” in humans. Biological Psychiatry, 61(6), 731–733. doi:10.1016/j.biopsych.2006.07.015
   PubMed Web of Science ®Google Scholar
• Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010). Effects of intranasal oxytocin on emotional face processing in women. Psychoneuroendocrinology, 35(1), 83–93. doi:10.1016/j.psyneuen.2009.06.016
   PubMed Web of Science ®Google Scholar
• Drwecki, B. B., Moore, C. F., Ward, S. E., & Prkachin, K. M. (2011). Reducing racial disparities in pain treatment: The role of empathy and perspective-taking. Pain, 152(5), 1001–1006. doi:10.1016/j.pain.2010.12.005
   PubMed Web of Science ®Google Scholar
• Echols, S., & Correll, J. (2012). It’s more than skin deep: Empathy and helping behavior across social groups. In J. Decety (Ed.), Empathy: from Bench to Bedside (pp. 55–71). Cambridge, MA: MIT Press.
   Google Scholar
• Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., & Pelphery, K. A. (2013). Oxytocin enhances brain function in children with autism. Proceedings of the National Academy of Sciences USA, 110(52), 20953–20958. doi:10.1073/pnas.1312857110
   PubMed Web of Science ®Google Scholar
• Goubert, L., Craig, K. D., Vervoort, T., Morley, S., Sullivan, M. J., Dec. Williams, A. C., … Crombez, G. (2005). Facing others in pain: The effects of empathy. Pain, 118(3), 285–288. doi:10.1016/j.pain.2005.10.025
   PubMed Web of Science ®Google Scholar
• Groppe, S. E., Gossen, A., Rademacher, L., Hahn, A., Westphal, L., Gründer, G., & Spreckelmeyer, K. N. (2013). Oxytocin influences processing of socially relevant cues in the ventral tegmental area of the human brain. Biological Psychiatry, 74(3), 172–179. doi:10.1016/j.biopsych.2012.12.023
   PubMed Web of Science ®Google Scholar
• Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010). Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders. Biological Psychiatry, 67(7), 692–694. doi:10.1016/j.biopsych.2009.09.020
   PubMed Web of Science ®Google Scholar
• Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008). Oxytocin increases gaze to the eye region of human faces. Biological Psychiatry, 63(1), 3–5. doi:10.1016/j.biopsych.2007.06.026
   PubMed Web of Science ®Google Scholar
• Hein, G., Silani, G., Preuschoff, K., Batson, C. D., & Singer, T. (2010). Neural responses to ingroup and outgroup members’ suffering predict individual differences in costly helping. Neuron, 68(1), 149–160. doi:10.1016/j.neuron.2010.09.003
   PubMed Web of Science ®Google Scholar
• Heinrichs, M., Von Dawans, B., & Domes, G. (2009). Oxytocin, vasopressin, and human social behavior. Frontiers in Neuroendocrinology, 30(4), 548–557. doi:10.1016/j.yfrne.2009.05.005
   PubMed Web of Science ®Google Scholar
• Hurlemann, R., Patin, A., Onur, O. A., Cohen, M. X., Baumgartner, T., Metzler, S., & Kendrick, K. M. (2010). Oxytocin enhances amygdala-dependent, socially reinforced learning and emotional empathy in humans. Journal of Neuroscience, 30(14), 4999–5007. doi:10.1523/JNEUROSCI.5538-09.2010
   PubMed Web of Science ®Google Scholar
• Jackson, P. L., Brunet, E., Meltzoff, A. N., & Decety, J. (2006). Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain. Neuropsychologia, 44(5), 752–761. doi:10.1016/j.neuropsychologia.2005.07.015
   PubMed Web of Science ®Google Scholar
• Jackson, P. L., Meltzoff, A. N., & Decety, J. (2005). How do we perceive the pain of others? A window into the neural processes involved in empathy. Neuroimage, 24(3), 771–779. doi:10.1016/j.neuroimage.2004.09.006
   PubMed Web of Science ®Google Scholar
• Juif, P. E., & Poisbeau, P. (2013). Neurohormonal effects of oxytocin and vasopressin receptor agonists on spinal pain processing in male rats. Pain, 154(8), 1449–1456. doi:10.1016/j.pain.2013.05.003
   PubMed Web of Science ®Google Scholar
• Kessner, S., Sprenger, C., Wrobel, N., Wiech, K., & Bingel, U. (2013). Effect of oxytocin on placebo analgesia: A randomized study. Jama, 310(16), 1733–1735. doi:10.1001/jama.2013.277446
   PubMed Web of Science ®Google Scholar
• Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., & Meyer-Lindenberg, A. (2005). Oxytocin modulates neural circuitry for social cognition and fear in humans. Journal of Neuroscience, 25(49), 11489–11493. doi:10.1523/JNEUROSCI.3984-05.2005
   PubMed Web of Science ®Google Scholar
• Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005). Oxytocin increases trust in humans. Nature, 435(7042), 673–676. doi:10.1038/nature03701
   PubMed Web of Science ®Google Scholar
• Lamm, C., Batson, C. D., & Decety, J. (2007). The neural substrate of human empathy: Effects of perspective-taking and cognitive appraisal. Journal of Cognitive Neuroscience, 19(1), 42–58.
   PubMed Web of Science ®Google Scholar
• Lamm, C., Decety, J., & Singer, T. (2011). Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain. Neuroimage, 54(3), 2492–2502. doi:10.1016/j.neuroimage.2010.10.014
   PubMed Web of Science ®Google Scholar
• Lamm, C., Nusbaum, H. C., Meltzoff, A. N., & Decety, J. (2007). What are you feeling? Using functional magnetic resonance imaging to assess the modulation of sensory and affective responses during empathy for pain. PLoS One, 2(12), e1292. doi:10.1371/journal.pone.0001292
   PubMed Web of Science ®Google Scholar
• Luminet, O., Grynberg, D., Ruzette, N., & Mikolajczak, M. (2011). Personality-dependent effects of oxytocin: Greater social benefits for high alexithymia scorers. Biological Psychology, 87(3), 401–406. doi:10.1016/j.biopsycho.2011.05.005
   PubMed Web of Science ®Google Scholar
• Lynn, S. K., Hoge, E. A., Fischer, L. E., Barrett, L. F., & Simon, N. M. (2014). Gender differences in oxytocin-associated disruption of decision bias during emotion perception. Psychiatry Research, 219(1), 198–203. doi:10.1016/j.psychres.2014.04.031
   PubMed Web of Science ®Google Scholar
• Olff, M., Frijling, J. L., Kubzansky, L. D., Bradley, B., Ellenbogen, M. A., Cardoso, C., & Van Zuiden, M. (2013). The role of oxytocin in social bonding, stress regulation and mental health: An update on the moderating effects of context and interindividual differences. Psychoneuroendocrinology, 38(9), 1883–1894. doi:10.1016/j.psyneuen.2013.06.019
   PubMed Web of Science ®Google Scholar
• Pedersen, C. A., Gibson, C. M., Rau, S. W., Salimi, K., Smedley, K. L., Casey, R. L., & Penn, D. L. (2011). Intranasal oxytocin reduces psychotic symptoms and improves Theory of Mind and social perception in schizophrenia. Schizophrenia Research, 132(1), 50–53. doi:10.1016/j.schres.2011.07.027
   PubMed Web of Science ®Google Scholar
• Perry, A., Bentin, S., Ben-Ami Bartal, I., Lamm, C., & Decety, J. (2010). “Feeling” the pain of those who are different from us: Modulation of EEG in the mu/alpha range. Cognitive Affective and Behavioral Neuroscience, 10(4), 493–504. doi:10.3758/CABN.10.4.493
   PubMed Web of Science ®Google Scholar
• Pincus, D., Kose, S., Arana, A., Johnson, K., Morgan, P. S., Borckardt, J., & Nahas, Z. (2010). Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: A double-blind placebo controlled FMRI study. Frontiers in Psychiatry, 1, 134. doi:10.3389/fpsyt.2010.00134
   Google Scholar
• Preston, S. D., & De Waal, F. B. (2002). Empathy: Its ultimate and proximate bases. Behavioral and Brain Sciences, 25(1), 1–20; discussion 20–71
   PubMed Web of Science ®Google Scholar
• Reniers, R. L., Völlm, B. A., Elliott, R., & Corcoran, R. (2014). Empathy, ToM, and self-other differentiation: An fMRI study of internal states. Social Neuroscience, 9(1), 50–62. doi:10.1080/17470919.2013.861360
   PubMed Web of Science ®Google Scholar
• Rosenfeld, A. J., Lieberman, J. A., & Jarskog, L. F. (2011). Oxytocin, dopamine, and the amygdala: A neurofunctional model of social cognitive deficits in schizophrenia. Schizophrenia Bulletin, 37(5), 1077–1087. doi:10.1093/schbul/sbq015
   PubMed Web of Science ®Google Scholar
• Ruby, P., & Decety, J. (2004). How would you feel versus how do you think she would feel? A neuroimaging study of perspective-taking with social emotions. Journal of Cognitive Neuroscience, 16(6), 988–999.
   PubMed Web of Science ®Google Scholar
• Shamay-Tsoory, S. G. (2011). The neural bases for empathy. The Neuroscientist, 17(1), 18–24. doi:10.1177/1073858410379268
   PubMed Web of Science ®Google Scholar
• Shamay-Tsoory, S. G., Abu-Akel, A., Palgi, S., Sulieman, R., Fischer-Shofty, M., Levkovitz, Y., & Decety, J. (2013). Giving peace a chance: Oxytocin increases empathy to pain in the context of the Israeli-Palestinian conflict. Psychoneuroendocrinology, 38(12), 3139–3144. doi:10.1016/j.psyneuen.2013.09.015
   PubMed Web of Science ®Google Scholar
• Shamay-Tsoory, S. G., Fischer, M., Dvash, J., Harari, H., Perach-Bloom, N., & Levkovitz, Y. (2009). Intranasal administration of oxytocin increases envy and schadenfreude (gloating). Biological Psychiatry, 66(9), 864–870. doi:10.1016/j.biopsych.2009.06.009
   PubMed Web of Science ®Google Scholar
• Singer, T., Snozzi, R., Bird, G., Petrovic, P., Silani, G., Heinrichs, M., & Dolan, R. J. (2008). Effects of oxytocin and prosocial behavior on brain responses to direct and vicariously experienced pain. Emotion, 8(6), 781–791. doi:10.1037/a0014195
   PubMed Web of Science ®Google Scholar
• Smith, K. E., Porges, E. C., Norman, G. J., Connelly, J. J., & Decety, J. (2014). Oxytocin receptor gene variation predicts empathic concern and autonomic arousal while perceiving harm to others. Social Neuroscience, 9(1), 1–9. doi:10.1080/17470919.2013.863223
   PubMed Web of Science ®Google Scholar
• Striepens, N., Kendrick, K. M., Maier, W., & Hurlemann, R. (2011). Prosocial effects of oxytocin and clinical evidence for its therapeutic potential. Frontiers in Neuroendocrinology, 32(4), 426–450. doi:10.1016/j.yfrne.2011.07.001
   PubMed Web of Science ®Google Scholar
• Sturmer, S., Snyder, M., Kropp, A., & Siem, B. (2006). Empathy-motivated helping: The moderating role of group membership. Personality and Social Psychology Bulletin, 32(7), 943–956. doi:10.1177/0146167206287363
   PubMed Web of Science ®Google Scholar
• Theodoridou, A., Rowe, A. C., & Mohr, C. (2013). Men perform comparably to women in a perspective taking task after administration of intranasal oxytocin but not after placebo. Frontiers in Human Neuroscience, 7, 197. doi:10.3389/fnhum.2013.00197
   PubMed Web of Science ®Google Scholar
• Van Der Heiden, L., Scherpiet, S., Konicar, L., Birbaumer, N., & Veit, R. (2013). Inter-individual differences in successful perspective taking during pain perception mediates emotional responsiveness in self and others: An fMRI study. Neuroimage, 65, 387–394. doi:10.1016/j.neuroimage.2012.10.003
   PubMed Web of Science ®Google Scholar
• Wright, S. C., Aron, A., & Tropp, L. R. (2002). Including others (and groups) in the self: Self expansion and intergroup relations. In J. P. Forgas & K. D. Williams (Eds.), The social self: Cognitive, interpersonal, and intergroup perspectives (pp. 343–363). New York, NY: Psychology Press.
   Google Scholar